428 research outputs found
Crow Wing County Family Services Collaborative Service Worker Program Evaluation - A Parent\u27s Perspective
An evaluation of the Collaborative Service Worker Program from
the parent’s perspective was completed using a mixed method survey
design. A sample of 202 families was drawn from referrals made to the
Collaborative Service Worker Program in the past 18 months to receive a
self-administered questionnaire. Results show that parents see this early
intervention in a respectful, non-governmental based manner as
beneficial to both the child and their families. The evaluation of the
effectiveness of the Collaborative Service Worker Program added to the
body of knowledge supporting the success of early intervention with at
risk children and families and provided, direction for a developing
program
Governing Adult Learning Through Influencing Public Debate:How the Media Use PIAAC Data in Denmark, Italy and the United Kingdom
Managing Opportunities and Challenges of Co-Authorship
Research with the largest impact on practice and science is often conducted by teams with diverse substantive, clinical, and methodological expertise. Team and interdisciplinary research has created authorship groups with varied expertise and expectations. Co-authorship among team members presents many opportunities and challenges. Intentional planning, clear expectations, sensitivity to differing disciplinary perspectives, attention to power differentials, effective communication, timelines, attention to published guidelines, and documentation of progress will contribute to successful co-authorship. Both novice and seasoned authors will find the strategies identified by the Western Journal of Nursing Research Editorial Board useful for building positive co-authorship experiences
Accuracy of the CT numbers of simulated lung nodules imaged with multiâ detector CT scanners
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135050/1/mp9332.pd
Community‐specific impacts of exotic earthworm invasions on soil carbon dynamics in a sandy temperate forest
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116978/1/ecy201394122827.pd
Evaluation of the transmitted exposure through lead equivalent aprons used in a radiology department, including the contribution from backscatter
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135071/1/mp3207.pd
FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
Background: Malignant mesothelioma (MM) is a very aggressive type of cancer, with a dismal prognosis and inherent resistance to chemotherapeutics. Development and evaluation of new therapeutic approaches is highly needed. Immunosuppressant FTY720, approved for multiple sclerosis treatment, has recently raised attention for its anti-tumor activity in a variety of cancers. However, its therapeutic potential in MM has not been evaluated yet. Methods: Cell viability and anchorage-independent growth were evaluated in a panel of MM cell lines and human mesothelial cells (HM) upon FTY720 treatment to assess in vitro anti-tumor efficacy. The mechanism of action of FTY720 in MM was assessed by measuring the activity of phosphatase protein 2A (PP2A)-a major target of FTY720. The binding of the endogenous inhibitor SET to PP2A in presence of FTY720 was evaluated by immunoblotting and immunoprecipitation. Signaling and activation of programmed cell death were evaluated by immunoblotting and flow cytometry. A syngeneic mouse model was used to evaluate anti-tumor efficacy and toxicity profile of FTY720 in vivo. Results: We show that FTY720 significantly suppressed MM cell viability and anchorage-independent growth without affecting normal HM cells. FTY720 inhibited the phosphatase activity of PP2A by displacement of SET protein, which appeared overexpressed in MM, as compared to HM cells. FTY720 promoted AKT dephosphorylation and Bcl-2 degradation, leading to induction of programmed cell death, as demonstrated by caspase-3 and PARP activation, as well as by cytochrome c and AIF intracellular translocation. Moreover, FTY720 administration in vivo effectively reduced tumor burden in mice without apparent toxicity. Conclusions: Our preclinical data indicate that FTY720 is a potentially promising therapeutic agent for MM treatment
Quantitative CT of lung nodules: Dependence of calibration on patient body size, anatomic region, and calibration nodule size for singleâ and dualâ energy techniques
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134901/1/mp8536.pd
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