The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs)

Heparansulfate (HS) modifications are master regulators of the cross-talk between cell and matrix and modulate the biological activity of an array of HS binding proteins, including growth factors and chemokines, morphogens and immunity cell receptors. This review will highlight the importance of HS maturation mediated by N-deactetylase/sulfotransferases, 2O- and 6O-sulfotransferases in cancer biology, and will focus on the 3O-sulfotransferases and on the terminal, rare 3O-sulfation, and their important but still enigmatic impact in cancer progression. The review will also discuss the molecular mechanisms of action of these HS modifications with regards to ligand interactions and signaling in the cancer process and their clinical significance

FULLY CONVOLUTIONAL NEURAL NETWORK-BASED SEGMENTATION OF INDIVIDUAL MUSCLES IN MR IMAGES USING MUSCLES AND BORDERS PARCELLATIONS

International audienc

Synthesis of oligosaccharides of the linkage region of proteoglycans using regioselective glycosylation

International audienc

Efficacy and Safety of 4.7 mg Deslorelin Acetate Implants in Suppressing Oestrus Cycle in Prepubertal Female Dogs

Our multicentric, masked, controlled and randomised study aimed to assess the efficacy and safety of Suprelorin® 4.7 mg (Virbac, Carros, France) regarding oestrus prevention in prepubertal intact bitches. Twelve- to eighteen-week-old females (n = 83) were allocated either a deslorelin implant (n = 62) or 0.9% sodium chloride (n = 21) group. Clinical assessment (heat signs), 17β oestradiol and progesterone assays, and vaginal cytology were performed at day (D)0, D7, D21, month (M)3 and M6 after product administration, and were then performed every other month until reaching puberty. Trained owners assessed heat signs between each veterinary visit. All bitches (n = 83) reached puberty before M30. Deslorelin significantly extended the median time to sexual maturity when compared to the control group (377 days versus 217 days after D0, p < 0.0001). Three females, implanted between 16 and 18 weeks of age, expressed an induced oestrus. Additional descriptive data, collected over a 24 month-period, showed functional reproductive abilities in both deslorelin (n = 52) and control (n = 21) groups once puberty was achieved. In conclusion, Suprelorin® 4.7 mg seems to be an effective and safe option for postponing the onset of oestrus when administered to prepubertal female dogs aged from 12 to 16 weeks

Acquisition de résistance croisée chez Candida glabrata chez les patients exposés aux antifongiques en réanimation chirurgicale

International audienc

Development of oligosaccharide effectors targeting the chondroitin-sulfate N-acetylgalactosaminyltransferase-I (CSGalNAcT-I), a key step to control chondroitin-sulfate initiation?

International audienc

Fluorescent screening of glyco-active compounds with GlycoFluo technology

International audienc

Synthetic Modifications of the Linkage Region of Proteoglycans and Impact on CSGalNAcT‐1

International audienceMulti-step synthesis of a library of variously modified disaccharides and trisaccharides of the linkage region of proteoglycans (PGs) having a d-galactose modified at position C-2, C-4 or C-6 position by replacing the hydroxyl group by methoxy or deoxy moieties is described. Preliminary results of the impact of these modifications upon CSGalNAcT-1 are also reported