463 research outputs found
Queensland Drug Trends 2019: Key Findings from the Ecstasy and Related Drugs Reporting System (EDRS) Interviews
This report describes annual data and 20-year trends in the use of ecstasy and related drugs, harms associated with use, and drug markets in Queensland.\ua0 It forms part of a nationwide, annual series of reports prepared for the Commonwealth Government and distributed widely to state government health and law enforcement agencies, and is used to inform policy and treatment responses.\ua0In the 2019 sample, cannabis and ecstasy were the drugs of choice nominated\ua0(28% and 23%), while cannabis and alcohol were the drugs used most often\ua0(54% and 21%). A quarter of recent users consumed ecstasy weekly or more often; most perceived it easy or very easy to obtain. One in 4 participants had recently used methamphetamine, 67% cocaine, 53% LSD, 56% nitrous oxide and 27% ketamine
A New Method for the Solution and Solid Phase Synthesis of Chiral b-Sulfonopeptides Under Mild Conditions.
Escoliosis dolorosa en la infancia: osteoblastoma costal.
Las principales causas de dolor de espalda en la infancia son los traumatismos, las infecciones,
los procesos oncológicos y otras enfermedades que pueden causar dolor referido a dicho nivel. Es ampliamente
admitido que la escoliosis idiopática en la infancia no es un proceso doloroso, por lo tanto, ante la presencia de
una
escoliosis
dolorosa
se
debe
realizar
un
estudio
detallado
para
localizar
la
causa
del
dolor.
Presentamos
el
caso
de una niña con escoliosis dolorosa producida por un osteoblastoma costal. Localización rara para este tumor y
causa poco frecuente de escoliosis.The
main
causes
of
back
pain
in
children
are
injury,
infections,
cancer
and
other
diseases
proces
-
ses
that
can
cause
referred
pain
to
that
level.
It
is
widely
accepted
that
idiopathic
scoliosis
in
childhood
is
not
a
painful
process,
therefore,
in
the
presence
of
a
painful
scoliosis
should
conduct
a
detailed
study
to
find
the
cause
of pain. We report the case of a girl with painful scoliosis caused by a rib osteoblastoma, this is a rare location of
the osteoblastoma and is a rare cause of scoliosis
Beyond the primary influences of parents and peers on very young adolescent alcohol use: evidence of independent community effects
This study examined the extent to which young adolescent alcohol use was related to alcohol-related norms and law enforcement of underage alcohol use, after accounting for known strong parent and peer correlates. Our sample consisted of 7,674 students ((X) over bar age = 12 years) from 30 Australian communities. Two-level (individuals nested within communities) binary logistic regression was used to examine relationships between recent alcohol use (last 30 days) and perceived community norms about alcohol use, perceived law enforcement of underage alcohol use, parent alcohol use, parent permissiveness of adolescent alcohol use, peer alcohol use, and demographic factors. Results indicated that community norms and perceived law enforcement of alcohol use were associated with alcohol use and this association was independent of parent and peer factors. After accounting for proximal social correlates, community factors were significantly associated with alcohol use among very young adolescents
EL TAMANO DEL CUERPO COMO FACTOR DIFERENCIADOR DE LA FECUNDIDAD DE HAEMATOPOTA ZTALZCA MEIG. (DZPTERA TABANZDAE)
The potential fecundity and body size were evaluated in Haematopota italica Meig. from the analysis of ovariole number and wing length in 460 field-collected females. This correlation looks representative (r=0.618) and the population potential fecundity without disection can be deduced. It has a very great deal importante, for field biology, in order to know the role played by tabanids in the posible disease transmission from cattle or man.Se ha determinado la relación existente entre la fecundidad potencial y el tamaño del cuerpo en Haematopota italica Meig. por la comparación entre el número de ovariolos y la longitud del ala en 460 hembras de campo. Dicha relación parece ser significativa (r=0.618) y permite deducir la fecundidad potencial de la población sin necesidad de disección. Este hecho es de gran importancia en estudios de campo cuando se pretende conocer el papel desempeñado por los tábanos en la posible transmisión de patógenos al ganado y hombre
Flexibilidad energética en barrio de edificios residenciales mediante la activación de la masa termica. Resultados experimentales en un entorno semivirtual
CIES2020 - XVII Congresso Ibérico e XIII Congresso Ibero-americano de Energia SolarRESUMEN: En los próximos años los edificios se convertirán en productores y consumidores de energía al mismo tiempo. Por esta razón, la gestión de la demanda a nivel de edificio y a nivel de barrio a través de un agregador independiente requerirá de sistemas de control inteligentes con el objetivo de optimizar y gestionar dos aspectos: maximizar el uso de energía renovable local y usar la energía de la red en el momento más oportuno. El presente estudio se enfoca en los resultados de un sistema de algoritmos de optimización multi-nivel testeados en tiempo real. El experimento desarrollado reproduce, en dos laboratorios físicamente alejados 100 km, el comportamiento de dos edificios de un mismo barrio mediante un sistema semi-virtual donde unos modelos del edificio determinan su demanda energética emulandola en los laboratorios haciendo actuar al equipamiento físico en condiciones reales de trabajo. Los resultados muestran que la gestión inteligente de la masa térmica del edificio con los algoritmos de optimización puede aportar los mismos beneficios que instalar una batería eléctrica actuando con algoritmos inteligentes o de autoconsumo.ABSTRACT: In the coming years, buildings will become energy producers and consumers at the same time. To optimize the system operation, smart control algorithms shall manage the energy demand of an individual building and of entire districts of buildings. The algorithms goals shall maximize the use of the renewable energy produced on-site and using the energy from the electric grid at the most appropriate time. The current study focus on the results of a multilevel optimization system tested in real-time. The experiment performed reproduces, in two laboratories 100 km away, the behavior of two buildings of similar characteristics hypothetically located in the same district. This is done with energy building models which allows emulating their energy demands connected to real laboratory equipment (heat pumps, PV, batteries and management and control systems). Results of the experiments show that the smart activation of the building’s thermal mass can bring similar benefits than installing an electric battery that acts following smart or self-consumption management strategies.info:eu-repo/semantics/publishedVersio
The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia
Article number: 1610 (2018)[EN]Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the attenuation of cell damage pathways, including the apoptotic cell death. In this context, p53 is a stress sensor that accumulates during brain ischemia leading to neuronal death. The murine double minute 2 gene (MDM2), a p53-specific E3 ubiquitin ligase, is the main cellular antagonist of p53, mediating its degradation by the proteasome. Here, we study the role of MDM2-p53 pathway on PC-induced neuroprotection both in cultured neurons (in vitro) and rat brain (in vivo). Our results show that PC increased neuronal MDM2 protein levels, which prevented ischemia-induced p53 stabilization and neuronal death. Indeed, PC attenuated ischemia-induced activation of the p53/PUMA/caspase-3 signaling pathway. Pharmacological inhibition of MDM2-p53 interaction in neurons abrogated PC-induced neuroprotection against ischemia. Finally, the relevance of the MDM2-p53 pathway was confirmed in rat brain using a PC model in vivo. These findings demonstrate the key role of the MDM2-p53 pathway in PC-induced neuroprotection against a subsequent ischemic insult and poses MDM2 as an essential target in ischemic tolerance
The Need to Develop Standard Measures of Patient Adherence for Big Data: Viewpoint
Despite half a century of dedicated studies, medication adherence remains far from perfect, with many patients not taking their medications as prescribed. The magnitude of this problem is rising, jeopardizing the effectiveness of evidence-based therapies. An important reason for this is the unprecedented demographic change at the beginning of the 21st century. Aging leads to multimorbidity and complex therapeutic regimens that create a fertile ground for nonadherence. As this scenario is a global problem, it needs a worldwide answer. Could this answer be provided, given the new opportunities created by the digitization of health care? Daily, health-related information is being collected in electronic health records, pharmacy dispensing databases, health insurance systems, and national health system records. These big data repositories offer a unique chance to study adherence both retrospectively and prospectively at the population level, as well as its related factors. In order to make full use of this opportunity, there is a need to develop standardized measures of adherence, which can be applied globally to big data and will inform scientific research, clinical practice, and public health. These standardized measures may also enable a better understanding of the relationship between adherence and clinical outcomes, and allow for fair benchmarking of the effectiveness and cost-effectiveness of adherence-targeting interventions. Unfortunately, despite this obvious need, such standards are still lacking. Therefore, the aim of this paper is to call for a consensus on global standards for measuring adherence with big data. More specifically, sound standards of formatting and analyzing big data are needed in order to assess, uniformly present, and compare patterns of medication adherence across studies. Wide use of these standards may improve adherence and make health care systems more effective and sustainable
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