Atypical presentation of pellucid marginal degeneration: case report

The authors report an unusual clinical presentation of pellucid marginal degeneration with 360º peripheral corneal thinning diagnosed in a younger male patient. We discuss the findings of topographic maps, ultrasound pachymetry and the proposed treatment.Os autores relatam o caso de paciente jovem do sexo masculino que desenvolveu quadro de degeneração marginal pelúcida bilateral atípica, com afinamento corneal periférico de 360º, abordando ainda os aspectos dos mapas topográficos e os resultados obtidos com a paquimetria ultra-sônica, além do tratamento adotado.Hospital Oftalmológico de SorocabaHospital Oftalmológico de Sorocaba Setor de CórneaHospital Oftalmológico de Sorocaba Setor de Córnea e Doenças ExternasPontifícia Universidade Católica de SorocabaUNIFESP Departamento de OftalmologiaUNIFESP, Depto. de OftalmologiaSciEL

Intracranial hypertension with ocular manifestation during the use of tetracycline: case report

The authors describe a young female patient with intracranial hypertension associated with ocular manifestations, during treatment with tetracycline. This is a rare adverse effect described in the medication warnings, and in a few reported cases in the scientific literature.Os autores relatam o caso de uma paciente jovem, do sexo feminino, que desenvolveu quadro de hipertensão intracraniana benigna com manifestações oculares em concomitância ao uso de tetraciclina para o tratamento de otite. Esta é uma reação adversa rara deste medicamento, descrito em bula e com alguns relatos de caso em literatura internacional.Hospital oftalmológico de SorocabaUniversidade Federal de São Paulo (UNIFESP)Pontifícia Universidade Católica de SorocabaUNIFESPSciEL

Investigação cinética da pirólise de biomassa amazônica por termogravimetria / Kinetic investigation of amazon biomass pyrolysis by thermogravimetry

A energia presente na biomassa pode ser aproveitada através de processos de conversão que a transformam em combustíveis líquidos, sólidos e gasosos. O Brasil apresenta grandes dimensões cultiváveis de biomassas agrícolas e florestais que geram grande quantidade de resíduos e podem ser utilizados para a geração de energia. Este trabalho teve como objetivo investigar o comportamento térmico e realizar o estudo cinético da pirólise de biomassa amazônica in natura e torrada através de uma série de ensaios de análise imediata e termogravimétrica em atmosfera não oxidante em diversas taxas de aquecimento: 5, 10, 20 e 30 K/min. As curvas termogravimétricas foram submetidas à avaliação cinética por métodos dinâmicos. Verificou-se as três estapas da pirolise de biomassas lignocelulósica: remoção da água, pirólise ativa e pirolise passiva. Na etapa considerada de pirólise ativa, a energia de ativação e o fator pré-exponencial variaram com a conversão de massa para os modelos cinéticos considerados. Os parâmetros cinéticos foram determinados pelos métodos: Kissinger, Kissinger-Akahira-Sunose (KAS), Flynn-Wall-Ozawa (FWO) e Friedman. O processo de volatização foi matematicamente descrito por uma reação de primeira ordem

AGREEMENT ON MRI DIAGNOSIS IN COMPRESSIVE MALIGNANT VERTEBRAL FRACTURES

ABSTRACT Objective: Verify interobserver and intraobserver agreement of malignant compressive vertebral fractures (MCVF) diagnosis using magnetic resonance imaging (MRI). Methods: We retrospectively included a lumbar spine MRI of 63 patients with non-traumatic compressive vertebral fracture diagnoses. Each lumbar vertebra was classified as: without fracture, with fracture of benign characteristics, or with fracture of malignant characteristics. Two medical residents in radiology, one musculoskeletal radiologist fellow, one musculoskeletal radiologist, and two spine surgeons evaluated MRI exams, independently and blindly. Each observer performed two readings, with a 15-day interval between evaluations. A simple Kappa coefficient was used to calculate the intra and interobserver agreement. The reference standard classification was based on bone biopsy or clinical, and imaging follow-up of at least two years, for diagnostic performance analysis. Diagnostic performance was assessed by calculating sensitivity, specificity, accuracy, and positive and negative predictive values with a 95% confidence interval (CI). Results: We observed substantial to perfect intraobserver agreement (kappa: 0.80 to 1.00) and substantial interobserver agreement (kappa 0.64 to 0.77). In general, the sensitivity for the detection of MCVF was moderate, except for the second-year radiology resident that achieved a lower sensitivity. The specificity, accuracy, and negative predictive value were high for all observers. Conclusion: MCVF diagnosis using MRI showed substantial interobserver agreement. The second-year medical resident achieved lower sensitivity but high specificity for MCVF. Regarding the seniors, there was no statistical significance between spine surgeons and the musculoskeletal radiologist. Level of Evidence III; Diagnostic

Pharmacokinetic interactions between clopidogrel and rosuvastatin: Effects on vascular protection in subjects with coronary heart disease

Universidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, BrazilUniv São Paulo, Inst Phys, Natl Inst Complex Fluids, São Paulo, BrazilGaleno Lab, Campinas, SP, BrazilUniversidade Federal de São Paulo, Dept Med, Div Cardiol, São Paulo, BrazilWeb of Scienc

Chemical Composition and Antibacterial Activity of the Essential Oil of <em>Mesosphaerum suaveolens</em> (Lamiaceae)

Mesosphaerum suaveolens (Lamiaceae) is a medicinal plant commonly used in Brazil for the treatment of diseases related to the digestive tract and respiratory diseases, so we hypothesized that the essential oil of this species may have antibacterial activity. Thus, we aimed to evaluate the in vitro antibacterial and modulatory activity of the essential oil of M. suaveolens as well as to characterize its chemical composition. The identification of the constituents was performed by gas chromatography-flame ionization detector (GC-FID) and the antibacterial and modulating activity by the plate microdilution method. We found the oil had sesquiterpene β-caryophyllene as the major component. This compound may account for the antibacterial activity against Staphylococcus aureus strains, since the essential oil had a MIC of 64 μg/mL for the standard strain and 256 μg/mL for the multiresistant strain, demonstrated that the oil does not exhibit drug modulating activity. Thus, M. suaveolens oil has bioactive compounds which can be used in the preparation of drugs

I Diretriz brasileira de cardio-oncologia pediátrica da Sociedade Brasileira de Cardiologia

Sociedade Brasileira de Oncologia PediátricaUniversidade Federal de São Paulo (UNIFESP) Instituto de Oncologia Pediátrica GRAACCUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo Faculdade de Medicina Instituto do Coração do Hospital das ClínicasUniversidade Federal do Rio Grande do Sul Hospital de Clínicas de Porto AlegreInstituto Materno-Infantil de PernambucoHospital de Base de BrasíliaUniversidade de Pernambuco Hospital Universitário Oswaldo CruzHospital A.C. CamargoHospital do CoraçãoSociedade Brasileira de Cardiologia Departamento de Cardiopatias Congênitas e Cardiologia PediátricaInstituto Nacional de CâncerHospital Pequeno PríncipeSanta Casa de Misericórdia de São PauloInstituto do Câncer do Estado de São PauloUniversidade Federal de São Paulo (UNIFESP) Departamento de PatologiaHospital Infantil Joana de GusmãoUNIFESP, Instituto de Oncologia Pediátrica GRAACCUNIFESP, Depto. de PatologiaSciEL