1,162 research outputs found
A study of laser wave scattering due to refractive index perturbations in the propagating medium Final report, 5 Oct. 1965 - 15 Aug. 1966
Data recording and processing systems for GT-7 LASER communicator experiment - laser wave scattering due to refractive index perturbations in propagating mediu
Stanfordâs Unconceived Alternatives from the Perspective of Epistemic Obligations
Kyle Stanford's reformulation of the problem of underdetermination has the potential to highlight the epistemic obligations of scientists. Stanford, however, presents the phenomenon of unconceived alternatives as a problem for realists, despite critics' insistence that we have contextual explanations for scientists' failure to conceive of their successors' theories. I propose that responsibilist epistemology and the concept of ârole oughts,â as discussed by Lorraine Code and Richard Feldman, can pacify Stanford's critics and reveal broader relevance of the ânew induction.â The possibility of unconceived alternatives pushes us to question our contemporary expectation for scientists to reason outside of their historical moment
Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital
Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD). Serious side-effects of such an immunomodulating therapy are speculated and therefore we reviewed our clinical experience in a retrospective safety study looking upon a single cohort of 100 IBD patients from a large German University Hospital. Methods: 100 patients with severe Crohn's disease (n = 92), ulcerative colitis (n = 7) or indeterminate colitis (n = 1) treated with infliximab (5 mg/kg) from January 2000 to December 2003 were retrospectively analysed for acute and subacute adverse events by chart review. Results: Overall, infliximab therapy was generally well tolerated. No fatal complications, malignancies, autoimmune diseases, neurologic or cardiovascular complications were observed in the cohort during the study period. Overall, adverse events were observed in 10 patients: 2 patients showed an acute infusion reaction, 1 patient a serum sickness-like reaction, in 4 patients a bacterial or viral infection occurred, in 1 patient pancytopenia and 2 patients developed surgical complications. Only 6 patients with adverse events required admission to hospital. A case of tuberculosis after infliximab was not found. The lack of adverse side-effects was associated with young median age and infrequent comorbidities of the cohort. Conclusion: Regarding its strong immunomodulating capacity, infliximab appears to be an efficient and relatively safe therapeutic option for patients with severe IBD. However, the use of infliximab requires careful screening and close patient monitoring to identify patients at risk and the infrequent, but sometimes serious complications of infliximab. Copyright (C) 2004 S. Karger AG, Basel
In Defense of the Epistemic Imperative
Sample (2015) argues that scientists ought not to believe that their theories are true because they cannot fulfill the epistemic obligation to take the diachronic perspective on their theories. I reply that Sampleâs argument imposes an inordinately heavy epistemic obligation on scientists, and that it spells doom not only for scientific theories but also for observational beliefs and philosophical ideas that Samples endorses. I also delineate what I take to be a reasonable epistemic obligation for scientists. In sum, philosophers ought to impose on scientists only an epistemic standard that they are willing to impose on themselves
A high resolution atlas of the galactic plane at 12 microns and 25 microns
High resolution images of the 12 micron and 25 micron IRAS survey data from each HCON crossing the Galactic Plane are being created for those regions that the original IRAS processing labeled as confused. This encompasses the area within 100 deg longitude of the Galactic Center and within 3 deg to 10 deg of the Plane. The procedures used to create the images preserve the spatial resolution inherent in the IRAS instrument. The images are separated into diffuse and point source components and candidate sources are extracted from the point source image after non-linear spatial sharpening. Fluxes are estimated by convolving the candidate sources with the point response function and cross-correlating with the original point source image. A source is considered real if it is seen on at least two HCON's with a rather generous flux match but a stringent position criterion. A number of fields spanning a range of source densities from low to high have been examined. Initial analysis indicates that the imaging and extraction works quite well up to a source density of about 100 sources per square degree or down to roughly 0.8 Janskys
VerdictDB: Universalizing Approximate Query Processing
Despite 25 years of research in academia, approximate query processing (AQP)
has had little industrial adoption. One of the major causes of this slow
adoption is the reluctance of traditional vendors to make radical changes to
their legacy codebases, and the preoccupation of newer vendors (e.g.,
SQL-on-Hadoop products) with implementing standard features. Additionally, the
few AQP engines that are available are each tied to a specific platform and
require users to completely abandon their existing databases---an unrealistic
expectation given the infancy of the AQP technology. Therefore, we argue that a
universal solution is needed: a database-agnostic approximation engine that
will widen the reach of this emerging technology across various platforms.
Our proposal, called VerdictDB, uses a middleware architecture that requires
no changes to the backend database, and thus, can work with all off-the-shelf
engines. Operating at the driver-level, VerdictDB intercepts analytical queries
issued to the database and rewrites them into another query that, if executed
by any standard relational engine, will yield sufficient information for
computing an approximate answer. VerdictDB uses the returned result set to
compute an approximate answer and error estimates, which are then passed on to
the user or application. However, lack of access to the query execution layer
introduces significant challenges in terms of generality, correctness, and
efficiency. This paper shows how VerdictDB overcomes these challenges and
delivers up to 171 speedup (18.45 on average) for a variety of
existing engines, such as Impala, Spark SQL, and Amazon Redshift, while
incurring less than 2.6% relative error. VerdictDB is open-sourced under Apache
License.Comment: Extended technical report of the paper that appeared in Proceedings
of the 2018 International Conference on Management of Data, pp. 1461-1476.
ACM, 201
Patients with an ICD Can Safely Resume Work in Industrial Facilities Following Simple Screening for Electromagnetic Interference
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74026/1/j.1460-9592.2003.t01-1-00251.x.pd
The MAGIC of CINEMA: First in-flight science results from a miniaturised anisotropic magnetoresistive magnetometer
We present the first in-flight results from a novel miniaturised anisotropic
magnetoresistive space magnetometer, MAGIC (MAGnetometer from Imperial
College), aboard the first CINEMA (CubeSat for Ions, Neutrals, Electrons
and MAgnetic fields) spacecraft in low Earth orbit. An attitude-independent
calibration technique is detailed using the International Geomagnetic
Reference Field (IGRF), which is temperature dependent in the case of the
outboard sensor. We show that the sensors accurately measure
the expected absolute field to within 2% in attitude mode and 1%
in science mode. Using a simple method we are able to estimate the
spacecraft's attitude using the magnetometer only, thus characterising
CINEMA's spin, precession and nutation. Finally, we show that the
outboard sensor is capable of detecting transient physical signals
with amplitudes of ~ 20â60 nT. These include field-aligned currents
at the auroral oval, qualitatively similar to previous observations,
which agree in location with measurements from the DMSP
(Defense Meteorological Satellite Program) and POES
(Polar-orbiting Operational Environmental Satellites) spacecraft.
Thus, we demonstrate and discuss the potential science capabilities
of the MAGIC instrument onboard a CubeSat platform
Jamming and Fluctuations in Granular Drag
We investigate the dynamic evolution of jamming in granular media through
fluctuations in the granular drag force. The successive collapse and formation
of jammed states give a stick-slip nature to the fluctuations which is
independent of the contact surface between the grains and the dragged object --
thus implying that the stress-induced collapse is nucleated in the bulk of the
granular sample. We also find that while the fluctuations are periodic at small
depths, they become "stepped" at large depths, a transition which we interpret
as a consequence of the long-range nature of the force chains.Comment: 7 pages, 4 figures, RevTe
- âŠ