895 research outputs found
Real-Time Operating System/360
RTOS has a cost savings advantage for real-time applications, such as those with random inputs requiring a flexible data routing facility, display systems simplified by a device independent interface language, and complex applications needing added storage protection and data queuing
Preliminary evidence from a tagging study for a Gag Mycteroperca microlepis spawning migration with notes on the use of Oxytetracycline for chemical tagging
THERMAL PERFORMANCE AND FLAME TEMPERATURES ON LPG RADIAL BURNERS IN DOMESTIC COOKERS
The objective is to investigate radial burners through experimental tests, looking for its thermal performance behavior. Gas burners in domestic cookers operate on LPG, typically with two different geometries and five thermal power conditions. Usually, those thermal equipment lacks information on its whole operating conditions range for higher energy conversion efficiency and lower fuel consumption; it is not pointed out by the manufacturer or by energy efficiency labeling, what could result in a recommendation for widely effective performance. Appropriate instrumentation was used to carry out the measurements and methodology used as a guideline regulations from INMETRO/CONPET, ABNT - Brazilian Technical Standards Normative, and ANP - National Agency of Petroleum, Natural Gas and Biofuels. Experimental measurements and uncertainties are for the following parameters: fuel mass consumption (kg.s-1), test time elapsed (s), temperature (°C), water mass (kg) and flame temperature by K-type thermocouples (quantitative) and a thermal camera (qualitative). Main conclusions are: a) Operating domestic cookers with handle position selector on middle position (TP3) provides almost the same temperature rise as maximum fuel consumption (TP5), i.e., ΔT in the water container; b) Heat is better transferred (Qgas → Qwater) with the handle position selector fully opened (TP5@B1) and just before fully opening (TP4@B2); c) A non-linear behavior occurs for ηThermal, when moving forward the handle position selector; maximum efficiency occurs at fully open (TP5@B2) and middle opening (TP3@B1); d) Higher values for TPexperimental occurs for B2, in comparison to B1, in whole operational condition ranges; differences are mainly due to geometric parameters (ARB2/ARB1~0.82). In general, B2 has a better geometric design; e) Uncertainty analysis indicate values lower than ±3%, proving to be a suitable methodology for the experimental results in this work; f) Flame temperatures are entirely consistent with both, ηThermal and heat energy delivered, reaching higher temperature values at TP4 for both burners; 751.5°C (B1) and 830.7°C (B2)
Embryonic Exposures to Perfluorooctanesulfonic Acid (PFOS) Disrupt Pancreatic Organogenesis in the Zebrafish, Danio rerio
Perfluorooctanesulfonic acid (PFOS) is a ubiquitous environmental contaminant, previously 16 utilized as a non-stick application for consumer products and firefighting foam. It can cross the 17 placenta, and has been repeatedly associated with increased risk for diabetes in epidemiological 18 studies. Here, we sought to establish the hazard posed by embryonic PFOS exposures on the 19 developing pancreas in a model vertebrate embryo, and develop criteria for an adverse outcome 20 pathway (AOP) framework to study the developmental origins of metabolic dysfunction. 21 Zebrafish (Danio rerio) embryos were exposed to 16, 32, or 64 μM PFOS beginning at the mid-22 blastula transition. We assessed embryo health, size, and islet morphology in Tg(insulin-GFP) 23 embryos at 48, 96 and 168 hpf, and pancreas length in Tg(ptf1a-GFP) embryos at 96 and 168 24 hpf. QPCR was used to measure gene expression of endocrine and exocrine hormones, digestive 25 peptides, and transcription factors to determine whether these could be used as a predictive 26 measure in an AOP. Embryos exposed to PFOS showed anomalous islet morphology and 27 decreased islet size and pancreas length in a U-shaped dose-response curve, which resemble 28 congenital defects associated with increased risk for diabetes in humans. Expression of genes 29 encoding islet hormones and exocrine digestive peptides followed a similar pattern, as did total 30 larval growth. Our results demonstrate that embryonic PFOS exposures can disrupt pancreatic 31 organogenesis in ways that mimic human congenital defects known to predispose individuals to 32 diabetes; however, future study of the association between these defects and metabolic 33 dysfunction are needed to establish an improved AOP framework
A meteorological report for the Mount Hopkins Observatory - 1968 - 1969
Meteorological data for Mt. Hopkins Observatory for 1968 and 196
Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model
The pancreatic islets, largely comprised of insulin-producing beta cells, play a critical role in endocrine signaling and glucose homeostasis. Because they have low levels of antioxidant defenses and a high perfusion rate, the endocrine islets may be a highly susceptible target tissue of chemical exposures. However, this endpoint, as well as the integrity of the surrounding exocrine pancreas, is often overlooked in studies of developmental toxicology. Disruption of development by toxicants can alter cell fate and migration, resulting in structural alterations that are difficult to detect in mammalian embryo systems, but that are easily observed in the zebrafish embryo model (Danio rerio). Using endogenously expressed fluorescent protein markers for developing zebrafish beta cells and exocrine pancreas tissue, we documented differences in islet area and incidence rates of islet morphological variants in zebrafish embryos between 48 and 96 h post fertilization (hpf), raised under control conditions commonly used in embryotoxicity assays. We identified critical windows for chemical exposures during which increased incidences of endocrine pancreas abnormalities were observed following exposure to cyclopamine (2–12 hpf), Mono-2-ethylhexyl phthalate (MEHP) (3–48 hpf), and Perfluorooctanesulfonic acid (PFOS) (3–48 hpf). Both islet area and length of the exocrine pancreas were sensitive to oxidative stress from exposure to the oxidant tert-butyl hydroperoxide during a highly proliferative critical window (72 hpf). Finally, pancreatic dysmorphogenesis following developmental exposures is discussed with respect to human disease
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Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, \u3cem\u3eDanio rerio\u3c/em\u3e
Perfluorooctanesulfonic acid (PFOS) is a persistent environmental contaminant previously found in consumer surfactants and industrial fire-fighting foams. PFOS has been widely implicated in metabolic dysfunction across the lifespan, including diabetes and obesity. However, the contributions of the embryonic environment to metabolic disease remain uncharacterized. This study seeks to identify perturbations in embryonic metabolism, pancreas development, and adiposity due to developmental and subchronic PFOS exposures and their persistence into later larval and juvenile periods. Zebrafish embryos were exposed to 16 or 32 μM PFOS developmentally (1–5 days post fertilization; dpf) or subchronically (1–15 dpf). Embryonic fatty acid and macronutrient concentrations and expression of peroxisome proliferator-activated receptor (PPAR) isoforms were quantified in embryos. Pancreatic islet morphometry was assessed at 15 and 30 dpf, and adiposity and fish behavior were assessed at 15 dpf. Concentrations of lauric (C12:0) and myristic (C14:0) saturated fatty acids were increased by PFOS at 4 dpf, and PPAR gene expression was reduced. Incidence of aberrant islet morphologies, principal islet areas, and adiposity were increased in 15 dpf larvae and 30 dpf juvenile fish. Together, these data suggest that the embryonic period is a susceptible window of metabolic programming in response to PFOS exposures, and that these early exposures alone can have persisting effects later in the lifecourse
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