Initial mass function of intermediate mass black hole seeds

We study the Initial Mass Function (IMF) and host halo properties of Intermediate Mass Black Holes (IMBH, 10^{4-6} Msun) formed inside metal-free, UV illuminated atomic cooling haloes (virial temperature T_vir > 10^4 K) either via the direct collapse of the gas or via an intermediate Super Massive Star (SMS) stage. We achieve this goal in three steps: (a) we derive the gas accretion rate for a proto-SMS to undergo General Relativity instability and produce a direct collapse black hole (DCBH) or to enter the ZAMS and later collapse into a IMBH; (b) we use merger-tree simulations to select atomic cooling halos in which either a DCBH or SMS can form and grow, accounting for metal enrichment and major mergers that halt the growth of the proto-SMS by gas fragmentation. We derive the properties of the host halos and the mass distribution of black holes at this stage, and dub it the "Birth Mass Function"; (c) we follow the further growth of the DCBH due to accretion of leftover gas in the parent halo and compute the final IMBH mass.We consider two extreme cases in which minihalos (T_vir < 10^4 K) can (fertile) or cannot (sterile) form stars and pollute their gas leading to a different IMBH IMF. In the (fiducial) fertile case the IMF is bimodal extending over a broad range of masses, M= (0.5-20)x10^5 Msun, and the DCBH accretion phase lasts from 10 to 100 Myr. If minihalos are sterile, the IMF spans the narrower mass range M= (1-2.8)x10^6 Msun, and the DCBH accretion phase is more extended (70-120 Myr). We conclude that a good seeding prescription is to populate halos (a) of mass 7.5 < log (M_h/Msun) < 8, (b) in the redshift range 8 < z < 17, (c) with IMBH in the mass range 4.75 < log (M_BH/Msun) < 6.25.Comment: MNRAS, in press. Comments welcom

A new CH carbonaceous chondrite from Acfer, Algeria

A single stone weighing 1456 g was found in November 2002 in the Acfer area, Algeria. Oxygen isotope, chondrules-matrix ratio as well as other petrographic features point to a classification as CH carbonaceous chondrite

A new CO carbonaceous chondrite from Acfer, Algeria

Many small fragments, totally weighing 118 g were found in the Acfer area by an Italian dealer. Chondrules size and types (predominance of granular olivine type), occurrence of twinned clinoenstatite and absence of plagioclase suggested a classification as CO carbonaceous chondrite

A new CK carbonaceous chondrite from Hammada Al Hamra, Libya

A single stone weighing 198 g was found in 2001 in the Hammada al Hamra region of Libya. Petrographic features (mean chondrules dimensions, coarse grained matrix and presence of AOIs and CAIs) point to a classification as CK carbonaceous chondrite

Estimating strategies for Multiparameter Multivariate Extreme value copulas

Abstract. Multivariate Extreme Value models are a fundamental tool in order to assess potentially dangerous events. Exploiting recent theoretical developments in the theory of Copulas, new multiparameter models can be easily constructed. In this paper we suggest several strategies in order to estimate the parameters of the selected copula, according to different criteria: these may use a single station approach, or a cluster strategy, or exploit all the pair-wise relationships between the available gauge stations. An application to flood data is also illustrated and discussed

Textural and minerochemical features of NWA 1807 and 2180, two new CV3 chondrites from northwest Africa

A textural and minerochemical study has been performed on NWA 1807 and 2180 chondrites in order to determine sizes and typologies of chondrules, relative abundances of mineral phases, compositions of main phases and bulk oxygen isotope composition

Implementation of Non-Reflecting Boundary Conditions in a Finite Volume Unstructured Solver for the Study of Turbine Cascades

The analysis of component interaction in the turbomachinery field is nowadays of growing importance. This leads to the combination of different approaches, such as Large Eddy Simulation for combustors and Unsteady Reynolds-Averaged Navier-Stokes equations for turbines, and is responsible for the increase of both computational effort and required accuracy of the numerical tools. To guarantee accurate results and efficient convergence rates, numerical schemes must handle the spurious reflecting waves coming from the boundaries of truncated domains. This can be achieved by means of Non-Reflecting Boundary Conditions. The research activity described in the present paper is aimed at implementing the method of Non-Reflecting Boundary Conditions for the Linearized Euler Equations proposed by Giles in an in-house finite volume implicit time-marching solver. The methodology is validated using the available experimental data obtained at the von Karman Institute for Fluid Dynamics on the LS89 High-Pressure Turbine vane for both subsonic and transonic working condition. The implemented approach demonstrates its importance for the correct evaluation of the pressure distribution both on the vane surface and in the pitchwise direction when the computational domain is truncated at the experimental probe's position

Design and assessment of adjustable telescopic props with innovative shape

The design of optimal props (in terms of weight) that conform to the European standard EN 1065 is not a straightforward task. For some classes of props, when the collapse mechanism is the failure of the prop base, large tubes thicknesses or large tubes diameters are required to keep the failure mechanism under control, although the substantial strength of the tubes remains unexploited. This observation motivates the seek for innovative shapes. The present work aims at showing a new proposal of efficient design of props in agreement with the standard EN 1065. Theoretical and numerical analysis are carried out in order to identify the effective gain of weight of this new design configuration

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia

Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy caused by systemic inflammation is a major clinical feature of cachexia, leading to weight loss, dampening patients' quality of life, and reducing patients' response to anticancer therapy. RAGE (receptor for advanced glycation end-products) is a multiligand receptor of the immunoglobulin superfamily and a mediator of muscle regeneration, inflammation, and cancer. Methods: By using murine models consisting in the injection of colon 26 murine adenocarcinoma&nbsp;(C26-ADK) or Lewis lung carcinoma (LLC) cells in BALB/c and C57BL/6 or Ager−/− (RAGE-null) mice, respectively, we investigated the involvement of RAGE signalling in the main features of cancer cachexia, including the inflammatory state. In vitro experiments were performed using myotubes derived from C2C12 myoblasts or primary myoblasts isolated from C57BL/6 wild type and Ager−/− mice treated with the RAGE ligand, S100B (S100 calcium-binding protein B), TNF (tumor necrosis factor)α±IFN (interferon) γ, and tumour cell- or masses-conditioned media to analyse hallmarks of muscle atrophy. Finally, muscles of wild type and Ager−/− mice were injected with TNFα/IFNγ or S100B in a tumour-free environment. Results: We demonstrate that RAGE is determinant to activate signalling pathways leading to muscle protein degradation in the presence of proinflammatory cytokines and/or tumour-derived cachexia-inducing factors. We identify the RAGE ligand, S100B, as a novel factor able to induce muscle atrophy per se via a p38 MAPK (p38 mitogen-activated protein kinase)/myogenin axis and STAT3 (signal transducer and activator of transcription 3)-dependent MyoD (myoblast determination protein 1) degradation. Lastly, we found that in cancer conditions, an increase in serum levels of tumour-derived S100B and HMGB1 (high mobility group box 1) occurs leading to chronic activation/overexpression of RAGE, which induces hallmarks of cancer cachexia (i.e. muscle wasting, systemic inflammation, and release of tumour-derived pro-cachectic factors). Absence of RAGE in mice translates into reduced serum levels of cachexia-inducing factors, delayed loss of muscle mass and strength, reduced tumour progression, and increased survival. Conclusions: RAGE is a molecular determinant in inducing the hallmarks of cancer cachexia, and molecular targeting of RAGE might represent a therapeutic strategy to prevent or counteract the cachectic syndrome

Intermittent and periodic fasting, hormones, and cancer prevention

The restriction of proteins, amino acids or sugars can have profound effects on the levels of hormones and factors including growth hormone, IGF-1 and insulin. In turn, these can regulate intra-cellular signaling pathways as well as cellular damage and aging, but also multisystem regeneration. Both intermittent (IF) and periodic fasting (PF) have been shown to have both acute and long-term effects on these hormones. Here, we review the effects of nutrients and fasting on hormones and genes established to affect aging and cancer. We describe the link between dietary interventions and genetic pathways affecting the levels of these hormones and focus on the mechanisms responsible for the cancer preventive effects. We propose that IF and PF can reduce tumor incidence both by delaying aging and preventing DNA damage and immunosenescence and also by killing damaged, pre-cancerous and cancer cells