The discovery of an evolving dust scattered X-ray halo around GRB 031203

We report the first detection of a time-dependent, dust-scattered X-ray halo around a gamma-ray burst. GRB 031203 was observed by XMM-Newton starting six hours after the burst. The halo appeared as concentric ring-like structures centered on the GRB location. The radii of these structures increased with time as t^{1/2}, consistent with small-angle X-ray scattering caused by a large column of dust along the line of sight to a cosmologically distant GRB. The rings are due to dust concentrated in two distinct slabs in the Galaxy located at distances of 880 and 1390 pc, consistent with known Galactic features. The halo brightness implies an initial soft X-ray pulse consistent with the observed GRB.Comment: 4 pages. 4 figures. Accepted for publication in ApJ Letter

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project

INTRODUCTION: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. RESULTS: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. DISCUSSION: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series

Steps toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei. XIII. Ultraviolet Observations of the Broad-Line Radio Galaxy 3C 390.3

As part of an extensive multi-wavelength monitoring campaign, the International Ultraviolet Explorer satellite was used to observe the broad-line radio galaxy 3C 390.3 during the period 1994 December 31-1996 March 5. Spectra were obtained every 6È10 days. The UV continuum varied by a factor of 7 through the campaign, while the broad emission lines varied by factors of 2È5. Unlike previously monitored Seyfert 1 galaxies, in which the X-ray continuum generally varies with a larger amplitude than the UV, in 3C 390.3 the UV continuum light curve is similar in both amplitude and shape to the X-ray light curve observed by ROSAT . The UV broad emission-line variability lags that of the UV continuum by 35È70 days for Lyα and C IV, values larger than those found for Seyfert 1 galaxies of comparable UV luminosity. These lags are also larger than those found for the Balmer lines in 3C 390.3 over the same period. The red and blue wings of C IV and Lyα vary in phase, suggesting that radial motion does not dominate the kinematics of the UV line-emitting gas. Comparison with archival data provides evidence for velocity-dependent changes in the Lyα and C IV line profiles, indicating evolution in the detailed properties and/or distribution of the broad-line emitting gas. Joint Institute for Nuclear Research, Dubna, Russi