On derivatives of polynomials over finite fields through integration

In this note, using rather elementary technique and the derived formula that relates the coefficients of a polynomial over a finite field and its derivative, we deduce many interesting results related to derivatives of Boolean functions and derivatives of mappings over finite fields. For instance, we easily identify several infinite classes of polynomials which cannot possess linear structures. The same technique can be applied for deducing a nontrivial upper bound on the degree of so-called planar mappings

Specifying cycles of minimal length for commonly used linear layers in block ciphers

With the advances of Internet-of-Things (IoT) applications in smart cities and the pervasiveness of network devices with limited resources, lightweight block ciphers have achieved rapid development recently. Due to their relatively simple key schedule, nonlinear invariant attacks have been successfully applied to several families of lightweight block ciphers. This attack relies on the existence of a nonlinear invariant g:\F_2^n \rightarrow \F_2 for the round function $F_k$ so that $g(x) + g(F_k(x))$ is constant for any input value $x$. Whereas invariants of the entire $S$-box layer has been studied in terms of the corresponding cycle structure [TLS16,WRP20] (assuming the use of bijective S-boxes), a similar analysis for the linear layer has not been performed yet. In this article, we provide a theoretical analysis for specifying the minimal length of cycles for commonly used linear permutations (implementing linear layers) in lightweight block ciphers. Namely, using a suitable matrix representation, we exactly specify the minimal cycle lengths for those (efficiently implemented) linear layers that employ ShiftRows, Rotational-XOR and circular Boolean matrix operations which can be found in many well-known families of block ciphers. These results are practically useful for the purpose of finding nonlinear invariants of the entire encryption rounds since these can be specified using the intersection of cycles corresponding to the linear and S-box layer. We also apply our theoretical analysis practically and specify minimal cycle lengths of linear layers for certain families of block ciphers including some NIST candidates

Integral Distinguishers of the Full-Round Lightweight Block Cipher SAT_Jo

Integral cryptanalysis based on division property is a powerful cryptanalytic method whose range of successful applications was recently extended through the use of Mixed-Integer Linear Programming (MILP). Although this technique was demonstrated to be efficient in specifying distinguishers of reduced round versions of several families of lightweight block ciphers (such as SIMON, PRESENT, and few others), we show that this method provides distinguishers for a full-round block cipher SAT_Jo. SAT_Jo cipher is very similar to the well-known PRESENT block cipher, which has successfully withstood the known cryptanalytic methods. The main difference compared to PRESENT, which turns out to induce severe weaknesses of SAT_Jo algorithm, is its different choice of substitution boxes (S-boxes) and the bit-permutation layer for the reasons of making the cipher highly resource-efficient. Even though the designers provided a security analysis of this scheme against some major generic cryptanalytic methods, an application of the bit-division property in combination with MILP was not considered. By specifying integral distinguishers for the full-round SAT_Jo algorithm using this method, we essentially disapprove its use in intended applications. Using a 30-round distinguisher, we also describe a subkey recovery attack on the SAT_Jo algorithm whose time complexity is about 266 encryptions (noting that SAT_Jo is designed to provide 80 bits of security). Moreover, it seems that the choice of bit-permutation induces weak division properties since replacing the original bit-permutation of SAT_Jo by the one used in PRESENT immediately renders integral distinguishers inefficient

Cohort profile: the ESC EURObservational Research Programme Non-ST-segment elevation myocardial infraction (NSTEMI) Registry

Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Non-ST-segment elevation myocardial infarction (NSTEMI) Registry aims to identify international patterns in NSTEMI management in clinical practice and outcomes against the 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without ST-segment-elevation. Methods and results Consecutively hospitalised adult NSTEMI patients (n = 3620) were enrolled between 11 March 2019 and 6 March 2021, and individual patient data prospectively collected at 287 centres in 59 participating countries during a two-week enrolment period per centre. The registry collected data relating to baseline characteristics, major outcomes (inhospital death, acute heart failure, cardiogenic shock, bleeding, stroke/transient ischaemic attack, and 30-day mortality) and guideline-recommended NSTEMI care interventions: electrocardiogram pre- or in-hospital, prehospitalization receipt of aspirin, echocardiography, coronary angiography, referral to cardiac rehabilitation, smoking cessation advice, dietary advice, and prescription on discharge of aspirin, P2Y12 inhibition, angiotensin converting enzyme inhibitor (ACEi)/angiotensin receptor blocker (ARB), beta-blocker, and statin. Conclusion The EORP NSTEMI Registry is an international, prospective registry of care and outcomes of patients treated for NSTEMI, which will provide unique insights into the contemporary management of hospitalised NSTEMI patients, compliance with ESC 2015 NSTEMI Guidelines, and identify potential barriers to optimal management of this common clinical presentation associated with significant morbidity and mortality

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)