Authoritariansim and Collectivism: Antecedents and Consequences Among College Students

Moral Foundations Theory (MFT) suggests there are five distinct moral dimensions, which define morality as a whole. MFT can be broken down into two groups binding: in group/loyalty, authority/respect, and purity/sanctity-which encompass group morality. Harm/Care, fairness/reciprocity are individualizing dimensions, which highlight individual morality. Recent work has found MFT predicts sociopolitical ideologies, as well as sociopolitical attitudes. In an effort to better understand the existing relationships we investigate MFT as a predictor of sociopolitical parties, and attitudes Right-Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO). We also draw on similarities between Individualism/Collectivism and MFT. Specifically we demonstrate individualizing foundations, and dimensions of individualism predict SDO, where as Binding dimensions and dimensions of Collectivism relate to RWA

Method And System For Automatically Generating Artificial Intelligence Powered Prototypes

The present disclosure relates to a method and a system for automatically generating Artificial Intelligence (AI) powered prototypes. Here, a plurality of AI models is provided in a user interface of the system. Further, a selection of a set of the AI models is received via the user interface. For each of the set of the AI models, identification of input features and data sources is received via the user interface for training each of the plurality of AI models. Further, a selection of one or more rules for aggregating model inputs and model outputs is received via the user interface to form one or more searchable tables of sample data for at least one of the artificial intelligence models. The one or more rules include one or more categories of filtering criteria for populating the one or more searchable tables. In response to the user input, the model inputs in the data sources as defined by the input features are identified and a link between the model inputs and the artificial intelligence model is defined. Further, the one or more searchable tables having one or more columns corresponding to the one or more categories are created. Further, an order of operation of the set of artificial intelligence models is received via the user interface. In the order of operation, an output of one or more first AI models is used as an input for one or more second AI models. Thereafter, an AI ensemble that comprises the set of AI models is generated

Coffee Genogram: An Analysis of the Tradition of the Rural Family in Southwest Columbia

The analysis of the family context in rural communities can provide helpful insight to promote technology appropriation processes. For this study, the family context and its influence on the coffee tradition were investigated within the framework of a proposal to build knowledge and transfer technology. To address this aim, the construction of genograms was carried out, accompanied by semi-structured interviews with coffee women from a producer’s association in the department of Huila, Colombia. Key elements around their training process as coffee growers were analyzed based on the consolidation of a tradition derived from parents and grandparents, but with unknowns regarding their continuity in future generations. The findings showed a group of women, most of whom have lived and grown around coffee farming, where their role has changed from a position of support in the home to become leading actors in the coffee production processes. Opportunities and challenges were found in the face of the possibilities in the role of woman in the coffee growing development, but important questions arise regarding the role that the following generations may have in the future

Genome of Mycoplasma haemofelis, unraveling its strategies for survival and persistence

Mycoplasma haemofelis is a mycoplasmal pathogen (hemoplasma) that attaches to the host's erythrocytes. Distributed worldwide, it has a significant impact on the health of cats causing acute disease and, despite treatment, establishing chronic infection. It might also have a role as a zoonotic agent, especially in immunocompromised patients. Whole genome sequencing and analyses of M. haemofelis strain Ohio2 was undertaken as a step toward understanding its survival and persistence. Metabolic pathways are reduced, relying on the host to supply many of the nutrients and metabolites needed for survival. M. haemofelis must import glucose for ATP generation and ribose derivates for RNA/DNA synthesis. Hypoxanthine, adenine, guanine, uracil and CMP are scavenged from the environment to support purine and pyrimidine synthesis. In addition, nicotinamide, amino acids and any vitamins needed for growth, must be acquired from its environment. The core proteome of M. haemofelis contains an abundance of paralogous gene families, corresponding to 70.6% of all the CDSs. This "paralog pool" is a rich source of different antigenic epitopes that can be varied to elude the host's immune system and establish chronic infection. M. haemofelis also appears to be capable of phase variation, which is particularly relevant to the cyclic bacteremia and persistence, characteristics of the infection in the cat. The data generated herein should be of great use for understanding the mechanisms of M. haemofelis infection. Further, it will provide new insights into its pathogenicity and clues needed to formulate media to support the in vitro cultivation of M. haemofelis

UK science press officers, professional vision and the generation of expectations

Science press officers can play an integral role in helping promote expectations and hype about biomedical research. Using this as a starting point, this article draws on interviews with 10 UK-based science press officers, which explored how they view their role as science reporters and as generators of expectations. Using Goodwin’s notion of ‘professional vision’, we argue that science press officers have a specific professional vision that shapes how they produce biomedical press releases, engage in promotion of biomedical research and make sense of hype. We discuss how these insights can contribute to the sociology of expectations, as well as inform responsible science communication.This project was funded by the Wellcome Trust (Wellcome Trust Biomedical Strategic Award 086034)

P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments

Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human fibroblast cell line is sufficient to drive multiple migratory and invasive phenotypes. The invasive phenotype is greatly enhanced by the presence of a gradient of serum or platelet-derived growth factor, and is dependent upon the expression of functional PDGF receptor β. Consistently, the invasiveness of WM852 melanoma cells, which endogenously express P-Rex1 and PDGFRβ, is opposed by siRNA of either of these proteins. Furthermore, the current model of P-Rex1 activation is advanced through demonstration of P-Rex1 and PDGFRβ as components of the same macromolecular complex. These data suggest that P-Rex1 has an influence on physiological migratory processes, such as invasion of cancer cells, both through effects upon classical Rac1-driven motility and a novel association with RTK signalling complexes

Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo

Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage

Confirmed 6-Month Disability Improvement and Worsening Correlate with Long-term Disability Outcomes in Alemtuzumab-Treated Patients with Multiple Sclerosis: Post Hoc Analysis of the CARE-MS Studies.

INTRODUCTION In the 2-year CARE-MS trials (NCT00530348; NCT00548405) in patients with relapsing-remitting multiple sclerosis, alemtuzumab showed superior efficacy versus subcutaneous interferon beta-1a. Efficacy was maintained in two consecutive extensions (NCT00930553; NCT02255656). This post hoc analysis compared disability outcomes over 9 years among alemtuzumab-treated patients according to whether they experienced confirmed disability improvement (CDI) or worsening (CDW) or neither CDI nor CDW. METHODS CARE-MS patients were randomized to receive two alemtuzumab courses (12 mg/day; 5 days at baseline; 3 days at 12 months), with additional as-needed 3-day courses in the extensions. CDI or CDW were defined as ≥ 1.0-point decrease or increase, respectively, in Expanded Disability Status Scale (EDSS) score from core study baseline confirmed over 6 months, assessed in patients with baseline EDSS score ≥ 2.0. Improved or stable EDSS scores were defined as ≥ 1-point decrease or ≤ 0.5-point change (either direction), respectively, from core study baseline. Functional systems (FS) scores were also assessed. RESULTS Of 511 eligible patients, 43% experienced CDI and 34% experienced CDW at any time through year 9 (patients experiencing both CDI and CDW were counted in each individual group); 29% experienced neither CDI nor CDW. At year 9, patients with CDI had a -0.58-point mean EDSS score change from baseline; 88% had stable or improved EDSS scores. Improvements occurred across all FS, primarily in sensory, pyramidal, and cerebellar domains. Patients with CDW had a +1.71-point mean EDSS score change; 16% had stable or improved EDSS scores. Patients with neither CDI nor CDW had a -0.10-point mean EDSS score change; 98% had stable or improved EDSS scores. CONCLUSION CDI achievement at any point during the CARE-MS studies was associated with improved disability at year 9, highlighting the potential of alemtuzumab to change the multiple sclerosis course. Conversely, CDW at any point was associated with worsened disability at year 9