Malay reserve land: how to turn a basketful of problems into a bouquet of opportunities / Nurdeenie Abdul Rashid and Samira Khalili

Too many people have commented on the policy of Malay Reserve Land. You have a group of people that holds it a sentiment to heart and then you have the group averse to the whole idea of the policy. What is undoubtedly agreed by all parties however, is that attached to a Malay Reserve Land is an abundance of problems; a basketful of problems. Therefore, this paper is aimed to look in to the ways in which this basketful of problems can be turned into a bouquet of opportunities. Therefore, this paper is aimed to look in to the ways in which this basketful of problems can be turned into a bouquet of opportunities. The focal purpose of this paper is to determine the problems underlying Malay Reserve Lands and to offer recommendations on how to resolve it. Firstly, the fact that the lands are of a lower value than other normal lands will be looked at and the reasons as to why it is so. The policy of Malay Reserve Land under land acquisition by the government will also be looked at. Besides that, a comparison will also be made between the Malay Reservation Enactment 1933 (Cap. 142) that involves the former Federated Malay States with the five other State Enactments involving the former Unfederated Malay States, and in doing so, proving the need of uniformity and cohesiveness of laws regarding Malay Reserve Land. The study will also dissect each scheme of prohibition in all the significant laws

High-power intracavity few-cycle THz pulse generation using thin lithium niobate

Resonant enhancement both in passive and active resonators is a well-known technique for boosting the efficiency of nonlinear frequency conversion at high repetition rates. However, this route has remained poorly explored for the generation of few-cycle broadband THz transients due to the inadequacy of typically employed nonlinear crystals. Here, we demonstrate that thin lithium niobate crystals are a promising platform to circumvent current difficulties. Using a 50-um thin lithium niobate plate intracavity of a compact high-power mode-locked thin-disk laser, we generate broadband THz pulses with a spectrum extending up to 3 THz at 44.8 MHz repetition rate, driven by 264 W of intracavity average power. This approach opens the door to efficient high-power single-cycle THz generation at high repetition rates, scalable to kilowatt-level driving power with low cost and complexity

The Prevalence of Polycystic Ovary Syndrome, Its Phenotypes and Cardio-Metabolic Features in a Community Sample of Iranian Population : Tehran Lipid and Glucose Study

publishedVersio

Developement and validation of flourishing questionnaire based on seligman's model among Iranian university students

The main purpose of this study was designing a questionnaire to measure human flourishing based on Seligman’s model. Therefore, based on an extensive literature review of existing measures, an initial questionnaire with 50 questions was prepared. Sample was selected randomly in two stages. In the initial stage, a sample of 50 people were selected in order to assessment the reliability, and then a sample of 400 for performing factor analysis. According to the results of factor analysis, the 28 items which were positively correlated with the total test and at least had a factor loading of 35/0 or higher on a factor, were selected for the final questionnaire. The questionnaire of 28 items, was named human flourishing. Validity of the human flourishing questionnaire (HFQ) was calculated via the correlation coefficient of this scale with "The Ahvaz self-actualization questionnaire ", Diener’s flourishing questionnaire and depression questionnaire of Beck. Accordingly, a four-factor structure was achieved including positive emotions, relationships, meaning, and achievement. In addition, the HFQ’s reliability was determined using internal consistency (Cronbach's alpha). The result in this study showed that FQ has satisfactory reliability and validity coefficients so can be used in psychological research and measuring studies in order to measure human flourishing

Is there any association between contrast-induced nephropathy and serum uric acid levels?

Introduction: During the recent years, several studies have investigated that hyperuricemia is associated with greater incidence of contrast induced nephropathy (CIN). Most of them are in acute conditions like primary percutaneous coronary interventions. This study aimed to assess the relationship between high serum uric acid and incidence of acute kidney injury in patients undergoing elective angiography and angioplasty. Methods: This prospective study was conducted on 211 patients who were admitted to hospital for elective coronary angiography or angioplasty. The researchers measured serum creatinine and uric acid on admission and repeated creatinine measurement in 48 hours and seven days after the procedure. According to serum uric acid, the patients were divided into two groups; group 1 with normal uric acid and group 2 with hyperuricemia which was defined as uric acid more than 6 mg/dL in women and 7 mg/dL in men. CIN is defined as an increased creatinine level of more than 0.5 mg/dL or 25% from the baseline in 48 hours after the intervention. Results: In total, 211 patients with mean age of 60.58 years were enrolled in the study. Of these, 87 (41.2%) patients were in the high uric acid group and 124 (58.8%) were in the normal uric acid group. CIN was occurred in 16 patients (7.5%). Seven out of 16 (8.04%) were in the high uric acid and nine (7.2%) were in the normal uric acid group. There were no significant differences between the two groups (P =0.831). Conclusion: The frequency of CIN development was not different in the patients with hyperuricemia

Expression variation in connected recombinant populations of Arabidopsis thaliana highlights distinct transcriptome architectures

<p>Abstract</p> <p>Background</p> <p>Expression traits can vary quantitatively between individuals and have a complex inheritance. Identification of the genetics underlying transcript variation can help in the understanding of phenotypic variation due to genetic factors regulating transcript abundance and shed light into divergence patterns. So far, only a limited number of studies have addressed this subject in Arabidopsis, with contrasting results due to dissimilar statistical power. Here, we present the transcriptome architecture in leaf tissue of two RIL sets obtained from a connected-cross design involving 3 commonly used accessions. We also present the transcriptome architecture observed in developing seeds of a third independent cross.</p> <p>Results</p> <p>The utilisation of the novel R/eqtl package (which goal is to automatize and extend functions from the R/qtl package) allowed us to map 4,290 and 6,534 eQTLs in the Cvi-0 × Col-0 and Bur-0 × Col-0 recombinant populations respectively. In agreement with previous studies, we observed a larger phenotypic variance explained by eQTLs in linkage with the controlled gene (potentially <it>cis</it>-acting), compared to distant loci (acting necessarily indirectly or in <it>trans</it>). Distant eQTLs hotspots were essentially not conserved between crosses, but instead, cross-specific. Accounting for confounding factors using a probabilistic approach (VBQTL) increased the mapping resolution and the number of significant associations. Moreover, using local eQTLs obtained from this approach, we detected evidence for a directional allelic effect in genes with related function, where significantly more eQTLs than expected by chance were up-regulated from one of the accessions. Primary experimental data, analysis parameters, eQTL results and visualisation of LOD score curves presented here are stored and accessible through the QTLstore service database <url>http://qtlstore.versailles.inra.fr/</url>.</p> <p>Conclusions</p> <p>Our results demonstrate the extensive diversity and moderately conserved eQTL landscape between crosses and validate the utilisation of expression traits to explore for candidates behind phenotypic variation among accessions. Furthermore, this stresses the need for a wider spectrum of diversity to fully understand expression trait variation within a species.</p

Does fasting plasma glucose values 5.1-5.6 mmol/l in the first trimester of gestation a matter?

ObjectivesThe aim of the study was to investigate the effect of treatment on pregnancy outcomes among women who had fasting plasma glucose (FPG) 5.1-5.6 mmol/l in the first trimester of pregnancy.MethodsWe performed a secondary-analysis of a randomized community non-inferiority trial of gestational diabetes mellitus (GDM) screening. All pregnant women with FPG values range 5.1-5.6 mmol/l in the first trimester of gestation were included in the present study (n=3297) and classified to either the (i) intervention group who received treatment for GDM along with usual prenatal care (n=1,198), (ii) control group who received usual-prenatal-care (n=2,099). Macrosomia/large for gestational age (LGA) and primary cesarean-section (C-S) were considered as primary-outcomes. A modified-Poisson-regression for binary outcome data with a log link function and robust error variance was used to RR (95%CI) for the associations between GDM status and incidence of pregnancy outcomes.ResultsThe mean maternal age and BMI of pregnant women in both study groups were similar. There were no statistically significant differences in the adjusted risks of adverse pregnancy outcomes, including macrosomia, primary C-S, preterm birth, hyperbilirubinemia, preeclampsia, NICU-admission, birth trauma, and LBW both groups.ConclusionsIt is found that treating women with first-trimester FPG values of 5.1-5.6 mmol/l could not improve adverse pregnancy outcomes including macrosomia, Primary C-S, Preterm birth, hypoglycemia, hypocalcemia, preeclampsia, NICU admission, Birth trauma and LBW. Therefore, extrapolating the FPG cut-off point of the second trimester to the first –which has been proposed by the IADPSG, might therefore not be appropriate.Clinical Trial Registrationhttps://www.irct.ir/trial/518, identifier IRCT138707081281N1

Effect of Intermediate-Dose vs Standard-Dose Prophylactic Anticoagulation on Thrombotic Events, Extracorporeal Membrane Oxygenation Treatment, or Mortality among Patients with COVID-19 Admitted to the Intensive Care Unit: The INSPIRATION Randomized Clinical Trial

Importance: Thrombotic events are commonly reported in critically ill patients with COVID-19. Limited data exist to guide the intensity of antithrombotic prophylaxis. Objective: To evaluate the effects of intermediate-dose vs standard-dose prophylactic anticoagulation among patients with COVID-19 admitted to the intensive care unit (ICU). Design, Setting, and Participants: Multicenter randomized trial with a 2 � 2 factorial design performed in 10 academic centers in Iran comparing intermediate-dose vs standard-dose prophylactic anticoagulation (first hypothesis) and statin therapy vs matching placebo (second hypothesis; not reported in this article) among adult patients admitted to the ICU with COVID-19. Patients were recruited between July 29, 2020, and November 19, 2020. The final follow-up date for the 30-day primary outcome was December 19, 2020. Interventions: Intermediate-dose (enoxaparin, 1 mg/kg daily) (n = 276) vs standard prophylactic anticoagulation (enoxaparin, 40 mg daily) (n = 286), with modification according to body weight and creatinine clearance. The assigned treatments were planned to be continued until completion of 30-day follow-up. Main Outcomes and Measures: The primary efficacy outcome was a composite of venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days, assessed in randomized patients who met the eligibility criteria and received at least 1 dose of the assigned treatment. Prespecified safety outcomes included major bleeding according to the Bleeding Academic Research Consortium (type 3 or 5 definition), powered for noninferiority (a noninferiority margin of 1.8 based on odds ratio), and severe thrombocytopenia (platelet count &lt;20 �103/µL). All outcomes were blindly adjudicated. Results: Among 600 randomized patients, 562 (93.7) were included in the primary analysis (median interquartile range age, 62 50-71 years; 237 42.2% women). The primary efficacy outcome occurred in 126 patients (45.7%) in the intermediate-dose group and 126 patients (44.1%) in the standard-dose prophylaxis group (absolute risk difference, 1.5% 95% CI,-6.6% to 9.8%; odds ratio, 1.06 95% CI, 0.76-1.48; P =.70). Major bleeding occurred in 7 patients (2.5%) in the intermediate-dose group and 4 patients (1.4%) in the standard-dose prophylaxis group (risk difference, 1.1% 1-sided 97.5% CI,-� to 3.4%; odds ratio, 1.83 1-sided 97.5% CI, 0.00-5.93), not meeting the noninferiority criteria (P for noninferiority &gt;.99). Severe thrombocytopenia occurred only in patients assigned to the intermediate-dose group (6 vs 0 patients; risk difference, 2.2% 95% CI, 0.4%-3.8%; P =.01). Conclusions and Relevance: Among patients admitted to the ICU with COVID-19, intermediate-dose prophylactic anticoagulation, compared with standard-dose prophylactic anticoagulation, did not result in a significant difference in the primary outcome of a composite of adjudicated venous or arterial thrombosis, treatment with extracorporeal membrane oxygenation, or mortality within 30 days. These results do not support the routine empirical use of intermediate-dose prophylactic anticoagulation in unselected patients admitted to the ICU with COVID-19. Trial Registration: ClinicalTrials.gov Identifier: NCT04486508. © 2021 American Medical Association. All rights reserved

A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

In recent decades, the use of nanomaterials has received much attention in industrial and medical fields. However, some reports have mentioned adverse effects of these materials on the biological systems and cellular components. There are several major mechanisms for cytotoxicity of nanoparticles (NPs) such as physicochemical properties, contamination with toxic element, fibrous structure, high surface charge and radical species generation. In this review, a brief key mechanisms involved in toxic effect of NPs are given, followed by the in vitro toxicity assays of NPs and prooxidant effects of several NPs such as carbon nanotubes, titanium dioxide NPs, quantum dots, gold NPs and silver NPs

Evaluating of Drought Tolerance of Doubled Haploid Barley (Hordeum vulgare L.) Lines using Toleance Indices

To identify drought tolerant genotypes from 40 doubled haploid and 5 barley cultivars an experiment in a randomized complete block design with three replications was conducted both at normal irrigation and water deficit stress conditions at the Agricultural Research Station of West Azarbayjan, at Miyandoab during 1390-91 crop years. A significant difference was observed among the genotypes concering grain yield, which indicates a high genetic diversity for this trait among genotypes under study. Genotypes No. 35, 24, 21 and 3 were highest yielders in both irrigation conditions. In this study, during tolerance of genotypes under both stress and normal irrigation conditions, were evaluated by using mean productivity (MP), tolerance (TOL), geometric mean productivity (GMP), stress susceptibility (SSI), and stress tolerance (STI) indices. According SSI and TOL indices genotypes 13, 16, 1, 19, 8 and 5 were identified as tolerant genotypes to water stress. Genotypes 3, 24 and 35 were found to have highest STI, MP and GMP indices. Correlation coefficients indicated that STI, MP and GMP were the best indices to select barley tolerant genotypes to water deficit stress in this study. It was also revealed that genotypes 3, 21, 24 and 35 which were highest yielders under normal irrigation and did have the least reduction in their yield under deficit irrigation. Thus, they can be recommended to the experimental site as the top producers