Effect of Fabric Reinforcement on the Flexural Properties of EPS-Core Surfboard Constructions

Effect of Fabric Reinforcement on the Flexural Properties of EPS-Core Surfboard Construction

Numerical Investigation of the Hydrodynamic Characteristics of 3-Fin Surfboard Configurations

Surfing is a popular sport, with the associated market forecast to reach 2.6 billion US dollars by 2027. In the published literature, there is a range of investigations into the performance of surfboard fins. Some studies model a single fin or review the performance of different fin layouts and surface designs. However, the effects of individual fin design features on flow dynamics are not well understood. This study provides numerical analysis into the thruster fin aspects (rake, depth, and base length) and resultant key performance indicators (i) lift and drag coefficients, and (ii) turbulent kinetic energy. The models were simulated in Ansys Fluent R19.1, solving steady Reynolds-averaged Navier–Stokes equations using the SST k−ω turbulence model at a velocity of 7 m/s. The results indicate the performance of fins varies more post-stall. The variations in rake showed the biggest impact on the turbulence intensity at an angle ≥20°. The variations in base length exhibited coefficient trends with greater lift at small angles but significant lift losses at high angles of attack. The variations in depth affected the forces on the fins rather than the performance indicators. Based on these simulations, a proposed fin set was developed that presented the lowest lift losses after the stall point

An Experimental Investigation of the Mechanical Performance of EPS Foam Core Sandwich Composites Used in Surfboard Design

Surfboard manufacturing has begun to utilise Expanded Polystyrene as a core material; however, surf literature relatively ignores this material. This manuscript investigates the mechanical behaviour of Expanded Polystyrene (EPS) sandwich composites. An epoxy resin matrix was used to manufacture ten sandwich-structured composite panels with varying fabric reinforcements (carbon fibre, glass fibre, PET) and two foam densities. The flexural, shear, fracture, and tensile properties were subsequently compared. Under common flexural loading, all composites failed via compression of the core, which is known in surfing terms as creasing. However, crack propagation tests indicated a sudden brittle failure in the E-glass and carbon fibre facings and progressive plastic deformation for the recycled polyethylene terephthalate facings. Testing showed that higher foam density increased the flex and fracture mechanical properties of composites. Overall, the plain weave carbon fibre presented the highest strength composite facing, while the single layer of E-glass was the lowest strength composite. Interestingly, the double-bias weave carbon fibre with a lower-density foam core presented similar stiffness behaviour to standard E-glass surfboard materials. The double-biased carbon also improved the flexural strength (+17%), material toughness (+107%), and fracture toughness (+156%) of the composite compared to E-glass. These findings indicate surfboard manufacturers can utilise this carbon weave pattern to produce surfboards with equal flex behaviour, lower weight and improved resistance to damage in regular loading

Novel Phlebovirus with Zoonotic Potential Isolated from Ticks, Australia

Recently discovered tick-borne phleboviruses have been associated with severe disease and death among persons in Asia and the United States. We report the discovery of a novel tick phlebovirus in Tasmania State, Australia, that is closely related to those zoonotic viruses found in Asia and North America

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Endogenous costimulatory molecules on T cells such as 4-1BB (CD137) can be leveraged for cancer immunotherapy. Systemic administration of agonistic anti-4-1BB antibodies, although effective preclinically, has not advanced to phase 3 trials because they have been hampered by both dependency on Fc gamma receptor-mediated hyperclustering and hepatotoxicity. To overcome these issues, we engineered proteins simultaneously targeting 4-1BB and a tumor stroma or tumor antigen: FAP-4-1BBL (RG7826) and CD19-4-1BBL. In the presence of a T cell receptor signal, they provide potent T cell costimulation strictly dependent on tumor antigen-mediated hyperclustering without systemic activation by Fc gamma R binding. We could show targeting of FAP-4-1BBL to FAP-expressing tumor stroma and lymph nodes in a colorectal cancer-bearing rhesus monkey. Combination of FAP-4-1BBL with tumor antigen-targeted T cell bispecific (TCB) molecules in human tumor samples led to increased IFN-gamma and granzyme B secretion. Further, combination of FAP- or CD19-4-1BBL with CEA-TCB (RG7802) or CD20-TCB (RG6026), respectively, resulted in tumor remission in mouse models, accompanied by intratumoral accumulation of activated effector CD8(+) T cells. FAP- and CD19-4-1BBL thus represent an off-the-shelf combination immunotherapy without requiring genetic modification of effector cells for the treatment of solid and hematological malignancies