5 research outputs found
Design and Interdisciplinary Simulations of a Hand-Held Device for Internal-Body Temperature Sensing Using Microwave Radiometry
- Author
- Publication venue
- 'Institute of Electrical and Electronics Engineers (IEEE)'
- Publication date
- Field of study
Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial
- Author
- Abad Sebastien
- Ackermann Félix
- Adda Anne
- Adda Mireille
- Aguilar Claire
- Ait Hamou Zakaria
- Alary Stéphanie
- Alby-Laurent Fanny
- Allanic Laure
- Allenbach Yves
- Alyanakian Marie-Alexandra
- Amara Yaël
- Andres Emmanuel
- Anguel Nadia
- Annonay Laurence
- Antignac Marie
- Aratus Gladys
- Archer Gabrielle
- Arlet Jean-Benoit
- Arzoine Jérémy
- Asselate Belkacem
- Aunay Lucie
- Azoulay Elie
- Bachelard Antoine
- Baghli Kamyl
- Bah Aïcha
- Bakouboula Prissile
- Bardou Marc
- Bariz Thinhinane
- Baron Gabriel
- Bastard Jean-Philippe
- Baudry Elodie
- Bayer Sophie
- Becker Guillaume
- Belaube Nicolas
- Belazouz Syllia
- Belilita Ridha
- Bellenfant Florence
- Belloul Mohamed
- Ben-Mabrouk Ines
- Benafla Moustafa
- Benainous Ruben
- Benarab Souad
- Benattia Amira
- Benghanem Sarah
- Benhida Jaouad
- Benoit Philippe
- Benveniste Olivier
- Berard Laurence
- Berbour Férial
- Bergeron Anne
- Bergerot Damien
- Bernard Lise
- Berton Laure
- Bertrand Eliane
- Beurton Alexandra
- Beziriganyan Kristina
- Biard Lucie
- Bienvenu Boris
- Bironne Timothee
- Blanc Frédéric
- Blanchard Anne
- Blanche Philippe
- Blin Emmanuelle
- Bloch Queyrat Coralie
- Boleto Gonçalo
- Bondeelle Louise
- Bonnet Nicolas
- Borie Raphael
- Boudali Yacine
- Bouhris Marion
- Bounhiol Agathe
- Bouras Chaouki
- Bourgoin Alexandre
- Boussard Catherine
- Boutboul David
- Brahmi Sabrina
- Brin Stéphane
- Brindele Isabelle
- Briois Sandrine
- Broissand Christine
- Buffet Alexandre
- Bugnet Emmanuelle
- Bulifon Sophie
- Bureau Côme
- Bureau Serge
- Burger Carole
- Burlacu Ruxandra
- Cacoub Patrice
- Cadranel Jacques
- Cailhol Johann
- Caillat-Zucman Sophie
- Camara-Clayette Valérie
- Campos-Vega Clara
- Camuset Juliette
- Canellas Antony
- Canoui Etienne
- Cardet Kévin
- Carlier Nicolas
- Castelain Vincent
- Cavelot Sébastien
- Celli Lebras Karine
- Chabert Julien
- Chaigne Benjamin
- Chalal Lynda
- Chalal Solaya
- Chambrin-Lauvray Helene
- Champtiaux Nicolas
- Chansombat Malikhone
- Charbonnier Fanny
- Charreteur Robin
- Chas Julie
- Chatelus Emmanuel
- Chatron Eva
- Chauffier Jeanne
- Chavarot Nathalie
- Cheref Kahina
- Chitour Kamil
- Choinier Pascaline
- Cholley Bernard
- Chopin Dorothée
- Choupeaux Laure
- Chousterman Benjamin
- Cisse Mamadou Salif
- Clan Hew Wai Aurélie
- Clarac Ulrich
- Clarke Ada
- Clavere Gaelle
- Clovet Olivier
- Clément Melissa
- Codorniu Anaïs
- Cohen Yves
- Collange Olivier
- Colomba Emeline
- Comarmond Cloé
- Comparon Celine
- Contejean Adrien
- Cordel Hugues
- Cornic Mathias
- Corvol Jean-Christophe
- Costedoat-Chalumeau Nathalie
- Coupez Elisabeth
- Courtin Claire
- Cransac Amélie
- Crespin Paul
- Crestani Bruno
- Cylly Laurent
- d'Ortenzio Eric
- da Silva Rosa
- Daconceicao Olivia
- Daguenel-Nguyen Anne
- Dalibey Sarah
- Danion François
- Darmont Michaël
- Dautel Dominique
- Davoine Claire
- de Blay Frédéric
- de Castro Nathalie
- de Lastours Victoire
- de Sarcus Martin
- Debrix Isabelle
- Decavele Maxence
- Deconinck Laurene
- Defrancq Fanny
- Dehais Mélanie
- Dejean Valérie
- Delaugerre Constance
- Delemazure Julie
- Deleris Robin
- Demerville Lauren
- Demonsant Eric
- Demoule Alexandre
- Denies Fanette
- Denis Blandine
- Derridj Nawal
- Desbois Anne Claire
- Deslée Gaetan
- Dhote Robin
- Diehl Jean-Luc
- Diemunsch Pierre
- Diemunsch Sophie
- Dieude Philippe
- Dieye Thierno
- Djadel Mourad
- Djadi-Prat Juliette
- Djaghout Lalia
- Domont Fanny
- Dossier Antoine
- Dougados Maxime
- Dournon Nathalie
- Dres Martin
- Drouard Laurence
- Drouet Elodie
- Dubert Marie
- Duceau Baptiste
- Duchemann Boris
- Duclos-Vallée Jean-Charles
- Ducrocq Greggory
- Dunogue Bertrand
- Dupin Clairelyne
- Dupland Pierre
- Dupré Celine
- Durand Philippe
- Duranteau Jacques
- Durel - Maurisse Aurélie
- Dusanter Isabelle
- Duée Frédéric
- Ebstein Nathan
- El Amine Younes
- Elisee Virginie
- Emmerich Joseph
- Escaut Lelia
- Estellat Candice
- Fabre Solène
- Fain Olivier
- Fallet Vincent
- Fartoukh Muriel
- Faure Morgane
- Fauvaux Catherine
- Faye Pierre
- Fayol Antoine
- Fellahi Soraya
- Felten Renaud
- Feredj Elsa
- Ferfar Yasmina
- Feyeux Delphine
- Figueiredo Samy
- Fillon Julie
- Flamand Saskia
- Flamarion Edouard
- Fodil Hanane
- Fois Elena
- Fournier Benjamin
- Fourreau Alain
- François Hélène
- Frazier Aline
- Fremont Dimitri
- Fuentes Axelle
- Galicier Lionel
- Gamany Naura
- Gambier Nicolas
- Garcia Gilles
- Garnier Marc
- Gaudefroy Caroline
- Gauzit Remy
- Georgin-Lavialle Sophie
- Geri Guillaume
- Gernez Coralie
- Gervais Anne
- Ghembaza Amine
- Ghosn Jade
- Gilbert Marie
- Gimeno Linda
- Giroux-Leprieur Benedicte
- Godier Anne
- Goichot Bernard
- Gorget Thomas
- Gottenberg Jacques-Eric
- Goupil de Bouille Jeanne
- Grailles Guillaume
- Granville Sophie
- Greigert Valentin
- Grimaldi Lamiae
- Grisot Paul Henri
- Gros Antoine
- Gros Hélène
- Guerin Corinne
- Guffroy Aurélien
- Guidet Bertrand
- Guillaud Constance
- Guillaume-Jugnot Perrine
- Guillot Emmanuelle
- Guinot Pierre-Grégoire
- Gysembergh-Houal Anne
- Hadjam Tassadit
- Hai Dhiaa Meriem
- Hamada Sophie-Rym
- Hamiria Samir
- Hammal Soumeya
- Hansmann Yves
- Harrois Anatole
- Haudebourg Luc
- Hauw-Berlemont Caroline
- Heger Bob
- Henriques Mickael
- Henry Estelle
- Hermine Olivier
- Honsel Vasco
- Hulot Jean-Sébastien
- Humbert Marc
- Hutt Anne
- Isernia Valentina
- Ismael Sophie
- Issorat Elodie
- Jacob Aude
- Jacolot Anne
- Jallouli Moez
- Jambon Julie
- Jaubert Paul
- Jauréguiberry Stéphane
- Jaïs Xavier
- Jegu Anne Lise
- Jesuthasan Denis,
- Jevnikar Mitja
- Joly Veronique
- Joseph Adrien
- Jouany Pauline
- Joumaa Hassan
- Jourdaine Clément
- Jouve Charléne
- Jozwiak Mathieu
- Julia Zelie
- Junquera Ramon
- Kaeuffer Charlotte
- Karachi Carine
- Kassegne Loic
- Kebir Amina
- Kedzia Cécile
- Keo Vixra
- Kerneis Solen
- Keroumi Younes
- Kiouris Elena
- Klasen Alison
- Knosp Camille
- Kolta Sami
- Korganow Anne Sophie
- Koumis Ilias
- Kozaliewicz Ewa
- Krause Le Garrec Jessica
- Lachatre Marie
- Lacombe Karine
- Lafoeste Hélène
- Lambotte Olivier
- Lancon Victor
- Languille Laetitia
- Larcheveque Cecile
- Lariven Sylvie
- Le Borgne Pierrick
- Le Bourlout Catherine
- Le Gac Sylvie
- Le Guen Pierre
- Le Marchand Mathilde
- Le Marec Julien
- Le Pluart Diane
- Le Tiec Clotilde Le Tiec
- Lebeaux David
- Lecomte Laurence
- Lecronier Marie
- Lefebvre Nicolas
- Lefèvre Edouard
- Lefèvre Guillaume
- Legendre Paul
- Legros Marie-Hélène
- Lehir Isabelle
- Lehmann Blandine
- Lelievre Jean-Daniel
- Lemagner Christine
- Lemarié Nadège
- Lemoine Matthieu
- Lengliné Etienne
- Lenoir Olivia
- Leplay Céline
- Leprun Gaël
- Leroux Gaelle
- Lescure F-Xavier
- Licois Marion
- Lim Pascal
- Livrozet Marine
- Liégeon Geoffroy
- London Jonathan
- Lorillon Gwenaël
- Louapre Céline
- Louis Zeina
- Louni Francoise
- Luong Nguyen Liem Binh
- Maalouf Georgina
- Mabrouki Asmaa
- Madelaine Claire
- Madeleine Isabelle
- Mahevas Matthieu
- Mahtal Nassim
- Mameri Lakhdar
- Mamoune Asmaa
- Manivet Philippe
- Marey Jonathan
- Mariani Louise-Laure
- Mariette Xavier
- Marin Nathalie
- Mariotte Eric
- Marquis Eric
- Martel Pascal
- Martin de Frémont Grégoire
- Martin Karine
- Martin Tristan
- Matignon Marie
- Maurer Agnes
- Mayaux Julien
- Mcavoy Chloe
- Meddah Hakim
- Meftali Ramdane
- Megarbane Bruno
- Mekid Yasmina
- Mekinian Arsène
- Mekontso-Dessaps Armand
- Melica Giovanna
- Menage Nathalie
- Mertes Paul Michel
- Messaoudi Yasmine
- Metzger Catherine
- Meunier Jeanne
- Meunier Martine
- Meyer Nicolas
- Michel Marc
- Michon Adrien
- Michot Jean-Marie
- Mirouse Adrien
- Mohebbi Abolfazl
- Molina Jean-Michel
- Molinari Domitille
- Monnet Xavier
- Montani David
- Montlahuc Claire
- Moores Alexandre
- Mora Pierre
- Morawiec Elise
- Morbieu Caroline
- Morel Alexandre
- Morgand Marjolaine
- Morin Florence
- Mourad Jean-Jacques
- Mourvillier Bruno
- Mouthon Luc
- Nadal Marine
- Ndiaye Awa
- Nemlaghi Safaa
- Neuschwander Arthur
- Nguyen Lee
- Nguyen Yann
- Nisand Gabriel
- Nizard Mandy
- Noaillon Mathilde
- Noel Nicolas
- Noll Eric
- Nunes Hilario
- Nyanou Corine
- Oberlin Mathieu
- Ohlmann-Caillard Sophie
- Oksenhendler Eric
- Olivier Olivier
- Ouamri Sabrine
- Oziel Johanna
- Pacanowski Jerome
- Pacheco Claire
- Palmieri Lola-Jade
- Papo Thomas
- Paquet Valérie
- Pari Marie Hélène
- Parisey Marion
- Parrot Antoine
- Patin Florence
- Pattyn Anne
- Pavot Arthur
- Pavy Stéphan
- Peffault de Latour Régis
- Peigney Isabelle
- Pene Frédéric
- Penet Marie-Aude
- Pereira Maria
- Pernin Claire
- Pernot Corinne
- Perrodeau Elodie
- Petit-Hoang Camille
- Phibel Audrey
- Phung Bao
- Pialoux Gilles
- Pierron Cédric
- Planquette Benjamin
- Poindron Vincent
- Poissy Julien
- Pommeret Fanny
- Porcher Raphaël
- Pottecher Julien
- Pouliquen Anne-Lise
- Pourbaix Annabelle
- Pourchet-Martinez Valérie
- Pradon Caroline
- Provitolo Vincent
- Puéchal Oriane
- Rachline Anne
- Rahli Roza
- Raked Nabil
- Ranque Brigitte
- Rathouin Vanessa
- Ravato Sylviane
- Ravaud Philippe
- Razurel Anaïs
- Rech Jean-Simon
- Regent Alexis
- Renaud Stéphane
- Renet Sophie
- Resche-Rigon Matthieu
- Resmini Léa
- Richard Christian
- Richette Pascal
- Rigal Marthe
- Rigolet Aude
- Rioux Christophe
- Riveline Jean-Pierre
- Rolland-Debord Camille
- Roques Anne-Marie
- Rossi Geoffrey
- Roulot Dominique
- Roux Damien
- Rouzaud Claire
- Rozensztajn Nathalie
- Ruch Yvon
- Sabatier Brigitte
- Sacco Emmanuelle
- Sacleux Sophie-Caroline
- Sadaoui Thiziri
- Sakkal Madona
- Saleh-Mghir Samira
- Saliba Faouzi
- Sambin Sara
- Sanchez Olivier
- Saussereau Julien
- Sautereau Aurelie
- Savale Laurent
- Schlemmer Frédéric
- Schmitz David
- Semaille Caroline
- Semerano Luca
- Semri Hala
- Sene Damien
- Senet Patricia
- Servettaz Amélie
- Sguiouar Naima
- Siguier Martin
- Simon Tabassome
- Sitbon Olivier
- Smati Julie
- Soria Angèle
- Soyez-Herkert Loren
- Stan Emilia
- Steg Gabriel
- Stoclin Annabelle
- Suarez Lydia
- Sublon Cédric
- Szwebel Tali-Anne
- Tantet Claire
- Tarhini Hassan
- Tayebi Hakim
- Tazi Abdellatif
- Teboul Jean-Louis
- Terrier Benjamin
- Tharaux Pierre-Louis
- Thibaut Pélagie
- Thiemele Alaki
- Tibi Annick
- Tissieres Pierre
- Toquet Segolene
- Tremorin Marie-Thérèse
- Tréhan Anne
- Tubach Florence
- Tudesq Jean-Jacques
- Urbina Tomas
- Uzunhan Yurdagul
- Uzzan Matthieu
- Valayer Simon
- Vallet Mathilde
- Vallois Dorothee
- Vanhoye Damien
- Vasquez-Ibarra Miguel Alejandro
- Vauboin Pernelle
- Vautier Mathieu
- Vayssettes Marie
- Vermes Paul
- Verny Christiane
- Verstuyft Céline Verstuyft
- Vicaut Eric
- Vieira Matheus
- Vigna Véronique
- Vimpere Damien
- Virlouvet Myriam
- Virolle Sara
- Volle Geoffroy
- Volpe Thomas
- Walter-Petrich Anouk
- Weill François
- Weiss Emmanuel
- Willekens Chistophe
- Wilpotte Celine
- Wynckel Alain
- Yazdanpanah Yazdan
- Yelles Nessima
- Yelnik Cécile
- Zafrani Lara
- Zahrate-Ghoul Aida
- Zaidan Mohamad
- Zarrouk Virginie
- Zerbit Jérémie
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/03/2021
- Field of study
International audienc
Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia
- Author
- Abad Sebastien
- Ackermann Félix
- Adda Anne
- Adda Mireille
- Aguilar Claire
- Ait Hamou Zakaria
- Alary Stéphanie
- Alby-Laurent Fanny
- Allanic Laure
- Allenbach Yves
- Alyanakian Marie-Alexandra
- Amara Yaël
- Andres Emmanuel
- Anguel Nadia
- Annonay Laurence
- Antignac Marie
- Aratus Gladys
- Archer Gabrielle
- Arlet Jean-Benoit
- Arzoine Jérémy
- Asselate Belkacem
- Aunay Lucie
- Azoulay Elie
- Bachelard Antoine
- Baghli Kamyl
- Bah Aïcha
- Bakouboula Prissile
- Bardou Marc
- Bariz Thinhinane
- Baron Gabriel
- Bastard Jean-Philippe
- Baudry Elodie
- Bayer Sophie
- Becker Guillaume
- Belaube Nicolas
- Belazouz Syllia
- Belilita Ridha
- Bellenfant Florence
- Belloul Mohamed
- Ben-Mabrouk Ines
- Benafla Moustafa
- Benainous Ruben
- Benarab Souad
- Benattia Amira
- Benghanem Sarah
- Benhida Jaouad
- Benoit Philippe
- Benveniste Olivier
- Berard Laurence
- Berbour Férial
- Bergeron Anne
- Bergerot Damien
- Bernard Lise
- Berton Laure
- Bertrand Eliane
- Beurton Alexandra
- Beziriganyan Kristina
- Biard Lucie
- Bienvenu Boris
- Bironne Timothee
- Blanc Frédéric
- Blanchard Anne
- Blanche Philippe
- Blin Emmanuelle
- Bloch Queyrat Coralie
- Boleto Gonçalo
- Bondeelle Louise
- Bonnet Nicolas
- Borie Raphael
- Boudali Yacine
- Bouhris Marion
- Bounhiol Agathe
- Bouras Chaouki
- Bourgoin Alexandre
- Boussard Catherine
- Boutboul David
- Brahmi Sabrina
- Brin Stéphane
- Brindele Isabelle
- Briois Sandrine
- Broissand Christine
- Buffet Alexandre
- Bugnet Emmanuelle
- Bureau Côme
- Bureau Serge
- Burger Carole
- Burlacu Ruxandra
- Cacoub Patrice
- Cadranel Jacques
- Cailhol Johann
- Caillat-Zucman Sophie
- Camara-Clayette Valérie
- Campos-Vega Clara
- Camuset Juliette
- Canellas Antony
- Canoui Etienne
- Cardet Kévin
- Carlier Nicolas
- Castelain Vincent
- Cavelot Sébastien
- Celli Lebras Karine
- Chabert Julien
- Chaigne Benjamin
- Chalal Lynda
- Chalal Solaya
- Chambrin-Lauvray Helene
- Champtiaux Nicolas
- Chansombat Malikhone
- Charbonnier Fanny
- Charreteur Robin
- Chas Julie
- Chatelus Emmanuel
- Chatron Eva
- Chauffier Jeanne
- Chavarot Nathalie
- Cheref Kahina
- Chitour Kamil
- Choinier Pascaline
- Cholley Bernard
- Chopin Dorothée
- Choupeaux Laure
- Chousterman Benjamin
- Cisse Mamadou Salif
- Clan Hew Wai Aurélie
- Clarac Ulrich
- Clarke Ada
- Clavere Gaelle
- Clovet Olivier
- Clément Melissa
- Codorniu Anaïs
- Cohen Yves
- Collange Olivier
- Colomba Emeline
- Comarmond Cloé
- Comparon Celine
- Contejean Adrien
- Cordel Hugues
- Cornic Mathias
- Corvol Jean-Christophe
- Costedoat-Chalumeau Nathalie
- Coupez Elisabeth
- Courtin Claire
- Cransac Amélie
- Crespin Paul
- Crestani Bruno
- Cylly Laurent
- d'Ortenzio Eric
- da Silva Rosa
- Daconceicao Olivia
- Daguenel Nguyen Anne
- Dalibey Sarah
- Danion François
- Darmont Michaël
- Dautel Dominique
- Davoine Claire
- de Blay Frédéric
- de Castro Nathalie
- de Lastours Victoire
- de Sarcus Martin
- Debrix Isabelle
- Decavele Maxence
- Deconinck Laurene
- Defrancq Fanny
- Dehais Mélanie
- Dejean Valérie
- Delaugerre Constance
- Delemazure Julie
- Deleris Robin
- Demerville Lauren
- Demonsant Eric
- Demoule Alexandre
- Denies Fanette
- Denis Blandine
- Derridj Nawal
- Desbois Anne Claire
- Deslée Gaetan
- Dhote Robin
- Diehl Jean-Luc
- Diemunsch Pierre
- Diemunsch Sophie
- Dieude Hilippe
- Dieye Thierno
- Djadel Mourad
- Djadi-Prat Juliette
- Djaghout Lalia
- Domont Fanny
- Dossier Antoine
- Dougados Maxime
- Dournon Nathalie
- Dres Martin
- Drouard Laurence
- Drouet Elodie
- Dubert Marie
- Duceau Baptiste
- Duchemann Boris
- Duclos-Vallée Jean-Charles
- Ducrocq Greggory
- Dunogue Bertrand
- Dupin Clairelyne
- Dupland Pierre
- Dupré Celine
- Durand Philippe
- Duranteau Jacques
- Durel - Maurisse Aurélie
- Dusanter Isabelle
- Duée Frédéric
- Ebstein Nathan
- El Amine Younes
- Elie Caroline
- Elisee Virginie
- Emmerich Joseph
- Escaut Lelia
- Estellat Candice
- Fabre Solène
- Fain Olivier
- Fallet Vincent
- Fartoukh Muriel
- Faure Morgane
- Fauvaux Catherine
- Faye Pierre
- Fayol Antoine
- Fellahi Soraya
- Felten Renaud
- Feredj Elsa
- Ferfar Yasmina
- Feyeux Delphine
- Figueiredo Samy
- Fillon Julie
- Flamand Saskia
- Flamarion Edouard
- Fodil Hanane
- Fois Elena
- Fournier Benjamin
- Fourreau Alain
- François Hélène
- Frazier Aline
- Fremont Dimitri
- Fuentes Axelle
- Galicier Lionel
- Gamany Naura
- Gambier Nicolas
- Garcia Gilles
- Garnier Marc
- Gaudefroy Caroline
- Gauzit Remy
- Georgin-Lavialle Sophie
- Geri Guillaume
- Gernez Coralie
- Gervais Anne
- Ghembaza Amine
- Ghosn Jade
- Gilbert Marie
- Gimeno Linda
- Giroux-Leprieur Benedicte
- Godier Anne
- Goichot Bernard
- Gorget Thomas
- Gottenberg Jacques-Eric
- Goupil de Bouille Jeanne
- Grailles Guillaume
- Granville Sophie
- Greigert Valentin
- Grimaldi Lamiae
- Grisot Paul Henri
- Gros Antoine
- Gros Hélène
- Guerin Corinne
- Guffroy Aurélien
- Guidet Bertrand
- Guillaud Constance
- Guillaume-Jugnot Perrine
- Guillot Emmanuelle
- Guinot Pierre-Grégoire
- Gysembergh-Houal Anne
- Hadjam Tassadit
- Hai Dhiaa Meriem
- Hamada Sophie-Rym
- Hamiria Samir
- Hammal Soumeya
- Hansmann Yves
- Harrois Anatole
- Haudebourg Luc
- Hauw-Berlemont Caroline
- Heger Bob
- Henriques Mickael
- Henry Estelle
- Hermine Olivier
- Honsel Vasco
- Hulot Jean- Sébastien
- Humbert Marc
- Hutt Anne
- Isernia Valentina
- Ismael Sophie
- Issorat Elodie
- Jacob Aude
- Jacolot Anne
- Jallouli Moez
- Jambon Julie
- Jaubert Paul
- Jauréguiberry Stéphane
- Jegu Anne Lise
- Jesuthasan Denis,
- Jevnikar Mitja
- Joly Veronique
- Joseph Adrien
- Jouany Pauline
- Joumaa Hassan
- Jourdaine Clément
- Jouve Charlène
- Jozwiak Mathieu
- Julia Zelie
- Junquera Ramon
- Kaeuffer Charlotte
- Karachi Carine
- Kassegne Loic
- Kebir Amina
- Kedzia Cécile
- Keo Vixra
- Kerneis Solen
- Keroumi Younes
- Kiouris Elena
- Klasen Alison
- Knosp Camille
- Kolta Sami
- Korganow Anne Sophie
- Koumis Ilias
- Kozaliewicz Ewa
- Krause Le Garrec Jessica
- Lachatre Marie
- Lacombe Karine
- Lafoeste Hélène
- Lambotte Olivier
- Lancon Victor
- Languille Laetitia
- Larcheveque Cecile
- Lariven Sylvie
- Le Borgne Pierrick
- Le Bourlout Catherine
- Le Gac Sylvie
- Le Guen Pierre
- Le Marchand Mathilde
- Le Marec Julien
- Le Pluart Diane
- Le Tiec Clotilde Le Tiec
- Lebeaux David
- Lecomte Laurence
- Lecronier Marie
- Lefebvre Nicolas
- Lefèvre Edouard
- Lefèvre Guillaume
- Legendre Paul
- Legros Marie-Hélène
- Lehir Isabelle
- Lehmann Blandine
- Lelievre Jean-Daniel
- Lemagner Christine
- Lemarié Nadège
- Lemoine Matthieu
- Lengliné Etienne
- Lenoir Olivia
- Leplay Céline
- Leprun Gaël
- Leroux Gaelle
- Lescure Xavier
- Licois Marion
- Lim Pascal
- Livrozet Marine
- Liégeon Geoffroy
- London Jonathan
- Lorillon Gwenaël
- Louapre Céline
- Louis Zeina
- Louni Francoise
- Luong Nguyen Liem Binh
- Maalouf Georgina
- Mabrouki Asmaa
- Madeleine Claire
- Madeleine Isabelle
- Mahevas Matthieu
- Mahtal Nassim
- Mameri Lakhdar
- Mamoune Asmaa
- Manivet Philippe
- Marey Jonathan
- Mariani Louise-Laure
- Mariette Xavier
- Marin Nathalie
- Mariotte Eric
- Marquis Eric
- Martel Pascal
- Martin de Frémont Grégoire
- Martin Karine
- Martin Tristan
- Matignon Marie
- Maurer Agnes
- Mayaux Julien
- Mcavoy Chloe
- Meddah Hakim
- Meftali Ramdane
- Megarbane Bruno
- Mekid Yasmina
- Mekinian Arsène
- Mekontso-Dessaps Armand
- Melica Giovanna
- Menage Nathalie
- Mertes Paul Michel
- Messaoudi Yasmine
- Metzger Catherine
- Meunier Jeanne
- Meunier Martine
- Meyer Nicolas
- Michel Marc
- Michon Adrien
- Michot Jean-Marie
- Mirouse Adrien
- Mohebbi Abolfazl
- Molina Jean-Michel
- Molinari Domitille
- Monnet Xavier
- Montani David
- Montlahuc Claire
- Moores Alexandre
- Mora Pierre
- Morawiec Elise
- Morbieu Caroline
- Morel Alexandre
- Morgand Marjolaine
- Morin Florence
- Mourad Jean-Jacques
- Mourvillier Bruno
- Mouthon Luc
- Nadal Marine
- Ndiaye Awa
- Nemlaghi Safaa
- Neuschwander Arthur
- Nguyen Lee
- Nguyen Yann
- Nisand Gabriel
- Nizard Mandy
- Noel Nicolas
- Noll Eric
- Nunes Hilario
- Nyanou Corine
- Oberlin Mathieu
- Ohlmann-Caillard Sophie
- Oksenhendler Eric
- Ouamri Sabrine
- Oziel Johanna
- Pacanowski Jerome
- Pacheco Claire
- Palmieri Lola-Jade
- Papo Thomas
- Paquet Valérie
- Pari Marie Hélène
- Parisey Marion
- Parrot Antoine
- Patin Florence
- Pattyn Anne
- Pavy Stéphan
- Peffault de Latour Régis
- Peigney Isabelle
- Pene Frédéric
- Penet Marie-Aude
- Pereira Maria
- Pernin Claire
- Pernot Corinne
- Perrodeau Elodie
- Petit-Hoang Camille
- Phibel Audrey
- Phung Bao
- Pierron Cédric
- Planquette Benjamin
- Poindron Vincent
- Poissy Julien
- Pommeret Fanny
- Porcher Raphaël
- Pottecher Julien
- Pouliquen Anne-Lise
- Pourbaix Annabelle
- Pourchet-Martinez Valérie
- Pradon Caroline
- Provitolo Vincent
- Puéchal Oriane
- Rachline Anne
- Rahli Roza
- Raked Nabil
- Ranque Brigitte
- Rathouin Vanessa
- Ravato Sylviane
- Ravaud Philippe
- Rech Jean-Simon
- Regent Alexis
- Renaud Stéphane
- Renet Sophie
- Resche-Rigon Matthieu
- Resmini Léa
- Richard Christian
- Richette Pascal
- Rigal Marthe
- Rigolet Aude
- Rioux Christophe
- Riveline Jean-Pierre
- Rolland-Debord Camille
- Roques Anne-Marie
- Roulot Dominique
- Roux Damien
- Rouzaud Claire
- Rozensztajn Nathalie
- Ruch Yvon
- Sabatier Brigitte
- Sacco Emmanuelle
- Sacleux Sophie-Caroline
- Sadaoui Thiziri
- Saleh-Mghir Samira
- Saliba Faouzi
- Sambin Sara
- Sanchez Olivier
- Saussereau Julien
- Sautereau Aurelie
- Savale Laurent
- Schlemmer Frédéric
- Schmitz David
- Semaille Caroline
- Semerano Luca
- Semri Hala
- Sene Damien
- Senet Patricia
- Servettaz Amélie
- Sguiouar Naima
- Siguier Martin
- Simon Tabassome
- Smati Julie
- Soria Angèle
- Soyez-Herkert Loren
- Stan Emilia
- Steg Gabriel
- Stoclin Annabelle
- Suarez Lydia
- Sublon Cédric
- Szwebel Tali-Anne
- Tantet Claire
- Tayebi Hakim
- Tazi Abdellatif
- Teboul Jean-Louis
- Terrier Benjamin
- Tharaux Pierre-Louis
- Tharini Hassan
- Thibaut Pélagie
- Thiemele Alaki
- Tibi Annick
- Tissieres Pierre
- Toquet Segolene
- Tremorin Marie-Thérèse
- Tréhan Anne
- Tubach Florence
- Tudesq Jean-Jacques
- Urbina Tomas
- Uzunhan Yurdagul
- Uzzan Matthieu
- Valayer Simon
- Vallet Mathilde
- Vallois Dorothee
- Vanhoye Damien
- Vasquez-Ibarra Miguel Alejandro
- Vauboin Pernelle
- Vautier Mathieu
- Vayssettes Marie
- Vermes Paul
- Verny Christiane
- Verstuyft Céline Verstuyft
- Vicaut Eric
- Vieira Matheus
- Vigna Véronique
- Vimpere Damien
- Virlouvet Myriam
- Virolle Sara
- Volle Geoffroy
- Volpe Thomas
- Walter-Petrich Anouk
- Weill François
- Weiss Emmanuel
- Willekens Chistophe
- Wilpotte Celine
- Wynckel Alain
- Yazdanpanah Yazdan
- Yelles Nessima
- Yelnik Cécile
- Zafrani Lara
- Zahrate-Ghoul Aida
- Zaidan Mohamad
- Zarrouk Virginie
- Zerbit Jérémie
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/01/2021
- Field of study
International audienceImportance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a common presentation of coronavirus disease 2019 (COVID-19).Objective To determine whether tocilizumab (TCZ) improves outcomes of patients hospitalized with moderate-to-severe COVID-19 pneumonia.Design, Setting, and Particpants This cohort-embedded, investigator-initiated, multicenter, open-label, bayesian randomized clinical trial investigating patients with COVID-19 and moderate or severe pneumonia requiring at least 3 L/min of oxygen but without ventilation or admission to the intensive care unit was conducted between March 31, 2020, to April 18, 2020, with follow-up through 28 days. Patients were recruited from 9 university hospitals in France. Analyses were performed on an intention-to-treat basis with no correction for multiplicity for secondary outcomes.Interventions Patients were randomly assigned to receive TCZ, 8 mg/kg, intravenously plus usual care on day 1 and on day 3 if clinically indicated (TCZ group) or to receive usual care alone (UC group). Usual care included antibiotic agents, antiviral agents, corticosteroids, vasopressor support, and anticoagulants.Main Outcomes and Measures Primary outcomes were scores higher than 5 on the World Health Organization 10-point Clinical Progression Scale (WHO-CPS) on day 4 and survival without need of ventilation (including noninvasive ventilation) at day 14. Secondary outcomes were clinical status assessed with the WHO-CPS scores at day 7 and day 14, overall survival, time to discharge, time to oxygen supply independency, biological factors such as C-reactive protein level, and adverse events.Results Of 131 patients, 64 patients were randomly assigned to the TCZ group and 67 to UC group; 1 patient in the TCZ group withdrew consent and was not included in the analysis. Of the 130 patients, 42 were women (32%), and median (interquartile range) age was 64 (57.1-74.3) years. In the TCZ group, 12 patients had a WHO-CPS score greater than 5 at day 4 vs 19 in the UC group (median posterior absolute risk difference [ARD] −9.0%; 90% credible interval [CrI], −21.0 to 3.1), with a posterior probability of negative ARD of 89.0% not achieving the 95% predefined efficacy threshold. At day 14, 12% (95% CI −28% to 4%) fewer patients needed noninvasive ventilation (NIV) or mechanical ventilation (MV) or died in the TCZ group than in the UC group (24% vs 36%, median posterior hazard ratio [HR] 0.58; 90% CrI, 0.33-1.00), with a posterior probability of HR less than 1 of 95.0%, achieving the predefined efficacy threshold. The HR for MV or death was 0.58 (90% CrI, 0.30 to 1.09). At day 28, 7 patients had died in the TCZ group and 8 in the UC group (adjusted HR, 0.92; 95% CI 0.33-2.53). Serious adverse events occurred in 20 (32%) patients in the TCZ group and 29 (43%) in the UC group (P = .21).Conclusions and Relevance In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS scores lower than 5 at day 4 but might have reduced the risk of NIV, MV, or death by day 14. No difference on day 28 mortality was found. Further studies are necessary for confirming these preliminary results.Trial Registration ClinicalTrials.gov Identifier: NCT0433180
Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial
- Author
- Abad Sebastien
- Abisror Noémie
- Ackermann Félix
- Adda Anne
- Adda Mireille
- Aguilar Claire
- Ait Hamou Zakaria
- Alary Stéphanie
- Alby-Laurent Fanny
- Allanic Laure
- Allenbach Yves
- Alyanakian Marie-Alexandra
- Amara Yaël
- Andres Emmanuel
- Anguel Nadia
- Annonay Laurence
- Antignac Marie
- Aratus Gladys
- Archer Gabrielle
- Arlet Jean-Benoit
- Arzoine Jérémy
- Asselate Belkacem
- Aunay Lucie
- Azoulay Elie
- Bachelard Antoine
- Baghli Kamyl
- Bah Aïcha
- Bakouboula Prissile
- Bardou Marc
- Bariz Thinhinane
- Baron Gabriel
- Bastard Jean-Philippe
- Baudry Elodie
- Bayer Sophie
- Becker Guillaume
- Belaube Nicolas
- Belazouz Syllia
- Belilita Ridha
- Bellenfant Florence
- Belloul Mohamed
- Ben-Mabrouk Ines
- Benafla Moustafa
- Benainous Ruben
- Benarab Souad
- Benattia Amira
- Benghanem Sarah
- Benhida Jaouad
- Benoit Philippe
- Benveniste Olivier
- Berard Laurence
- Berbour Férial
- Bergeron Anne
- Bergerot Damien
- Bernard Lise
- Berton Laure
- Bertrand Eliane
- Beurton Alexandra
- Beziriganyan Kristina
- Biard Lucie
- Bienvenu Boris
- Bironne Timothee
- Blanc Frédéric
- Blanchard Anne
- Blanche Philippe
- Blin Emmanuelle
- Bloch Queyrat Coralie
- Boleto Gonçalo
- Bondeelle Louise
- Bonnet Nicolas
- Borie Raphael
- Boudali Yacine
- Bouhris Marion
- Bounhiol Agathe
- Bouras Chaouki
- Bourgoin Alexandre
- Boussard Catherine
- Boutboul David
- Brahmi Sabrina
- Brin Stéphane
- Brindele Isabelle
- Briois Sandrine
- Broissand Christine
- Buffet Alexandre
- Bugnet Emmanuelle
- Bulifon Sophie
- Bureau Côme
- Bureau Serge
- Burger Carole
- Burlacu Ruxandra
- Cacoub Patrice
- Cadranel Jacques
- Cailhol Johann
- Caillat-Zucman Sophie
- Camara-Clayette Valérie
- Campos-Vega Clara
- Camuset Juliette
- Canellas Antony
- Canoui Etienne
- Cardet Kévin
- Carlier Nicolas
- Castelain Vincent
- Cavelot Sébastien
- Celli Lebras Karine
- Chabert Julien
- Chaigne Benjamin
- Chalal Lynda
- Chalal Solaya
- Chambrin-Lauvray Helene
- Champtiaux Nicolas
- Chansombat Malikhone
- Charbonnier Fanny
- Charreteur Robin
- Chas Julie
- Chatelus Emmanuel
- Chatron Eva
- Chauffier Jeanne
- Chavarot Nathalie
- Cheref Kahina
- Chitour Kamil
- Choinier Pascaline
- Cholley Bernard
- Chopin Dorothée
- Choupeaux Laure
- Chousterman Benjamin
- Cisse Mamadou Salif
- Clan Hew Wai Aurélie
- Clarac Ulrich
- Clarke Ada
- Clavere Gaelle
- Clovet Olivier
- Clément Melissa
- Codorniu Anaïs
- Cohen Yves
- Collange Olivier
- Colomba Emeline
- Comarmond Cloé
- Comparon Celine
- Contejean Adrien
- Cordel Hugues
- Cornic Mathias
- Corvol Jean-Christophe
- Costedoat-Chalumeau Nathalie
- Coupez Elisabeth
- Courtin Claire
- Cransac Amélie
- Crespin Paul
- Crestani Bruno
- Cylly Laurent
- d'Ortenzio Eric
- da Silva Rosa
- Daconceicao Olivia
- Daguenel-Nguyen Anne
- Dalibey Sarah
- Danion François
- Darmont Michaël
- Dautel Dominique
- Davoine Claire
- De Blay Frédéric
- de Castro Nathalie
- de Lastours Victoire
- de Sarcus Martin
- Debrix Isabelle
- Decavele Maxence
- Deconinck Laurene
- Defrancq Fanny
- Dehais Mélanie
- Dejean Valérie
- Delaugerre Constance
- Delemazure Julie
- Deleris Robin
- Demerville Lauren
- Demonsant Eric
- Demoule Alexandre
- Denies Fanette
- Denis Blandine
- Derridj Nawal
- Desbois Anne Claire
- Deslée Gaetan
- Dhote Robin
- Diehl Jean-Luc
- Diemunsch Pierre
- Diemunsch Sophie
- Dieude Philippe
- Dieye Thierno
- Djadel Mourad
- Djadi-Prat Juliette
- Djaghout Lalia
- Domont Fanny
- Dossier Antoine
- Dougados Maxime
- Dournon Nathalie
- Dres Martin
- Drouard Laurence
- Drouet Elodie
- Dubert Marie
- Duceau Baptiste
- Duchemann Boris
- Duclos-Vallée Jean-Charles
- Ducrocq Greggory
- Dunogue Bertrand
- Dupin Clairelyne
- Dupland Pierre
- Dupré Celine
- Durand Philippe
- Duranteau Jacques
- Durel - Maurisse Aurélie
- Dusanter Isabelle
- Duée Frédéric
- Ebstein Nathan
- El Amine Younes
- Elisee Virginie
- Emmerich Joseph
- Escaut Lelia
- Estellat Candice
- Fabre Solène
- Fain Olivier
- Fallet Vincent
- Fartoukh Muriel
- Faure Morgane
- Fauvaux Catherine
- Faye Pierre
- Fayol Antoine
- Fellahi Soraya
- Felten Renaud
- Feredj Elsa
- Ferfar Yasmina
- Feyeux Delphine
- Figueiredo Samy
- Fillon Julie
- Flamand Saskia
- Flamarion Edouard
- Fodil Hanane
- Fois Elena
- Fournier Benjamin
- Fourreau Alain
- François Hélène
- Frazier Aline
- Fremont Dimitri
- Fuentes Axelle
- Galicier Lionel
- Gamany Naura
- Gambier Nicolas
- Garcia Gilles
- Garnier Marc
- Gaudefroy Caroline
- Gauzit Remy
- Georgin-Lavialle Sophie
- Geri Guillaume
- Gernez Coralie
- Gervais Anne
- Ghembaza Amine
- Ghosn Jade
- Gilbert Marie
- Gimeno Linda
- Giroux-Leprieur Benedicte
- Godier Anne
- Goichot Bernard
- Gorget Thomas
- Gottenberg Jacques-Eric
- Goupil de Bouille Jeanne
- Grailles Guillaume
- Granville Sophie
- Greigert Valentin
- Grimaldi Lamiae
- Grisot Paul Henri
- Gros Antoine
- Gros Hélène
- Guerin Corinne
- Guffroy Aurélien
- Guidet Bertrand
- Guillaud Constance
- Guillaume-Jugnot Perrine
- Guillot Emmanuelle
- Guinot Pierre-Grégoire
- Gysembergh-Houal Anne
- Hadjam Tassadit
- Hai Dhiaa Meriem
- Hamada Sophie-Rym
- Hamiria Samir
- Hammal Soumeya
- Hansmann Yves
- Harrois Anatole
- Haudebourg Luc
- Hauw-Berlemont Caroline
- Heger Bob
- Henriques Mickael
- Henry Estelle
- Hermine Olivier
- Honsel Vasco
- Hulot Jean-Sébastien
- Humbert Marc
- Hutt Anne
- Isernia Valentina
- Ismael Sophie
- Issorat Elodie
- Jachiet Vincent
- Jacob Aude
- Jacolot Anne
- Jallouli Moez
- Jambon Julie
- Jaubert Paul
- Jauréguiberry Stéphane
- Jaïs Xavier
- Jegu Anne Lise
- Jesuthasan Denis
- Jevnikar Mitja
- Joly Veronique
- Joseph Adrien
- Jouany Pauline
- Joumaa Hassan
- Jourdaine Clément
- Jouve Charléne
- Jozwiak Mathieu
- Julia Zelie
- Junquera Ramon
- Kaeuffer Charlotte
- Karachi Carine
- Kassegne Loic
- Kebir Amina
- Kedzia Cécile
- Keo Vixra
- Kerneis Solen
- Keroumi Younes
- Kiouris Elena
- Klasen Alison
- Knosp Camille
- Kolta Sami
- Korganow Anne Sophie
- Koumis Ilias
- Kozaliewicz Ewa
- Krause Le Garrec Jessica
- Lachatre Marie
- Lacombe Karine
- Lafoeste Hélène
- Lambotte Olivier
- Lancon Victor
- Languille Laetitia
- Larcheveque Cecile
- Lariven Sylvie
- Le Borgne Pierrick
- Le Bourlout Catherine
- Le Gac Sylvie
- Le Guen Pierre
- Le Marchand Mathilde
- Le Marec Julien
- Le Pluart Diane
- Le Tiec Clotilde Le Tiec
- Lebeaux David
- Lecomte Laurence
- Lecronier Marie
- Lefebvre Nicolas
- Lefèvre Edouard
- Lefèvre Guillaume
- Legendre Paul
- Legros Marie-Hélène
- Lehir Isabelle
- Lehmann Blandine
- Lelievre Jean-Daniel
- Lemagner Christine
- Lemarié Nadège
- Lemoine Matthieu
- Lengliné Etienne
- Lenoir Olivia
- Leplay Céline
- Leprun Gaël
- Leroux Gaelle
- Lescure F-Xavier
- Licois Marion
- Lim Pascal
- Livrozet Marine
- Liégeon Geoffroy
- London Jonathan
- Lorillon Gwenaël
- Louapre Céline
- Louis Zeina
- Louni Francoise
- Luong Nguyen Liem Binh
- Maalouf Georgina
- Mabrouki Asmaa
- Madelaine Claire
- Madeleine Isabelle
- Mahevas Matthieu
- Mahtal Nassim
- Mameri Lakhdar
- Mamoune Asmaa
- Manivet Philippe
- Marey Jonathan
- Mariani Louise-Laure
- Mariette Xavier
- Marin Nathalie
- Mariotte Eric
- Marquis Eric
- Martel Pascal
- Martin de Frémont Grégoire
- Martin Karine
- Martin Tristan
- Matignon Marie
- Maurer Agnes
- Mayaux Julien
- Mcavoy Chloe
- Meddah Hakim
- Meftali Ramdane
- Megarbane Bruno
- Mekid Yasmina
- Mekinian Arsène
- Mekontso-Dessaps Armand
- Melica Giovanna
- Menage Nathalie
- Mertes Paul Michel
- Messaoudi Yasmine
- Metzger Catherine
- Meunier Jeanne
- Meunier Martine
- Meyer Nicolas
- Michel Marc
- Michon Adrien
- Michot Jean-Marie
- Mirouse Adrien
- Mohebbi Abolfazl
- Molina Jean-Michel
- Molinari Domitille
- Monnet Xavier
- Montani David
- Montlahuc Claire
- Moores Alexandre
- Mora Pierre
- Morawiec Elise
- Morbieu Caroline
- Morel Alexandre
- Morgand Marjolaine
- Morin Florence
- Mourad Jean-Jacques
- Mourvillier Bruno
- Mouthon Luc
- Nadal Marine
- Ndiaye Awa
- Nemlaghi Safaa
- Neuschwander Arthur
- Nguyen Lee
- Nguyen Yann
- Nisand Gabriel
- Nizard Mandy
- Noaillon Mathilde
- Noel Nicolas
- Noll Eric
- Nunes Hilario
- Nyanou Corine
- Oberlin Mathieu
- Ohlmann-Caillard Sophie
- Oksenhendler Eric
- Olivier Olivier
- Ouamri Sabrine
- Oziel Johanna
- Pacanowski Jerome
- Pacheco Claire
- Palmieri Lola-Jade
- Papo Thomas
- Paquet Valérie
- Pari Marie Hélène
- Parisey Marion
- Parrot Antoine
- Patin Florence
- Pattyn Anne
- Pavot Arthur
- Pavy Stéphan
- Peffault de Latour Régis
- Peigney Isabelle
- Pene Frédéric
- Penet Marie-Aude
- Pereira Maria
- Pernin Claire
- Pernot Corinne
- Perrodeau Elodie
- Petit-Hoang Camille
- Phibel Audrey
- Phung Bao
- Pialoux Gilles
- Pierron Cédric
- Planquette Benjamin
- Poindron Vincent
- Poissy Julien
- Pommeret Fanny
- Porcher Raphael
- Pottecher Julien
- Pouliquen Anne-Lise
- Pourbaix Annabelle
- Pourchet-Martinez Valérie
- Pradon Caroline
- Provitolo Vincent
- Puéchal Oriane
- Rachline Anne
- Rahli Roza
- Raked Nabil
- Ranque Brigitte
- Rathouin Vanessa
- Ravato Sylviane
- Ravaud Philippe
- Razurel Anaïs
- Rech Jean-Simon
- Regent Alexis
- Renaud Stéphane
- Renet Sophie
- Resche-Rigon Matthieu
- Resmini Léa
- Richard Christian
- Richette Pascal
- Rigal Marthe
- Rigolet Aude
- Rioux Christophe
- Riveline Jean-Pierre
- Rolland-Debord Camille
- Roques Anne-Marie
- Rossi Geoffrey
- Roulot Dominique
- Roux Damien
- Rouzaud Claire
- Rozensztajn Nathalie
- Ruch Yvon
- Sabatier Brigitte
- Sacco Emmanuelle
- Sacleux Sophie-Caroline
- Sadaoui Thiziri
- Sakkal Madona
- Saleh-Mghir Samira
- Saliba Faouzi
- Sambin Sara
- Sanchez Olivier
- Saussereau Julien
- Sautereau Aurelie
- Savale Laurent
- Schlemmer Frédéric
- Schmitz David
- Semaille Caroline
- Semerano Luca
- Semri Hala
- Sene Damien
- Senet Patricia
- Servettaz Amélie
- Sguiouar Naima
- Siguier Martin
- Simon Tabassome
- Sitbon Olivier
- Smati Julie
- Soria Angèle
- Soyez-Herkert Loren
- Stan Emilia
- Steg Gabriel
- Stoclin Annabelle
- Suarez Lydia
- Sublon Cédric
- Szwebel Tali-Anne
- Tantet Claire
- Tarhini Hassan
- Tayebi Hakim
- Tazi Abdellatif
- Teboul Jean-Louis
- Terrier Benjamin
- Tharaux Pierre-Louis
- Thibaut Pélagie
- Thiemele Alaki
- Tibi Annick
- Tissieres Pierre
- Toquet Segolene
- Tremorin Marie-Thérèse
- Tréhan Anne
- Tubach Florence
- Tudesq Jean-Jacques
- Urbina Tomas
- Uzunhan Yurdagul
- Uzzan Matthieu
- Valayer Simon
- Vallet Mathilde
- Vallois Dorothee
- Vanhoye Damien
- Vasquez-Ibarra Miguel Alejandro
- Vauboin Pernelle
- Vautier Mathieu
- Vayssettes Marie
- Vermes Paul
- Verny Christiane
- Verstuyft Céline
- Vicaut Eric
- Vieira Matheus
- Vigna Véronique
- Vimpere Damien
- Virlouvet Myriam
- Virolle Sara
- Volle Geoffroy
- Volpe Thomas
- Walter-Petrich Anouk
- Weill François
- Weiss Emmanuel
- Willekens Chistophe
- Wilpotte Celine
- Wynckel Alain
- Yazdanpanah Yazdan
- Yelles Nessima
- Yelnik Cécile
- Zafrani Lara
- Zahrate-Ghoul Aida
- Zaidan Mohamad
- Zarrouk Virginie
- Zerbit Jérémie
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
International audienc
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
- Abad Jorge
- Abad Sebastien
- Abassi Radhiya
- Abdelhadi Nour Mekki
- Abdellaoui Abdelrafie
- Abdelmalek Abdelkrim
- Abdoul Hendy
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abergel Helene
- Abeud Fariza
- Abgrall Sophie
- Abisror Noemie
- Abolhassani Hassan
- Abou Tayoun Ahmad
- Accordino Giulia
- Achille Cristian
- Adechian Marylise
- Aderdour Nordine
- Admane Hakeem Farid
- Adnet Frederic
- Afritt Sara
- Agostini Helene
- Agra Juan José Cáceres
- Aguilar Claire
- Aguilera-Albesa Sergio
- Aguiló-Cucurull Aina
- Agut Sophie
- Aiello Tommaso Francesco
- Aiuti Alessandro
- Ajeenthiravasan Gokula
- Akcan Özge Metin
- Al-Muhsen Saleh
- Al-Muhsen Saleh Zaid
- Al-Mulla Fahd
- Alauzy Virginie
- Alavi Darazam Ilad
- Alavoine Loubna
- Alba Camille
- Albisures Jonathan Antonio Roblero
- Alby-Laurent Fanny
- Aldave Juan C.
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- AlKhater Suzan A.
- Allard Lucie
- Allardet-Servent Jerome
- Allende Luis M.
- Alonso-Arias Rebeca
- Alosaimi Mohammed Faraj
- Alshahrani Mohammed S.
- Alsina Laia
- Alsohime Fahad M.
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Alyanakian Marie-Alexandra
- Amam Sabrina
- Amara Yasmina Ould
- Amat Karine
- Amoura Zahir
- Amrouche Lucile
- Amsterdam UMC Covid-19 Biobank [missing]
- Anderson Mark S.
- Andreakos Evangelos
- Andrejak Claire
- Andronikof Marc
- Anglicheau Dany
- Angoulvant François
- Anguel Nadia
- Annane Djillali
- Antolí Arnau
- Aounzou Mohammed
- Aparicio Caroline
- Appelman Brent
- Aratus Gladys
- Arias Andrés A.
- Arias Andrés Augusto
- Arlet Jean-Benoit
- Arquero Miguel Fernandez
- Arranz María Jesús
- Arrestier Romain
- Arzoine Jeremy
- Asano Takaki
- Aslangul Elisabeth
- Assefi Mona
- Aubart Mélodie
- Aubry Adeline
- Audiffred Laetitia
- Audureau Etienne
- Auger Christelle Nathalie
- Auguet Teresa
- Auregan Jean-Charles
- Avramenko Iryna
- Awotar Celine
- Aytekin Gokhan
- Aytekin Gökhan
- Aytekin Selma Erol
- Azan Delphine
- Azemar Laurene
- Azot Axelle
- Azzouguen Billal
- Bachelet Delphine
- Badsi Aïda
- Baghdadi Jamila El
- Bahram Seiamak
- Bajolle Fanny
- Bakouboula Prissile
- Balcerowiak Coline
- Baldanti Fausto
- Balde Fanta
- Baldivia Elodie
- Baldolli Aurélie
- Ballester Maite
- Bangamingo Eliane-Flore
- Baptiste Amandine
- Baran-Marszak Fanny
- Barau Caroline
- Barget Nathalie
- Baris-Feldman Hagit
- Baronnet Flore
- Barrou Benoit
- Barthelemy Romain
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Baudel Jean-Luc
- Baudry Camille
- Baudry Elodie
- Bauters Fre
- Bax Diane
- Bayhan Gulsum Iclal
- Beaugerie Laurent
- Behilill Sylvie
- Behillil Sylvie
- Belamri Adel
- Belaube Nicolas
- Belilita Rhida
- Bellani Giacomo
- Bellassen Pierre
- Belmokhtar Rawan
- Belot Alexandre
- Belot Alexandre
- Beltran Isabel
- Beluze Marine
- Benainous Ruben
- Benallaoua Mourad
- Benamouzig Robert
- Benbara Amélie
- Benhida Jaouad
- Benkerrou Dehbia
- Benkhelouf Anis
- Benlagha Jihene
- Benmostafa Chahinez
- Benothmane Skander
- Bentifraouine Miassa
- Berard Laurence
- Beretta Ilaria
- Bergman Peter
- Berkell Matilda
- Bernier Quentin
- Bertholon Frédérique
- Berti Enora
- Bertier Astrid
- Berton Laure
- Bessis Simon
- Bettini Laura Rachele
- Beudel Martijn
- Beurton Alexandra
- Bezrodnik Liliana
- Bhavsar Krishna
- Bianco Celine
- Bianquis Clara
- Bidar Frank
- Biggs Catherine M.
- Bilbao Agurtzane
- Biondi Andrea
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanche Philippe
- Blanco Ignacio
- Blandinières Adeline
- Blayau Clarisse
- Bleibtreu Alexandre
- Bleibtreu Alexandre
- Blin Emmanuelle
- Bloch-Queyrat Coralie
- Bloomfield Marketa
- Blázquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boissier Marie-Christophe
- Boisson Bertrand
- Boisson-Dupuis Stephanie
- Boland Anne
- Bolivar-Prados Mireia
- Bollens Diane
- Bolze Alexandre
- Bolzoni Marion
- Bomers Marije
- Bompard Rudy pierre
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondesan Simone
- Bonnet Nicolas
- Bonnouvrier Justine
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels Cedric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botha Shirmonecrystal
- Botta Michela
- Bouadma Lila
- Boucenna Wissam
- Bouchama Fatiha
- Bouchaud Olivier
- Bouchez Sabelline
- Bouchghoul Hanane
- Boudjebla Taoueslylia
- Boudjema Noel
- Bouffard Catherine
- Bougle Adrien
- Bouguerra Meriem
- Bouiller Kévin
- Boulanger Cécile
- Bouras Leila
- Bourcier Agnes
- Bourgeon Marilou
- Bourrier Anne
- Bouscambert Maude
- Bouscarat Fabrice
- Bousfiha Ahmed A.
- Bousfiha Ahmed A.
- Bousquet Aurore
- Boutolleau David
- Bouvattier Claire
- Bouvry Diane
- Bouziri Nesrine
- Bouzrara Ons
- Boyarchuk Oksana
- Bozdemir Şefika Elmas
- Bravais Juliette
- Bribier Sarah
- Briones M. Luisa
- Brodin Petter
- Brouwer Matthijs C.
- Brugier Delphine
- Bruneau Léa
- Brunel Melanie
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bryceson Yenan T.
- Bueno Maria Rita P.
- Bugiani Marianna
- Bui Eida
- Buis David T. P.
- Buisson Anne
- Bukhari Huda
- Bukreyeva Iryna
- Bulle Esther
- Burdet Charles
- Bureau Côme
- Bureau Serge
- Bustamante Carlos D.
- Bustamante Jacinta
- Bustos Ingrid G.
- Butte Manish J.
- Cabrera-Marante Oscar
- Cadranel Jacques
- Cailhol Johann
- Calin Ruxandra
- Canavaggio Pauline
- Cancella Marta
- Cantin Delphine
- Cao Albert
- Capra Ruggero
- Carapito Raphael
- Carbillon Lionel
- Carcel Sheila
- Carelli Valerio
- Carlier Nicolas
- Carrabba Maria
- Carrera Paola
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Cassard Clementine
- Castelle Martin
- Castelli Francesco
- Castor Guylaine
- Castro Mateus V.
- Catherinot Emilie
- Cauchy Marion
- Cazzaniga Marina
- Celik Jale Bengi
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Cha Olivier
- Chachoua Abla
- Chahine Abir
- Chaigne Benjamin
- Chair Anissa
- Chakravorty Samya
- Chaldebas Matthieu
- Challal Salima
- Chalumeau Martin
- Chalumeau Nathalie Costedoat
- Champion Karine
- Charbit Bruno
- Chariot Patrick
- Charpentier Charlotte
- Chas Julie
- Chauveau Simon
- Chauvin Anthony
- Chauvin Clement
- Chavarot Nathalie
- Chaïbi Khalil
- Chebbout Kamélia
- Cheng Matthew P.
- Cherai Mustapha
- Cherubini Ilaria
- Chevalier Amelie
- Chiarabini Thibault
- Chinet Thierry
- Chirouze Catherine
- Chirouze Catherine
- Chocron Richard
- Choinier Pascaline
- Chommeloux Juliette
- Choquet Christophe
- Choupeaux Laure
- Chousterman Benjamin
- Christelle Kouakam
- Christodoulou John
- Ciocan Dragosmarius
- Citerio Giuseppe
- Clarke Ada
- Clavere Gaëlle
- Clavier Florian
- Clavé Père
- Clement Karine
- Clerc Sebastien
- Cloherty Osoul Chouchane Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Cohen Adrien
- Cohen Fleur
- Cohen Yves
- Cohen Yves
- Coilly Audrey
- Colboc Hester
- Colin Pauline
- Collet Magalie
- Colobran Roger
- Comarmond Chloé
- Comarmond Cloé
- Combacon Emeline
- Combe Caroline Lascoux
- Combes Alain
- Combes Alain
- Comoli Patrizia
- Comparon Celine
- Condino-Neto Antonio
- Constantin Jean-Michel
- Constantinescu Stefan N.
- Contro Ernesto
- Cooper Megan A.
- Cordel Hugues
- Cordier Anne-Gael
- Corsico Angelo G.
- Costantini Adrien
- Couffignal Camille
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coupeau Doriane
- CoV-Contact Cohort [missing]
- COVID Clinicians [missing]
- COVID Human Genetic Effort [missing]
- COVID-STORM Clinicians [missing]
- COVIDeF Study Group [missing]
- Covill Laura E.
- Coşkuner Taner
- Creange Alain
- Cuadros Esmeralda Nuñez
- Cvetkovski Aleksandar
- Cyrus Cyril
- Da Silveira Charlène
- Dalgard Clifton L.
- Dalmau David
- Danielson Jeffrey J.
- Danion François
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- De Bouille Jeanne Goupil
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- De Castro Nathalie
- De Chambrun Marc Pineton
- de Chambrun Marc Pineton
- de Diego Rebeca Pérez
- De Farcy Pauline Mary
- de Jong Menno D.
- De Munter Paul
- de Pontual Loic
- de Rotte Maurits C. F. J.
- De Rycke Yann
- de Vera Martín Castillo
- de Vries Heder
- Debray Marie-Pierre
- Dechanet Aline
- Declercq Jozefien
- Deconinck Lauren
- Dehban Amin
- Del Pozo Lucie
- del Prado Maria Yolanda Ruiz
- Delannoy Quentin
- Delay Mathieu
- Deleris Robin
- Deleuze Jean-François
- Delforge Juliette
- Delmonte Ottavia M.
- Delphine Laëtitia
- Delplancq Geoffroy
- Demar Magalie
- Demare Noemie
- Demeret Sophie
- Demerville Lauren
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Demoule Alexandre
- Deniau Aurore
- Deplanque Dominique
- Deplanque Dominique
- Depret François
- Derolez Sophie
- Derradji Ouda
- Derridj Nawal
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Descamps Vincent
- Deschamps Lydia
- Desconclois Celine
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desnos Cyrielle
- Desongins Karine
- Desvallée Mathilde
- Devouge Eglantine Ferrand
- Dhote Robin
- Di Sabatino Antonio
- Diallo Alpha
- Diallo Benjamin
- Didier Morgane
- Diehl Jean-Luc
- Diemer Myriam
- Diez Stephane
- Dijkstra Mirjam
- Diouf Alphonsine
- Djadi-Prat Juliette
- Djebara Siham
- Djebra Naoual
- Djietcheu Minette
- Djillali Hadjer
- Djossou Félix
- Djouadi Nouara
- Dobbelaere Stephanie
- Dobbs Kerry
- Domínguez-Garrido Elena
- Dongelmans Dave A.
- Donneger Severine
- Dorival Céline
- Dos Santos Catarina
- Dournon Nathalie
- Dres Martin
- Droctove Laura
- Drogrey Marie
- Drolet Beth A.
- Dropy Margot
- Drouet Elodie
- Dubos François
- Dubosq Valérie
- Dubost Clément
- Dubreucq Evelyne
- Dubus Estelle
- Duchemann Boris
- Duchenoy Thibault
- Dudoignon Emmanuel
- Dufau Romain
- Dujardin Romein W. G.
- Dumas Florence
- Duran Clara
- Durand Anne Bourgarit
- Duron Emmanuelle
- Durrbach Antoine
- Duval Xavier
- Duval Xavier
- Duvivier Claudine
- D’Angio’ Mariella
- d’Ortenzio Eric
- Ebstein Nathan
- Ecobichon Jean-Luc
- Ekwall Olov
- El Zein Loubna
- Elabbadi Alexandre
- Elbers Paul
- Elharrar Brigitte
- Elie Caroline
- Elnagdy Marwa H.
- Eloy Philippine
- Elrufaai Marwa Bachir
- Emiroglu Melike
- Endo Akifumi
- Enouf Vincent
- Enouf Vincent
- Erdeniz Emine Hafize
- Ernotte Gabriel
- Esling Anne
- Esperou Hélène
- Espinosa-Padilla Sara
- Esposito-Farese Marina
- Espérou Hélène
- Etienne Manuel
- Etienne Martin
- Euvrard Romain
- Eyer Xavier
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fartoukh Muriel
- Fartoukh Muriel sarah
- Faure Morgane
- Fayali Takoua
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fermaut Marion
- Ferrer Ricard
- Ferreres Jose
- Fiorentino Alessio
- Fiorentino Arianna
- Fleuren Lucas
- Fliss Souha
- Flores Carlos
- Florkin Benoit
- Foti Giuseppe
- Fouchard Julie
- Fournier Benjamin
- Fournier Marie-Céline
- Franco Jose Luis
- Franco José Luis
- Francois Bruno
- Francois Hélène
- French COVID Cohort Study Group [missing]
- Freynet Olivia
- Frezouls Wahiba
- Frigout Yvann
- Froidure Antoine
- Fromont Isaure
- Fuentes Axelle
- Fumadó Victoria
- Fung Kitty S. C.
- Furet Thomas
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Galand Joris
- Garnier Marc
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaubert Agnes
- Gaudry Stéphane
- Gaugain Samuel
- Gault Nathalie
- Gaussem Pascale
- Gauthier Damien
- Gautier Maxime
- Gaymard Alexandre
- Gayretli Zeynep
- Geijtenbeek Suzanne Geerlings Theo
- Georgin-Lavialle Sophie
- Geromin Daniela
- Gervais Adrian
- Ghalayini Mohamed
- Ghaleh Bijan
- Ghezal Myriam
- Ghosn Jade
- Gibelin Aude
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilg Morgane
- Gimeno Linda
- Girard Benoit
- Girbes Armand
- Girona-Alarcón Mònica
- Gissot Valérie
- Goas Carole L. E.
- Godínez Karen Alejandra Cifuentes
- Goffard Jean-Christophe
- Gomes Doryan
- Gomes-Pires Elisabete
- Gonzales Nacho
- Gonzalez-Granado Luis I.
- González-Montelongo Rafaela
- Goorhuis Bram
- Gorochov Guy
- Gouge Anne
- Gouja Amel
- Goulet Helene
- Goupil Sylvain
- Gras Julien
- Greffe Segolene
- Gregersen Peter K.
- Grimaldi Lamiae
- Grobusch Martin P.
- Guedeney Paul
- Guedj Jérémie
- Guerder Antoine
- Guidet Bertrand
- Guillo Matthias
- Gulczynski Mariechristelle
- Gumucio Victor Daniel
- Gunst Jan
- Gut Marta
- Gysembergh-Houal Anne
- Gérardin Patrick
- Gülhan Belgin
- Hadjadj Jérôme
- Hadjam Tassadit
- Haerynck Filomeen
- Hafkamp Florianne
- Hagens Laura
- Hagin David
- Haguenauer Didier
- Halwani Rabih
- Hamann Jorg
- Hammal Soumeya
- Hammarström Lennart
- Hammoudi Nadjib
- Hancerli Selda
- Hanitsch Leif Gunnar
- Hanon Olivier
- Hariyan Tetyana
- Harris Vanessa
- Harrois Anarole
- Hatipoglu Nevin
- Hatipoğlu Nevin
- Hausfater Pierre
- Hautem Coraline
- Heath James R.
- Heijmans Catherine
- Hekimian Guillaume
- Heming Nicholas
- Hemke Robert
- Hendou Samia
- Henrickson Sarah E.
- Heppekcan Deniz
- Hermine Olivier
- Hernandez-Brito Elisa
- Heunks Sabine M. Hermans Leo
- Ho Po-ki
- Ho Sylvie
- Hoctin Alexandre
- Hoffmann Isabelle
- Holanda-Peña María Soledad
- Hollmann Markus
- Horcajada Juan P.
- Horn Janneke
- Hoste Eric
- Hoste Levi
- Houas Ikram
- Houhou Nadhira
- Houllier Marie
- Hovius Joppe W.
- Hraiech Sami
- Hsieh Elena W. Y.
- Hulot Jean-Sébastien
- Humbert Linda
- Hung Ivan F. N.
- Huot Benjamin
- Hupalo Daniel N.
- Huscenot Tessa
- Husebye Eystein
- Iglesias Alejandro D.
- Ikherbane Ghilas
- Imai Kohsuke
- Imarazene Meriem
- Imberti Luisa
- Ingiliz Patrick
- Iratni Lina
- Itan Yuval
- Jaafoura Salma
- Jamme Matthieu
- Jarvis Erich D.
- Jaureguiberry Stephane
- Jean-Marc Jean-Francois
- Jeulin Hélène
- Jeyarajasingham Deleena
- Jimeno Marie-Thérèse
- Jordan Iolanda
- Jouanguy Emmanuelle
- Jouany Pauline
- Jouis Veronique
- Jourdaine Clement
- Kaci Marc Ait
- Kafif Ouifiya
- Kafif Ouifiya
- Kafif Ouifiya
- Kaguelidou Florentia
- Kahn-Kirby Amanda
- Kali Sabrina
- Kallala Rim
- Kara Yalcin Burak
- Karahan Aydın
- Karamitros Timokratis
- Karbuz Adem
- Kasapcopur Ozgur
- Kashimada Kenichi
- Katsahian Sandrine
- Kayani Sandrine Dautheville Guibal El
- Keles Sevgi
- Kelesyan Lilit
- Keo Vixra
- Kermanach Nathalie Saidenberg
- Ketz Flora
- Khalifa Jihane El
- Khalil Antoine
- Khamis Warda
- Khan Coralie
- Khan Taj Ali
- Khelili Enfel
- Khellaf Mehdi
- Kido Yasutoshi
- Kılıç Ahmet Osman
- Kisand Kai
- Kizil Can
- Klocperk Adam
- Koning Rutger
- Kounis Ilias
- Koutsoukou Antonia
- Kpalma Gaelle
- Krause Jessica
- Król Zbigniew J.
- Ksouri Hatem
- Ku Cheng-Lung
- Kuentz Paul
- Kwan Arthur M. C.
- Kwan Yat Wah M.
- Kwok Janette S. Y.
- Kyheng Christèle
- Labbe Vincent
- Lack Justin
- Lacombe Karine
- Lacorte Jean-Marc
- Lafont Anne Gaelle
- Lafont Emmanuel
- Lagha Lynda
- Lagier Jean-Christophe
- Laine Fabrice
- Lam David S. Y.
- Lamarre Yannie Cuvillier
- Lambrecht Bart
- Lamhaut Lionel
- Lampropoulou Vicky
- Lancelot Aymeric
- Landman Cecilia
- Lanternier Fanny
- Lanternier Fanny
- Laouénan Cédric
- Larcheveque Cecile
- Laribi Samira
- Larmurier Isabelle Nion
- Lasa Maria Pilar Etxart
- Lassel Ludovic
- Lau Yu-Lung
- Laverdant Benjamin
- Lavergne Christophe
- Lavillegrand Jean-Rémi
- Laviolle Bruno
- Lazureanu Pompilia
- Le Bourgeois Fleur
- Le Guennec Loïc
- Le Hingrat Quentin
- Le Mestre Soizic
- Le Nagard Hervé
- Le Minh
- Leberre Lamia
- Leblanc Claire
- Leboyer Marion
- Lecomte Francois
- Lecorre Marine
- Leenhardt Romain
- Lefebvre Bénédicte
- Lefebvre Marylou
- Lefévre Benjamin
- Legendre Paul
- Leger Anne
- Legrand Karine
- Legros Laurence
- Legrosse Justyna
- Lehacaut Jonathan
- Lehuunghia Sébastien
- Lemarec Julien
- Leo Yee-Sin
- Leon-Lopez Rafael
- Leporrier-Ext Jeremie
- Leprieur Bénédicte Giroux
- Lermine Alban
- Lescure François-Xavier
- Lesein Manon
- Lesur Hubert
- Letrou Sophie
- Letrou Sophie
- Leung Daniel
- Levin Michael
- Levy Albert
- Levy Michael
- Levy Vincent
- Levy Yves
- Li Zhi
- Lien Olivia Tran Dinh Thanh
- Lifton Richard P.
- Lilleri Daniele
- Lim Endry H. T.
- Lima Breno Melo
- Lima Edson Jose Adrian Bolanos
- Lina Bruno
- Lina Bruno
- Ling Yun
- Lingas Guillaume
- Linglart Agnes
- Llovich Alex Serra
- Lomazzi Sandra
- Lopes Amanda
- Lopes Edwige
- Lopez Rafael Leon
- Lopez Vanessa
- Lopinto Julien
- Lorenzo-Salazar José M.
- Lortholary Olivier
- Louadah Badr
- Louapre Céline
- Loze Bénédicte
- Lubetzki Catherine
- Lucarelli Aude
- Lucas Carrie L.
- Lucas Marie-Laure
- Lucasamichi Axelle
- Lucet Jean Christophe
- Lucet Jean-Christophe
- Lung Kwok-Cheung
- Luong Liem Binh
- Luyt Charles-Edouard
- Lye David C.
- Lévy Romain
- López-Collazo Eduardo
- Magazimama-Ext Arouna
- Magnone Cinthia
- Maillot Adrien
- Maingret David
- Malhotra Surbi
- Malvy Denis
- Malvy Denis
- Mambert Marina
- Mameri Lakhdar
- Manchon Pauline
- Maniatis Tom
- Manivet Philippe
- Manry Jeremy
- Mansouri Cylia
- Mansouri Davood
- Marcault Estelle
- Marchal Astrid
- Marchioni Enrico
- Marey Jonathan
- Marin Nathalie
- Marioli Carola
- Marjani Majid
- Marois Clémence
- Marques Laura
- Martin Olivier
- Martin-Nalda Andrea
- Martineau Lou
- Martinez Antonio Morales
- Martinez-Lopez Cannelle
- Martinez-Picado Javier
- Martyniuck Pierre
- Martín-Nalda Andrea
- Marzana Iciar
- Marzouk Nessrine
- Maródi László
- Masmoudi Rafik
- Mata-Martínez Carmen
- Mathian Alexis
- Matos Larissa R. B.
- Matthews Gail V.
- Mattiaccio Alessandro
- Matuozzo Daniela
- Mayaux Julien
- McLaughlin-Garcia Raquel
- Mebazaa Alexandre
- Mechai Frédéric
- Mecozzi Fabio
- Medina Yeray Novoa
- Mediouni Chamseddine
- Meersseman Philippe
- Megarbane Bruno
- Meghadecha Mohamed
- Mejean Élodie
- Mekinian Arsene
- Mekni Rania
- Mekontso-Dessap Armand
- Meliti Thinhinan Sabrina
- Melián Abián Montesdeoca
- Melki Isabelle
- Meloni Federica
- Meng Paris
- Mentre France
- Mentré France
- Merbah Soraya
- Mergeay-Fabre Mayka
- Meritet Jean-François
- Merlani Paolo
- Messani Fadhila
- Messaoudi Yasmine
- Metin Akcan Ozge
- Meunier Alexandre
- Mewasing Baboo-Irwinsingh
- Meyts Isabelle
- Meyts Isabelle
- Meyts Isabelle
- Meziane Amina
- Meziane Lydia
- Mezidi Mehdi
- Michelot-Burger Carole
- Migaud Maria-Claire
- Migeotte Isabelle
- Mignot Françoise
- Milisavljevic Baptiste
- Milla Sonia Ayllon
- Millereux Maude
- Million Matthieu
- Milner Joshua D.
- Minka Fadi Hillary
- Mirault Tristan
- Mircher Clotilde
- Mironska Kristina
- Mirsaeidi Mehdi
- Miyara Makoto
- Mizoguchi Yoko
- Modi Bhavi P.
- Mogensen Trine H.
- Moine Pierre
- Mojoli Francesco
- Molina Jean-Michel
- Moncomble Elsa
- Monnory Fatima-Zohra Djamouri
- Montagne Samatha
- Montegnies-Boulet Anaïs
- Monti Alexandra
- Montlahuc Claire
- Montout Anne-Lise
- Moores Alexandre
- Morandeira Francisco
- Morange Pierre-Emmanuel
- Morbieu Caroline
- Mordacq Cléemence
- Morelle Guillaume
- Morio Tomohiro
- Mortelette Helene
- Mouly Stéphane
- Mouly Stéphane J.
- Mouquet Hugo
- Mullaert Jimmy
- Muzaffar Rosita
- Muñoz-Barrera Adrián
- Mège Jean-Louis
- Nacerddine Cherifa Iness
- Nadal Marine
- Nadif Hajer
- Nadji Seyed Alireza
- Naesens Leslie
- Nafati Cyril
- Nagashima Shintaro
- Nakagama Yu
- Narvaez Rafael Usubillaga
- Nassarmadji Kladoum
- Natella Pierre
- Ndingamondze Sandrine
- Neant Nadège
- Nellen Jeaninne
- Neraal Stefan
- Neven Bénédicte
- Neves João Farela
- Ng Lisa F. P.
- Ng Lisa F. P.
- Ng Yuk-Yung
- Nguyen Caroline
- Nguyen Duc
- Nguyen Duc
- NIAID-USUHS COVID Study Group [missing]
- Nicolas Leturque
- Nielly hubert
- Nlomenyengue Luc
- Noel Nicolas
- Noret Marion
- Nossent Esther J.
- Notarangelo Luigi D.
- Notarangelo Luigi D.
- Nouroudine Mariama
- Novelli Antonio
- Novelli Giuseppe
- Nseir Saad
- Nunes Hilario
- Nussbaum Robert
- N’Guyen Bao
- Ocejo-Vinyals J. Gonzalo
- Okada Satoshi
- Okamoto Keisuke
- Oler Andrew J.
- Omar Edris
- Orchestra Working Group [missing]
- Oualha Mehdi
- Ouazene Zineb
- Ouedrani Amani
- Ouedraogo Elise
- Ouelaa Wassila
- Oufella Hafid Ait
- Oukhedouma Anissa
- Oya Herve
- Ozcelik Tayfun
- Oziel Johanna
- Ozkaya-Parlakay Aslinur
- O’Farrelly Cliona
- Padilla Thomas
- Pagani Michele
- Paillaud Elena
- Paiva Solenne
- Palabiyik Figen
- Pan-Hammarström Qiang
- Papadaki Maria
- Papadopoulos Aurélie
- Parfait Beatrice
- Paris Christophe
- Parize Perrine
- Parizot Christophe
- Parizot Christophe
- Parola Philippe
- Parrot Antoine
- Pascreau Tiffany
- Paul Christelle
- Paul Stéphane
- Paulus Frederique
- Pavot Arthur
- Payet Christine
- Paz-Artal Estela
- Peaudecerf Laetitia
- Pedraza Sigifredo
- Peiffer-Smadja Nathan
- Pellecer Nancy Carolina González
- Pellegrini Silvia
- Pene Frédéric
- Pepin Marion
- Pereira Jesus Marquez
- Pernet Julie
- Pernin Claire
- Perpoint Thomas
- Perreau Pauline
- Pesci Alberto
- Peters Edgar
- Petit Mylène
- Petrov-Sanchez Ventzislava
- Peyrony Olivier
- Peytavin Gilles
- Pham Huong
- Philippe Aurélien
- Philippot Quentin
- Picod Adrien
- Picone Olivier
- Pietri Marie-Pierre
- Pietri Olivia
- Pina-Fuentes Dan A. I.
- Pinson Michelle
- Pintado Claire
- Pippucci Tommaso
- Piquard Valentine
- Piquard Valentine
- Piquard Valentine
- Piralla Antonio
- Pires Christine
- Pistone Thierry
- Planas Anna M.
- Planas-Serra Laura
- Planquette Benjamin
- Pleguezuelo Daniel E.
- Ploin Dominique
- Poirier Sandrine
- Poissy Julien
- Pomel Anne-Laure
- Poncelet Géraldine
- Pons Stéphanie
- Ponscarme Diane
- Poulakou Garyphallia
- Pouletty Marie S.
- Pourcelot Annegaelle
- Pourcher Valérie
- Pourshahnazari Persia
- Pouvaret Anne
- Prando Carolina
- Preckel Bennedikt
- Prever Florian
- Previlon Miresta
- Prevost Margot
- Prins Jan M.
- Provoost Marie-Julie
- Puel Anne
- Pueyo David Martínez
- Pujol Aurora
- Puéchal Oriane
- Pérez-Fernández Xosé Luis
- Qiu-Chen Jia Li
- Quaresima Virginia
- Quemeneur Cyril
- Quentric Paul
- Quintana-Murci Lluis
- Quintin Caroline
- Quiros-Roldan Eugenia
- Raasveld Jorinde
- Rabaud Christian
- Rafat Cédric
- Ramaswamy Sathishkumar
- Rambaud Thomas
- Rami Agathe
- Ramos Miquel Alfonso
- Ranque Brigitte
- Raoult Didier
- Raoult Violette
- Raphael Maurice
- Raphalen Jean Herle
- Rastoin Anna
- Raux Mathieu
- Rebai Amani
- Rebillat Anne-Sophie
- Reby Michael
- Redin Claire
- Regent Alexis
- Regrag Asma
- Reijnders Tom
- Renia Laurent
- Resche-Rigon Matthieu
- Resmini Léa
- Resnick Igor
- Ressaire Quentin
- Reyes Luis Felipe
- Ricart Pilar
- Richard Christian
- Richard Jean-Christophe
- Richard Lucie
- Richard Mariecaroline
- Rigo-Bonnin Raúl
- rivet Nadia
- Rivière Jacques G.
- Robert Maxence
- Rocamora-Blanch Gemma
- Rodero Mathieu P.
- Rodrigo Carlos
- Rodriguez Luis Antonio
- Rodriguez-Gallego Carlos
- Rodriguez-Palmero Agustí
- Rodríguez-Gallego Carlos
- Rohaut Benjamin
- Rojas Julian
- Rolland-Debord Camille
- Romero Carolina Soledad
- Ropers Jacques
- Roque-Afonso Anne-Marie
- Rosa-Calatrava Manuel
- Rosenberger John
- Rossi Camillo
- Rossignol Bénédicte
- Rossignol Patrick
- Rosso Charlotte
- Rothenbuhler Anya
- Roufai Layidé
- Rousseaux Mélanie
- Rousseaux Nabila
- Roux Damien
- Roux Lorène
- Roux Swasti
- Rouzaud Claire
- Rovere-Querini Patrizia
- Rovina Nikoletta
- Roy Carine
- Rozenberg Flore
- Rozes Antoine
- Rubenstein Emma
- Ruch Yvon
- Ruiz Montse
- Ruiz-Rodriguez Juan Carlos
- Sabate Jean-Marc
- Sabater-Riera Joan
- Sabet Sheila
- Sacleux Sophie-Caroline
- Saied Wafa Ibn
- Saks Kai
- Salagianni Maria
- Saliba Faouzi
- Salmon Dominique
- Sanchez Oliver
- Sancho-Shimizu Vanessa
- Savale Laurent
- Savary Guillaume
- Sberro Rebecca
- Scemla Anne
- Schidlowski Laire
- Schinkel Michiel
- Schlemmer Frederic
- Schluter Agatha
- Schlüter Agatha
- Schmidt Julien
- Schmidt Matthieu
- Schneider Marion
- Schrauwen Femke A. P.
- Schuetz Catharina
- Schultz Marcus J.
- Schuurmans Alex
- Schuurmans Jaap
- Schwartz Mathieu
- Schweitzer Cyril E.
- Scolari Francesco
- Sedfi Saïd
- Sediva Anna
- Sediva Anna
- Seeleuthner Yoann
- Sefir-Kribel Samia
- Seijo Luis
- Seksik Philippe
- Sellier Pierre
- Selves Agathe
- Sembach Nicole
- Semerano Luca
- Seminario Analia Gisela
- Senat Marie-Victoire
- Sene Damien
- Sene Damien
- Seng Piseth
- Senoglu Sevtap
- Seppänen Mikko
- Seppänen Mikko R. J.
- Seri Marco
- Serris Alexandra
- Sese Lucile
- Sghiouar Naima
- Shahrooei Mohammad
- Shcherbina Anna
- Shcherbina Anna
- Sigaloff Kim
- Sigaux Johanna
- Siguier Martin
- Siguret Virginie
- Silvain Johanne
- Simon Noémie
- Simon Tabassome
- Siouti Eleni
- Skandri Lina Innes
- Slabbynck Hans
- Slaby Ondrej
- Slim Marleen A.
- Slimani Miassa
- Smadja David M.
- Smeele Patrick
- Smit Marry
- Smith Nikaia
- Snauwaert Aurélie
- Snow Andrew L.
- Snow Andrew L.
- Sobh Ali
- Sokol Harry
- Solanich Xavier
- Soler Catherine
- Soler-Palacin Pere
- Soler-Palacín Pere
- Soler-Palacín Pere
- Soliman Heithem
- Solis Blanca Garcia
- Soltani Nisrine
- Solé-Violán Jordi
- Sottini Alessandra
- Soyer Benjamin
- Sozeri Betul
- Spaan András N.
- Steg Gabriel
- Stella Giulia Maria
- Stepanovskiy Yuriy
- Stijnis Cornelis S.
- Stilma Willemke
- Stoclin Annabelle
- Su Helen C.
- Su Helen C.
- Su Richa
- Suarez Lydia
- Sukumar Gauthaman
- Szwebel Tali-Anne
- Sánchez-Montalvá Adrián
- Sánchez-Ramón Silvia
- Sözeri Betül
- Taccone Fabio
- Tacconelli Evelina
- Taffame Kossi
- Talouarn Estelle
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tangye Stuart G.
- Tantet Claire
- Tardivon Coralie
- Tardy Bernard
- Tateo Mariagrazia
- Taupin Jean-Luc
- Tavernier Simon
- Tellier Marie-Capucine
- Tello Loreto Vidaur
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Theodose Igor
- Thiebaud Pierre clement
- Thiery Guillaume
- Thomas Caroline
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiercelet Kelly
- Timsit Jean-François
- Tipu Imran
- Tisserand Julie
- Tolstrup Martin
- Tomasoni Gabriele
- Tomczak Carole
- Tompkins Miranda F.
- Torelino Krystel
- Touam-Ext Fatima
- Toubiana Julie
- Toumi Lilia
- Toury Gustave
- Toy-Miou Mireille
- Trandinh Alexy
- Treluyer Jean-Marc
- Tresoldi Cristina
- Triantafyllia Vasiliki
- Trinque Baptiste
- Trouillet-Assant Sophie
- Troya Jesus
- Troya Jesús
- Truchot Jennifer
- Tsang Owen T. Y.
- Tserel Liina
- Tso Eugene Y. K.
- Tsonas Anissa M.
- Tual Christelle
- Tubach Florence
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter R.
- Tunesi Simone
- Turpin Agathe
- Turpin Matthieu
- Turvey Stuart E.
- Téoulé François
- Uddin Furkan
- Uddin Mohammed J.
- Urbina Tomas
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Uzunhan Yurdagul
- Vabres Pierre
- Vacher Yannick
- Vaittinadaayar Prabakar
- Valencia-Ramos Juan
- Valent Arnaud
- Valentian Maelle
- Valin Nadia
- Vallet Hélène
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- Van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- Van Den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- Van Der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- Van Praet Jens
- van Vugt Michèle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vaz Marina
- Vazquezibarra Miguel-Alejandro
- Vedie Benoit
- Veelo Denise
- Vega Clara Campos
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Velly Laetitia
- Verstuyft Celine
- Viallette Cedric
- Vicaut Eric
- Vidaud Michel
- Vidigal Mateus C.
- Viel Sébastien
- Vignali Valérie
- Vignes Dorothee
- Vilaire-Meunier Marie E.
- Villain Cédric
- Villar-García Judit
- Vimpere Damien
- Vincent Audrey
- Vinh Donald C.
- Virlouvet Myriam
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander P. J.
- Voiriot Guillaume
- Voiriot Guillaume
- Voisot Lena
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- Vught Lonneke A.
- Vuotto Fanny
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Weiss Emmanuel
- Weiss Nicolas
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wilkerson Matthew D.
- Winchenne Anaïs
- Wouters Dorien
- Wu Alan K. L.
- Wu Tak-Chiu
- Yahşi Aysun
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yesilbas Osman
- Yildiz Mehmet
- Yordanov Youri
- Youkou Christy Gaëlla Kotokpo
- Young Barnaby E.
- Yüksek Saliha Kanık
- Yükselmiş Ufuk
- Zafrani Lara
- Zaidan Mohamad
- Zaidi Wissem
- Zak Cathia
- Zarhrate-Ghoul Aida
- Zatout Ouassila
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zecca Marco
- Zeino Suzanne
- Zeitouni Michel
- Zemirli Naïma
- Zerah Lorene
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Xijun
- Zhang Yu
- Zia Ounsa
- Ziol Marianne
- Zolario Oceane
- Zuber Julien
- Zuccaro Valentina
- Zwinderman A. H.
- Íñigo-Campos Antonio
- Öz Şadiye Kübra Tüter
- Özkan Esra Akyüz
- Özçelik Tayfun
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/01/2023
- Field of study
BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old