SCIENTOMETRIC ANALYSIS OF LITERATURE ON GRAVITY

The present study explores the quantitative analysis of literature on gravity from 2015 to 2019 based on INSPEC database. Scientometric is the study of quantitative analysis of scientific documents. For the present study data was collected from the INSPEC database published by Elsevier during the period from 2015 to 2019. The study evaluated the different dimensions of the scientometric analysis like, growth of literature, institution wise distribution, most prolific author, relative growth rate and doubling time etc. Highest number (7562) of articles published in the year 2018. The relating growth rate is decreasing and doubling time is increasing over the period. Majority of the articles are in the form of journals, China is the most productive country in global level, Sharif, M is the most prolific author in the field of gravity for the period of 2015 to 2019

PERCEPTION AND USAGE OF HEALTH INFORMATION SOURCES AND SERVICES AMONG THE URBAN COMMUNITY USERS OF PUBLIC LIBRARIES: A CASE STUDY OF BHADRAVATHI

The study examined the perception and usage of health information sources and services by the urban community users of public libraries. The study investigated 110 users from two public libraries in Bhadravathi. Findings revealed that majority of the users not enrolling library membership. 44.54% of users were visit library daily and large numbers of respondents were get health information through newspaper followed by television, advertisements and pamphlet/brochures. Education and sports were the most frequently preferred topics by the users. Arogya column published by Prajavani Kannada newspaper was most preferred newspaper column for getting health information by the users followed by VK Health column published by Vijaya Karnataka was stood in 2nd position to get health information by the users. Most of the users preferred Sudha, Gruhashobha and Taranga magazines to get health information. Stimulatingly, large number of the users frequently listen health related programs in Radio. The study also revealed that most of the users were aware about H1N1, DPT, Polio, BCG, TT, AIDS Control, 108 Arogya Kavacha, Malaria Cholera Dengue, Family Planning, Chicken Gunya district health programs of Karnataka state

Interleukin-1β Inhibition for Chronic Kidney Disease in Obese Mice With Type 2 Diabetes

Inflammasome-driven release of interleukin(IL)-1β is a central element of many forms of sterile inflammation and has been evident to promote the onset and progression of diabetic kidney disease. We microdissected glomerular and tubulointerstitial samples from kidney biopsies of patients with diabetic kidney disease and found expression of IL-1β mRNA. Immunostaining of such kidney biopsies across a broad spectrum of diabetic kidney disease stages revealed IL-1β positivity in a small subset of infiltrating immune cell. Thus, we speculated on a potential of IL-1β as a therapeutic target and neutralizing the biological effects of murine IL-1β with a novel monoclonal antibody in uninephrectomized diabetic db/db mice with progressive type 2 diabetes- and obesity-related single nephron hyperfiltration, podocyte loss, proteinuria, and progressive decline of total glomerular filtration rate (GFR). At 18 weeks albuminuric mice were randomized to intraperitoneal injections with either anti-IL-1β or control IgG once weekly for 8 weeks. During this period, anti-IL-1β IgG had no effect on food or fluid intake, body weight, and fasting glucose levels. At week 26, anti-IL-1β IgG had reduced renal mRNA expression of kidney injury markers (Ngal) and fibrosis (Col1, a-Sma), significantly attenuated the progressive decline of GFR in hyperfiltrating diabetic mice, and preserved podocyte number without affecting albuminuria or indicators of single nephron hyperfiltration. No adverse effect were observed. Thus, IL-1β contributes to the progression of chronic kidney disease in type 2 diabetes and might therefore be a valuable therapeutic target, potentially in combination with drugs with different mechanisms-of-action such as RAS and SGLT2 inhibitors

Modulation of Sn concentration in ZnO nanorod array: intensification on the conductivity and humidity sensing properties

Tin (Sn)-doped zinc oxide (ZnO) nanorod arrays (TZO) were synthesized onto aluminum-doped ZnO-coated glass substrate via a facile sonicated sol–gel immersion method for humidity sensor applications. These nanorod arrays were grown at different Sn concentrations ranging from 0.6 to 3 at.%. X-ray diffraction patterns showed that the deposited TZO arrays exhibited a wurtzite structure. The stress/strain condition of the ZnO film metamorphosed from tensile strain/compressive stress to compressive strain/tensile stress when the Sn concentrations increased. Results indicated that 1 at.% Sn doping of TZO, which has the lowest tensile stress of 0.14 GPa, generated the highest conductivity of 1.31 S cm− 1. In addition, 1 at.% Sn doping of TZO possessed superior sensitivity to a humidity of 3.36. These results revealed that the optimum performance of a humidity-sensing device can be obtained mainly by controlling the amount of extrinsic element in a ZnO film

Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes

While numerous studies have implicated copy number variants (CNVs) in a range of neurological phenotypes, the impact relative to disease severity has been difficult to ascertain due to small sample sizes, lack of phenotypic details, and heterogeneity in platforms used for discovery. Using a customized microarray enriched for genomic hotspots, we assayed for large CNVs among 1,227 individuals with various neurological deficits including dyslexia (376), sporadic autism (350), and intellectual disability (ID) (501), as well as 337 controls. We show that the frequency of large CNVs (>1 Mbp) is significantly greater for ID–associated phenotypes compared to autism (p = 9.58×10−11, odds ratio = 4.59), dyslexia (p = 3.81×10−18, odds ratio = 14.45), or controls (p = 2.75×10−17, odds ratio = 13.71). There is a striking difference in the frequency of rare CNVs (>50 kbp) in autism (10%, p = 2.4×10−6, odds ratio = 6) or ID (16%, p = 3.55×10−12, odds ratio = 10) compared to dyslexia (2%) with essentially no difference in large CNV burden among dyslexia patients compared to controls. Rare CNVs were more likely to arise de novo (64%) in ID when compared to autism (40%) or dyslexia (0%). We observed a significantly increased large CNV burden in individuals with ID and multiple congenital anomalies (MCA) compared to ID alone (p = 0.001, odds ratio = 2.54). Our data suggest that large CNV burden positively correlates with the severity of childhood disability: ID with MCA being most severely affected and dyslexics being indistinguishable from controls. When autism without ID was considered separately, the increase in CNV burden was modest compared to controls (p = 0.07, odds ratio = 2.33)

Infliximab versus second intravenous immunoglobulin for treatment of resistant Kawasaki disease in the USA (KIDCARE): a randomised, multicentre comparative effectiveness trial

Background Although intravenous immunoglobulin (IVIG) is effective therapy for Kawasaki disease, 10–20% of patients have recrudescent fever as a sign of persistent inflammation and require additional treatment. We aimed to compare infliximab with a second infusion of IVIG for treatment of resistant Kawasaki disease. Methods In this multicentre comparative effectiveness trial, patients (aged 4 weeks to 17 years) with IVIG resistant Kawasaki disease and fever at least 36 h after completion of their first IVIG infusion were recruited from 30 hospitals across the USA. Patients were randomly assigned (1:1) to second IVIG (2 g/kg over 8–12 h) or intravenous infliximab (10 mg/kg over 2 h without premedication), by using a randomly permuted block randomisation design with block size of two or four. Patients with fever 24 h to 7 days following completion of first study treatment crossed over to receive the other study treatment. The primary outcome measure was resolution of fever at 24 h after initiation of study treatment with no recurrence of fever attributed to Kawasaki disease within 7 days post-discharge. Secondary outcome measures included duration of fever from enrolment, duration of hospitalisation after randomisation, and changes in markers of inflammation and coronary artery Z score. Efficacy was analysed in participants who received treatment and had available outcome values. Safety was analysed in all randomised patients who did not withdraw consent. This clinical trial is registered with ClinicalTrials.gov, NCT03065244. Findings Between March 1, 2017, and Aug 31, 2020, 105 patients were randomly assigned to treatment and 103 were included in the intention-to-treat population (54 in the infliximab group, 49 in the second IVIG group). Two patients randomised to infliximab did not receive allocated treatment. The primary outcome was met by 40 (77%) of 52 patients in the infliximab group and 25 (51%) of 49 patients in the second IVIG infusion group (odds ratio 0·31, 95% CI 0·13–0·73, p=0·0076). 31 patients with fever beyond 24 h received crossover treatment: nine (17%) in the infliximab group received second IVIG and 22 (45%) in second IVIG group received infliximab (p=0·0024). Three patients randomly assigned to infliximab and two to second IVIG with fever beyond 24h did not receive crossover treatment. Mean fever days from enrolment was 1·5 (SD 1·4) for the infliximab group and 2·5 (2·5) for the second IVIG group (p=0·014). Mean hospital stay was 3·2 days (2·1) for the infliximab group and 4·5 days (2·5) for the second IVIG group (p<0·001). There was no difference between treatment groups for markers of inflammation or coronary artery outcome. 24 (44%) of 54 patients in the infliximab group and 33 (67%) of 49 in the second IVIG group had at least one adverse event. A drop in haemoglobin concentration of at least 2g/dL was seen in 19 (33%) of 58 patients who received IVIG as either their first or second study treatment (three of whom required transfusion) and in three (7%) of 43 who received only infliximab (none required transfusion; p=0·0028). Haemolytic anaemia was the only serious adverse events deemed definitely or probably related to study treatment, and was reported in nine (15%) of 58 patients who received IVIG as either their first or second study treatment and none who received infliximab only. Interpretation Infliximab is a safe, well tolerated, and effective treatment for patients with IVIG resistant Kawasaki disease, and results in shorter duration of fever, reduced need for additional therapy, less severe anaemia, and shorter hospitalisation compared with second IVIG infusion

INFORMATION NEEDS OF MEDIA PROFESSIONALS: A STUDY

This paper is an attempt to know the information use pattern of media professionals working in four zones of Karnataka state i.e. Bengaluru, Mysuru, Mangalore, and Shivamogga. The study is confined to 112 journalists belonged to the four zones. The study found that reporting is the major activity performed by journalists. The majority of media professionals have an interest in areas like education and the environment. Newspapers, newspaper apps are the major source of information for journalists. Further, it is found that Social media, blogs, television, personal contacts, letters from readers have provided news content. Writing a news article, knowing the background of the event, getting the story angle are the major purposes of using information resources. The paper discusses the hazards related to the effective use of information. Insufficient infrastructure, lack of support from higher authorities seem to be the problems in the effective use of information

SCIENTOMETRIC ANALYSIS OF LITERATURE ON GRAVITY

The present study explores the quantitative analysis of literature on gravity from 2015 to 2019 based on INSPEC database. Scientometric is the study of quantitative analysis of scientific documents. For the present study data was collected from the INSPEC database published by Elsevier during the period from 2015 to 2019. The study evaluated the different dimensions of the scientometric analysis like, growth of literature, institution wise distribution, most prolific author, relative growth rate and doubling time etc. Highest number (7562) of articles published in the year 2018. The relating growth rate is decreasing and doubling time is increasing over the period. Majority of the articles are in the form of journals, China is the most productive country in global level, Sharif, M is the most prolific author in the field of gravity for the period of 2015 to 2019