Modelling the failure risk for water supply networks with interval-censored data

[EN] In reliability, sometimes some failures are not observed at the exact moment of the occurrence. In that case it can be more convenient to approximate them by a time interval. In this study, we have used a generalized non-linear model developed for interval-censored data to treat the life time of a pipe from its time of installation until its failure. The aim of this analysis was to identify those network characteristics that may affect the risk of failure and we make an exhaustive validation of this analysis. The results indicated that certain characteristics of the network negatively affected the risk of failure of the pipe: an increase in the length and pressure of the pipes, a small diameter, some materials used in the manufacture of pipes and the traffic on the street where the pipes are located. Once the model has been correctly fitted to our data, we also provided simple tables that will allow companies to easily calculate the pipe's probability of failure in a future.The research by A. Debón was supported by the Ministerio de Ciencia e Innovación of Spain under grant no. MTM2013-45381-PGarcía Mora, MB.; Debón Aucejo, AM.; Santamaría Navarro, C.; Carrión García, A. (2015). Modelling the failure risk for water supply networks with interval-censored data. Reliability Engineering & System Safety. 144:311-318. https://doi.org/10.1016/j.ress.2015.08.003S31131814

Ti(III) Catalysts for CO2/Epoxide Copolymerization at Unusual Ambient Pressure Conditions

Titanium compounds in low oxidation states are highly reducing species and hence powerful tools for the functionalization of small molecules. However, their potential has not yet been fully realized because harnessing these highly reactive complexes for productive reactivity is generally challenging. Advancing this field, herein we provide a detailed route for the formation of titanium(III) orthophenylendiamido (PDA) species using [LiBHEt3] as a reducing agent. Initially, the corresponding lithium PDA compounds [Li2(ArPDA)(thf)3] (Ar = 2,4,6-trimethylphenyl (MesPDA), 2,6-diisopropylphenyl (iPrPDA)) are combined with [TiCl4(thf)2] to form the heterobimetallic complexes [{TiCl(ArPDA)}(?-ArPDA){Li(thf)n}] (n = 1, Ar = iPr 3 and n = 2, Ar = Mes 4). Compound 4 evolves to species [Ti(MesPDA)2] (6) via thermal treatment. In contrast, the transformation of 3 into [Ti(iPrPDA)2] (5) only occurs in the presence of [LiNMe2], through a lithium-assisted process, as revealed by density functional theory (DFT). Finally, the Ti(IV) compounds 3?6 react with [LiBHEt3] to give rise to the Ti(III) species [Li(thf)4][Ti(ArPDA)2] (Ar = iPr 8, Mes 9). These low-valent compounds in combination with [PPN]Cl (PPN = bis(triphenylphosphine)iminium) are proved to be highly selective catalysts for the copolymerization of CO2 and cyclohexene epoxide. Reactions occur at 1 bar pressure with activity/selectivity levels similar to Salen? Cr(III) compounds.Comunidad de MadridUniversidad de AlcaláPrograma Estímulo a la Investigación de Jóvenes Investigadore

Evaluación de la competencia transversal “Análisis y resolución de problemas” (CT3) en la titulación de GADE de la Facultad de ADE de la Universitat Politècnica de Valéncia

[ES] En este artículo se describe el desarrollo y las conclusiones alcanzadas en una reunión celebrada el 6 de mayo de 2019 de los profesores de la Facultad de Administración y Dirección de Empresas (FADE) responsables de asignaturas que son punto de control de la competencia transversal “Análisis y resolución de problemas” (CT3) en primer y segundo nivel. Los profesores compartieron su experiencia en la implementación de las directrices del proyecto de competencias transversales de la UPV y la correspondiente evaluación en cada una de las asignaturas. Se concluye que el profesor se encuentra solo y tiene que ingeniárselas para realizar una evaluación de la CT3 fiable y coherente. Además, se propone una reducción en las CTs asignadas a cada asignatura.[EN] This paper describes the development and the conclusion of the meeting the professors of the Faculty of Business Administration in charge of the “point of control” subjects of the soft skill “Problem Analysis and Solving” (CT3) in the first and second level, held May 6th, 2019. The professors share their experience in implementing assessment methods in every subject following the guidelines of the general project of the UPV. The main conclusion is that the professor feels alone and has to find imaginative methods to assess the soft skill in a reliable way. Also, extant multiplicity of assessments of the skill contribute to certain confusion in the final consequence of the assessment in each subject, and hence a simplification is proposed.Cortés López, JC.; Mateos-Ronco, A.; Santamaría Navarro, C.; Villanueva Micó, RJ. (2019). Evaluación de la competencia transversal “Análisis y resolución de problemas” (CT3) en la titulación de GADE de la Facultad de ADE de la Universitat Politècnica de Valéncia. En JIDDO. I Jornada de innovación en docencia universitaria para la dirección de organizaciones públicas y privadas. Editorial Universitat Politècnica de València. 24-31. https://doi.org/10.4995/JIDDO2019.2019.10184OCS243

Evaluación de la competencia transversal “Pensamiento crítico” en el GADE-UPV

[ES] En este artículo se describen las diferentes maneras en que se evalúa la competencia transversal “Pensamiento crítico” en la Facultad de Administración y Dirección de Empresas de la UPV. Existe un proyecto institucional de competencias transversales en la universidad que enmarca este proceso. Mostramos que se dan diferentes formas de evaluación de la competencia transversal, incluso con cambios entre cursos dentro de una misma asignatura. Esta situación se debe a dificultades encontradas en relación al tiempo disponible, a la actitud de los alumnos hacia las competencias transversales y al tamaño de grupo. Además, es difícil evaluar aisladamente la adquisición de esta competencia transversal de otras como por ejemplo resolución de problemas. La diversidad de formas de evalua r esta competencia contribuye a cierta confusión acerca de las consecuencias de la evaluación particular en cada asignatura, y por tanto, se concluye proponiendo una simplificación.[EN] This paper describes how different subjects in the Business Administration Faculty of the UPV assess the soft skill called “critical thought”. This assessment is carried out within the framework of a university program for soft skills, that sets the framework of the process. We show that different assessment procedures are carried out, even with variations over time within a subject. This variability is due to difficulties related to time availability, students attitude and group size. It is also caused by the fact that disentangling this soft skill from otherssuch as problems solving is not always an easy task. Extant multiplicity of assessments of the skill contribute to certain confusion in the final consequence of the assessment in each subject, and hence a simplification is proposed.Martinez Gómez, VD.; Escribá Pérez, C.; Calafat Marzal, MC.; Martínez Gómez, M.; Santamaría Navarro, C.; Villanueva Micó, RJ. (2019). Evaluación de la competencia transversal “Pensamiento crítico” en el GADE-UPV. En JIDDO. I Jornada de innovación en docencia universitaria para la dirección de organizaciones públicas y privadas. Editorial Universitat Politècnica de València. 60-68. https://doi.org/10.4995/JIDDO2019.2019.10171OCS606

Valoración del impacto de género en la salud de mujeres y hombres

El objetivo es ensayar la utilidad de incorporar variables sensibles al género, fundamentalmente, las relacionadas con la desigual distribución del trabajo productivo y reproductivo, para identificar posibles desigualdades de salud asociadas al género como determinante de salud. Se han realizado entrevistas clínicas, que incluyen exploraciones y un cuestionario complementario con los que se han recogido variables sobre el estado de salud y variables sociodemográficas, incluidas variables sensibles al género. Los datos del cuestionario y la entrevista clínica se han registrado en una base diseñada ad hoc y se ha analizado con el programa SPSS v. 14, aplicando un análisis descriptivo y un análisis de dependencias bivariant

Prevalence of rhinitis and asthma respiratory symptoms in Spanish working population

Licencia para reproducir, transmitir y exhibir los documentos para cualquier propósito responsable sin fines de lucro, con la condición del reconocimiento apropiado de los créditos a la revista.[ES] Introducción: en salud laboral interesa conocer la prevalencia de los síntomas respiratorios relacionados con la rinitis y el asma en trabajadores españoles y sus variaciones por factores demográfi cos y laborales. El objetivo de esta investigación fue interrelacionar los síntomas respiratorios de vías altas y bajas. Métodos: se solicitó a 2603 trabajadores de distintos sectores y provincias españolas contestar una encuesta que fue supervisada por un médico del trabajo. Resultados: 438 trabajadores presentaron síntomas nasales crónicos (16.9 %) y 193 (7.5 %), síntomas pulmonares. De los 438 con síntomas nasales, 124 (28.3 %) presentaron síntomas pulmonares. Se observaron variaciones en los síntomas nasales por sexo, sector profesional, área de trabajo, tabaquismo y variaciones en los síntomas pulmonares por sector laboral, con mayor prevalencia en el sanitario, postal y transporte, en comparación con los sectores de la construcción, mueble o el metal. Conclusiones: la prevalencia de los síntomas nasales en la población trabajadora fue más elevada que la de los síntomas pulmonares. Los trabajadores afectados estaban infratratados, a pesar de padecer síntomas. Se observó interrelación entre los síntomas pulmonares y nasales de los trabajadores afectados.[EN] Objective: the aims were to examine the prevalence of respiratory symptoms associated with rhinitis and asthma in Spanish workers and its variations by age, sex, work sector, location in the workplace, smok- ing habits and the relationship between symptoms in the upper and lower respiratory tract. Methods: the sample was of 2603 workers in different sectors and regions throughout the country. They agreed and answered the ques- tions regarding respiratory symptoms, with the supervision of the com- pany s physician. Results: chronic nasal symptoms were present in 438 workers (16.9 %); 193 (7.5 %) had pulmonary symptoms. With nasal and pulmonary symp- toms were 124 patients (28.3 %). Likewise, of the 190 workers with pulmonary symptoms, 124 (64.2 %) had also nasal manifestations. We observed variations in nasal symptoms by sex, professional sector, work area and smoking habits, and variations in pulmonary symptoms by work sector. A higher prevalence was noted in the healthcare, postal, and transport sector as opposed to the construction, furniture or metal sector. Conclusions: the prevalence of nasal symptoms was higher than that of pulmonary symptoms in the working population. The workers affected by these pathologies were not treated adequately, despite they were pre- senting symptoms. We observed a relationship between pulmonary and nasal symptomsVicente Herrero, MT.; Prieto Andrés, L.; López González, ÁA.; Pérez Francés, C.; Ramirez Iñiguez De La Torre, MV.; Santamaria Navarro, C.; Terradillos García, MJ.... (2014). Síntomas respiratorios de rinitis y asma en población laboral española. Revista Medica- Instituto Mexicano Del Seguro Social. 52(1):50-59. http://hdl.handle.net/10251/62647S505952

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

The influence of geographical concentration and structural characteristics on the survival chance of textile firms

[EN] Purpose The purpose of this paper is to evaluate the contribution of location (geographical concentration) and firm structure (age and subsector) to the risk of business failure. Design/methodology/approach The Markov s regression analysis was made for a sample of over 11,700 Spanish textile-clothing firms. Findings The results obtained from the analysis suggest that the risk of business failure is increased by some risk factors relative to the structural characteristics of the firms (younger firms and specialization in low-tech activities), and under determined locational circumstances. Research limitations/implications Our conclusions have been obtained starting from a sample of manufacturing firms in the Spanish textile sector. An extension of this work would be to test its robustness in other countries (for example, Italy or Portugal) and/or for other industries such as footwear and furniture. Practical implications Explaining the different levels of risk business failure shown by firms in an industry. Originality/value Work that has studied the failure of the textile firms within this location- subsector relationship is still scarce. Given that the viability of clusters and of European textile have been put into question, our work evidences that the risk of failure related to the firm s location and structure needs to be tested jointly, so that the way in which the firm addresses environmental changes can be appraised.This investigation was supported by the Research Project GV2011-025 of the Generalitat Valenciana (Spain).Puig, F.; García Mora, MB.; Santamaría Navarro, C. (2013). The influence of geographical concentration and structural characteristics on the survival chance of textile firms. Journal of Fashion Marketing and Management. 17(1):6-19. https://doi.org/10.1108/13612021311305100S61917

An analysis of recurrence-progression process in bladder carcinoma by means of joint frailty models

Multiple sequential recurrences are one of the most important characteristics of superficial transitional cell carcinoma of the bladder, more than 50% of the patients will have recurrences (reappearance of a new superficial tumor). When in the same subject recurrent events are considered and these observed events are clustered into groups, independence between the clustered survival times cannot be assumed. A natural way to model the dependence of clustered event times is through the introduction of a cluster-specific random effect: the frailty term. On the other hand, between 10% and 30% of patients diagnosed with bladder carcinoma will present a muscle invasive progression, so the observation process of recurrences could be interrupted by a major failure event (progression). In this regard, a joint modelling of the two processes could make the study of a joint evolution over time possible, giving unbiased and efficient parameters. We jointly analyze recurrences and progression processes by means of the joint frailty model.Santamaría Navarro, C.; García Mora, MB.; Rubio Navarro, G.; Lujan Marco, S. (2011). An analysis of recurrence-progression process in bladder carcinoma by means of joint frailty models. Mathematical and Computer Modelling. 54:1946-1950. doi:10.1016/j.mcm.2010.11.004S194619505