Comparison of physiological and psychobiological acute responses between high intensity functional training and high intensity continuous training

Little is known about the physiological and psychobiological responses that occur during and after high intensity functional training (HIFT). We compared physiological and psychobiological responses during and after a HIFT session with a high intensity continuous training (HICT) session. Twenty-one trained and healthy men were submitted to 20-min session of HIFT and HICT on separate days. The heart rate, blood lactate concentration [Lac], levels of state anxiety, rates of perceived exertion (RPE) and perceived discomfort (RPE-D), and affective valence were measured. Exercise intensity of the HICT was adjusted to the mean heart rate obtained in the HIFT session. The highest heart rate in the training sessions was significantly higher in HIFT (mean ​± ​standard deviation [SD]: [187 ​± ​9] bpm) than in HICT (mean ​± ​SD: [178 ​± ​8] bpm, p ​< ​0.001). The [Lac] was significantly higher immediately after the HIFT (median [interquartile range (IQR)]: 6.8 [4.4] mmol/L) than the HICT (median [IQR]: 3.2 [1.9], p ​= ​0.021) and 10 ​min after (median [IQR]: HIFT ​= ​6.8 [4.9] mmol/L, HICT ​= ​2.9 [2.4] mmol/L, p ​= ​0.003). The RPE was also significantly higher in the HIFT (median [IQR]: HIFT ​= ​20 [2], HICT ​= ​15 [5], p ​= ​0.009). The physiological and psychobiological responses compared between HIFT and HICT sessions are similar, except for the higher heart rate obtained during the sessions, [Lac] and RPE. Probably, the results found for the higher heart rate obtained during the sessions, [Lac] and RPE may be explained by the higher participation of the anaerobic glycolytic metabolism during the HIFT session

Motivation for Brazilian Older Adult Women to Join a Community Physical Activity Program Before COVID-19 Pandemic

Background: Intrinsic and extrinsic motivational factors can affect the levels of adherence of physical activity (PA) during the aging process. Objectives: Investigate the intrinsic and extrinsic aspects and motivation that led older women to enroll in and adhere to a community PA program before the COVID-19 pandemic. Methods: Data were collected via transversal survey before the COVID-19 pandemic. The sample consisted of 21 women, participants of a PA workshop, aged between 60 to 86 years [< 1-year (n = 8) and ≥ 1-year (n = 13) groups]. Motivation was assessed by the Motivation Inventory for Regular Physical Activity Practice (IMPRAF-54), using the 60th percentile to categorize high and low motivation, and two open questions. For qualitative assessment, content analysis was used and the answers were framed into subcategories regarding the motivation factors for adherence and permanence. Results: That adherence to the program was motivated by sociability purposes [total score: 36.0 (6.0), median (interquartile range)] and pleasure [34.0; (6.0)], while the main motivation for permanence was health [40.0 (11.0)]. Differences were noticed between the groups for sociability [38.0 (3.0) P = 0.030] and competitiveness [9.50 (12.0); P = 0.037] highest medians for the < 1 year group. Furthermore, the factors that least motivated older women were competitiveness and aesthetics. Conclusions: Health and sociability were the main motivators for the practice of physical activity among older adult women. Motivation played a fundamental role in the permanence of older adult women in the physical activity program

Environmental Implications of a Stabilization Pond Effluent Released in Paraná River at Ilha Solteira, Brazil: The Quality of Water and Sediment

Sewage treatment plants in Ilha Solteira City, which consist of stabilization ponds, have been modifying water and sediment characteristics around sewage outfall area. Water quality parameters such as dissolved oxygen (OD) and conductivity were directly influenced by the sewage outfall. OD values were reported before (6.36 mg L-1) and after (2.94 mg L-1) the sewage outfall. Measurement of organic matter content in the sediment showed the same pattern, with values of 1.34% and 4.80% for the SP1 and SP3 samples, respectively. A copper and zinc analysis indicated that metals are being transported through the water column, and SP3 is an important sedimentation zone. The total concentrations reported for copper are 6.48, 26.97, 37.54, 27.12 and 18.55 mg kg-1&nbsp;for SP1, SP2, SP3, SP4 and SP5, respectively, and the total concentrations for zinc are 11.21, 48.53, 67.41, 58.62 and 24.76 mg kg-1. Bureau Community of Reference (BCR) sequential extraction indicated the following bioavailability order of copper and zinc: SP1 &lt; SP5 &lt; SP4 &lt; SP3 &lt; SP2. At SP2, more than 70% of the copper and zinc is found in bioavailable fractions. Benthic organism’s analysis indicates that the Oligochaetes correlation with organic matter content is related to the decrease in water quality. DOI:&nbsp;http://dx.doi.org/10.17807/orbital.v7i4.77

A Comprehensive Workflow for General-Purpose Neural Modeling with Highly Configurable Neuromorphic Hardware Systems

In this paper we present a methodological framework that meets novel requirements emerging from upcoming types of accelerated and highly configurable neuromorphic hardware systems. We describe in detail a device with 45 million programmable and dynamic synapses that is currently under development, and we sketch the conceptual challenges that arise from taking this platform into operation. More specifically, we aim at the establishment of this neuromorphic system as a flexible and neuroscientifically valuable modeling tool that can be used by non-hardware-experts. We consider various functional aspects to be crucial for this purpose, and we introduce a consistent workflow with detailed descriptions of all involved modules that implement the suggested steps: The integration of the hardware interface into the simulator-independent model description language PyNN; a fully automated translation between the PyNN domain and appropriate hardware configurations; an executable specification of the future neuromorphic system that can be seamlessly integrated into this biology-to-hardware mapping process as a test bench for all software layers and possible hardware design modifications; an evaluation scheme that deploys models from a dedicated benchmark library, compares the results generated by virtual or prototype hardware devices with reference software simulations and analyzes the differences. The integration of these components into one hardware-software workflow provides an ecosystem for ongoing preparative studies that support the hardware design process and represents the basis for the maturity of the model-to-hardware mapping software. The functionality and flexibility of the latter is proven with a variety of experimental results

Comparing autism phenotypes in children born extremely preterm and born at term

Children born preterm are at increased risk for autism spectrum disorder (ASD). There is limited knowledge about whether ASD phenotypes in children born preterm differ from children born at term. The objective of this study was to compare ASD core symptoms and associated characteristics among extremely preterm (EP) and term-born children with ASD. EP participants (n = 59) from the Extremely Low Gestational Age Newborn Study who met diagnostic criteria for ASD at approximately 10 years of age were matched with term-born participants from the Simons Simplex Collection on age, sex, spoken language level, and nonverbal IQ. Core ASD symptomatology was evaluated with the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). Developmental milestones, anthropometrics, seizure disorder, and psychiatric symptoms were also investigated. The EP group had lower parent-reported symptom scores on ADI-R verbal communication, specifically stereotyped language, and restricted, repetitive behaviors. There were no between-group differences on ADI-R nonverbal communication and ADI-R reciprocal social interaction or with direct observation on the ADOS-2. The EP group was more likely to have delayed speech milestones and lower physical growth parameters. Results from female-only analyses were similar to those from whole-group analyses. In sum, behavioral presentation was similar between EP and IQ- and sex-matched term-born children assessed at age 10 years, with the exception of less severe retrospectively reported stereotyped behaviors, lower physical growth parameters, and increased delays in language milestones among EP-born children with ASD

Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population

In the current model of early Solar System evolution, the stable members of the Jovian and Neptunian Trojan populations were captured into resonance from the leftover reservoir of planetesimals during the outward migration of the giant planets. As a result, both Jovian and Neptunian Trojans share a common origin with the primordial disk population, whose other surviving members constitute today's trans-Neptunian object (TNO) populations. The cold classical TNOs are ultra-red, while the dynamically excited "hot" population of TNOs contains a mixture of ultra-red and blue objects. In contrast, Jovian and Neptunian Trojans are observed to be blue. While the absence of ultra-red Jovian Trojans can be readily explained by the sublimation of volatile material from their surfaces due to the high flux of solar radiation at 5AU, the lack of ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation models. In this work we report the discovery by the Dark Energy Survey (DES) of two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both with inclinations i >30 degrees, making them the highest-inclination known stable Neptunian Trojans. We have measured the colors of these and three other dynamically stable Neptunian Trojans previously observed by DES, and find that 2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such, 2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using a simulation of the DES TNO detection efficiency, we find that there are 162 +/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based on this result, we discuss the possible origin of the ultra-red Neptunian Trojan population and its implications for the formation history of Neptunian Trojans

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease

Chronic beryllium disease (CBD) is a granulomatous disorder characterized by an influx of beryllium (Be)-specific CD4+ T cells into the lung. The vast majority of these T cells recognize Be in an HLA-DP–restricted manner, and peptide is required for T cell recognition. However, the peptides that stimulate Be-specific T cells are unknown. Using positional scanning libraries and fibroblasts expressing HLA-DP2, the most prevalent HLA-DP molecule linked to disease, we identified mimotopes and endogenous self-peptides that bind to MHCII and Be, forming a complex recognized by pathogenic CD4+ T cells in CBD. These peptides possess aspartic and glutamic acid residues at p4 and p7, respectively, that surround the putative Be-binding site and cooperate with HLA-DP2 in Be coordination. Endogenous plexin A peptides and proteins, which share the core motif and are expressed in lung, also stimulate these TCRs. Be-loaded HLA-DP2–mimotope and HLA-DP2–plexin A4 tetramers detected high frequencies of CD4+ T cells specific for these ligands in all HLA-DP2+ CBD patients tested. Thus, our findings identify the first ligand for a CD4+ T cell involved in metal-induced hypersensitivity and suggest a unique role of these peptides in metal ion coordination and the generation of a common antigen specificity in CBD

CD4\u3csup\u3e+\u3c/sup\u3e T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope

Löfgren’s syndrome (LS) is an acute form of sarcoidosis characterized by a genetic association with HLA-DRB1*03 (HLA-DR3) and an accumulation of CD4+ T cells of unknown specificity in the bronchoalveolar lavage (BAL). Here, we screened related LS-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 (NDPD) of Aspergillus nidulans that stimulated these CD4+ T cells in an HLA-DR3–restricted manner. Using ELISPOT analysis, a greater number of IFN-γ– and IL-2–secreting T cells in the BAL of DR3+ LS subjects compared with DR3+ control subjects was observed in response to the NDPD peptide. Finally, increased IgG antibody responses to A. nidulans NDPD were detected in the serum of DR3+ LS subjects. Thus, our findings identify a ligand for CD4+ T cells derived from the lungs of LS patients and suggest a role of A. nidulans in the etiology of LS