Gene Therapy: The Current Codon Status

Scenes of scientists exploiting the genetic material from an amber trapped mosquito which had apparently sucked the blood of a ferocious dinosaur to finally create a monster had captured the imagination of audience world wide. Genetic engineering has since then gradually emerged from the shadows of fantastic and novelistic ideas depicted in the wildly successful Jurassic Park to the box-office flop Alien: Resurrection . The image of creating a seemingly flawless piece of genetic thread finely entwined following years of research spent in solving the genetic jigsaw has captured the imagination of the world. The implications are huge and often exaggerated but never thought to be beyond the reach of the ever-so impatient man. The impact of genetic engineering on the society is often debated but a final decision will unfortunately have to wait

Complete reversal of stereoselectivity in cyclopropanation of 2-arylidene-1-tetralone tricarbonylchromium complexes

Cyclopropanation of 2-arylidene-1-tetralone tricarbonylchromium complexes with dimethylsulfoxonium methylide under phase-transfer catalysis condition provided cyclopropanes exclusively from the endo-face

High diastereoselectivity in Hosomi-Sakurai reaction on metal-complexed acyclic enones: Role of out-of-plane coordination of Lewis acid†

1063-1071Efficient diastereocontrol is achieved in Hosomi-Sakurai reaction of flexible acyclic enones anchored on arenetricarbonylchromium template. Relative stereochemistry of groups in the products is compared with those obtained by allylmagnesium bromide addition followed by an anionic oxy-Cope rearrangement. The results indicate an endo-selective conjugate addition dictated by an out-of-plane bound Lewis acid in the Hosomi-Sakurai reaction, similar to the trend established earlier for rigid substrate structures

Stereodivergent C-C bond formation on arene-chromium template: endo-selective allylation by Hosomi-Sakurai reaction

This article does not have an abstract

Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Coenzyme Q10 (CoQ10) is a lipid soluble, endogenous antioxidant present at highest levels in the heart followed by the kidney and liver. The reduced CoQ10 ubiquinol is well known for its chemical instability and low bioavailability. The present study was designed to synthesize ubiquinol acetate, which is more stable and biologically active, and further evaluate its safety and genotoxic potential. Synthesized ubiquinol acetate showed better stability than that of ubiquinol at the end of 3 months. In vitro genotoxicity studies (AMES test, in vitro micronucleus and chromosomal aberration) showed ubiquinol acetate as nongenotoxic with no clastogenic or aneugenic effects at high dose of 5000 and 62.5 μg/mL, respectively. In subchronic toxicity study, ubiquinol acetate was administered orally to Sprague Dawley rats at 150, 300, and 600 mg/kg/day for 90 days. No treatment related adverse effects were observed in males at 600 mg/kg/day; however, females showed treatment related increase in AST and ALT with small focal irregular white-yellow spots in liver on gross necropsy examination. Histopathological evaluation revealed hepatocellular necrosis in high dose females which was considered as adverse. Based on the results, the No-Observed-Adverse-Effect Level (NOAEL) of ubiquinol acetate in males and females was determined as 600 and 300 mg/kg/day, respectively