Seasonal variation of arbuscular mycorrhiza fungi colonization with some medicinal plant species of Chittagong BCSIR forest

This study aimed to evaluate the effects of seasonality on mycorrhizal colonization characteristics as hyphal, vesicular and arbuscular colonization with some medicinal plants species of Chittagong BCSIR forest of Bangladesh. Ten highly valued medicinal plants were selected randomly from Chittagong BCSIR forest to conduct the research. Root samples were collected and examined to determine fungal colonization in three times (Dry, Rainy and Winter) during the year in 2014. The result revealed that the medicinal plants of BCSIR forest were mycorrhizal. The highest hyphal colonization was obtained during rainy season of the corresponding year but decreased during dry and winter season. Vesicular colonization was attenuated during rainy season but increased in dry and winter season but arbuscular colonization was higher proportion in rainy and winter season whereas arbuscular colonization reduced in dry season. This result indicates that AMF colonization varies seasonally as well as depending on some factors like as climate, edaphic, plant host relationship and species diversity

Genetic variations of CYP2R1 (rs10741657) in Bangladeshi adults with low serum 25(OH)D level—A pilot study

BACKGROUND: Some studies revealed that despite having sufficient sun exposure and dietary supply, the level of serum 25(OH)D in Bangladeshi adults is lower than its normal range. Genetic pattern of an individual is also an essential factor that regulates the level of serum 25(OH)D. However, the genetic variations of CYP2R1 (rs10741657) and their association with low serum 25(OH)D level in Bangladeshi adults are yet to be explored. OBJECTIVE: This study was conducted to determine the frequency of variants of rs10741657 of CYP2R1 gene and its association with low serum 25(OH)D level among Bangladeshi adults. METHOD: This pilot study was conducted among thirty individuals with low serum 25(OH)D level as the study population and ten subjects with sufficient serum 25(OH)D level as controls based on the inclusion and exclusion criteria. Genetic analysis of rs10741657 of CYP2R1 including primer designing, DNA extraction, PCR of target region with purification and Sanger sequencing of the PCR products were done accordingly. For statistical analysis, One-way ANOVA followed by LSD test, Freeman-Halton extension of Fisher’s exact test, Chi-square test (χ(2)) test and unpaired student t-test were performed. RESULTS: In this study, genetic variants of CYP2R1 (rs10741657) among the study population were genotype GG (63.30%), GA (30%) and AA (6.7%). Minor allele frequency of the study population was 0.217. The association between GG and GA genotypes of CYP2R1 (rs10741657) with low serum 25(OH)D level among the study population was found and it was statistically significant. Statistically significant differences were also observed between the genotypes and alleles of the study population and controls. CONCLUSIONS: The presence of ‘GG’ and ‘GA’ genotypes of rs1041657 in CYP2R1 gene is associated with low serum 25(OH)D level among Bangladeshi adults in this pilot study

Numerical simulation of lead-free vacancy ordered Cs 2 PtI 6 based perovskite solar cell using SCAPS-1D

In recent years, vacancy-ordered halide double perovskites have emerged as promising non-toxic and stable alternatives for their lead-based counterparts in optoelectronic applications. In particular, vacancy ordered Cs2PtI6 has emerged as a star material because of its high absorption coefficient, band gap of 1.37 eV, and long minority carrier lifetime. Despite substantial experimental research on this new class of material, theoretical simulations of their device properties remain scarce. In this work, a novel n-i-p device architecture (FTO/SnO2/Cs2PtI6/MoO3/C) is theoretically investigated using a solar cell capacitance simulator (SCAPS-1D). Theoretical investigations are carried out in order to optimize the device performance structure by varying the perovskite and selective charge transport layer thickness, absorber and interface defect density, operating temperature, back contact, series and shunt resistance, respectively. The optimized device showed an impressive power conversion efficiency (PCE) of 23.52% at 300 K, which is higher than the previously reported values. Subsequent analysis of the device's spectral response indicated that it possessed 98.9% quantum efficiency (QE) and was visibly active. These findings will provide theoretical guidelines for enhancing the performance of Cs2PtI6-based photovoltaic solar cells (PSCs) and pave the way for the widespread implementation of environmentally benign and stable perovskites

Prevalence, Symptomatology and Herbal Management of Polycystic Ovarian Syndrome

Polycystic Ovarian Syndrome (PCOS) is multi-organ syndrome that affects 6–25% of females during reproductive age. It disrupts normal hormone levels of females and affects adrenal hormone and sex hormones along with pituitary hormones including adrenocorticotropic, growth hormone and gonadotropins hormones. It results in several secondary characteristics in females such as infertility, hormonal imbalance, oligomenorrhea, amenorrhea, obesity and hirsutism. Polycystic ovarian syndrome is associated with mental and reproductive disorder and almost 4–18% mature female students are affected by polycystic ovarian syndrome. Female affected by polycystic ovarian syndrome have increased risk of infertility, ovarian cancer, skin problems and psychological problems such as anxiety, depression and changes in sleep along with mood swings. This chapter discusses the Prevalence, Symptomatology and Management of Polycystic Ovarian Syndrome. For the management of PCOS, the role of some medicinal plants including Asparagus racemosus, Tinospora cordifolia, Foeniculum vulgare, Ocimum tenuiflorum, Actaea racemosa, and Lepidium meyenii have also been discussed in addition to other treatment modalities. The literature data was searched out and compiled using relevant original research articles and reviews published and indexed in Google Scholar, Scientific Information Database, Elsevier, PubMed and Science Direct

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

A facile one-step solution synthesis of Cs2SnI6-xBrx using less-toxic methanol solvent for application in dye-sensitized solar cells

Cs2SnX6 (X = I, Br, and Cl), a vacancy-ordered double perovskite, has recently emerged as a promising lead-free perovskite for optoelectronic applications. The low quality of solution-processed Cs2SnX6 perovskites, on the other hand, precludes further improvement of their performance in the devices. In this work, we developed a facile one-step solution strategy for synthesizing high-quality Cs2SnI6-xBrx material with the less-toxic methanol solvent. A series of Cs2SnI6-xBrx perovskites was synthesized by carefully tuning each stage of the process and using thorough structural and optical characterizations as feedback. We identified two critical parameters that affect the quality of perovskite material through this detailed characterization: the reactant ratio and the annealing temperature. The optimal precursor ratio for the synthesized perovskite was determined to be 1:1 with an annealing temperature of 100 degrees C. Leveraging this, we investigated the optimized perovskite material as a hole transport material (HTM) in a dye-sensitized solar cell (ss-DSSC) and achieved an outstanding PCE of 3.2% without using any modifiers. We envisage that our findings may open the door for the growth of nonhazardous synthesis approaches for Sn-based optoelectronic devices. Novelty Statement The preparation methods and high costs associated with the organic HTMs and the use of toxic solvents are the major obstacles to developing efficient materials for photovoltaic applications. With the possibility of commercialization of solution-processable solar cells, it is critical to find less hazardous perovskite formation approaches. Leveraging this, we developed a facile one-step solution method and investigated the potential of Cs2SnI6-xBrx perovskite as a promising hole transport material (HTM) for solid-state dye-sensitized solar cell (ss-DSSC).The authors sincerely acknowledge the Quaid e Azam University and National Center for Physics Islamabad, Pakistan for all the facilities provided and contribution to the work. The author acknowledges the special support from Solar Energy Institute, Ege universitesi for providing XRD and XPS facilities under Turkey Bruslari Scholarship.Solar Energy Institut

4,4-Nitrophenoxyaniline derived Azo ester: Structural elucidation, DFT simulation, and DNA interactional studies via wet and in silico methods

A new ester namely,1-((4-(4-nitrophenoxy)phenyl)diazenyl)biphenyl benzoate, has been synthesized by esterification reaction between reported nitro terminated azo alcohol and benzoyl chloride. Complete structural elucidation of the synthesized ester was done by different spectroscopic techniques including (FT-IR), (Proton and Carbon-13 NMR), (UV/VIS) spectroscopy, and single-crystal XRD analysis and cyclic voltammetry. XRD structural elucidation revealed the ester 1a to be in Triclinic crystal system with P-1 space groups, showing two-dimensional supramolecular structure, involving only one intermolecular interaction between O4-O9...H9. DFT simulations were also performed to illustrate structural ramification of synthesized ester. Further, Drug DNA interaction was used to determine the biological significance of the produced ester. UV-VIS spectroscopy, hydrodynamic measurement, and molecular docking were used to determine the preferred binding mode of interaction of the synthesized ester with Salmon Sperm (SS) DNA and found that molecule interacts in groove binding fashion with DNA molecule. 2021 Elsevier Ltd. All rights reserved. (c) 2021 Elsevier B.V. All rights reserved

Personality and Teaching: An Investigation into Prospective Teachers' Personality

Abstrac

Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction