Intellectual property framework responses to health emergencies – options for Africa.

We debate whether intellectual property (IP) protection of medical products and devices required to prevent, treat and contain COVID-19 should be waived, as proposed by South Africa and India, under the World Trade Organization (WTO)’s Agreement on Trade-related aspects of Intellectual Property Rights (TRIPS Agreement). We discuss existing public policy mechanisms under the TRIPS Agreement and how these have been implemented at national level in Africa, and find that these have proven inadequate and that they have been sub-optimally implemented. We then consider the TRIPS Waiver proposal which has been tabled due to the inadequacy of existing mechanisms and outline the EU’s counter proposal which is founded on existing mechanisms. Both proposals have served at multiple WTO council meetings and would have been the subject of the 2021 WTO Ministerial Conference, which was postponed and is now set to be held in June 2022. Meanwhile, the proposal has been the subject of negotiations between India, South Africa, the EU and the USA (‘the quad’) and, as of May 2022, has been opened for consideration by all Members. Whatever the outcome of WTO deliberations, African states must take necessary national IP regulatory reforms and cooperate at sub-regional and continental level to improve access to medical products and devices to meet their citizenry’s healthcare needs.Significance:• There is need for a sustainable and comprehensive intellectual property framework that is responsive to health emergencies. Existing public policy mechanisms have not proven effective.• Adaptation and innovation are required at the international norm-setting level as evidenced by the two inprogress proposals for a TRIPS Agreement waiver and for an International Treaty on Pandemics. Both are contested and may only actualise in the medium to long term.• In the context of such uncertainty and delay, timely action should be taken at national level, through legislative reform coupled with necessary manufacturing capacity, which will be boosted by cooperation between African states

Sedimentary organic carbon and nitrogen stocks of intertidal seagrass meadows in a dynamic and impacted wetland: Effects of coastal infrastructure constructions and meadow establishment time

Seagrass meadows, through their large capacity to sequester and store organic carbon in their sediments, contribute to mitigate climatic change. However, these ecosystems have experienced large losses and degrada-tion worldwide due to anthropogenic and natural impacts and they are among the most threatened ecosystems on Earth. When a meadow is impacted, the vegetation is partial-or completely lost, and the sediment is exposed to the atmosphere or water column, resulting in the erosion and remineralisation of the carbon stored. This paper addresses the effects of the construction of coastal infrastructures on sediment properties, organic carbon, and total nitrogen stocks of intertidal seagrass meadows, as well as the size of such stocks in relation to meadow establishing time (recently and old established meadows). Three intertidal seagrass meadows impacted by coastal constructions (with 0% seagrass cover at present) and three adjacent non-impacted old-established meadows (with 100% seagrass cover at present) were studied along with an area of bare sediment and two recent-established seagrass meadows. We observed that the non-impacted areas presented 3-fold higher per-centage of mud and 1.5 times higher sedimentary organic carbon stock than impacted areas. Although the impacted area was relatively small (0.05-0.07 ha), coastal infrastructures caused a significant reduction of the sedimentary carbon stock, between 1.1 and 2.2 Mg OC, and a total loss of the carbon sequestration capacity of the impacted meadow. We also found that the organic carbon stock and total nitrogen stock of the recent -established meadow were 30% lower than those of the old-established ones, indicating that OC and TN accu-mulation within the meadows is a continuous process, which has important consequences for conservation and restoration actions. These results contribute to understanding the spatial variability of blue carbon and nitrogen stocks in coastal systems highly impacted by urban development.info:eu-repo/semantics/publishedVersio

The 9-Anthroate chromophore as a fluorescent probe for water

Water quenches the fluorescence of methyl 9-anthroate with a rate constant showing little dependence on solvent viscosity or polarity. In dioxane, at 20ºC the value of the rate constant is 9.6 X 10^6 M^(-1) s^(-1) , and the activation energy found for the process is 14.1 kJ mol^(-1). The quenching process is entropy-controlled and is likely to involve a hydrogen-bonded complex as an intermediate. Since the fluorescence lifetime of methyl 9-anthroate does not depend on the solvent properties other than its hydrogen-bonding ability, the concentration of nearby water can be estimated directly. Values of 3, 54, and 14 M were obtained for the solubilization site of methyl 9-anthroate in micelles of Triton X-100, sodium dodecyl sulfate (SDS), and dodecyltrimethylammonium chloride (DTAC), respectively. From the ring current effect of the anthroate group on the 'H NMR chemical shifts of the surfactant protons, it is concluded that the anthroate fluorescent probe is preferentially located in the surface region of the SDS and DTAC micelles; however, in Triton X-100, it resides in the micelle interior near the phenoxy groups of the surfactant molecule

New aspect in seagrass acclimation: leaf mechanical properties vary spatially and seasonally in the temperate species Cymodocea nodosa Ucria (Ascherson)

Seagrasses may acclimate to environmental heterogeneity through phenotypic plasticity. In contrast to leaf morphology, which has been a central point in seagrass acclimation studies, plasticity in leaf biomechanics and fibre content is poorly understood, despite being crucial in plant ecological performance, especially regarding physical forces. We hypothesised that mechanical traits (e.g. breaking force, strength, toughness, and stiffness) and fibre content of seagrass leaves vary as morphology does under differential environments. Cymodocea nodosa was seasonally monitored at three locations around Ca´diz Bay (southern Spain) with hydrodynamic regime as the most noticeable difference between them. Leaves showed plasticity in both morphology and mechanical traits, with wave-exposed individuals presenting short but extensible and tough leaves. Leaf fibre content was invariant along the year and with little spatial variability. Cross-sectional area rather than material properties or fibre content differentiates leaf mechanical resistance. Seagrass capacity to thrive under a range of mechanical forces may be dictated by their plasticity in morpho-biomechanical traits, a key element for the hydrodynamical performance and, hence, for species colonisation and distribution.info:eu-repo/semantics/publishedVersio

Exportações de calçados na Paraíba- uma análise da competitividade sistêmica

"A reestruturação do setor produtivo em decorrência do processo de abertura comercial e privatizações além de exigir um aumento de eficiência e competitividade na indústria nacional favoreceram a entrada de concorrentes estrangeiros e dificultaram as exportações nacionais. Estas pressões competitivas incentivaram o deslocamento de empresas calçadistas em direção à região Nordeste, em particular para o estado da Paraíba, o qual se destacou como exportador em decorrência de vantagens competitivas “espúrias”, tais como, disponibilidade e baixo custo da mão-de-obra e incentivos fiscais, as quais não garantem sustentabilidade de longo prazo. O presente estudo busca destacar a importância do desenvolvimento da infra-estrutura física e institucional local como fator sistêmico de competitividade para o futuro da indústria exportadora de calçados localizada no estado da Paraíba. Para efetivar esse objetivo houve aplicações de questionários e de entrevista aos empresários e instituições ligadas diretamente ao setor calçadista paraibano. O resultado da análise desses dados primários e secundários foi que a infra-estrutura institucional tem um maior impacto sobre a competitividade presente do setor no Estado. E, que a infra-estrutura física se constitui em um obstáculo à competitividade futura do setor. "

Robótica'2001 - Festival Nacional de Robótica

O ROBÓTICA’2001 – Festival Nacional de Robótica visa promover desenvolvimentos técnicos e científicos na área da Robótica Móvel e áreas afins (electrónica, mecânica, programação, visão por computador, inteligência artificial, navegação, controlo, etc) através de um problema motivador, a ser resolvido por diferentes grupos de investigadores e estudantes. Procura-se ainda difundir a Ciência e a Tecnologia junto do público em geral e dos jovens em particular, nomeadamente motivando estes últimos para a aprendizagem experimental da Ciência. O objectivo principal dos participantes no evento deverá ser pois aprender e partilhar a sua aprendizagem com os colegas, tendo em vista a evolução da Robótica. Este evento consistiu em três actividades paralelas: uma competição de robótica móvel (em duas modalidades), um encontro científico e ainda várias demonstrações de outros robôs móveis e/ou autónomos

Effects of Sensory Behavioral Tasks on Pain Threshold and Cortical Excitability

Background/objective: Transcutaneous electrical stimulation has been proven to modulate nervous system activity, leading to changes in pain perception, via the peripheral sensory system, in a bottom up approach. We tested whether different sensory behavioral tasks induce significant effects in pain processing and whether these changes correlate with cortical plasticity. Methodology/principal findings: This randomized parallel designed experiment included forty healthy right-handed males. Three different somatosensory tasks, including learning tasks with and without visual feedback and simple somatosensory input, were tested on pressure pain threshold and motor cortex excitability using transcranial magnetic stimulation (TMS). Sensory tasks induced hand-specific pain modulation effects. They increased pain thresholds of the left hand (which was the target to the sensory tasks) and decreased them in the right hand. TMS showed that somatosensory input decreased cortical excitability, as indexed by reduced MEP amplitudes and increased SICI. Although somatosensory tasks similarly altered pain thresholds and cortical excitability, there was no significant correlation between these variables and only the visual feedback task showed significant somatosensory learning. Conclusions/significance: Lack of correlation between cortical excitability and pain thresholds and lack of differential effects across tasks, but significant changes in pain thresholds suggest that analgesic effects of somatosensory tasks are not primarily associated with motor cortical neural mechanisms, thus, suggesting that subcortical neural circuits and/or spinal cord are involved with the observed effects. Identifying the neural mechanisms of somatosensory stimulation on pain may open novel possibilities for combining different targeted therapies for pain control