17,716 research outputs found
The action of neutrino ponderomotive force on supernova dynamics
Collective interactions of a beam of neutrinos/antineutrinos traversing a
dense magnetized plasma of electrons/positrons, protons and neutrons are
studied with particular reference to the case of a Supernova. We find that the
ponderomotive force exerted by neutrinos gives, contrary to expectations, a
negligible contribution to the revival of the shock for a successful Supernova
explosion, although new types of convection and plasma cooling processes
induced by the ponderomotive force could be, in principle, relevant for the
dynamics itself.Comment: latex, 14 pages; numerical error corrected, conclusions changed; to
be published in Mod. Phys. Lett.
Transient Analysis of High-Speed Channels via Newton-GMRES Waveform Relaxation
This paper presents a technique for the numerical simulation of coupled high-speed channels terminated by arbitrary nonlinear drivers and receivers. The method builds on a number of existing techniques. A Delayed-Rational Macromodel is used to describe the channel in compact form, and a general Waveform Relaxation framework is used to cast the solution as an iterative process that refines initial estimates of transient scattering waves at the channel ports. Since a plain Waveform Relaxation approach is not able to guarantee convergence, we turn to a more general class of nonlinear algebraic solvers based on a combination of the Newton method with a Generalized Minimal Residual iteration, where the Waveform Relaxation equations act as a preconditioner. The convergence of this scheme can be proved in the general case. Numerical examples show that very few iterations are indeed required even for strongly nonlinear termination
Do we need another heart failure biomarker. focus on soluble suppression of tumorigenicity 2 (sST2)
If sST2 indeed turns into the HbA1c of heart failure, its value should increase exponentially in our management of patients with heart failure. Serial sST2 levels should allow us to titrate therapy and monitor
the clinical state of the patient. In addition, since sST2 is such a strong marker of the risk of death, it would not be surprising to see a level be used to make decisions when patients are on the cusp of such
therapies as ICD, CRT, CardioMems implantation and even left ventricular assist devices.
A discussion about the use of biomarkers would not be complete without mentioning the issue of surrogates for determining the therapy effectiveness of some of the newer heart failure drugs. Novartis’s
EntrestoVR , the brand name for its recently CE marked and FDA approved ARNI1 drug (previously known as LCZ696) and Servier’s ivabradine drug CorlanorVR (marketed by Amgen in the USA), also CE
marked and FDA approved, while offering exciting potential benefits to heart failure patients—even being hailed ‘game-changer’ drugs by some—raises the thorny issue of cost vs. benefit. These new drugs
are several times the cost of the generics that have become the mainstay of heart failure treatment, i.e. ACE inhibitors, angiotensin receptor blocker (ARBs), beta-blockers, etc. Pushback is therefore
expected from payers. Because sST2 changes rapidly with the underlying condition of the patient, is not affected by normal confounding factors, and has a single cut point, it may be ideally suited to help clinicians determine if these newer mediations are effective for each patient, are improving quality of life, and whether dosing needs to be titrated or changed. The new reality of heart failure care is that while more treatment options have opened up, which can literally be a lifesaver for millions of patients, the burden on healthcare systems has skyrocketed. Biomarkers, and particularly sST2, could offer physicians and payers a way to bring treatment down to an individual patient level, providing
Compressed Passive Macromodeling
This paper presents an approach for the extraction of passive macromodels of large-scale interconnects from their frequency-domain scattering responses. Here, large scale is intended both in terms of number of electrical ports and required dynamic model order. For such structures, standard approaches based on rational approximation via vector fitting and passivity enforcement via model perturbation may fail because of excessive computational requirements, both in terms of memory size and runtime. Our approach addresses this complexity by first reducing the redundancy in the raw scattering responses through a projection and approximation process based on a truncated singular value decomposition. Then we formulate a compressed rational fitting and passivity enforcement framework which is able to obtain speedup factors up to 2 and 3 orders of magnitude with respect to standard approaches, with full control over the approximation errors. Numerical results on a large set of benchmark cases demonstrate the effectiveness of the proposed techniqu
Boron-containing organosilane polymers and ceramic materials thereof
The present invention relates to a polyorgano borosilane ceramic precursor polymer comprising a plurality of repeating units of the formula: (R(sup 1) single bond B)(sub p) being linked together at B by second units of the formula: single bond (R sup 2) single bond (Si single bond R sup 3) single bond (sub q), where R(sup 1) is a lower alkyl, cycloalkyl, phenyl, or (R(sup 2)R(sup 3) single bond Si single bond B single bond)(sub n) and R(sup 2) and R(sup 3) are each independently selected from hydrogen, lower alkyl, vinyl, cycloalkyl, or aryl, n is an integer between 1 and 100; p is an integer between 1 and 100; and q is an integer between 1 and 100. These materials are prepared by combining an organo borohalide of the formula R(sup 4) single bond B single bond (X sup 1) (sub 2) where R(sup 4) is selected from halogen, lower alkyl, cycloalkyl, or aryl, and an organo halosilane of the formula: R(sup 2)(R sup 3)Si(X sup 2)(sub 2) where R(sup 2) and R (sup 3) are each independently selected from lower alkyl, cycloalkyl, or aryl, and X(sup 1) and X(sup 2) are each independently selected from halogen, in an anhydrous aprotic solvent having a boiling point at ambient pressure of not greater than 160 C with in excess of four equivalents of an alkali metal, heating the reaction mixture and recovering the polyorgano borosilane. These silicon boron polymers are useful to generate high-temperature ceramic materials, such as SiC, SiB4, and B4C, upon thermal degradation above 600 C
Preparation of B-trichloroborazine
The present invention relates to a method of preparing B-trichloroborazine. Generally, the method includes the combination of gaseous boron trichloride in an anhydrous aprotic organic solvent followed by addition of excess gaseous ammonia at ambient temperature or below. The reaction mixture is heated to about 100 to 140 C followed by cooling, removal of the solid ammonium chloride at ambient temperature, distillation of the solvent under vacuum if necessary at a temperature of up to about 112 C, and recovery of the B-trichloroborazine. Solvents include toluene, benzene, xylene, chlorinated hydrocarbons, chlorinated aromatic compounds, or mixtures thereof. Toluene is a preferred solvent. The process provides a convenient synthesis of a material which often decomposes on standing. B-trichloroborazine is useful in a number of chemical reactions, and particularly in the formation of high temperature inorganic polymers and polymer precursors
String duality transformations in gravity from Noether symmetry approach
We select gravity models that undergo scale factor duality
transformations. As a starting point, we consider the tree-level effective
gravitational action of bosonic String Theory coupled with the dilaton field.
This theory inherits the Busher's duality of its parent String Theory. Using
conformal transformations of the metric tensor, it is possible to map the
tree-level dilaton-graviton string effective action into gravity,
relating the dilaton field to the Ricci scalar curvature. Furthermore, the
duality can be framed under the standard of Noether symmetries and exact
cosmological solutions are derived. Using suitable changes of variables, the
string-based Lagrangians are shown in cases where the duality
transformation becomes a parity inversion.Comment: v1: 13 pages; v2: minor rephrasings, published versio
Lyapunov stabilization of discrete-time feedforward dynamics
The paper discusses stabilization of nonlinear discrete-time dynamics in feedforward form. First it is shown how to define a Lyapunov function for the uncontrolled dynamics via the construction of a suitable cross-term. Then, stabilization is achieved in terms of u-average passivity. Several constructive cases are analyzed
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