Probabilistic data association: the orbit set

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cAMP/PKA Signaling Modulates Mitochondrial Supercomplex Organization

The oxidative phosphorylation (OXPHOS) system couples the transfer of electrons to oxygen with pumping of protons across the inner mitochondrial membrane, ensuring the ATP production. Evidence suggests that respiratory chain complexes may also assemble into supramolecular structures, called supercomplexes (SCs). The SCs appear to increase the efficiency/capacity of OXPHOS and reduce the reactive oxygen species (ROS) production, especially that which is produced by complex I. Studies suggest a mutual regulation between complex I and SCs, while SCs organization is important for complex I assembly/stability, complex I is involved in the supercomplex formation. Complex I is a pacemaker of the OXPHOS system, and it has been shown that the PKA-dependent phosphorylation of some of its subunits increases the activity of the complex, reducing the ROS production. In this work, using in ex vivo and in vitro models, we show that the activation of cAMP/PKA cascade resulted in an increase in SCs formation associated with an enhanced capacity of electron flux and ATP production rate. This is also associated with the phosphorylation of the NDUFS4 subunit of complex I. This aspect highlights the key role of complex I in cellular energy production

On the effects of bilateral agreements in world wine trade

During the last decades there have been significant changes in trade regulations that are modifying the global trade of wine. The number of non-tariff measures (NTMs) adopted in the wine sector is relevant. Similarly, a large number of bilateral trade agreements have been adopted. Despite the regulation is heavy, the impact of these policy instruments on trade is not always clear, nor quantified at global scale. We investigate the effects that bilateral NTMs are showing on global imports of wine. In particular, we estimate a gravity model to explain how bilateral NTMs influence wine trade, and we disentangle these effects for different segments of the international market of wine. Our results suggest that bilateral NTMs tend to favour imports of wine. Differences emerge across market segments and types of regulations. In particular, the Technical Barriers to Trade favour (friction) bottled (bulk) wine; pre-shipment inspections enhance imports of bottled wine; the Sanitary and Phytosanitary Standards are the most trade-enhancing NTMs, regardless of the market segment

Computing at SuperB

Domenico Del Prete*, Fabrizio Bianchi, Vania Boccia, Vincenzo Ciaschini, Marco Corvo, Guglielmo De Nardo, Andrea Di Simone, Giacinto Donvito, Armando Fella, Paolo Franchini, Francesco Giacomini, Alberto Gianoli, Giuliano Laccetti, Stefano Longo, Steffen Luitz, Eleonora Luppi, Matteo Manzali, Leonardo Merola, Silvio Pardi, Alejandro Perez, Matteo Rama, Guido Russo, Bruno Santeramo, Roberto Stroili, Luca Tommasett

A THRESHOLD-VAR APPROACH TO ASSESS THE EFFICACY OF THE EU IMPORT REGIME

The efficacy of the entry price policy in the European fresh fruits and vegetables sector is not well understood. We investigate econometrically the efficacy of the import policy. The analysis estimates a threshold vector autoregressive model using data on imports the main competing country on the European Union domestic markets. Our results allow concluding on the insulating effects induced by the entry price system. We argue that the quota restrictions are likely to provide larger contribution to the domestic market stabilization. Policy implications are provided