The tradeoff between an open or closed unit for residents with dementia:A qualitative study

Achtergrond: Er is groeiende aandacht voor bewegingsvrijheid als onderdeel van persoonsgerichte dementiezorg. Hoewel een gesloten deur veiligheidsrisico’s kan terugdringen, vermindert het doorgaans ook de kwaliteit van leven. Zorgorganisatie tanteLouise streeft naar maximale verantwoorde vrijheid voor bewoners met dementie. Toch worden bewoners soms overgeplaatst van een open naar gesloten psychogeriatrie (PG) afdeling.Doel: Inzicht krijgen in de overwegingen van zorgprofessionals bij overplaatsing van bewoners met dementie van een open naar een gesloten PG-afdeling binnen tanteLouise.Methode: Semigestructureerde diepte-interviews met verzorgenden en verpleegkundigen van open en gesloten PGafdelingen en een multidisciplinaire focusgroep. De data zijn thematisch geanalyseerd.Resultaten: Zowel open als gesloten PG kunnen volgens de deelnemers een passende woonomgeving bieden, afhankelijk van individuele bewoners. Open PG faciliteert vrijheid en eigen regie, en gesloten PG biedt veiligheid, structuur en deskundigebegeleiding. Het multidisciplinaire team bespreekt voor een overplaatsing de mogelijkheden en risico’s op open PG. Desondanks verhuizen bewoners regelmatig naar gesloten PG zonder geldige reden. Deelnemers streven naar meer vrijheid voor bewoners met dementie, waarvoor volgens hen nog randvoorwaarden ontbreken.Conclusie: De geboden structuur en deskundige begeleiding op gesloten PG, moet ook op open PG aanwezig zijn om vrijheid voor bewoners met dementie te behouden. Daarnaast zijn een cultuuromslag en randvoorwaarden vanuit deorganisatie noodzakelijk

The importance of the intensive care unit environment in sleep-A study with healthy participants

Sleep disruption is common among intensive care unit patients, with potentially detrimental consequences. Environmental factors are thought to play a central role in ICU sleep disruption, and so it is unclear why environmental interventions have shown limited improvements in objectively assessed sleep. In critically ill patients, it is difficult to isolate the influence of environmental factors from the varying contributions of non-environmental factors. We thus investigated the effects of the ICU environment on self-reported and objective sleep quality in 10 healthy nurses and doctors with no history of sleep pathology or current or past ICU employment participated. Their sleep at home, in an unfamiliar environment ('Control'), and in an active ICU ('ICU') was evaluated using polysomnography and the Richard-Campbell Sleep Questionnaire. Environmental sound, light and temperature exposure were measured continuously. We found that the control and ICU environment were noisier and warmer, but not darker than the home environment. Sleep on the ICU was perceived as qualitatively worse than in the home and control environment, despite relatively modest effects on polysomnography parameters compared with home sleep: mean total sleep times were reduced by 48 min, mean rapid eye movement sleep latency increased by 45 min, and the arousal index increased by 9. Arousability to an awake state by sound was similar. Our results suggest that the ICU environment plays a significant but partial role in objectively assessed ICU sleep impairment in patients, which may explain the limited improvement of objectively assessed sleep after environmental interventions

Nonpathological Extracellular Amyloid Is Present during Normal Epididymal Sperm Maturation

Amyloids are aggregated proteins characterized by a specific cross-β-sheet structure and are typically associated with neurodegenerative diseases including Alzheimer's disease. Recently, however, several nonpathological amyloids have been found in intracellular organelles of normal mammalian tissues suggesting that amyloid may also carry out biological functions. We previously have shown that the epididymal cystatin CRES (cystatin-related epididymal spermatogenic), cst8, a reproductive-specific member of the cystatin superfamily of cysteine protease inhibitors, forms amyloid in vitro suggesting that CRES amyloid may also form in vivo within the epididymal lumen. Here we show that amyloid structures containing CRES are a component of the normal mouse epididymal lumen without any apparent cytotoxic effects on spermatozoa and that these structures change along the length of the tubule. These studies suggest the presence of a functional amyloid structure that may carry out roles in sperm maturation or maintenance of the luminal milieu and which itself may undergo maturational changes along the epididymis. In contrast to previous examples of functional amyloid which were intracellular, our studies now show that nonpathological/functional amyloid can also be extracellular. The presence of an extracellular and nonpathological amyloid in the epididymis suggests that similar amyloid structures may be present in other organ systems and may carry out distinctive tissue-specific functions

Methodological concerns with laser speckle contrast imaging in clinical evaluation of microcirculation

Background Laser Speckle Contrast Imaging (LSCI) is a non-invasive and fast technique for measuring microvascular blood flow that recently has found clinical use for burn assessment and evaluation of flaps. Tissue motion caused by for example breathing or patient movements may however affect the measurements in these clinical applications, as may distance between the camera and the skin and tissue curvature. Therefore, the aims of this study were to investigate the effect of frame rate, number of frames/image, movement of the tissue, measuring distance and tissue curvature on the measured perfusion. Methods Methyl nicotinate-induced vasodilation in the forearm skin was measured using LSCI during controlled motion at different speeds, using different combinations of frame rate and number of frames/image, and at varying camera angles and distances. Experiments were made on healthy volunteers and on a cloth soaked in a colloidal suspension of polystyrene microspheres. Results Measured perfusion increased with tissue motion speed. The relation was independent of the absolute perfusion in the skin and of frame rate and number of frames/image. The measured perfusion decreased with increasing angles (16% at 60, p = 0.01). Measured perfusion did not vary significantly between measurement distances from 15 to 40 cm (p = 0.77, %CV 0.9%). Conclusion Tissue motion increases and measurement angles beyond 45 decrease the measured perfusion in LSCI. These findings have to be taken into account when LSCI is used to assess moving or curved tissue surfaces, which is common in clinical applications.Funding Agencies|ALF grants, Region Ostergotland</p

Clinical monitoring of activated clotting time during cardiothoracic surgery: comparing the Hemochron® Response and Hemochron® Signature Elite

Introduction: The Activated Clotting Time (ACT) is commonly used to manage anticoagulation during cardiac surgery. The aim of this study was to compare the older manually operated Hemochron® Response and the automated Hemochron® Signature Elite. Methods: In this observational study the clinically relevant differences of both devices were investigated simultaneously, using duplicate measurements, in 29 patients who underwent a Coronary Artery Bypass Grafting (CABG) or Aortic Valve Replacement (AVR) in order to determine reliability, bias, and to detect which method has the lowest variation. Blood samples were obtained from the arterial line prior to surgery, after administration of 300 IU/kg heparin, 5 minutes after initiation of cardiopulmonary bypass and successively every 30 minutes, and after protamine administration. Results: A total of 202 measurements were performed. Of these 10 measurements were out of range in the Response and 9 in the Elite. About 27 single unstable magnet errors were seen in the Response versus no measurement errors in the Elite. No statistically significant differences between the Response (p = 0.22, Wilcoxon rank) and Elite (p = 0.064) duplicates were observed. The Response values were consistently higher during heparinization than the Elite measurements (p = 0.002, repeated measurements) with an average positive bias of around 56 seconds during heparinization (Bland-Altman). Overall, the coefficient of variation (CoV) increased during heparinization. Conclusion: The Elite was more reliable, but the variation was higher for the Elite than the Response. The observed positive bias in the Response compared to the Elite could affect heparin administration during surgery making the two systems not interchangeable

System settings used in the investigation of motion in calibration fluid and in the skin of the forearm of 8 healthy subjects.

<p>System settings used in the investigation of motion in calibration fluid and in the skin of the forearm of 8 healthy subjects.</p

Relation between motion and measured perfusion in calibration fluid using different system settings (frame rate and number of frames).

<p>Relation between motion and measured perfusion in calibration fluid using different system settings (frame rate and number of frames).</p

Areas in which different concentrations of methyl nicotinate were applied (1: 40 mM, 2: 10 mM, 3: 2.5 mM) on the volar side of the forearm at different speeds (A: 0 mm/s, B: 25 mm/s, C: 41 mm/s, D: 90 mm/s).

<p>Areas in which different concentrations of methyl nicotinate were applied (1: 40 mM, 2: 10 mM, 3: 2.5 mM) on the volar side of the forearm at different speeds (A: 0 mm/s, B: 25 mm/s, C: 41 mm/s, D: 90 mm/s).</p

The setup of the experiment in healthy subjects.

<p>When investigating the effect of tissue motion, the forearm was resting on a laboratory shaker that generated motion at controlled speeds. When investigating the effect of camera angle and distance, the forearm was still and the camera head was tilted and moved up and down in relation to the skin surface of the forearm.</p

Influence of distance and angle on the measured perfusion in vivo on the dorsal side of the forearm.

<p>Influence of distance and angle on the measured perfusion in vivo on the dorsal side of the forearm.</p