Directional motion of forced polymer chains with hydrodynamic interaction

We study the propulsion of a one-dimensional (1D) polymer chain under sinusoidal external forces in the overdamped (low Reynolds number) regime. We show that, when hydrodynamical interactions are included, the polymer presents directional motion which depends on the phase differences of the external force applied along the chain. Moreover, the velocity shows a maximum as a function of the frequency. We discuss the relevance of all these results in light of recent nanotechnology experiments.Comment: 5 pages, 6 figure

Paths to equilibrium in non-conformal collisions

We extend our previous analysis of holographic heavy ion collisions in non-conformal theories. We provide a detailed description of our numerical code. We study collisions at different energies in gauge theories with different degrees of non-conformality. We compare four relaxation times: the hydrodynamization time (when hydrodynamics becomes applicable), the EoSization time (when the average pressure approaches its equilibrium value), the isotropization time (when the longitudinal and transverse pressures approach each other) and the condensate relaxation time (when the expectation value of a scalar operator approaches its equilibrium value). We find that these processes can occur in several different orderings. In particular, the condensate can remain far from equilibrium even long after the plasma has hydrodynamized and EoSized. We also explore the rapidity distribution of the energy density at hydrodynamization. This is far from boost-invariant and its width decreases as the non-conformality increases. Nevertheless, the velocity field at hydrodynamization is almost exactly boost-invariant regardless of the non-conformality. This result may be used to constrain the initialization of hydrodynamic fields in heavy ion collisions

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Paths to equilibrium in non-conformal collisions

We extend our previous analysis of holographic heavy ion collisions in non-conformal theories. We provide a detailed description of our numerical code. We study collisions at different energies in gauge theories with different degrees of non-conformality. We compare four relaxation times: the hydrodynamization time (when hydrodynamics becomes applicable), the EoSization time (when the average pressure approaches its equilibrium value), the isotropization time (when the longitudinal and transverse pressures approach each other) and the condensate relaxation time (when the expectation value of a scalar operator approaches its equilibrium value). We find that these processes can occur in several different orderings. In particular, the condensate can remain far from equilibrium even long after the plasma has hydrodynamized and EoSized. We also explore the rapidity distribution of the energy density at hydrodynamization. This is far from boost-invariant and its width decreases as the non-conformality increases. Nevertheless, the velocity field at hydrodynamization is almost exactly boost-invariant regardless of the non-conformality. This result may be used to constrain the initialization of hydrodynamic fields in heavy ion collisions

Are gait characteristics and ground reaction forces related to energy cost of running in elite Kenyan runners?

The aim of this study was to determine whether gait cycle characteristics are associated with running economy in elite Kenyan runners. Fifteen elite Kenyan male runners completed two constant-speed running sets on a treadmill (12 km ·h−1 and 20 km ·h−1). VO2 and respiratory exchange ratio values were measured to calculate steady-state oxygen and energy cost of running. Gait cycle characteristics and ground contact forces were measured at each speed. Oxygen cost of running at different velocities was 192.2 ± 14.7 ml· kg−1· km−1 at 12 km· h−1 and 184.8 ± 9.9 ml· kg−1· km−1 at 20 km· h−1, which corresponded to a caloric cost of running of 0.94 ± 0.07 kcal ·kg−1·km−1 and 0.93 ± 0.07 kcal· kg−1· km−1. We found no significant correlations between oxygen and energy cost of running and biomechanical variables and ground reaction forces at either 12 or 20 km· h−1. However, ground contact times were ~10.0% shorter (very large effect) than in previously published literature in elite runners at similar speeds, alongside an 8.9% lower oxygen cost (very large effect). These results provide evidence to hypothesise that the short ground contact times may contribute to the exceptional running economy of Kenyan runners.Sin financiación2.539 JCR (2016) Q2, 17/81 Sport Sciences1.280 SJR (2016) Q1, 31/280 Orthopedics and Sports Medicine, 18/195 Physical Therapy, Sports Therapy and Rehabilitation, 29/127 Sports ScienceNo data IDR 2016UE

Maintained cerebral oxygenation during maximal self-paced exercise in elite Kenyan runners

The purpose of this study was to analyze the cerebral oxygenation response to maximal self-paced and incremental exercise in elite Kenyan runners from the Kalenjin tribe. On two separate occasions, 15 elite Kenyan distance runners completed a 5-km time trial (TT) and a peak treadmill speed test (PTS). Changes in cerebral oxygenation were monitored via near-infrared spectroscopy through concentration changes in oxy- and deoxyhemoglobin (Δ[O2Hb] and Δ[HHb]), tissue oxygenation index (TOI), and total hemoglobin index (nTHI). During the 5-km TT (15.2 ± 0.2 min), cerebral oxygenation increased over the first half (increased Δ[O2Hb] and Δ[HHb]) and, thereafter, Δ[O2Hb] remained constant (effect size, ES = 0.33, small effect), whereas Δ[HHb] increased until the end of the trial (P < 0.05, ES = 3.13, large effect). In contrast, during the PTS, from the speed corresponding to the second ventilatory threshold, Δ[O2Hb] decreased (P < 0.05, ES = 1.51, large effect), whereas Δ[HHb] continued to increase progressively until exhaustion (P < 0.05, ES = 1.22, large effect). Last, the TOI was higher during the PTS than during the 5-km TT (P < 0.001, ES = 3.08; very large effect), whereas nTHI values were lower (P < 0.001, ES = 2.36, large effect). This study shows that Kenyan runners from the Kalenjin tribe are able to maintain their cerebral oxygenation within a stable range during a self-paced maximal 5-km time trial, but not during an incremental maximal test. This may contribute to their long-distance running success.Sin financiación3.004 JCR (2015) Q1, 12/82 Sport Sciences; Q2, 27/83 PhysiologyUE

Brain oxygenation declines in elite Kenyan runners during a maximal interval training session

Sin financiación2.401 JCR (2017) Q2, 27/81 Sport sciences; Q3, 45/83 Physiology1.186 SJR (2017) Q1, 435/2878 Medicine (miscellaneous), 37/285 Orthopedics and Sports Medicine, 80/554 Public Health, Environmental and Occupational Health, 29/127 Sports Science; Q2, 36/107 Physiology (medical)No data IDR 2017UE

Thermodynamics, transport and relaxation in non-conformal theories

We study the equilibrium and near-equilibrium properties of a holographic five-dimensional model consisting of Einstein gravity coupled to a scalar field with a non-trivial potential. The dual four-dimensional gauge theory is not conformal and, at zero temperature, exhibits a renormalisation group flow between two different fixed points. We quantify the deviations from conformality both in terms of thermodynamic observables and in terms of the bulk viscosity of the theory. The ratio of bulk over shear viscosity violates Buchel’s bound. We study relaxation of small-amplitude, homogeneous perturbations by computing the quasi-normal modes of the system at zero spatial momentum. In this approximation we identify two different relaxation channels. At high temperatures, the different pressures first become approximately equal to one another, and subsequently this average pressure evolves towards the equilibrium value dictated by the equation of state. At low temperatures, the average pressure first evolves towards the equilibrium pressure, and only later the different pressures become approximately equal to one another