17 research outputs found
Emergent metallicity at the grain boundaries of higher-order topological insulators
- Publication venue
- Publication date
- 28/04/2023
- Field of study
Topological lattice defects, such as dislocations and grain boundaries (GBs),
are ubiquitously present in the bulk of quantum materials and externally
tunable in metamaterials. In terms of robust modes, localized near the defect
cores, they are instrumental in identifying topological crystals, featuring the
hallmark band inversion at a finite momentum (translationally active type).
Here we show that GB superlattices in both two- and three-dimensional
translationally active higher-order topological insulators harbor a myriad of
dispersive modes that are typically placed at finite energies, but always
well-separated from the bulk states. However, when the Burgers vector of the
constituting edge dislocations points toward the gapless corners or hinges,
both second- and third-order topological insulators accommodate self-organized
emergent topological metals in the GB mini Brillouin zone. We discuss possible
material platforms where our proposed scenarios can be realized through
band-structure and defect engineering.Comment: 6 Pages, 4 Figure
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M. S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G. R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N. S.
- Acquilini D.
- Adams C.
- Adams E. L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Aguero D.
- Ahmad N.
- Ahmadi S.
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- Ahmed C.
- Akeroyd L.
- Akhtar M. N.
- Akinkugbe O.
- Aksentijevich A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z. Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G. M.
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- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
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- Aleagha A. E.
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- Wyllie D. H.
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- Xue X.
- Yadav A.
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- Yates B.
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- Yun N.
- Zainy T.
- Zak A.
- Zaki A.
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- Zanella I.
- Zborowski A. C.
- Zeberg H.
- Zechner M.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zheng C.
- Zhou W.
- Zitter L.
- Zlatopolsky M.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
- David H. Wyllie
- David J. Porteous
- David J. Porteous
- David R. Morrison
- David Torrents
- Davide Grassi
- Davide Romani
- Deema AlZahrani
- Derrick W. Crook
- Dhryata Kamdar
- Diana Alaverdian
- Diego Ripamonti
- Dionysios Neofytos
- Doaa Shahin
- Domenico A. Coviello
- Dona Baraka
- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Elizabeth G. Atkinson
- Elizabeth W. Karlson
- Eman Barhoush
- Emanuele Catena
- Emanuele Di Angelantonio
- Emma F. Perez
- Emma L. Adams
- Ene Reimann
- Enrico Martinelli
- Eric E. Schadt
- Erik Solligard
- Erwin Schurr
- Esteban Lopera
- Esther Gonzalez-Villa
- Eugenia Quiros-Roldan
- Eurie L. Hong
- F. Kyle Satterstrom
- Fabio Lena
- Faisal Almalki
- Fatimah Alqubaishi
- Fawz Al Harthi
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- FHoGID RegCOVID
- Filippo Aucella
- Filippo Biscarini
- FinnGen
- Floriana Valentino
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Paciosi
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francisca Ruiz-Jaen
- Francisco Lozano
- Franco Maggiolo
- Frazer
- Frederic Frippiat
- G. Mark Lathrop
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- Gavin Band
- Geetha Chittoor
- Gemma Castano-Vinyals
- Gemma Serrano-Heras
- Genes &
- Genevieve Roberts
- Genni Spargi
- Georgia Chan
- Giada Beligni
- Gian Piero Caldarelli
- Gianfranco Parati
- Gilles Darcis
- Gillian M. Belbin
- Gina Peloso
- Giordano Botta`
- Girish N. Nadkarni
- Gita A. Pathak
- Gita A. Pathak
- Giulianini Franco
- Giuseppe Fiorentino
- Giuseppe Merla
- Giusy Tiseo
- Gloria Pessina
- Goncalo R. Abecasis
- Gopal Sarma
- Guillaume Butler-Laporte
- Guillaume ButlerLaporte
- Guillermo M. Albaiceta
- Hadeel AlBardis
- Hakon Hakonarson
- Hakon Hakonarson
- Hamed Abdollahi
- Hani Al-Afghani
- Hannah Polikowski
- Hanteera S. Moahmed
- Harendra Guturu
- Health Research Team
- Helene Alavere
- Hengameh Ansari Tadi
- Hilary C. Martin
- Hilary Finucane
- Howard D. Sesso
- Hugo Zeberg
- Hung-Hsin Chen
- Huy Nguyen
- Ilaria Meloni
- Ilaria Rancan
- Iman Almohammed
- Immacolata Andolfo
- Inge Ringmets
- Irene Salib
- Irene van Blokland
- Isabella Zanella
- Israel Fernandez-Cadenas
- Ivan Galvan-Femenia
- J. Brent Richards
- J. Brent Richards
- J. Michael Gaziano
- Jaana Pesukova
- Jack A. Kosmicki
- Jacob Armstrong
- Jacqueline I. Goldstein
- Jahad Alghamdi
- Jaime Masjuan
- James B. Meigs
- James F. Wilson
- Jara Carcel-Marquez
- Jean-Baptiste Giot
- Jehad K. Albakri
- Jehan J. El-Jawhari
- Jekaterina Tabri
- Jennifer Below
- Jennifer E. Huffman
- Jennifer R. Harris
- Jessica Jacques
- Jiannis Ragoussis
- Jing Hua Zhao
- Jiongming Wang
- Joan Marti-Fabregas
- Joan Montaner Villalonga
- JoAnn E. Manson
- Joel Starkopf
- John Danesh
- John Wright
- Jonathan Afilalo
- Jonathan Grip
- Jonathan Shortt
- Jonathon LeFaive
- Jordan W. Smoller
- Jordi Perez-Tur
- Josep L. Bedini
- Josep Maria Mercader
- Josep Mercader
- Joseph B. Leader
- Joseph B. McCormick
- Joseph D. Buxbaum
- Joseph R. Glessner
- Joseph T. Glessner
- Jouke Jan Hottenga
- Juan Gomez
- Judith Garcia-Aymerich
- Judith. M. Vonk
- Judy H. Cho
- Juha Karjalainen
- Julie E. Buring
- Julie E. Horowitz
- Julien Guiot
- Julien Guntz
- Junghyun Jung
- Justine K. Rudkin
- Kai Kisand
- Kamal Okasha
- Karen A. Hunt
- Kari North
- Karolina Chwialkowska
- Katherine Keller
- Kathleen C. Barnes
- Kathrin Aprile von Hohenstaufen
- Kati Donner
- Kati Hensen
- Kati Kristiansson
- Katia Capitani
- Katja Kivinen
- Keith Noto
- Kelly A
- Kelly Cho
- Kenton D’Mellow
- Kevin W. Li
- Konrad J. Karczewski
- Kristi Lall
- Kristi Niblo
- Kristian Hveem
- Kristin Rand
- Kristin Tsuo
- Kristina Zguro
- Kristjan Metsalu
- Kristy Crooks
- Kumar Veerapen
- Kumardeep Chaudhary
- Kyle Gettler
- Laetitia Laurent
- Laia Llucia-Carol
- Laila Al-Awdah
- Lara Lloret Iglesias
- Lara Tang
- Laura Bergantini
- Laura D. Venn
- Laura Di Sarno
- Laura G. Sloofman
- Laura M. Huckins
- Lauro Sumoy
- Leen Abu Safieh
- Leonardo Croci
- Leonardo Marquez
- Lia Crotti
- Liam L. Hiester
- Lili Milani
- Lill-Iren S. Trogstad
- Lindo Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambule
- Lindokuhle Nkambule
- Lorenzo Salerni
- Louis Petitjean
- Louise V. Wain
- Loukas Moutsianas
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Lude Franke Marike Boezen
- Luisa Tavecchia
- Luong Ruiz
- M. Arfan Ikram
- Maarja Lepamets
- Madeleine Durand
- Madonna M. Eltoukhy
- Maha Albeladi
- Mahmoud Abdel-Aziz
- Mairo Puusepp
- Malak Abedalthagafi
- Manal Alaamery
- Manolis Kogevinas
- Mansour Almutairi
- Manuel A. R. Ferreira
- Marc Afilalo
- Marcela Morris
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco Mandala`
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari Kaunisto
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria J. Arranz
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Coignet
- Marie Thys
- Mario Capasso
- Mario Tumbarello
- Mario Umberto Mondelli
- Marissa Zyndorf.
- Mark Daly
- Mark J. Caulfield
- Markus Perola
- Marta Corridi
- Marta Garcıa-Clemente
- Marta GuindoMartinez
- Marta L. DeDiego
- Martin D. Tobin
- Marwa H. Elnagdy
- Mary Ann Belli
- Mary K. Balaconis
- Marylyn D. Ritchie
- Masahiro Kanai
- Masahiro Kanai
- Masahiro Kanai
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Di Pietro
- Massimo Girardis
- Massimo Mangino
- Massimo Vaghi
- Mathieu Quinodoz
- Matsui Hiroko
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Matthew C. Gass
- Matthew Solomonson
- Matthew Solomonson
- Matti Pirinen
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Maureen Oliveira
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- May Alrashed
- Meike Bartels
- Melania Degli Antoni
- Menachem Zlatopolsky
- Meriem Bouab
- Miao Zhang
- Michael Gaddis
- Michael Hultstro¨ m
- Michael N. Cantor
- Michael Peruggia
- Michael Preuss
- Michae¨ l Chasse´
- Michel (M. G. ) Nivard
- Michel Georges
- Michel Moutschen
- Michelle Daya
- Mihael H. Polymeropoulos
- Miklos Lipcsey
- Milos Pavlovic
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Mohamed A. F. Hegazy
- Mohamed R. El-shanshory
- Mohamed S. Abd Elghafar
- Mohamed S. Torky
- Mohammad S. Fawzy
- Mohammed A. Eid
- Mona Sawaji
- Moneera Alswailm
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- Monnat Pongpanich
- Monpat Chamnanphon
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- Nadia Harerimana
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- Natalia Cullell
- Nathalie Brassard
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- Nathan Cheng
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- Nguyen Jennifer P
- Nicholas Rafaels
- Nick Shrine
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- Nicolas Arning
- Nicolas Tardif
- Nicole Soranzo
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- Noam D. Beckmann
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- Noor Mamlouk
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- Nour Albesher
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- Olav Rooyackers
- Olivier Malaise
- Olumide Adeleye
- Opass Putchareon
- Oreste De Vivo
- P-PredictUs SeroCOVID
- Pajaree Chariyavilaskul
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- Paolo Cameli
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- Patrick Turley
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- Paul M. Ridker
- Paul Naaber
- Paul O’Reilly
- Paul R. H. J. Timmers
- Pauline Lanting
- Per Magnus
- Pere Soler
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- Phil Tsao
- Philippe Le´ onard
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
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- Qin Qin Huang
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- Rafael de Cid
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- Raffaele Scala
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- Raili Allos
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- Ravaglia Sabrina
- Raymond K. Walters
- Reedik Magi
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- Renzo Scaggiante
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- Richard H. Scott
- Richard J. Packer
- Rita Perna
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- Robert C. Green
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- Robert P. Sebra
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- Rosangela Artuso
- Rossella Tita
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- Saeideh Ahmadi
- Salam Massadeh
- Saleh Alqahtani
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- Sam Bryant
- Sam Choi
- Sameer Chavan
- Sameera AlJohani
- Sami Koskelainen
- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
- Sara Alotaibi
- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Systematic Review of Potential Health Risks Posed by Pharmaceutical, Occupational and Consumer Exposures to Metallic and Nanoscale Aluminum, Aluminum Oxides, Aluminum Hydroxide and Its Soluble Salts
- Author
- Abd El-Rahman M
- Abd-Elghaffar SKH
- Abdel-Aal RA
- Abdel-Aal RA
- Abu-Taweel GM
- Abu-Taweel GM
- Abubakar MG
- Adamcakova-Dodd A
- Afriyie-Gyawu E
- Agah H
- Ahmed HH
- Akatsu H
- Akay C
- Akila R
- Akiyama H
- Akiyama H
- Al-Ashmawy MAM
- Albizzati A
- Alemmari A
- Alemmari A
- Alessio L
- Ali MA
- Alleyne T
- Altekruse EB
- Andreoli SP
- Andress DL
- Aremu DA
- Arenas MD
- Armstrong RA
- Arnich N
- Arnold CJ
- ASCN/ASPEN (American Society for Clinical Nutrition Working Group on Standards for Aluminum Content of Parenteral Nutrition Solutions)
- ATSDR (Agency for Toxic Substances and Disease Registry)
- Atwood CS
- Avcin S
- Azik FM
- Bachmanov AA
- Bakar C
- Baker DJ
- Balasubramanyam A
- Banasik A
- Barrow CJ
- Bast-Petterson R
- Bast-Petterson R
- Bates D
- Batista-Duharte A
- Baum L
- Beach JR
- Becaria A
- Belaid-Nouira Y
- Bell ML
- Berend K
- Bergfors E
- Bergfors E
- Berthon G
- Beveridge MG
- Bhadauria M
- Bhasin P
- Bishop NJ
- Bjertness E
- Bodhak S
- Bohrer D
- Bohrer D
- Bohrer D
- Bohrer D
- Bolognin S
- Bondy SC
- Bora T
- Borm PJA
- Bower C
- Bowler RM
- Bozynski MEA
- Bradford-Hill A
- Brady RC
- Braganca VL
- Bresson JL
- Buchta M
- Burdick D
- Burrell SA
- Bush AI
- Byrne JD
- Bémer D
- Calejo AI
- Calejo AI
- Calvin C. Willhite
- Campdelacreu J
- CAN/CSA-ISO (Canadian Standards Association)
- Cao H
- Carrasquillo MM
- Castorina A
- CDC (Centers for Disease Control)
- Chaitanya TV
- Chakrabarty M
- Chedid F
- Chen BB
- Chen L
- Chen TJ
- Chen TJ
- Chen WT
- Cheng D
- Childs CW
- Chiu HFK
- Chotpitayasunondh T
- Cifone MA
- Clapp T
- Coburn JW
- Colak S
- Contini del MC
- Costa C
- Couette M
- Crisponi G
- Crisponi G
- Crisponi G
- Cui X
- Czeizel AS
- Cárdenas O
- Da Silva SE
- Dabeka RW
- Daniel Krewski
- Darbre PD
- Darbre PD
- Darbre PD
- de Kom JF
- de Oliveira SR
- De Veer VM
- De-Paula VJ
- del Pilar Martínez MM
- Demont M
- Deveau M
- DFG (Deutsche Forschungsgemeinschaft)
- Di Virgilio AL
- DiVirgilio AL
- Dong E
- Donoghue AM
- Donoghue AM
- Dorea JG
- Dorea JG
- Dorea JG
- Dorea JG
- Dorea JG
- Drago D
- Drago D
- EC (European Commission)
- Edling NPG
- EFSA (European Food Safety Authority)
- Egan PM
- Ehrlich HJ
- Eickhoff TC
- Eisenbarth SC
- El-Demerdash FM
- El-Sayed WM
- Elsaid FG
- Elshamaa MF
- Erazi H
- Erkan N
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Exley C
- Fakri S
- Fanni D
- Felsenfeld AJ
- Fernandez-Lorenzo FJR
- Fewtrell MS
- Fiejka M
- Finnell RH
- Flarend R
- Flarend RE
- Flaten TP
- Floody MC
- Florent C
- Foglio E
- Fraga CG
- Franchi L
- Franco Momoli
- Frankowski M
- Franzmann AW
- Fraser PE
- Freundlich M
- Freundlich M
- Freundlich M
- Friesen MC
- Friesen MS
- Fritschi I
- Froment DH
- GACVS (Global Advisory Committee on Vaccine Safety)
- Garcia EM
- Garcia-Patos V
- Garg S
- Garrosa M
- Gartner H
- Gatta V
- Gatti AM
- Gault PM
- Geyikoĝlu F
- Gherardi R
- Ghribi O
- Ghribi O
- Ghribi O
- Ghribi O
- Giaccio L
- Gibbs AR
- Gibbs GW
- Gies WJ
- Giorgianni CM
- Glenny AT
- Goffin V
- Golub MS
- Golub MS
- González MA
- González-Muñoz MJ
- González-Weller D
- Good DP
- Goodman WG
- Goto N
- Grasso G
- Graves AB
- Graves AB
- Greger JL
- Greger JL
- Guerin T
- Guillard O
- Guillard O
- Gun RT
- Guo C-H
- Guo CH
- Gupta RK
- Gupta VK
- Gutteridge JMC
- Guyton AJ
- Guzelian PS
- Gómez M
- Gómez M
- Güngör N
- Hale LW
- Hall PL
- Hamdy RC
- Hanninen H
- Hannouche D
- Hansen B
- Hansen B
- Harold D
- Health Council of the Netherlands
- Hellstrom HO
- Hem SL
- Hermansen JE
- Hirata-Koizumi M
- Hirata-Koizumi M
- Hirayama M
- Hollender D
- Hollingworth P
- Hou X-H
- House E
- Huang J
- Hull MJ
- Hutchison S
- Hyman BT
- Ian M.F. Arnold
- IFA (Insitiut für Abreitsschutz der Deutschen Gesetzlichen Unfallversicherung)
- ILSI (International Life Science Institute)
- Ingram AJ
- Israeli E
- Jefferson T
- Jenkins DAS
- Jenkins W
- Jimenez PM
- Jin P
- Johnson VJ
- Kaizer RR
- Kaizer RR
- Kakkar V
- Kamalov J
- Kan W-C
- Kaneko N
- Karlik SJ
- Karube J
- Kasa P
- Kaste PJ
- Kawahara M
- Kawahara M
- Keitel WA
- Kelly BC
- Kelso JM
- Keshri AK
- Khalaf AE
- Kiesswetter E
- Kiesswetter E
- Kim IS
- Kirkland D
- Kirshenbaum K
- Klatzo I
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klein GL
- Klimisch H-J
- Kong S
- Kongerud J
- Koo WW
- Koo WW
- Kool M
- Kool M
- Kool M
- Koponen IK
- Krewski D
- Kumar A
- Kumar V
- Kumar V
- Kuroda E
- Lambert JC
- Lambrecht BN
- Landry M
- Landsberg JP
- Lankoff A
- Lauricella AM
- Lehman HK
- Lemire J
- Lemire J
- Leventhal JS
- Lewis RC
- Li H
- Li H
- Li W
- Li X
- Li X
- Li XB
- Liang XF
- Lidsky TI
- Lima PDL
- Lin JL
- Lind PM
- Lindblad EB
- Lindquist B
- Liu YQ
- Lordan S
- Lukiw WJ
- Lynch KM
- Maduray K
- Maghraoui S
- Mahalakshmi M
- Mahieu ST
- Mailloux RJ
- Makjanic J
- Malluche HH
- Manna GK
- Mannello F
- Manzoli L
- Manzoli L
- Maquire-Boyle SJ
- Marques RC
- Marrack P
- Martin SC
- Mayeux G
- McGrath KG
- McGrath KG
- McGregor SJ
- McKee AS
- McKhann G
- McKhann GM
- McKinnon AJ
- Mendez-Alvarez E
- Meurman JH
- Meyer-Baron M
- Mikkelsen L
- Millour S
- Mirick DK
- Mitkus R
- Miu AC
- Mizoroki T
- Monteiro-Riviere NA
- Moore PB
- Morefield GL
- Morita T
- Morita T
- Moselhy W
- Mui S
- Mujika JI
- Mujika JI
- Mujika JI
- Mujika JI
- Murdock RC
- Nagarajkumar Yenugadhati
- Nagasawa K
- Naim JO
- Najafpour MM
- Namer M
- Nataliya A. Karyakina
- National Kidney Foundation
- Nayak P
- Nayak P
- Nday CM
- Nel A
- Netterlid E
- Newell KL
- Niedowicz DM
- Niemoeller OM
- Nishanth RP
- Noe SM
- Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals and the Dutch Expert Committee on Occupational Safety
- NRC (National Research Council)
- Nøkleby H
- Oakley GP
- Oakley GP
- Oberdörster G
- Oberdörster G
- Oesterling E
- Ogimoto M
- Ohno K
- Olabanji O
- Oldham PD
- Orihuela D
- Ott SM
- Ou CY
- Pan SY
- Passeri E
- Patra AK
- Pauluhn J
- Pauluhn J
- Pechansky F
- Pei Y
- Pei Y
- Pennington JA
- Pepper R
- Percy ME
- Perl DP
- Pfefferkorn FE
- Phillips TD
- Pineau A
- Poirier J
- Polizzi S
- Poole RL
- Poole RL
- Poole RL
- Popinska K
- Potter H
- Powers KW
- Prabhakar PV
- Precioso AR
- Priest ND
- Priest ND
- Priest ND
- Priest ND
- Quatrale RP
- Rabe A
- Radzium E
- Ranau R
- Rao VS
- Rawlings W
- Reza SM
- Rezabal E
- Ribes D
- Ribes D
- Ricchelli F
- Riihimäki V
- Riihimäki V
- Rimaniol AC
- Robert A. Yokel
- Roberts NB
- Robertson JA
- Rocha MS
- Rosenlof K
- Rossbach B
- Rui D
- Rusina R
- Ryu RK
- Rödelsperger K
- Sadiq MI
- Sakula A
- Salib E
- Salusky IB
- Salusky IB
- Sandhu G
- Sandora TJ
- SanMartín CD
- Santibáñez M
- Sappino AP
- Sato K
- Savory J
- Savory J
- Savory J
- Schneider K
- Schrag M
- Schönholzer KW
- Seo J
- Sharma D
- Shati AA
- Shirodkar S
- Shoenfeld Y
- Shrivastava S
- Siegrist CA
- Sjogren B
- Slanina P
- Small GW
- Smith AJ
- Smith BS
- Sokolovska A
- Solfrizzi V
- Sood PK
- Sood PK
- Sorenson JR
- Stadler T
- Stahl T
- Steinhagen WH
- Stevanović ID
- Streker M
- Strozyk D
- Sumathi T
- Sun H
- Sun J
- Sun Z-Z
- Swaile DF
- Sánchez-Iglesias S
- Taiwo OA
- Tariba B
- Theeten H
- Theng BK
- Theng BKG
- Thinakaran G
- Thirunavukkarasu SV
- Thirunavukkarasu SV
- Thirunavukkarasu SV
- Thomas M. Wisniewski
- Toda S
- Tomljenovic L
- Tomljenovic L
- Tomljenovic L
- Tomljenovic L
- Touam M
- Tripathi S
- Tsaousi A
- Tsunoda M
- Turconi G
- Turkez H
- Turkez H
- Turkez H
- US DHHS (US Department of Health and Human Services)
- US DHHS (US Department of Health and Human Services)
- US FDA (US Food and Drug Administration)
- US FDA (US Food and Drug Administration)
- van der Put NM
- van der Voet GB
- Verbeken G
- Verdier F
- Verma NK
- Verstraeten SV
- Verstraeten SV
- Verstraeten T
- Viezeliene D
- Viezeliene D
- Vittori D
- Vota DM
- Wada K
- Wagner AJ
- Wagner L
- Wald N
- Walton JR
- Walton JR
- Walton JR
- Walton JR
- Wang B
- Wang N
- Watson LC
- Waxweiler RJ
- Weberg R
- Wei SH
- Weinbruch S
- Wharton SB
- Whitehead AS
- WHO (World Health Organization)
- Wier HA
- Wijnans L
- Wilhelm M
- Wilson JW
- Wilson JW
- Wisniewski HM
- Wisniewski HM
- Wood SJ
- Wu L
- Wu MJ
- Wu X
- Wu Z
- Xiao F
- Xie CX
- Yanagishita T
- Yang X
- Yang X
- Yang X
- Yates CM
- Yin da P
- Yiu G
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yokel RA
- Yoon PW
- Yoshida S
- Yousef MI
- Yu HY
- Yu SL
- Yu Z
- Yuan C-Y
- Yue CS
- Yumoto S
- Yumoto S
- Yumoto S
- Zagorski MG
- Zatta P
- Zeager M
- Zeng KW
- Zhang L
- Zhang QL
- Zhang QL
- Zhang QL
- Zhang QL
- Zhang XQ
- Zhu FC
- Zhu Y
- Zhu Y
- Zhu Y
- Zhu Y
- Zuo R
- Publication venue
- UKnowledge
- Publication date
- 01/10/2014
- Field of study
Aluminum (Al) is a ubiquitous substance encountered both naturally (as the third most abundant element) and intentionally (used in water, foods, pharmaceuticals, and vaccines); it is also present in ambient and occupational airborne particulates. Existing data underscore the importance of Al physical and chemical forms in relation to its uptake, accumulation, and systemic bioavailability. The present review represents a systematic examination of the peer-reviewed literature on the adverse health effects of Al materials published since a previous critical evaluation compiled by Krewski et al. (2007).
Challenges encountered in carrying out the present review reflected the experimental use of different physical and chemical Al forms, different routes of administration, and different target organs in relation to the magnitude, frequency, and duration of exposure. Wide variations in diet can result in Al intakes that are often higher than the World Health Organization provisional tolerable weekly intake (PTWI), which is based on studies with Al citrate. Comparing daily dietary Al exposures on the basis of “total Al”assumes that gastrointestinal bioavailability for all dietary Al forms is equivalent to that for Al citrate, an approach that requires validation. Current occupational exposure limits (OELs) for identical Al substances vary as much as 15-fold.
The toxicity of different Al forms depends in large measure on their physical behavior and relative solubility in water. The toxicity of soluble Al forms depends upon the delivered dose of Al+ 3 to target tissues. Trivalent Al reacts with water to produce bidentate superoxide coordination spheres [Al(O2)(H2O4)+ 2 and Al(H2O)6 + 3] that after complexation with O2•−, generate Al superoxides [Al(O2•)](H2O5)]+ 2. Semireduced AlO2• radicals deplete mitochondrial Fe and promote generation of H2O2, O2 • − and OH•. Thus, it is the Al+ 3-induced formation of oxygen radicals that accounts for the oxidative damage that leads to intrinsic apoptosis. In contrast, the toxicity of the insoluble Al oxides depends primarily on their behavior as particulates.
Aluminum has been held responsible for human morbidity and mortality, but there is no consistent and convincing evidence to associate the Al found in food and drinking water at the doses and chemical forms presently consumed by people living in North America and Western Europe with increased risk for Alzheimer\u27s disease (AD). Neither is there clear evidence to show use of Al-containing underarm antiperspirants or cosmetics increases the risk of AD or breast cancer. Metallic Al, its oxides, and common Al salts have not been shown to be either genotoxic or carcinogenic. Aluminum exposures during neonatal and pediatric parenteral nutrition (PN) can impair bone mineralization and delay neurological development. Adverse effects to vaccines with Al adjuvants have occurred; however, recent controlled trials found that the immunologic response to certain vaccines with Al adjuvants was no greater, and in some cases less than, that after identical vaccination without Al adjuvants.
The scientific literature on the adverse health effects of Al is extensive. Health risk assessments for Al must take into account individual co-factors (e.g., age, renal function, diet, gastric pH). Conclusions from the current review point to the need for refinement of the PTWI, reduction of Al contamination in PN solutions, justification for routine addition of Al to vaccines, and harmonization of OELs for Al substances
Whole-genome sequencing reveals host factors underlying critical COVID-19
- Author
- Abd Elghafar M.S.
- Abdel-Aziz M.
- Abdelrazik M.
- Abdollahi H.
- Abdullah T.
- Abecasis G.R.
- Abecasis G.R.
- Abedalthagafi M.
- Abel L.
- Abernathy C.
- Abraheem A.
- Abul-Husn N.S.
- Acquilini D.
- Adams C.
- Adams E.L.
- Adams K.
- Adamsara A.
- Adanini O.
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal S.
- Agüero D.
- Ahmad N.
- Ahmadi S.
- Ahmed A.
- Ahmed C.
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich A.
- Al Harthi F.
- Al Mutairi A.
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha A.E.
- Alexander P.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali A.
- Ali I.A.M.
- Ali S.
- Aliannejad R.
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Z.
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- Allen S.
- Allibone S.
- Allison K.S.
- Allos R.
- Almaden-Boyle C.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi A.
- Amitrano S.
- Anastasescu E.
- Anderson F.
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- Andolfo I.
- Andretta F.
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- Anemoli V.
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- Zöllner S.
- Åsvold B.O.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 07/07/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
A first update on mapping the human genetic architecture of COVID-19
- Author
- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdollahi Hamed
- Abdullah Tala
- Abecasis Goncalo R.
- Abedalthagafi Malak
- Abul-Husn Noura S.
- Acquilini Donatella
- Adams Emma L.
- Adamsara Alireza
- Adeleye Olumide
- Adra Darin
- Afilalo Jonathan
- Afilalo Marc
- Afrasiabi Zaman
- Agüero Daiana
- Ahmadi Saeideh
- Akhtar Shaheen
- Aksentijevich Alexandra
- Al-Afghani Hani
- Al-Awdah Laila
- Alaamery Manal
- Alahmadey Ziab Z.
- Alaverdian Diana
- Alavere Helene
- Albader Anoud
- Albaiceta Guillermo M.
- Albakri Jehad K.
- AlBardis Hadeel
- Albeladi Maha
- Albesher Nour
- Albrich W. C.
- Albrich Werner
- AlDhawi Nouf
- Aleagha Afshar Etemadi
- Alghamdi Bader
- Alghamdi Jahad
- Ali Altaf
- Aliannejad Rasoul
- Aljawini Nora
- AlJohani Sameera
- Alkwai Sarah
- Allos Raili
- AlMalik Abdulaziz
- Almalki Faisal
- Almohammed Iman
- Almutairi Mansour
- Alotaibi Sara
- Alowayn Albandary M.
- Alqahtani Saleh
- Alqubaishi Fatimah
- Alrashed May
- Alshareef Abdulraheem
- Alsolm Ebtehal
- Alswailm Moneera
- AlZahrani Deema
- Amirsavadkouhi Ali
- Amitrano Sara
- Andolfo Immacolata
- Andretta Francesca
- Andreucci Elena
- Andrews Shea J.
- Anedda Federico
- Anemoli Valentina
- Angelantonio Emanuele Di
- Annis Aubrey
- Antinori Andrea
- Antoni Melania Degli
- Anwar Mohammad
- Arabi Yaseen M.
- Arciero Elena
- Armstrong Jacob
- Arning Nicolas
- Arranz Maria J.
- Arribas Elisa
- Artuso Rosangela
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Samina
- Atkinson Elizabeth G.
- Aucella Filippo
- Auld Daniel
- AZARZAR Samira
- Bachetti Tiziana
- Baillie J. Kenneth
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- van Heel David A.
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- Verma Anurag
- Verma Shefali S.
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- Viala B.
- Villalonga Joan Montaner
- Vincenti Antonella
- Viollet R. Merlet
- Vivo Oreste De
- Voide Cathy
- Voide Cathy
- Vollenweider P.
- Vollenweider P.
- von Hohenstaufen Kathrin Aprile
- von Mering C.
- Vonk Judith. M.
- Vulesevic Branka
- Wain Louise V.
- Walker Susan
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- Wang Xueyang
- Wanying Zhu
- Warmerdam Robert
- Weiss Scott T.
- Wicks Stephen J.
- Willer Cristen
- Williams Alexander T.
- Wilson Daniel J.
- Wilson James F.
- Wolford Brooke
- Wolford Brooke
- Wolford Brooke
- Woolley Ann E.
- Wozniak H.
- Wright John
- Wright John
- Wyllie David H.
- Xue Xiaoqing
- Yadav Ashish
- Yassen Amr M.
- Zanella Isabella
- Zeberg Hugo
- Zguro Kristina
- Zhang Miao
- Zhao Jing Hua
- Zhou Wei
- Zhou Wei
- Zlatopolsky Menachem
- zu Bentrup F. Meyer
- Zucchi Patrizia
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- Zöllner Sebastian
- Åsvold Bjørn Olav
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
peer reviewe
The design and implementation of typed scheme
- Author
- Publication venue
- 'Association for Computing Machinery (ACM)'
- Publication date
- Field of study
Immune cell populations differ in patients undergoing revision total knee arthroplasty for arthrofibrosis
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/12/2022
- Field of study
Abstract Arthrofibrosis following total knee arthroplasty (TKA) is a debilitating condition typically diagnosed based on clinical findings. To gain insight into the histopathologic immune cell microenvironment of arthrofibrosis, we assessed the extent of tissue fibrosis and quantified immune cell populations in specific tissue regions of the posterior capsule. We investigated specimens from three prospectively-collected, matched cohorts, grouped as patients receiving a primary TKA for osteoarthritis, revision TKA for arthrofibrosis, and revision TKA for non-arthrofibrotic, non-infectious reasons. Specimens were evaluated using hematoxylin and eosin staining, picrosirius red staining, immunofluorescence, and immunohistochemistry with Aperio®-based digital image analysis. Increased collagen deposition and increased number of α-SMA/ACTA2 expressing myofibroblasts were present in the arthrofibrosis group compared to the two non-arthrofibrotic groups. CD163 + macrophages were the most abundant immune cell type in any capsular sample with specific enrichment in the synovial tissue. CD163 + macrophages were significantly decreased in the fibrotic tissue region of arthrofibrosis patients compared to the patients with primary TKA, and significantly increased in adipose tissue region of arthrofibrotic specimens compared to non-arthrofibrotic specimens. Synovial CD117 + mast cells were significantly decreased in arthrofibrotic adipose tissue. Together, these findings inform diagnostic and targeted therapeutic strategies by providing insight into the underlying pathogenetic mechanisms of arthrofibrosis
Cognitive Function and All-Cause Mortality in Maintenance Hemodialysis Patients
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Revision Total Hip Arthroplasty in Patients With Ankylosing Spondylitis: Long-Term Results
- Author
- Alberton
- Baraliakos
- Barrey
- Berry
- Berry
- Bhan
- Bisla
- Brandon R. Bukowski
- Brett A. Freedman
- Brinker
- Brooker
- Buckland
- Calin
- Chen
- Claudepierre
- Daniel J. Berry
- Feldtkeller
- Goldman
- Goodman
- Hamdi
- Harding
- Harris
- Iorio
- Joshi
- Lee
- Lie
- Malkani
- Matthew P. Abdel
- Michael J. Taunton
- Nicholas J. Clark
- Paprosky
- Raut
- Raychaudhuri
- Saglam
- Salib
- Sariali
- Sawacha
- Scrucca
- Sochart
- Springer
- Stolwijk
- Sweeney
- Tang
- Vander Cruyssen
- Vasileiadis
- Walker
- Wang
- Wetters
- Yim
- Zeidler
- Zheng
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study