Facing the Trial of Internationalizing Clinical Trials to Developing Countries: Some Evidence from Mexico

In pursuit of innovation, developing countries play an increasingly relevant role for multinational pharmaceutical firms. Driven partly by cost considerations but also by some host country-specific scientific and technological factors, global drug companies increasingly relocate part of their drug development activities to those countries. In particular, expansion of clinical trials performed in some of the more advanced developing countries is notable over the last years. This paper critically addresses some of these issues with particular reference to Mexico. The latter case equally illustrates some challenges developing countries face to accommodate and govern local performance of clinical trials according to strict internationally accepted regulatory and ethical principles.Internationalization of R&D, Governance of clinical trials, Developing countries, Mexico

Human resource management and learning for innovation: pharmaceuticals in Mexico

This paper investigates the influence of human resource management on learning from internal and external sources of knowledge. Learning for innovation is a key ingredient of catching-up processes. The analysis builds on survey data about pharmaceutical firms in Mexico. Results show that the influence of human resource management is contingent on the knowledge flows and innovation goals pursued by the firm. Practices such as training-- particularly from external partners; and remuneration for performance are conducive to learning for innovation.Learning, R&D, human resource management, pharmaceuticals, Mexico

Formulas for Consumer Price Index at the elementary aggregate - A new proposal from the economic point of view

The price level in the aggregate economy and, more concretely, controlling its changes, has become one of the high-priority objectives within the framework of the regional macroeconomic analysis. Its different evolution could modify the interregional capital and commercial flows, being able to cause strong shocks, and of asymmetric nature, in each economy. The first step to reach this objective is obtaining a trustworthy and comparable measurement of the inflation in the different regions to be compared. The Index Number Theory is then used to calculate Consumer Price Indexes (CPI) the regional level. The calculation of CPI is made, at least, in two phases. In the first one, Elementary Price Index is considered (EPI). In the second and later phases, these EPI are combined, along with weighting information based on household’s expenditure, to obtain CPI for different aggregation levels to the country level. As previous step to the calculation of the IPE and CPI, the set of goods and services has to be defined based on households’ consumption behaviour. These sets are grouped in layers, named elementary aggregates, based on their homogeneity of satisfying consumer’s necessities. The COICOP (Classification Of Individual Consumption by Purpose) has important implications at the time of analyzing the behaviour of the consumer within each elementary aggregate, because of a high possibility of substitution between products. Nevertheless, this possibility diminishes and can get to be null when the goods and services satisfy necessities with very different nature. Whether what is wanted it is to calculate an EPI that correctly reflects the consumer behaviour, the described homogenous character cannot be forgotten, especially if, in addition, we take into account that National Statistics Agencies have no expenditure information available for weighting purposes, only data of prices to calculate EPI. This paper is focussed on analysis of the formula used to obtain the IPE, with the limitations of available information just commented. The election of the formula for the IPE has not been widely studied in the economic literature, being the proposal by Carli in 1764 and Dutot in 1738 [ extracted Reference of OIT (2003), chapter 20, pages 12-13 ] the most often used for practical purposes. Nevertheless, Fisher (1922) had already recommended not using the Carli’s formula because of the bias to the rise that it introduces [Fisher (1922), pages 29-30]. Throughout the 20th century different authors has continued looking for the ideal formula extending possible approaches to the subject: the approach of Divisia, the stochastic approach, the economic approach and the axiomatic approach. The final summary of these studies can be synthesized in "Toward to Dwells Accurate Measure of The Cost of Living” by the Advisory Commission To The Study The Consumer Price Index presented in 1996. This report, also known as Boskin’s Report, suggests the use of geometric mean price indices at the elementary aggregate for the EPI, this formula is attributed to Jevons in 1983 [OIT (2003), chapter 20, pages 12-13 ]. In the present paper, we demonstrate that all usually formulas for the calculation of the IPE are incoherent with the theory of consumer behaviour, in an aggregate characterized by the high level of substitution caused by homogeneity in the consumption purpose. In addition, the formula proposed by Rodriguez, González and Rodriguez (2004), is not only superior from the axiomatic point of view, but also from the economic approach, is the only one that is able to reflect the expected consumer behaviour.

A measurement to analyze the relative change in the Absolute Parity of Power Purchase: An application to the European Union

In the present paper an index to measure the changes in the Absolute Purchasing Power Parity. in the short term of a group of territories that conform an unique market, using the information of the Harmonized Index of Consumer Prices and the Exchange Rates. This measurement is utilized to study the change in relative prices of the countries of the European Union for the period 1991-2002, and the fulfillment of the theory of the Relative Purchasing Power Parity, taking as a reference the Absolute Purchasing Power Parity in the reference time of the Price Index. The difficulties found to do these comparisons have given rise to multitude of jobs that can be classified in two large groups. In the first group are the efforts focused to find the best instrument to do comparable the figures of the distinct economies. In this line, it is emphasized the use and the advances in the index numbers theory [for a historic revision applied to price index see Diewert, W. (1993), for a theoretical revision see Balk, B. (1995) and Hill, T. (1988)] and the jobs carried out in the International Program of Comparison (ICP), program belonging to the statistical division of United Nations with near 35 years of life, and whose objective is to produce estimations of the National Gross Product and its components, that can be comparable among countries in real terms. It utilizes the concept of Purchasing Power Parity (PPP), [UN (1992)]. In the same line, the European Program of Comparison is developed by Eurostat and the OCDE since 1980. In the second group the investigations based in the unit price law and the theory of of the PPP to explain the behavior of the rate of change among two or more countries. In this case, the objective is focused in the analysis of the economic implications of its fulfillment or not, and how being able to test its fulfillment [Cheung, AND W., Lai, K. (2000), Engel, C. (2000), Reads, M. (1976), Taylor, A. (2001)] This job is inside of the first group of investigations. An index is defined to reflect changes in the Relative Purchasing Power Parity among a group of countries that do not share a common currency. This measurement can be obtained from Harmonized Index of Consumer Prices (HICP), and from the Exchange Rates among the currencies of the distinct countries. The results show the strong distorting effect that exchange rate has upon the Purchasing Power Parity among countries. The evolution of the internal prices of each country is a residual factor to explain the changes in the Purchasing Power Parity. In this sense, the apparition of euro contributes to a clear stability for the consumers whose countries have adopted the euro than those that have not adopted yet. However, in the euro zone systematic behaviours in some of the countries are detected that indicate that, their Purchasing Power Parity is changing in a systematic way, with regard to the average Purchasing Power Parity of the Monetary Union.

Markov Chain approach to Purchasing Power Convergence in the 15 European Union

In the present paper we study the degree of convergence in the European Union from the Purchasing Power Parity (PPP) point of view. The price of the shopping basket can be the cause of disparities in a global market in construction that, like the European Union, is formed by different countries with different consumption habits. In addition, in this construction process twelve out of fifteen countries of the EU have left its national currency to adopt the Euro like common currency. Therefore, it is necessary for the stability of the Union process in the long run that, among others, purchasing power of the different state members tends towards a same common value. Moreover, the question is whether that process of convergence within the European Union is taking place or not. In order to solve this question, the series of the Absolute Purchasing Power Parity (APPP) are estimated through the suggestion of Rodriguez et al (2004). These authors use the Harmonized Consumer Price Index in the European Union and the nominal exchange rates of the different currencies with euro. Monthly estimates of the APPP series for the 1995-2002 period are obtained for each of the fifteen countries. These figures show, for each country, their relative position to the average value of the European Union. Using these series we applied the Markov Chain methodology to study the time evolution of the distribution of APPP in the European Union. This methodology has been very used by its facility of calculation and interpretation of the results. Nevertheless, with the purpose of obtaining good estimations it is necessary to solve the discretization problem of a continuous variable. This is, to use a finite set, and relatively small number of states, for a variable with infinite values. In the present work different approaches are used to solve the problem. We test for structural change on the estimated probabilities using adapted test to Markov Chains. This allows us to study if an effect exists on the Purchasing Power Parity with the entrance of the Euro. Markov Chains are estimated by Maximum likelihood, and allow us to do different analyses. In the first place, we can study the mobility of the distribution, measured through the probabilities of permanence or not in the same state, and in the degree of diagonal structure of the resulting matrix. This objective can obtained by direct observation, calculating Mobility Index, or using expected time of first passage. Secondly, we can obtain the ergodic or long term distribution. This one shows the temporary evolution in the long run of the distribution, under the hypothesis of maintenance of the present conditions. This distribution would show the possible convergence or not of the whole distribution. We also estimate elasticities of ergodic probabilities, to analyze the effect of each probability in the Markov chain in the long run distribution. Results show differences with the Euro Entry, mobility towards convergence within the distribution is slow, with high elasticities of the ergodic distribution to changes in the transition probabilities.

The Creation and Implementation of A Spiritual Mentoring Program for Deployed Sailors and Marines on Board the USS Oak Hill

Purpose The purpose of this dissertation was to create, implement, and evaluate a Mentoring for Spirituality program for deployed sailors and marines on board the amphibious warship USS Oak Hill. This program endeavors to help military personnel grow in their relationship with God and, thus, help them overcome many of the emotional and behavioral problems they experience being away from home. Problem The spiritual lives of many United States Navy/Marine personnel under my chaplaincy direction are affected by long periods away from home. While away from their families and friends, many young sailors and marines often run the risk of being influenced by unscrupulous buddies that may lead to military discipline or poor long- range life choices like drinking, adultery, sexual immorality, divorce, gambling, etc. Also, they also are at risk of experiencing a wide variety of behavioral and emotional problems—depression, loneliness, anxiety, committing rape or physical violence towards a shipmate. These military personnel did not have a meaningful avenue to assist them in coping with these challenges. Method The project examined the biblical principles of spiritual mentoring and how it positively influenced some of the Bible’s main characters. The project also evaluated some of our nation’s leading thinkers on mentoring and how their current views on mentoring added value to our seminar. The Mentoring for Spirituality program has two components. First, the participants and I met four times a week as a group to study a spiritual lesson. Second, I scheduled a two-week rotation plan to personally meet with each individual for mentoring purposes. Studying the nightly lessons together provided the common ground by which my relationship with the proteges would deepen as we met one on one. Results This mentoring program personally blessed me because of the time I spent studying God’s Word and imparting the rich lesson material that paved the way for God to penetrate the minds of the proteges. The long-lasting relationships that I have with many of the proteges will always give me great joy. The project outcome surpassed my expectations and its success gave me renewed energy and satisfaction. Spiritual mentoring will continue to be a priority in my ministry and has reinforced how I interpret the intricacies of spiritual growth and sanctification. As an outcome of this seminar, most of the proteges adopted a more purposeful Christian lifestyle that included a strong commitment to daily studying and applying God’s Word, a willingness to become active in a local church body, meditation and reflection on positive and holy things, and, finally, a plan of action to avert or discourage temptations. Even though evangelism was not the project’s planned purpose, I was pleasantly surprised that twelve of the thirty-two proteges decided to become Seventh-day Adventists. Conclusion I am hoping that the Navy chaplains in the Fleet or local church pastors can use the principles and methodology of this mentoring project. Since my approach to spirituality is patently a Seventh-day Adventist view of sanctification, the curriculum content of this project needs to be adapted so as to reflect the specific faith background of other would-be mentors. This will help them meet the needs of general Protestant and Catholic participants

CONSUMER’S SATISFACTION - EXPLANATORY MODELS

When the first studies related to consumer satisfaction began to appear in the sixties, nobody could imagine protagonism that it would reach with the course of the time. Nowadays not only private sector companies dedicate part from their resources to the study of the degree of satisfaction of their clients, but satisfaction studies are more and more increasing preoccupation in the state sector, therefore works related to the satisfaction of the patients, the contributors or with the tourist destiny can be found. Firstly, a revision of the different models that have been used to explain customer satisfaction level is presented, using the cognitive and the affective-cognitive models. In the first case, human being is looking as a rational being that can process information about the different attributes of the services to form his personal satisfaction. The most useful model within this category is the expectation disconfirmation model. These kind of models explain satisfaction as a function of the degree and direction of the discrepancy between expectation and perceptions. It has evolved all over time resulting in a lot of different approaches. We have also studied the equity model, in which consumer does a benefit-cost analysis not only its owns but from the rest of people who take part in the transaction. Finally, in the affective-cognitive models, human being is seeing like a complex being that is not solely an information processor but experiences feelings and emotions that also influence in their judgments of satisfaction. Secondly, it has been realized an empirical application in which we have used the main variables in the expectation disconfirmation model: perceptions, expectations and discrepancies to estimate some logit models. The tourists who visit Tenerife are classified as satisfied or unsatisfied. Then, we model the probability of each characteristic using tourist’s scores on some destination attributes. Two samples have been used. The first one was obtained at the time of arriving; the second one has been made when leaving the island. Since tourists are not necessary the same in both samples, a statistic inference process has been made to use all the information available. The best model is obtained when expectations and perceptions are used at the same time, so we obtain a 75% of right classification. To sum up, we have found that perceptions are the main subject for the tourist’s satisfaction, although we can’t forget the importance of expectations to complete the model.

Interaction of particles with a cavitation bubble near a solid wall

Hard particle erosion and cavitation damage are two main wear problems that can affect the internal components of hydraulic machinery such as hydraulic turbines or pumps. If both problems synergistically act together, the damage can be more severe and result in high maintenance costs. In this work, a study of the interaction of hard particles and cavitation bubbles is developed to understand their interactive behavior. Experimental tests and numerical simulations using computational fluid dynamics (CFD) were performed. Experimentally, a cavitation bubble was generated with an electric spark near a solid surface, and its interaction with hard particles of different sizes and materials was observed using a high-speed camera. A simplified analytical approach was developed to model the behavior of the particles near the bubble interface during its collapse. Computationally, we simulated an air bubble that grew and collapsed near a solid wall while interacting with one particle near the bubble interface. Several simulations with different conditions were made and validated with the experimental data. The experimental data obtained from particles above the bubble were consistent with the numerical results and analytical study. The particle size, density and position of the particle with respect to the bubble interface strongly affected the maximum velocity of the particles

Re-Evaluating the Relationship Between Economic Development and Self-Employment, at the Macro-Level: A Bayesian Model Averaging Approach

We re-evaluate the relationship between stages of economic development and entrepreneurship, at the macro level. We first conduct a literature review of previous empirical research on cross-country determinants of entrepreneurship in order to put our contribution in perspective. To circumvent problems related to model uncertainty we use Bayesian Model Averaging (BMA) to evaluate the robustness of determinants of economic growth in a new dataset of 117 countries in the 2005-2019 period, allowing fixed effects and investigating the existence of heterogeneity allowing interactions of our focus variable with other regressors. Our empirical analysis then shows that the variation of self-employment rates across countries are mainly determined by variations in the unemployment, the stage of economic development and the variations in labor market frictions. When interactions are taken into account, results confirm that there is a differential effect of labor market frictions in countries with different levels of income. Frictions in labor market may encourage becoming self-employed in richer countries

Multi-axial fatigue strength of structural bolts in slip-critical connections under combined cyclic axial and shear demands

2018 Summer.Includes bibliographical references.High-Strength bolts are used extensively in structures and are regarded as the better option for connections subjected to fatigue as compared to welds and rivets. Studies have shown the superior resistance to fatigue and conclude that it should not be an issue when a bolt is properly pre-tensioned. Nevertheless, a recent application of properly pre-tensioned bolts subjected to shear stress reversals shows extensive fatigue cracking and total severing of up to 50% of the bolts in the connections. Sufficient evidence, based on experimental testing and field observations, exist to suggest the possibility of fully pre-tensioned bolts coming loose due to shear stress reversals. The problem of transverse vibrational loosening of bolts has been extensively researched as well as the issue of bolt fatigue. Only recently have they been considered together although no studies of this interaction have been done on high-strength bolts. Certain mechanisms mark the onset of bolt loosening and fatigue when bolts are subjected to cyclic shear or shear combined with tension. In this study, causes of bolt loosening and fatigue failure of bolted connections are explored. Especially the study pertains to structural bolts that are subjected to cyclic loads in multiple directions with shear reversals, which are typical of mitre gate to pintle socket connections. Certain mechanisms mark the onset of bolt loosening and fatigue when bolts are subjected to cyclic shear or shear combined with tension. The actual mechanisms and limits at which this occurs are explored in the literature and experimentally and recommendations are provided