67 research outputs found
Relaxation of Collective Excitations in LJ-13 Cluster
We have performed classical molecular dynamics simulation of
cluster to study the behavior of collective excitations. In the solid ``phase''
of the cluster, the collective oscillation of the monopole mode can be well
fitted to a damped harmonic oscillator. The parameters of the equivalent damped
harmonic oscillator-- the damping coefficient, spring constant, time period of
oscillation and the mass of the oscillator -- all show a sharp change in
behavior at a kinetic temperature of about . This marks yet another
characteristic temperature of the system, a temperature below which
collective excitations are very stable, and at higher temperatures the single
particle excitations cause the damping of the collective oscillations. We argue
that so long as the cluster remains confined within the global potential energy
minimum the collective excitations do not decay; and once the cluster comes out
of this well, the local potential energy minima pockets act as single particle
excitation channels in destroying the collective motion. The effect is manifest
in almost all the physical observables of the cluster.Comment: Revised and enlarged. 6 pages RevTeX style. 7 eps figures available
on request. To appear in J Chem Phy
Partographic analysis of labour by modified who partograph in primigravidae: a prospective observational study
Background: The objective of this study was to assess the role of partogram in the analysis of outcome of spontaneous labour in primigravidae at term with singleton pregnancy with vertex presentation.Methods: This prospective observational study was carried out in Chinmaya Mission Hospital, Bangalore over a period of 2 years, from February 2013 to March 2015. A partographic analysis of labour was done in 300 primigravidae using modified WHO partogram. The study population was divided into 3 groups, group I- cervical dilatation and descent curve falling to the left of alert line. Group II- cervical dilatation and descent curve falling to the right of alert line. Group III cervical dilatation and descent curve falling to the right of action line. Partographic analysis was done and maternal and neonatal outcomes were studied in these groups.Results: In this study, 300 primigravidae in labour were analysed. Of these 282(94%) women belonged to group I, 18(6%) belonged to group II. There were no cases in group III. Mean durations of active phases of labour were 4.75 hrs and 7.74 hrs in group I and II. In group I, 275(98%) women delivered vaginally, 7(2%) underwent LSCS and 96 (34%) had instrumental deliveries. In group II, 14(78%) women delivered vaginally, 4(23%) had instrumental delivery and 4(22%) underwent LSCS.Conclusions: The WHO modified partogram is highly effective in reducing both maternal and neonatal morbidity. It aids in assessing the progress of labour and to identify when intervention is necessary
Curvature fluctuations and Lyapunov exponent at Melting
We calculate the maximal Lyapunov exponent in constant-energy molecular
dynamics simulations at the melting transition for finite clusters of 6 to 13
particles (model rare-gas and metallic systems) as well as for bulk rare-gas
solid. For clusters, the Lyapunov exponent generally varies linearly with the
total energy, but the slope changes sharply at the melting transition. In the
bulk system, melting corresponds to a jump in the Lyapunov exponent, and this
corresponds to a singularity in the variance of the curvature of the potential
energy surface. In these systems there are two mechanisms of chaos -- local
instability and parametric instability. We calculate the contribution of the
parametric instability towards the chaoticity of these systems using a recently
proposed formalism. The contribution of parametric instability is a continuous
function of energy in small clusters but not in the bulk where the melting
corresponds to a decrease in this quantity. This implies that the melting in
small clusters does not lead to enhanced local instability.Comment: Revtex with 7 PS figures. To appear in Phys Rev
Evaluation of the efficacy of dentin hypersensitivity treatments - a systematic review and follow-up analysis
OBJECTIVES:
To compare the treatments used to treat dentin hypersensitivity (DH), based on its efficacy and effect duration.
METHODS:
Medline/PubMed, Cochrane Library, EMBASE, and ClinicalTrials were searched for articles published between January 1st , 2008 and November 14th , 2018, in English, Portuguese or Spanish, reporting clinical trials, completed and with results. This systematic review protocol was registered in PROSPERO, number CRD42019121986.
RESULTS:
74 randomized clinical trials were included in the systematic review, reporting patients from 16 to 65 years old, with a clinical diagnosis of DH, that evaluate the efficacy of a desensitizing product, compared to pre-treatment, used the evaporative method stimulation and the visual analogue scale. These studies evaluated 5366 patients and at least 9167 teeth. Seven follow-up periods were considered corresponding to an immediate, medium or long-time effect. 66 studies were included in the quantitative synthesis. Glutaraldehyde with HEMA, glass ionomer cements and Laser present significant immediate (until 7 days) DH reduction. Medium term (until 1 month) reduction was observed in stannous fluoride, glutaraldehyde with HEMA, hydroxyapatite, glass ionomer cements and Laser groups. Finally, long term significant reduction was seen at potassium nitrate, arginine, glutaraldehyde with HEMA, hydroxyapatite, adhesive systems, glass ionomer cements, and LASER.
CONCLUSIONS:
All active ingredients show efficacy in DH reduction in different follow-up times. Only in-office treatments are effective in immediate DH reduction, maintaining its efficacy over time. For long time effects, at home treatments can also be used. More standardized evaluation protocols should be implemented to increase the robustly of the results.info:eu-repo/semantics/publishedVersio
Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis
<div><p>Background</p><p>Using an organotypic culture system termed human Fetal Testis Assay (hFeTA) we previously showed that 0.01 μM BPA decreases basal, but not LH-stimulated, testosterone secreted by the first trimester human fetal testis. The present study was conducted to determine the potential for a long-term antiandrogenic effect of BPA using a xenograft model, and also to study the effect of BPA on germ cell development using both the hFETA and xenograft models.</p><p>Methods</p><p>Using the hFeTA system, first trimester testes were cultured for 3 days with 0.01 to 10 μM BPA. For xenografts, adult castrate male nude mice were injected with hCG and grafted with first trimester testes. Host mice received 10 μM BPA (~ 500 μg/kg/day) in their drinking water for 5 weeks. Plasma levels of total and unconjugated BPA were 0.10 μM and 0.038 μM respectively. Mice grafted with second trimester testes received 0.5 and 50 μg/kg/day BPA by oral gavage for 5 weeks.</p><p>Results</p><p>With first trimester human testes, using the hFeTA model, 10 μM BPA increased germ cell apoptosis. In xenografts, germ cell density was also reduced by BPA exposure. Importantly, BPA exposure significantly decreased the percentage of germ cells expressing the pluripotency marker AP-2γ, whilst the percentage of those expressing the pre-spermatogonial marker MAGE-A4 significantly increased. BPA exposure did not affect hCG-stimulated androgen production in first and second trimester xenografts as evaluated by both plasma testosterone level and seminal vesicle weight in host mice.</p><p>Conclusions</p><p>Exposure to BPA at environmentally relevant concentrations impairs germ cell development in first trimester human fetal testis, whilst gonadotrophin-stimulated testosterone production was unaffected in both first and second trimester testis. Studies using first trimester human fetal testis demonstrate the complementarity of the FeTA and xenograft models for determining the respective short-term and long term effects of environmental exposures.</p></div
Implementation of MGNREGA in Karnataka: Issues and challenges
India in general and Karnataka in particular have predominating number of workers in the unorganised sector. The workers in the unorganised sector are denied of basic social security measures such as health facility, income, employment etc. Against this backdrop, the MGNREGA is a refuge for employment source which is ploughed to make significant difference for providing livelihood security in rural areas especially rural poor. The MGNREGA was introduced in Karnataka since2006as an additional source of wage employment to eradicate poverty and unemployment. Rural areas of Karnataka have two-pronged issues i.e., poverty and unemployment, marred by low wages, seasonal agricultural employment and informal nature of work. However, it has been observed that the performance under MGNREGA in Karnataka is not inconsonance with the rate of poverty and unemployment in the State. The low performance in Karnataka in MGNREGA compared to many better performing States has been attributed to various programmatic and implementation issues. The paper explores on three objectives viz., (i) to analyse the status of rural poverty and unemployment in Karnataka (ii) to evaluate the performance of MGNREGA in Karnataka since inception and (Hi) to examine the issues and challenges in the implementation of MGNREGA in Karnataka and way forward. Overall, the paper assesses the programme on the pre-requisites for an inclusive growth model warranting reductions in unemployment and poverty alleviation in rural areas of Karnataka
N-(4-Nitrophenyl)-2-{2-[3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetamide
In the present investigation, the synthesis and spectroscopic characterization of N-(4-nitrophenyl)-2-{2-[3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5-dihydro-1H-pyrazol-1-yl]-4-oxo-4,5-dihydro-1,3-thiazol-5-yl}acetamide (2) is performed. The title compound (2) is synthesized by the reaction of 3-(4-chlorophenyl)-5-[4-(propan-2-yl)phenyl]-4,5- dihydro-1H-pyrazole-1-carbothioamide (1) with N-(4-nitrophenyl)maleimide. The cyclization of title compound is evidenced by FT-IR, NMR, and LCMS data
Partographic analysis of labour by modified who partograph in primigravidae: a prospective observational study
Background: The objective of this study was to assess the role of partogram in the analysis of outcome of spontaneous labour in primigravidae at term with singleton pregnancy with vertex presentation.Methods: This prospective observational study was carried out in Chinmaya Mission Hospital, Bangalore over a period of 2 years, from February 2013 to March 2015. A partographic analysis of labour was done in 300 primigravidae using modified WHO partogram. The study population was divided into 3 groups, group I- cervical dilatation and descent curve falling to the left of alert line. Group II- cervical dilatation and descent curve falling to the right of alert line. Group III cervical dilatation and descent curve falling to the right of action line. Partographic analysis was done and maternal and neonatal outcomes were studied in these groups.Results: In this study, 300 primigravidae in labour were analysed. Of these 282(94%) women belonged to group I, 18(6%) belonged to group II. There were no cases in group III. Mean durations of active phases of labour were 4.75 hrs and 7.74 hrs in group I and II. In group I, 275(98%) women delivered vaginally, 7(2%) underwent LSCS and 96 (34%) had instrumental deliveries. In group II, 14(78%) women delivered vaginally, 4(23%) had instrumental delivery and 4(22%) underwent LSCS.Conclusions: The WHO modified partogram is highly effective in reducing both maternal and neonatal morbidity. It aids in assessing the progress of labour and to identify when intervention is necessary
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