ENVIRONMENTAL RISK FACTORS FOR INFLAMMATORY BOWEL DISEASE: TRICLOSAN AND OTHER CONSUMER ANTIMICROBIALS

Inflammatory bowel disease (IBD) has become a serious health problem since the incidence and prevalence of IBD has dramatically increased throughout the world. There is evidence that environmental factors are primarily responsible for the increase of IBD, therefore, it is important to identify novel environmental risk factors to reduce the risk of IBD and its associated diseases. Antimicrobials used in consumer products might serve as environmental risk factors for IBD and its associated diseases. Triclosan (TCS), triclocarban (TCC), benzalkonium chloride (BAC), benzethonium chloride (BET), and chloroxylenol (PCMX) are widely used antimicrobial ingredients in consumer products and are ubiquitous contaminants in the environment. In 2016, the FDA removed TCS and TCC from over-the-counter handwashing products while allowing additional time to develop new safety and efficacy data for BAC, BET, and PCMX. Therefore, it is important and timely to better understand the effects of these antimicrobials on human health. Currently, there not much known about how chronic exposure to low-dose consumer antimicrobials affects gut health. Here, using various in vitro and animal models, we found that: 1) TCS is metabolically re-activated in the gut by the actions of gut microbiota, leading to the accumulation of microbiota-derived toxic metabolites in the colon and resulting in gut-specific toxicity; 2) exposure to low-dose TCC exaggerated the severity of colitis and exacerbated the development of colitis-associated colon tumorigenesis, via gut microbiota-dependent mechanisms; and 3) exposure to low doses of BAC, BET, and PCMX, increases dextran sodium sulfate (DSS)-induced colonic inflammation and exposure to BAC increases azoxymethane (AOM)/DSS-induced colon tumorigenesis in mice. Together, these results support that chronic exposure to consumer antimicrobials could be a novel risk factor for colitis and colitis-associated colon cancer through gut microbiota-dependent mechanisms. A better understanding of the impact antimicrobials on human health, specifically gut health, could lead to significant influence on public health and regulatory policies

Validation of an observational instrument for measuring role behavior in social work groups as one aspect of maturity

Thesis (M.S.)--Boston Universit

Milk of calcium renal disease

No Abstract

Boletín Extraordinario IMIENS

En el marco del Plan de Consolidación de la Investigación del IMIENS se han financiado hasta la fecha (años 2017 y 2018) un total de 13 proyectos en diferentes modalidades, se han concedio ayudas para la realización de dos congresos y se ha financiado una estancia investigadora en un centro de investigación. El pasado 11 de junio de 2019 se organizó la I Jornada de seguimiento de proyectos científicos IMIENS con el fin de dar a conocer los resultados de los proyectos que están realizando y los avances de los que están en desarrollo. Cada una de las presentaciones de los proyectos de la convocatoria de 2017 contó con 20 minutos de exposición y el resto dispuso de 15 minutos. La cita sirvió también para difundir en la comunidad IMIENS la investigación que se realiza con la colaboración de grupos de las dos instituciones, el ISCIII y la UNED. Compartimos en este boletín especial la relación de proyectos científicos IMIENS y una breve información de los mismos

Nota informativa del Ministerio de Sanidad y Consumo Recomercialización de clozapina y programa de seguimiento.

Sin resumen

Nota informativa del Ministerio de Sanidad y Consumo Recomercialización de clozapina y programa de seguimiento.

Sin resumen

Launching the new OIE

global information syste