A robust design methodology suitable for application to one-off products

Robust design is an activity of fundamental importance when designing large, complex, one-off engineering products. Work is described which is concerned with the application of the theory of design of experiments and stochastic optimization methods to explore and optimize at the concept design stage. The discussion begins with a description of state-of-the-art stochastic techniques and their application to robust design. The content then focuses on a generic methodology which is capable of manipulating design algorithms that can be used to describe a design concept. An example is presented, demonstrating the use of the system for the robust design of a catamaran with respect to seakeeping

A Deep \u3cem\u3eXMM-Newton\u3c/em\u3e Observation of the Quasar 3C 287

We report on an XMM-Newton observation of the z = 1.055 quasar and Gigahertz Peaked Spectrum (GPS) source 3C 287. Our 62.3 ks observation provides an exceptional X-ray view of a prominent member of this important subclass of active galactic nuclei (AGNs). The X-ray spectra of 3C 287 are consistent with a simple absorbed power law with a spectral index of Γ = 1.72 ± 0.02. Our fits imply a bolometric luminosity of L = 5.8 ± 0.2 × 1045 erg s-1 over the 0.3-10.0 keV band; this gives a mass lower limit of M BH min \u3e= 4.6 × 107 M sun assuming X-rays contribute 10% of the bolometric luminosity and radiation at the Eddington limit. Iron emission lines are common in the X-ray spectra of many AGNs, but the observed spectra appear to rule out strong emission lines in 3C 287. The simple power-law spectrum and the absence of strong emission lines may support a picture where our line of sight intersects a relativistic jet. Milliarcsecond radio imaging of 3C 287 appears to support this interpretation. We discuss our results in the context of different AGNs subclasses and the possibility that GPS sources harbor newly formed black hole jets

Two kinds of procedural semantics for privative modification

In this paper we present two kinds of procedural semantics for privative modification. We do this for three reasons. The first reason is to launch a tough test case to gauge the degree of substantial agreement between a constructivist and a realist interpretation of procedural semantics; the second is to extend Martin-L ̈f’s Constructive Type Theory to privative modification, which is characteristic of natural language; the third reason is to sketch a positive characterization of privation

Cystatins as calpain inhibitors: Engineered chicken cystatin- and stefin B-kininogen domain 2 hybrids support a cystatin-like mode of interaction with the catalytic subunit of μ-calpain

Within the cystatin superfamily, only kininogen domain 2 (KD2) is able to inhibit μ- and m-calpain. In an attempt to elucidate the structural requirements of cystatins for calpain inhibition, we constructed recombinant hybrids of human stefin B (an intracellular family 1 cystatin) with KD2 and Delta L110 deletion mutants of chicken cystatin-KD2 hybrids. Substitution of the N-terminal contact region of stefin B by the corresponding KD2 sequence resulted in a calpain inhibitor of K-i = 188 nM. Deletion of L110, which forms a beta -bulge in family 1 and 2 cystatins but is lacking in KD2, improved inhibition of mu -calpain 4- to 8-fold. All engineered cystatins were temporary inhibitors of calpain due to slow substrate-like cleavage of a single peptide bond corresponding to Gly9-Ala10 in chicken cystatin. Biomolecular interaction analysis revealed that, unlike calpastatin, the cystatin-type inhibitors do not bind to the calmodulin-like domain of the small subunit of calpain, and their interaction with the mu -calpain heterodimer is completely prevented by a synthetic peptide comprising subdomain B of calpastatin domain 1. Based on these results we propose that (i) cystatin-type calpain inhibitors interact with the active site of the catalytic domain of calpain in a similar cystatin-like mode as with papain and (ii) the potential for calpain inhibition is due to specific subsites within the papain-binding regions of the general cystatin fold

ISUOG Safety Committee updated recommendation on use of respirators by practitioners undertaking obstetric and gynecological ultrasound in context of SARS-CoV-2 Omicron variant of concern

status: publishe