19 research outputs found

    Driving Cars by Means of Genetic Algorithms

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    Proceedings of: 10th International Conference on Parallel Problem Solving From Nature, PPSN 2008. Dortmund, Germany, September 13-17, 2008The techniques and the technologies supporting Automatic Vehicle Guidance are an important issue. Automobile manufacturers view automatic driving as a very interesting product with motivating key features which allow improvement of the safety of the car, reducing emission or fuel consumption or optimizing driver comfort during long journeys. Car racing is an active research field where new advances in aerodynamics, consumption and engine power are critical each season. Our proposal is to research how evolutionary computation techniques can help in this field. As a first goal we want to automatically learn to drive, by means of genetic algorithms, optimizing lap times while driving through three different circuits.Publicad

    Genetic algorithms for the generation of models with micropopulations

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    Proceedings of: EvoWorkshops 2003: EvoBIO, EvoCOP, EvoIASP, EvoMUSART, EvoROB, and EvoSTIM Essex, UK, April 14–16, 2003The present article puts forward a method for an interactive model generation through the use of Genetic Algorithms applied to small populations. Micropopulations actually worsen the problem of the premature convergence of the algorithm, since genetic diversity is very limited. In addition, some key factors, which modify the changing likelihood of alleles, cause the likelihood of premature convergence to decrease. The present technique has been applied to the design of 3D models, starting from generic and standard pieces, using objective searches and searches with no defined objective

    Los dioses del panteón ugrio y la epopeya de La inundación del cielo y de la tierra

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    En este artículo traduzco y edito uno de los principales cantos mitológicos de los vogules. Agrego asimismo algunas nociones mitológicas, filológicas y folclorísticas fundamentales de las divinidades del panteón vogul. Mi propósito es ofrecer algunas herramientas para valorar los mitos obi-ugrios en su esencia poética y en comparación con otras tradiciones.In this article I translate one of the major mythological vogul songs. I add also some of the main mythological, philological and folcloristic notions of the vogul deities. My purpose is to offer some tools to value the Ob-ugrian myths in its poetic essence and in comparison with other traditions

    Entre el "epos", la balada y el cuento: tradiciones de "La doncella guerrera" en Hungría y Rumania

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    En la primera parte de este artículo describimos un patrón narrativo muy frecuente en los relatos internacionales de La doncella guerrera. En la segunda sección ofrecemos la traducción al español de dos magníficos paralelos literarios de la muchacha soldado: la gesta rumana de El rey Mizil y la crónica húngara del Anónimo de Sempte.In the first section of this article, we describe a very common narrative pattern of the Warrior maiden. In the second part, we offer the spanish translation of two magnificent parallels of the girl disguised as a soldier: the Romanian epic poem King Mizil and the Hungarian chronicle Sempte Anonymous

    Los dioses del panteón ugrio y la epopeya de La inundación del cielo y de la tierra

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    En este artículo traduzco y edito uno de los principales cantos mitológicos de los vogules. Agrego asimismo algunas nociones mitológicas, filológicas y folclorísticas fundamentales de las divinidades del panteón vogul. Mi propósito es ofrecer algunas herramientas para valorar los mitos obi-ugrios en su esencia poética y en comparación con otras tradiciones.In this article I translate one of the major mythological vogul songs. I add also some of the main mythological, philological and folcloristic notions of the vogul deities. My purpose is to offer some tools to value the Ob-ugrian myths in its poetic essence and in comparison with other traditions

    La deidad obi-ugria El Hombre que Vigila el Mundo y el mito de la Estrella Alce

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    En este artículo presento una descripción sucinta de la divinidad vogul el Hombre que Vigila el Mundo. Agrego además la traducción al español de tres cantos vogules protagonizados por El Hombre que Vigila el Mundo, los cuales narran la mítica partida de caza del dios que se relaciona con los orígenes de la Estrella Alce y de la Vía Láctea.In this article I present a brief description of the vogul divinity the Man who Oversees the World. I add also the Spanish translation of three vogul songs starring the Man who Oversees the World, that is in relation to the mythical elk-hunting related to the origin of the Elk-Star and the Milky Way

    Analysis of sub-atmospheric pressures during emptying of an Irregular pipeline without an air valve using a 2D CFD model

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    Studying sub-atmospheric pressure patterns in emptying pipeline systems is crucial because these processes could cause collapses depending on the installation conditions (the underground pipe covering height, type, fill, and pipeline stiffness class). Pipeline studies have focused more on filling than on emptying processes. This study presents an analysis of the following variables: air pocket pressure, water velocity, and water column length during the emptying of an irregular pipeline without an air valve by two-dimensional computational fluid dynamics (2D CFD) model simulation using the software OpenFOAM. The mathematical model predicts the experimental values of the study variables. Water velocity vectors are also analysed within the experimental facility, assessing the sensitivity of the drain valve to different openings and changes in water column length during the hydraulic phenomenon

    Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties

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    New organometallic gold(III) and platinum(II) complexes containing iminophosphorane ligands are described. Most of them are more cytotoxic to a number of human cancer cell lines than cisplatin. Cationic Pt(II) derivatives 4 and 5, which differ only in the anion, Hg2Cl62– or PF6– respectively, display almost identical IC50 values in the sub-micromolar range (25–335-fold more active than cisplatin on these cell lines). The gold compounds induced mainly caspase-independent cell death, as previously reported for related cycloaurated compounds containing IM ligands. Cycloplatinated compounds 3, 4, and 5 can also activate alternative caspase-independent mechanisms of death. However, at short incubation times cell death seems to be mainly caspase dependent, suggesting that the main mechanism of cell death for these compounds is apoptosis. Mercury-free compound 5 does not interact with plasmid (pBR322) DNA or with calf thymus DNA. Permeability studies of 5 by two different assays, in vitro Caco-2 monolayers and a rat perfusion model, have revealed a high permeability profile for this compound (comparable to that of metoprolol or caffeine) and an estimated oral fraction absorbed of 100%, which potentially makes it a good candidate for oral administration

    Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID)

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    Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study is to evaluate the short and long-term results of a multicenter series in order to determine the effect of surgical treatment on the prognosis of these patients. Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases, from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical characteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on short and long-term evolution after pancreatic resection were collected. Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metastases' resection was 87.35 months (ICR: 1.51-332.55). Distal pancreatectomy was the most performed technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo greater than IIIa in 14 %). The median follow-up time was 43 months (13-78). Overall survival (OS) rates at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and 5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free interval of less than 10 years (2.05 [1.13-3.72], p 0.02) and a history of previous extrapancreatic metastasis (2.44 [1.22-4.86], p 0.01). Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve higher overall survival and disease-free survival, even if extrapancreatic metastases were previously removed. The existence of intrapancreatic multifocal compromise does not always warrant the performance of a total pancreatectomy in order to improve survival. (C) 2021 The Authors. Published by Elsevier Ltd
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