2,968 research outputs found
Evaluating the existence of vertebrate deadfall communities from the Early Jurassic posidonienschiefer formation
Altres ajuts: CERCA Programme/Generalitat de CatalunyaLarge vertebrate carcasses contain significant amounts of nutrients that upon death are transferred from the water column to the benthos, enriching the immediate environment. The organisms exploiting these ephemeral resources vary as the carcass decays, creating an ecological succession: mobile scavengers arrive first, followed by enrichment opportunists, sulfophilic taxa, and lastly reef species encrusting the exposed bones. Such communities have been postulated to subsist on the carcasses of Mesozoic marine vertebrates, but are rarely documented in the Jurassic. In particular, these communities are virtually unknown from the Early Jurassic, despite the occurrence of several productive fossil Lagerstätte that have produced thousands of vertebrate bones and skeletons. We review published occurrences and present new findings related to the development of deadfall communities in the Toarcian Posidonienschiefer Formation of southwestern Germany, focusing on the classic locality of Holzmaden. We report the presence of the mobile scavenger, enrichment opportunist, and reef stages, and found potential evidence for the poorly documented sulfophilic stage. Although rare in the Posidonienschiefer Formation, such communities do occur in association with exceptionally preserved vertebrate specimens, complementing a growing body of evidence that a temporarily oxygenated benthic environment does not preclude exceptional vertebrate fossil preservation
Illuminating ATOM: Taking time across the colour category border
Walsh’s A Theory Of Magnitude (ATOM) contends that we represent magnitudes such as number, space, time and luminance on a shared metric, such that ‘more’ of one leads to the perception of ‘more’ of the other (e.g. Walsh, 2003). In support of ATOM, participants have been shown to judge intervals between stimuli that are more discrepant in luminance as having a longer duration than intervals between stimuli whose luminance differs by a smaller degree (Xuan, Zhang, He, & Chen, 2007). We tested the potential limits to the ability of luminance to influence duration perception by investigating the possibility that the luminance-duration relationship might be interrupted by a concurrent change in the colour of that luminance. We showed native Greek and native English speakers sequences of stimuli that could be either light or dark versions of green or blue. Whereas for both groups a shift in green luminance does not comprise a categorical shift in colour, for Greek speakers shifts between light and dark blue cross a colour category boundary (ghalazio and ble respectively). We found that duration judgements were neither interrupted nor inflated by a shift in colour category. These results represent the first evidence that the influence of luminance change on duration perception is resistant to interference from discrete changes within the same perceptual input
Evaluating a new generation of wearable high-density diffuse optical tomography (HD-DOT) technology via retinotopic mapping in the adult brain
We investigated the performance of a novel HD-DOT system by replicating a series of classic visual stimulation paradigms. Haemodynamic response functions and cortical activation maps replicated the results obtained with larger fibre-based systems
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Trends in the Population Prevalence of People Who Inject Drugs in US Metropolitan Areas 1992–2007
Background:
People who inject drugs (PWID) have increased risk of morbidity and mortality. We update and present estimates and trends of the prevalence of current PWID and PWID subpopulations in 96 US metropolitan statistical areas (MSAs) for 1992–2007. Current estimates of PWID and PWID subpopulations will help target services and help to understand long-term health trends among PWID populations.
Methodology:
We calculated the number of PWID in the US annually from 1992–2007 and apportioned estimates to MSAs using multiplier methods. We used four types of data indicating drug injection to allocate national annual totals to MSAs, creating four distinct series of component estimates of PWID in each MSA and year. The four component estimates are averaged to create the best estimate of PWID for each MSA and year. We estimated PWID prevalence rates for three subpopulations defined by gender, age, and race/ethnicity. We evaluated trends using multi-level polynomial models.
Results:
PWID per 10,000 persons aged 15–64 years varied across MSAs from 31 to 345 in 1992 (median 104.4) to 34 to 324 in 2007 (median 91.5). Trend analysis indicates that this rate declined during the early period and then was relatively stable in 2002–2007. Overall prevalence rates for non-Hispanic black PWID increased in 2005 as compared to other racial/ethnic groups. Hispanic prevalence, in contrast, declined across time. Importantly, results show a worrisome trend in young PWID prevalence since HAART was initiated – the mean prevalence was 90 to 100 per 10,000 youth in 1992–1996, but increased to >120 PWID per 10,000 youth in 2006–2007.
Conclusions:
Overall, PWID rates remained constant since 2002, but increased for two subpopulations: non-Hispanic black PWID and young PWID. Estimates of PWID are important for planning and evaluating public health programs to reduce harm among PWID and for understanding related trends in social and health outcomes
Investigating the Effects of Homocysteine as an Agonist on Invertebrate Glutamatergic Synapses
Hyperhomocysteinemia (HHcy) in mammals can produce neurological deficits, such as memory loss. The cause of the neurological issues is assumed to be due to homocysteine (HCY) binding to glutamatergic receptors in the central nervous system (CNS). High levels of HCY in the CNS are also associated with Amyotrophic Lateral Sclerosis (ALS) and Parkinson’s disease. Thus, understanding the detailed mechanisms of HCY in model preparations could be useful in developing potential treatments to neurodegenerative diseases with overlapping symptoms to HHcy. The aim of this study is to investigate the efficacy of HCY as an agonist at glutamatergic synapses in invertebrates. The glutamatergic synapses of the larval Drosophila melanogaster (D. melanogaster) and Procambarus clarkii (P. clarkii) neuromuscular junctions (NMJs) were utilized to examine the effects of applying HCY. Measurements of evoked synaptic transmission in both preparations revealed that 100 mM of HCY did not have any consistent effect. The expectation was that the acute action of HCY would have activated the glutamate receptors and then desensitized them so evoked transmission would be blocked. The pharmacological receptor profile of these NMJ receptors are of a quisqualate subtype and not a kainate, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) or N-methyl-D-aspartate receptor (NMDA) subtype. Consequently, HCY may not have any action on quisqualate glutamate receptor subtypes. The findings of this experiments could provide clinical implications regarding relevant pharmacological treatments in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson’s disease
Sigma model approach to string theory effective actions with tachyons
Motivated by recent discussions of actions for tachyon and vector fields
related to tachyon condensation in open string theory we review and clarify
some aspects of their derivation within sigma model approach. In particular, we
demonstrate that the renormalized partition function of boundary sigma
model gives the effective action for massless vectors which is consistent with
string S-matrix and beta function, resolving an old problem with this
suggestion in bosonic string case at the level of the leading
derivative corrections to Born-Infeld action. We give manifestly gauge
invariant definition of in non-abelian NSR open string theory and
check that its derivative reproduces the tachyon beta function in a particular
scheme. We also discuss derivation of similar actions for tachyon and massless
modes in closed bosonic and NSR (type 0) string theories.Comment: 26 pages, harvmac. To appear in the special issue of J. Math. Phys.
on Strings, Branes and M-theory. v4: minor editorial changes, version to
appear in JM
OSIRIS: A Decade of Scattered Light
Into year 11 of a 2-yr mission, OSIRIS is redefining how limb-scattered sunlight can be used to probe the atmosphere, even into the upper troposphere
Single electron-spin memory with a semiconductor quantum dot
We show storage of the circular polarisation of an optical field,
transferring it to the spin-state of an individual electron confined in a
single semiconductor quantum dot. The state is subsequently readout through the
electronically-triggered emission of a single photon. The emitted photon shares
the same polarisation as the initial pulse but has a different energy, making
the transfer of quantum information between different physical systems
possible. With an applied magnetic field of 2 Tesla, spin memory is preserved
for at least 1000 times more than the exciton's radiative lifetime.Comment: 7 pages, 4 figure
Dual wavelength spread-spectrum time-resolved diffuse optical instrument for the measurement of human brain functional responses
Near-infrared spectroscopy has proven to be a valuable method to monitor tissue oxygenation and haemodynamics non-invasively and in real-time. Quantification of such parameters requires measurements of the time-of-flight of light through tissue, typically achieved using picosecond pulsed lasers, with their associated cost, complexity, and size. In this work, we present an alternative approach that employs spread-spectrum excitation to enable the development of a small, low-cost, dual-wavelength system using vertical-cavity surface-emitting lasers. Since the optimal wavelengths and drive parameters for optical spectroscopy are not served by commercially available modules as used in our previous single-wavelength demonstration platform, we detail the design of a custom instrument and demonstrate its performance in resolving haemodynamic changes in human subjects during apnoea and cognitive task experiments
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