Implementasi Program Jaminan Sosial Ketenagakerjaan di Kota Manado

The Social Security National is a system of the implementation of the country andthe government to provide social protection, so that each of the population meet the basicneeds of the life, to the realization of social welfare for the entire population of Indonesia.The type of the social security encompasses health insurance, guarantee the accident, death,the old days, retirement. Implementation of the 5 (five) programs of social security in thesocial security system of national is expected to reach membership of the labor force arewidely an ongoing basis, so that the people can meet basic needs as well as a guarantee ofliving either working in the formal and informal. The program guarantees social employmentbe seen from 4 of the implementation according to Edward III that is communication,resources, disposisi, and the structure of bureaucracy.The research is using the method of approach to a qualitative descriptive through indepthinterviews to the 10 people was an informer. Observation and the additionaldocuments in the form of a list of guidelines for the interview, tape recorder, and the paper.The result showed that in general the implementation of the guarantee of employmentis not good

Efektivitas Pelayanan Mahasiswa pada Bagian Akademik Kantor Pusat Unsrat

The purpose of this research is to know the effectiveness of the Ministry on students whohad been given by the officers and employees that are on the honorary academic headquarters unsrat. In theframework of the management of higher education in accordance with the Government Regulation Number49 by 2013 about higher education, on article 11 explains that The Academic has the task of implementingthe service giver education, research and community service. In the framework of the management of highereducation in accordance with the Government Regulation Number 49 by 2013 about higher education, onarticle 11 explains that The Academic has the task of implementing the service giver education, research andcommunity service. So in this case can be in describing how the importance of the academic section at theUniversity of Sam Ratulangi.The research methods used in this research is qualitative, descriptive methods with gatheringtechniques by using the method of Observation and question form. as for the respondents/informants of thisresearch was 5 officers, five honorary degrees, and 10 students. So a Total of 20 people was the informant.The results showed that 50% of student respondents were not satisfied with the Ministry's officersthat there is the Head Office of academic Unsrat. According to this study of student dissatisfaction because ofthe way delivery of employee information on students who are less friendly and does not provide informationthat would be expected by the student convey information, both the study also shows that 50% of studentsrespond less well enough and with payment of tuition fee online because according to observation andresearch is less in case of disruption of students agree the internet is often the current payment of tuition feecan't be done and it is very detrimental for students. The results showed that students are less agree withclosing the online graduation registration 2 weeks before graduation day. Because of the internet studentopinions often have disorders that does impact on the clearance delay graduation by the student file.Referring to the discussion and conclusions on top then suggest employees should be able to provideservice and afford maximum to students because students are the main customers of the University of SamRatulangi. The friendly nature of the staff in providing service to give satisfaction in the student. Accurateinformation can be given to a student in any communication directly between the leadership with employeesfor example 1 Provost Academics should be down directly control and provide the latest information relatingto the existing services in the field of academic excellence in order to provide the information needed by thestudent is not Academic leaders can be expected to provide services manually for the payment of theregistration FEE, graduation and others in order to cope with the loss on students because in these days offrequent disruptions of the internet that could slow down the Affairs of the students ' needs

Strategi Implementasi Program Ekowisata di Kota Manado

The implementation of the regional autonomy law in force since 1999, actually had the basicconcept based on potential, preferences, and the aspirations of a democratic secarah area with include therole of the local community. one of the potential development and natural resource conservation throughecotourism which is a form of tourism that very closely with the principles of conservation, even in thedevelopment strategy of ecotourism is also using the strategy of conservation, ecotourism is thus very preciseand berdayaguna in maintaining the integrity and authenticity of the ecosystems in the area. Therefore,who became the Program's Implementation Strategy is the research of ecotourism in the city of Manado.This research uses Qualitative Research Methods using SWOT analysis. Analysis of internalfactors of yield factors of strength and weakness. Strength (Strenghts). the potential Natural touristdestinations, training or training for the improvement of HUMAN RESOURCES, Event or activity sectorof tourism, the presence of public awareness related to tourism, and the creation of access roads to thetourist destinations. Factors of weakness (Weakness), namely the lack of budget, lack of capital/humanresources expert at bidannya, Less the maximum transport facilities and infrastructure, the presence ofbeach reclamation in the Bay of manado, the lack of a Government policy or regulation that sustainprograms of ecotourism. External factors the factors generating opportunities and threats. A factor ofopportunity (Opportunities) that the development of information and technology, the growth of hotels andinns, and the presence of investment from outside. Factor threats (Threats), namely the existence of touristdestinations elsewhere, Adanaya negative issues in the city of Manado, and the existence of a naturaldisaster.Based on the SWOT analysis, the set of six strategies, namely: increase in the productivity of thetourism sector, increased promotion and competitiveness of the tourism sector, the development potential ofthe natural tourist destinations and the improvement of the management of access to information, openspace cooperation with investors, create a policy that supports the implementation of development in thefield of tourism, human resources and recruiting experts in the field of tourism development

Pengaruh Pemberdayaan Usaha Kecil terhadap Peningkatan Pendapatan Usaha di Kecamatan Singkil Kota Manado

Small business sector has been recognized as having a vital role in proving the nationseconomy. Because it is expected the government can give special attention to small businesses. Thisneeds to be done by the government because most businesses in Indonesia belloging to smallbusinesses. The phenomenon of the low quality of human resources for small businesses almostuniformly in all regions of Indonesia. This applies also for those belonging to small businesses in thedistrict. Because it attemps to foster the entrepereneurial spirit for small businesses is something thatshould be done to increase growth have to a little better so as to change the status of its business at thesame effect on the increase in their income.This study aimed to analyzed the relationship between theempowerment of small businesses to increase revenues in the District of Singkil in Manado City byusing purposive sampling and analysis of how to carry out the data collection isquestioner.Intepolation methods in order to predict the value of the variable income of smallbusinesses (Y) (Sudjana, 1983). By using statistical tools for data processing assisted by computersthrought the program SPSS version 20 for Windows.Factors strengthening human resources throughtthe provision of the venture capital loans partially contribute positively and significantly to the incomeof the small businesses

Конформационные особенности лактатдегидрогеназы: влияние температурного фактора в присутствии малых молекул, математическая модель

The aim of this work was to study the conformational changes of lactate dehydrogenase under the influence of different concentrations of intermediates (pyruvate, oxaloacetate) in the temperature gradient with the  subsequent building of a mathematical model.Materials and methods. Thermolability of lactate dehydrogenase was studied using the method of differential scanning fluorimetry to determine the change in endogenous fluorescence of tryptophan and tyrosine under the conditions of stable concentration of lactate dehydrogenase and changing concentrations of pyruvate and oxaloacetate. Further, a mathematical model was developed for a more in-depth consideration of the behavior of the catalytic protein.Results. We found that pyruvate and oxaloacetate in low concentrations have a thermostabilizing effect on lactate dehydrogenase conformation; the effect of pyruvate is statistically more significant in comparison with oxaloacetate (p < 0.05). The studied ligands in high concentrations reduce the thermal stability of lactate dehydrogenase.Conclusion. Understanding the role of small molecules in the regulation of biological and catalytic processes has long remained in the background of scientific interest, but today the work in this direction is reaching a new level. The data obtained indicate the possibility of small molecules acting as ligands when interacting with enzymes.  Цель. Исследовать конформационные изменения лактатдегидрогеназы под действием различных концентраций интермедиатов (пируват, оксалоацетат) в температурном градиенте с последующим построением математической модели.Материалы и методы. Изучение термолабильности лактатдегидрогеназы проводили с  использованием метода дифференциальной сканирующей флуориметрии по изменению  эндогенной флуоресценции триптофана и тирозина в условиях стабильной концентрации лактатдегидрогеназы и изменяющихся концентраций пирувата и оксалоацетата. Далее была разработана математическая модель для более углубленного рассмотрения поведения каталитического белка.Результаты. Было выявлено, что пируват и оксалоацетат в низких концентрациях оказывают термостабилизирующее воздействие на конформацию лактатдегидрогеназы, влияние пирувата статистически более значимо в сравнении с оксалоацетатом (p < 0,05). Изучаемые лиганды в высоких концентрациях снижают термостабильность лактатдегидрогеназы.Заключение. Понимание роли малых молекул в регуляции биологических и каталитических процессов долгое время оставалось в тени научного интереса, но сегодня работа в данном направлении выходит на качественно новый уровень.  Полученные данные свидетельствуют о возможности малых молекул выступать в качестве лигандов при взаимодействии с каталитическими белками

Determining minimal clinically important differences in the Hammersmith Functional Motor Scale Expanded for untreated spinal muscular atrophy patients: An international study

\ua9 2024 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology.Background and purpose: Spinal muscular atrophy (SMA) is a rare and progressive neuromuscular disorder with varying severity levels. The aim of the study was to calculate minimal clinically important difference (MCID), minimal detectable change (MDC), and values for the Hammersmith Functional Motor Scale Expanded (HFMSE) in an untreated international SMA cohort. Methods: The study employed two distinct methods. MDC was calculated using distribution-based approaches to consider standard error of measurement and effect size change in a population of 321 patients (176 SMA II and 145 SMA III), allowing for stratification based on age and function. MCID was assessed using anchor-based methods (receiver operating characteristic [ROC] curve analysis and standard error) on 76 patients (52 SMA II and 24 SMA III) for whom the 12-month HFMSE could be anchored to a caregiver-reported clinical perception questionnaire. Results: With both approaches, SMA type II and type III patients had different profiles. The MCID, using ROC analysis, identified optimal cutoff points of −2 for type II and −4 for type III patients, whereas using the standard error we found the optimal cutoff points to be 1.5 for improvement and −3.2 for deterioration. Furthermore, distribution-based methods uncovered varying values across age and functional status subgroups within each SMA type. Conclusions: These results emphasize that the interpretation of a single MCID or MDC value obtained in large cohorts with different functional status needs to be made with caution, especially when these may be used to assess possible responses to new therapies

Technical Design Report for the PANDA Solenoid and Dipole Spectrometer Magnets

This document is the Technical Design Report covering the two large spectrometer magnets of the PANDA detector set-up. It shows the conceptual design of the magnets and their anticipated performance. It precedes the tender and procurement of the magnets and, hence, is subject to possible modifications arising during this process.Comment: 10 pages, 14MB, accepted by FAIR STI in May 2009, editors: Inti Lehmann (chair), Andrea Bersani, Yuri Lobanov, Jost Luehning, Jerzy Smyrski, Technical Coordiantor: Lars Schmitt, Bernd Lewandowski (deputy), Spokespersons: Ulrich Wiedner, Paola Gianotti (deputy