IMPLEMENTATION OF PIPELINED DES USING VERILOG

An implementation of the Data Encryption Standard (DES) algorithm is described. Protection of data during transmission or while in storage may be necessary to maintain the confidentiality and integrity of the information represented by the data. The algorithms uniquely define the mathematical steps required to transform data into a cryptographic cipher and also to transform the cipher back to the original form. The proposed pipeline method is for improving the speed of execution when compare with the non-pipeline method

Evaluation of the effects of tramadol and diclofenac alone and in combination on post-cesarean pain

Background: Post-cesarean pain is a common cause of acute pain in the obstetrics. Pain in the postoperative period is an important impediment to recovery from surgery and anesthesia. This study was conducted to evaluate the efficacy of postoperative analgesia and incidence of side-effects of centrally acting drug tramadol with peripherally acting drug diclofenac alone and in combination in patients undergoing elective cesarean delivery under spinal anesthesia.Methods: The study population of 90 patients was randomly divided into three groups of 30 each to receive the following treatments: tramadol (Group T), diclofenac (Group D), tramadol and diclofenac at reduced doses (Group TD).Results: Combination of tramadol and diclofenac produced significantly early analgesia in comparison to tramadol or diclofenac alone and decrease in the incidence of side-effects.Conclusion: We conclude that a multimodal approach to post-cesarean management with a combination of tramadol and diclofenac produced better analgesia than individual drugs and a reduction in the side-effects. Such a combination approach to relieve pain is more effective and advantageous

Wound healing activity of topical application of Aloe vera gel in experimental animal models

Aloe vera gel of 50% and 96.4% were tested for its wound healing activity by topical application in experimental rats. The effect of Aloe vera gel on wound healing was evaluated by wound excision model and histopathology was used to study the effect on wound healing. The effect produced by Aloe vera gel with reference to wound contraction, wound closure, decrease in surface area of wound, tissue regeneration at the wound site and histopathological characteristics were significant in treated rats. The effect of Aloe vera gel on biochemical studies revealed significant increase in collagen and decreased hexosamine content and malondialdehyde levels when compared with control. The present study thus provided scientific rationale for the traditional use of Aloe vera gel for management of wounds

Vibrational assignment of the spectral data and thermodynamic properties of 2-chloro-4-fluorobenzophenone using DFT quantum chemical calculations

The FT-Raman (3500–100 cm−1) and FT-IR (4000–450 cm−1) spectra of 2-chloro-4-fluorobenzophenone were recorded in the solid phase. Density functional theory calculations with B3LYP/6-31G (d, p) basis set was used to determine the ground state molecular geometries (bond lengths and bond angles), harmonic vibrational frequencies, infrared intensities and Raman activities of this compound. Potential energy distributions (PEDs) and normal modes, for the spectral data computed at B3LYP/6-31G (d, p) level, have also been obtained from force-field calculations. The wavenumbers found after scaling of the force field showed very good agreement with the experimentally determined values. A comparison of the theoretical spectra and experimental FT-IR and FT-Raman spectra of the title molecule has been made and full vibrational assignments of the observed spectra have been proposed. On the basis of vibrational analyses, the thermodynamic properties of title compound at different temperatures have been calculated

Hydroquinoid Chromium Complexes Bearing an Acyclic Conjugated Bridge: Chromium-Templated Synthesis, Molecular Structure, and Haptotropic Metal Migration

The naphthohydroquinoid tricarbonyl chromium complexes 3 and 6, bearing a styryl or phenylazo moiety, have been synthesized and studied for the haptotropic metal migration along the extended π-system. Quantum chemical calculations suggested a feasible stepwise rearrangement of the Cr(CO)3 fragment from the hydroquinoid to the other terminal phenyl ring for the azo- rather than for the ethene-bridged system. An experimental and kinetic study of the ethene-bridged complex 3 revealed a haptotropic metal shift onto the adjacent naphthalene ring to give isomer 7 and suggested a competing intermolecular decomplexation−recomplexation pathway for the coordination of the terminal phenyl ring, affording bismetalated complexes 8 and 9. Attempts of a controlled metal migration in the azo complex analogue 6 under similar conditions were unsuccessful and resulted in partial decomposition

Structure of limonene synthase, a simple model for terpenoid cyclase catalysis

The crystal structure of (4 S )-limonene synthase from Mentha spic ata , a metal ion-dependent monoterpene cyclase that catalyzes the coupled isomerization and cyclization of geranyl diphosphate, is reported at 2.7-Å; resolution in two forms liganded to the substrate and intermediate analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain interactions in the homodimer and for changes in diphosphate–metal ion coordination and substrate binding conformation in the course of the multistep reaction

Effects of Combination of Estradiol with Selective Progesterone Receptor Modulators (SPRMs) on Human Breast Cancer Cells <i>In Vitro</i> and <i>In Vivo</i>

<div><p>Use of estrogen or estrogen / progestin combination was an approved regimen for menopausal hormonal therapy (MHT). However, more recent patient-centered studies revealed an increase in the incidence of breast cancer in women receiving menopausal hormone therapy with estrogen plus progestin rather than estrogen alone. Tissue selective estrogen complex (TSEC) has been proposed to eliminate the progesterone component of MHT with supporting evidences. Based on our previous studies it is evident that SPRMs have a safer profile on endometrium in preventing unopposed estrogenicity. We hypothesized that a combination of estradiol (E2) with selective progesterone receptor modulator (SPRM) to exert a safer profile on endometrium will also reduce mammary gland proliferation and could be used to prevent breast cancer when used in MHT. In order to test our hypothesis, we compared the estradiol alone or in combination with our novel SPRMs, EC312 and EC313. The compounds were effectively controlled E2 mediated cell proliferation and induced apoptosis in T47D breast cancer cells. The observed effects were found comparable that of BZD <i>in vitro</i>. The effects of SPRMs were confirmed by receptor binding studies as well as gene and protein expression studies. Proliferation markers were found downregulated with EC312/313 treatment <i>in vitro</i> and reduced E2 induced mammary gland proliferation, evidenced as reduced ductal branching and terminal end bud growth <i>in vivo</i>. These data supporting our hypothesis that E2+EC312/EC313 blocked the estrogen action may provide basic rationale to further test the clinical efficacy of SPRMs to prevent breast cancer incidence in postmenopausal women undergoing MHT.</p></div

Effect of EC13 on mammary gland morphology and uterine weight.

<p>A) Whole mounts of mammary glands of overiectomized C57BL/6 mice treated with E2, EC313 0.1 and 1.0 mg/kg. Magnification- upper panel-10X, lower panel-20X. B) Uterine weight of mice treated for 4 weeks with E2, EC313 0.1 and 1.0 mg/kg. Data represented are average uterine weight in milligrams ±SD (*P<0.001 vs E2-control). C-D) Total duct length and terminal end bud counts in the mammary gland whole mounts after 4 weeks of the treatment with test compounds (*P<0.001 vs E2-control).</p