Análisis bibliométrico de información en salud basado en PubMed disponible en las redes sociales: un estudio de La India

Social networks have long been used to disseminate health-related information and help, and this use has increased with the emergence of online social media. The goal of this study is to conduct a bibliometric analysis of health information in the context of India. The literature available in PubMed is the source of the study. The objective of this paper is to develop a better insight into the literature on social media-based health information using bibliometric analysis in the context of India. The software used for bibliometric analysis is profile research networking software from Harvard University and Vosviewer. From the study, it is clear that social media is important in the context of public health. We also found out that although the number of publications in journals is highest but video-audio content has been cited more. Although there is a significant increase in publication during 2020, but number of researchers are still very few. It is clear that social media is of greater importance for marginalized people; health care providers and regulators must take precautions to avoid possible negative outcomes.Las redes sociales se han utilizado durante mucho tiempo para difundir información y ayuda relacionadas con la salud, y este uso ha aumentado con la aparición de las redes sociales en línea. El objetivo de este estudio es realizar un análisis bibliométrico de la información sanitaria en el contexto de la India. La literatura disponible en PubMed es la fuente del estudio. El objetivo de este artículo es desarrollar una mejor comprensión de la literatura sobre la información de salud basada en las redes sociales utilizando el análisis bibliométrico en el contexto de la India. El software utilizado para el análisis bibliométrico es un software de redes de investigación de perfiles de la Universidad de Harvard y Vosviewer. Del estudio, queda claro que las redes sociales son importantes en el contexto de la salud pública. También descubrimos que aunque el número de publicaciones en revistas es mayor, se ha citado más contenido de video-audio. Aunque hay un aumento significativo de la publicación durante 2020, el número de investigadores sigue siendo muy reducido. Está claro que las redes sociales son de mayor importancia para las personas marginadas. Los proveedores de atención médica y los reguladores deben tomar precauciones para evitar posibles resultados negativos

Tibial Fracture in an Elderly Female Patient of Rheumatoid Arthritis: A Preventable Iatrogenic Injury

Oral systemic glucocorticoids widely used in the medical practice to treat various diseases like asthma, systemic connective tissue diseases, other autoimmune diseases and in transplantology, are considered the main cause of secondary and iatrogenic osteoporosis. The pathogenesis of glucocorticoid induced bone loss is multifactorial and complex. The exact mechanism remains undefined. The present report describes a case of 65 yr old female presenting with fracture in mid shaft of tibia after a very low velocity trauma. On medical history elicitation, she was found to be treated for rheumatoid arthritis with oral glucocorticoids. Causality, severity and preventability assessment was done for the reaction. Potentiality of glucocorticoids causing fractures is often neglected by professionals and ignored by patient and their caregivers. Given the potential for rapid bone loss with glucocorticoid therapy, frequent monitoring is warranted while bearing in mind that BMD is a surrogate marker for fracture risk and patients on glucocorticoids fracture at higher BMD than other patients. Once treatment is initiated, BMD should be monitored annually to ensure compliance and efficacy

Tibial Fracture in an Elderly Female Patient of Rheumatoid Arthritis: A Preventable Iatrogenic Injury

Oral systemic glucocorticoids widely used in the medical practice to treat various diseases like asthma, systemic connective tissue diseases, other autoimmune diseases and in transplantology, are considered the main cause of secondary and iatrogenic osteoporosis. The pathogenesis of glucocorticoid induced bone loss is multifactorial and complex. The exact mechanism remains undefined. The present report describes a case of 65 yr old female presenting with fracture in mid shaft of tibia after a very low velocity trauma. On medical history elicitation, she was found to be treated for rheumatoid arthritis with oral glucocorticoids. Causality, severity and preventability assessment was done for the reaction. Potentiality of glucocorticoids causing fractures is often neglected by professionals and ignored by patient and their caregivers. Given the potential for rapid bone loss with glucocorticoid therapy, frequent monitoring is warranted while bearing in mind that BMD is a surrogate marker for fracture risk and patients on glucocorticoids fracture at higher BMD than other patients. Once treatment is initiated, BMD should be monitored annually to ensure compliance and efficacy

Applications and Constraints of Plant Beneficial Microorganisms in Agriculture

At present time, chemical fertilizers are more in practice for crop production, which failed to upkeep soil and environment quality and affected the sustainability of the agricultural production system. Conversely, biofertilizers are ecosystem friendly, one of the best modern tools for agriculture, and are used to improve soil fertility and quality. Biofertilizers have now emerged as a highly potent alternative to inorganic fertilizers and offer an ecologically sound and economically attractive route for augmenting nutrient supply and increasing crop production. These include live cells of diverse genera of microorganisms and have the potential to fix atmospheric nitrogen and solubilize and mobilize plant nutrients from insoluble form through microbiological process. It has also the potential to diminish the gap between nutrient supply through fertilizers and nutrient removal by crops. Hence, biofertilizers can be a feasible option to the farmers to increase crop productivity and should find greater acceptance from the extension workers and commercial biofertilizer manufacturers

ANTIMICROBIAL DRUG ADMINISTRATION AND FOOD TIMINGS: CLINICO-PHARMACOLOGICAL CONSIDERATIONS

Food may alter the extent or rate of absorption through various mechanisms, but not all pharmacokinetic effects are clinically relevant. Understanding the possible clinical implications of taking a drug with or without a meal is important for achieving its quality use. Although the effect of food is not clinically important for many drugs, there are food-drug interactions which may have adverse consequences. These interactions can be avoided by taking the medicines with consideration of the time of taking meals

Unexpected role of sterol synthesis in RNA stability and translation in Leishmania

Leishmania parasites are trypanosomatid protozoans that cause leishmaniasis affecting millions of people worldwide. Sterols are important components of the plasma and organellar membranes. They also serve as precursors for the synthesis of signaling molecules. Unlike animals, Leishmania does not synthesize cholesterol but makes ergostane-based sterols instead. C-14-demethylase is a key enzyme involved in the biosynthesis of sterols and an important drug target. In Leishmania parasites, the inactivation of C-14-demethylase leads to multiple defects, including increased plasma membrane fluidity, mitochondrion dysfunction, hypersensitivity to stress and reduced virulence. In this study, we revealed a novel role for sterol synthesis in the maintenance of RNA stability and translation. Sterol alteration in C-14-demethylase knockout mutant leads to increased RNA degradation, reduced translation and impaired heat shock response. Thus, sterol biosynthesis in Leishmania plays an unexpected role in global gene regulation

Design and Synthesis of Fluorescent Carbon Dot Polymer and Deciphering Its Electronic Structure

Herein we report the one-pot synthesis of a fluorescent polymer-like material (pCD) by exploiting ruthenium-doped carbon dots (CDs) as building blocks. The unusual spectral profiles of pCDswith double-humped periodic excitation dependent photoluminescence (EDPL), and the regular changes in their corresponding average lifetime indicate the formation of high energy donor states and low energy aggregated states due to the overlap of molecular orbitals throughout the chemically switchable π-network of CDs on polymerization. To probe the electronic distribution of pCDs, we have investigated the occurrence of photoinduced electron transfer with a model electron acceptor, menadione using transient absorption technique, corroborated with low magnetic field, followed by identification of the transient radical ions generated through electron transfer. The experimentally obtained B_(1/2) value, a measure of the hyperfine interactions present in the system, indicates the presence of highly conjugated π-electron cloud in pCDs. The mechanism of formation of pCDs and the entire experimental findings have further been investigated through molecular modeling and computational modeling. The DFT calculations demonstrated probable electronic transitions from the surface moieties of pCDs to the tethered ligands

Design and Synthesis of Fluorescent Carbon Dot Polymer and Deciphering Its Electronic Structure

Herein we report the one-pot synthesis of a fluorescent polymer-like material (pCD) by exploiting ruthenium-doped carbon dots (CDs) as building blocks. The unusual spectral profiles of pCDswith double-humped periodic excitation dependent photoluminescence (EDPL), and the regular changes in their corresponding average lifetime indicate the formation of high energy donor states and low energy aggregated states due to the overlap of molecular orbitals throughout the chemically switchable π-network of CDs on polymerization. To probe the electronic distribution of pCDs, we have investigated the occurrence of photoinduced electron transfer with a model electron acceptor, menadione using transient absorption technique, corroborated with low magnetic field, followed by identification of the transient radical ions generated through electron transfer. The experimentally obtained B_(1/2) value, a measure of the hyperfine interactions present in the system, indicates the presence of highly conjugated π-electron cloud in pCDs. The mechanism of formation of pCDs and the entire experimental findings have further been investigated through molecular modeling and computational modeling. The DFT calculations demonstrated probable electronic transitions from the surface moieties of pCDs to the tethered ligands