Generation and stability of intense long flat bunches

This report surveys possible schemes for producing long, “flat”, intense bunches of about 5×1011 protons spaced by 50 ns, as are required by one of the proposed LHC upgrade scenarios. It also examines potential intensity limitations and instability thresholds for such beams

Longitudinal stability of Flat Bunches with Space-Charge or Inductive Impedance

We study the loss of Landau damping for the longitudinal plane via the "Sacherer formalism". Stability limits are calculated for several longitudinal beam distributions, in particular for two types of flat bunches, which could be of interest to the LHC upgrade. The resulting stability diagrams are computed and displayed for different azimuthal modes. A general recipe is given for calculating the threshold intensity in the case of a capacitive impedance below transition or, equivalently, for a purely inductive impedance above transition. The formalism was applied to the case of the PS Booster, as an example of space-charge impedance below transition, and to the SPS, as an example of inductive impedance above transition

Reducing the dimensionality effect in importance sampling simulations

The dimensionality effect is avoided by the use of sufficient statistics in event probability estimators realised by importance sampling. If the system function is not a sufficient statistic, an approach is proposed to reduce the dimensionality effect in the estimators. Simulation results of false-alarm probability estimations, applied to radar detection, confirm a clear concordance with the theoretical result

Gastrointestinal stromal tumor as cause of acute abdominal pain in a patient with neurofibromatosis type 1: case report and literature review

Acute abdomen is a common and sometimes dramatic clinical condition, which can be fatal if diagnosis is not made in time. There are many etiologies for acute abdominal pain; therefore, the diagnostic approach should be based on clinical assessment, including laboratory and image studies. Neurofibromatosis 1 (NF1) is an autosomal dominant condition, characterized by cutaneous pigmentation and tumor formation along nerves in the brain, skin and other organs, the gastrointestinal stromal tumors are rare mesenchymal neoplasms associated with NF1. The close correlation between both pathologies is well known, and the clinical relevance relies on the different pathogenesis from sporadic gastrointestinal stromal tumor (GIST), with important therapeutic implications as the use of imatinib prior or after surgery, regarding the individual context of the patient. This case report illustrates the management of an NF1 patient presenting with acute abdomen to the emergency room and follow-up

An X-ray study of the SNR G344.7-0.1 and the central object CXOU J170357.8-414302

Aims. We report results of an X-ray study of the supernova remnant (SNR) G344.7-0.1 and the point-like X-ray source located at the geometrical center of the SNR radio structure. Methods. The morphology and spectral properties of the remnant and the central X-ray point-like source were studied using data from the XMM-Newton and Chandra satellites. Archival radio data and infrared Spitzer observations at 8 and 24 $\mu$m were used to compare and study its multi-band properties at different wavelengths. Results. The XMM-Newton and Chandra observations reveal that the overall X-ray emission of G344.7-0.1 is extended and correlates very well with regions of bright radio and infrared emission. The X-ray spectrum is dominated by prominent atomic emission lines. These characteristics suggest that the X-ray emission originated in a thin thermal plasma, whose radiation is represented well by a plane-parallel shock plasma model (PSHOCK). Our study favors the scenario in which G344.7-0.1 is a 6 x 10^3 year old SNR expanding in a medium with a high density gradient and is most likely encountering a molecular cloud on the western side. In addition, we report the discovery of a soft point-like X-ray source located at the geometrical center of the radio SNR structure. The object presents some characteristics of the so-called compact central objects (CCO). However, its neutral hydrogen absorption column (N_{H}) is inconsistent with that of the SNR. Coincident with the position of the source, we found infrared and optical objects with typical early-K star characteristics. The X-ray source may be a foreground star or the CCO associated with the SNR. If this latter possibility were confirmed, the point-like source would be the farthest CCO detected so far and the eighth member of the new population of isolated and weakly magnetized neutron stars.Comment: 9 pages, 8 figures, accepted for publication in Astronomy and Astrophysics. Higher resolution figures can be seen on A&

Photo-detection using Bose-condensed atoms in a micro trap

A model of photo-detection using a Bose--Einstein condensate in an atom-chip based micro trap is analyzed. Atoms absorb photons from the incident light field, receive part of the photon momentum and leave the trap potential. Upon counting of escaped atoms within predetermined time intervals, the photon statistics of the incident light is mapped onto the atom-count statistics. Whereas traditional photo-detection theory treats the emission centers of photo electrons as distinguishable, here the centers of escaping atoms are condensed and thus indistinguishable atoms. From this an enhancement of the photon-number resolution as compared to the commonly known counting formula is derived.Comment: 11 pages, 5 figures; revised versio

Influence of cavity type and size of composite restorations on cuspal flexure

Objectives: The present study examines the influence of cavity type, and size of composite restorations on cuspal flexure due to polymerization shrinkage. Methods: Thirty healthy premolars were selected and divided into two experimental groups. Group 1: Mesial, mesiodistal, and MOD cavities were successively prepared in each tooth by means of the SONICSYS approx system (KaVo ®) using a nº 2 (small) diamond tip. Group 2: The same cavity preparation sequence was followed but a nº 3 (medium) tip was used. Cavity preparations were performed and afterwards restored using the same adhesive system and resin composite. Cuspal displacement was measured 15 min after completion of each type of restoration. Results: Under the experimental conditions used, polymerization shrinkage of composite restorations resulted in an inward deflection of the cusps in all the situations evaluated. The Friedman global test found significant differences according to the cavity type and size (p0.05). Conclusions: The present study demonstrates that significantly higher cuspal deflection is observed in MOD restorations, showing that the degree of dental removal influences the cuspal flexure from polymerization shrinkage of composite restorations

Epithelial-mesenchymal transition in cancer metastasis through the lymphatic syste

It was already in the 18th century when the French surgeon LeDran first noted that breast cancer patients with spread of tumor cells to their axillary lymph nodes had a drastically worse prognosis than patients without spread (LeDran et al., ). Since then, metastatic spread of cancer cells to regional lymph nodes has been established as the most important prognostic factor in many types of cancer (Carter et al., ; Elston and Ellis, ). However, despite its clinical importance, lymph metastasis remains an underexplored area of tumor biology. Fundamental questions, such as when, how, and perhaps most importantly, why tumor cells disseminate through the lymphatic system, remain largely unanswered. Accordingly, no treatment strategies exist that specifically target lymph metastasis. The identification of epithelial-mesenchymal transition (EMT) as a mechanism, which allows cancer cells to dedifferentiate and acquire enhanced migratory and invasive properties, has been a game changer in cancer research. Conceptually, EMT provides an explanation for why epithelial cancers with poor differentiation status are generally more aggressive and prone to metastasize than more differentiated cancers. Inflammatory cytokines, such as TGF-β, which are produced and secreted by tumor-infiltrating immune cells, are potent inducers of EMT. Thus, reactivation of EMT also links cancer-related inflammation to invasive and metastatic disease. Recently, we found that breast cancer cells undergoing TGF-β- induced EMT acquire properties of immune cells allowing them to disseminate in a targeted fashion through the lymphatic system similar to activated dendritic cells during inflammation. Here, we review our current understanding of the mechanisms by which cancer cells spread through the lymphatic system and the links to inflammation and the immune system. We also emphasize how imaging techniques have the potential to further expand our knowledge of the mechanisms of lymph metastasis, and how lymph nodes serve as an interface between cancer and the immune system

Exploring cellular markers of metabolic syndrome in peripheral blood mononuclear cells across the neuropsychiatric spectrum

Recent evidence suggests that comorbidities between neuropsychiatric conditions and metabolic syndrome may precede and even exacerbate long-term side-effects of psychiatric medication, such as a higher risk of type 2 diabetes and cardiovascular disease, which result in increased mortality. In the present study we compare the expression of key metabolic proteins, including the insulin receptor (CD220), glucose transporter 1 (GLUT1) and fatty acid translocase (CD36), on peripheral blood mononuclear cell subtypes from patients across the neuropsychiatric spectrum, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions (n = 25/condition), relative to typical controls (n = 100). This revealed alterations in the expression of these proteins that were specific to schizophrenia. Further characterization of metabolic alterations in an extended cohort of first-onset antipsychotic drug-naïve schizophrenia patients (n = 58) and controls (n = 63) revealed that the relationship between insulin receptor expression in monocytes and physiological insulin sensitivity was disrupted in schizophrenia and that altered expression of the insulin receptor was associated with whole genome polygenic risk scores for schizophrenia. Finally, longitudinal follow-up of the schizophrenia patients over the course of antipsychotic drug treatment revealed that peripheral metabolic markers predicted changes in psychopathology and the principal side effect of weight gain at clinically relevant time points. These findings suggest that peripheral blood cells can provide an accessible surrogate model for metabolic alterations in schizophrenia and have the potential to stratify subgroups of patients with different clinical outcomes or a greater risk of developing metabolic complications following antipsychotic therapy

Crustal and Mantle Structure Beneath the Southern Payenia Volcanic Province Using Gravity and Magnetic Data

The Auca Mahuida volcanic field lies on the southernmost Payenia Volcanic Province, one of the broadest retroarc volcanic plateaux in the southern Central Andes (~38°S). This voluminous basaltic flooding of Quaternary age was originated from a deep asthenospheric source, interpreted as a mantle plume product of changing slab dynamics. The geometry of this source is deduced from magnetotelluric data, but the limited spatial coverage of this array does not allow a detailed resolution of this anomaly. In order to present a detailed geometry of the conductive anomaly and related crustal magmatic bodies, we used multiple data sources. We combined Magnetic and Bouguer anomalies, Curie isotherm depth (T c ), Elastic Thickness (T e ) and Moho depth derived from the Global Earth Magnetic Anomaly Grid (EMAG2) and terrestrial gravity measurements, all together in a holistic geophysical analysis. The magnetic data depict a nearly 200-km-in-diameter circular anomaly that would correspond to a dense body according to the Bouguer anomaly. Geoid data from the Gravity Field Model (EIGEN-6c4) have been filtered in order to isolate deeper mass influences and visualize the asthenospheric upwelling previously described from magnetotelluric data. Moho inversion yields a crustal attenuation at 36- to 32-km depth coinciding with T e below 20-km depth and a shallow T c (≤15-km depth) at the site where Geoid positive undulation was calculated. Finally, surface analysis allowed defining a topographic swell, compatible with the dimensions of the identified magnetic anomaly, where the main rivers deviated, potentially due to a recent base level change.Fil: Astort, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Colavitto, Bruno. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Sagripanti, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Garcia, Hector Pedro Antonio. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Soler, Santiago Rubén. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Ruíz, F.. Universidad Nacional de San Juan. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto Geofísico Sismológico Volponi; ArgentinaFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentin