Intradialytic Aerobic Exercise in the United Arab Emirates: a Descriptive Study

Aim: Intradialytic exercise (IDE) improves hyperphosphatemia management in hemodialysis (HD) patient in addition to other clinical outcomes. The aim of the study is to present the strategies needed to integrate such a protocol in an HD unit in UAE and patients’ baseline characteristics.Methods: The largest HD unit in Sharjah emirate was chosen. All eligible patients (n=57) in the unit were included. Patients were stable adults HD patients who served as their own controls. The intervention included an aerobic low intensity IDE of 45 minutes per HD session, tailored to each patient’s fitness scale (BORG scale) for 6 months. Patients were educated on the importance of exercise. Outcome measures were barriers to exercise, serum phosphorus (P), urea reduction ratio (URR), malnutrition inflammation score, quality of life (QOL using euroqol5) collected at baseline and post intervention.Results: A total of 41 patients completed the study, 61% were males; 90.2%, 53.7% and 14.6% suffered from hypertension, diabetes and cardiovascular disease respectively. Hypherphosphatemia was prevalent among 75% of the patients with a mean of 5.76 ± 1.66 mg/dl. Mean age was 48 ± 14.37 years, BMI 24.98 ± 6.09 kg/m2, URR 71.88 ± 8.52%, and Kt/v 1.32 ± 1.09. The main barrier to exercise was identified to be fatigue on HD days by 58.5% of patients, followed by fear of getting hurt (36.6%). Finally, 80.4% of patients were mildly malnourished and QOL scale was 65.02% ± 18.54. Conclusion: Our study highlighted the widespread of hyperphosphatemia and malnutrition in our sample. The IDE regimen, if proven effective in future studies, could be integrated in the routine practice and may improve patients’ outcomes. 

Attitudes and Barriers to Physical Activity in Hemodialysis Patients: Could Intradialytic Exercise Modify These Factors?

Introduction: This study pioneers in determining the impact of Intradialytic Exercise (IDE) on attitudes and barriers to Physical Activity (PA) in Hemodialysis (HD) patients in the United Arab Emirates, a non-western country with different cultural backgrounds. Subjects and Methods: Forty-one adult HD patients from Al-Qassimi Hospital were recruited for a quasi-experimental intervention with pre-post evaluation. IDE patients trained for 45 minutes per HD session, 2-3 times per week, for 6 months on a static bicycle. Exercise intensity was assessed using the Borg Scale. Participants were educated on the importance of exercise. Results: 30 patients completed the study. The percentage of patients exercising was higher post intervention, but dropped to baseline at the follow up period. At post intervention and follow-up, patient’s knowledge about the benefits and safety of exercise increased, with some patients facing no barrier to PA at the end of the study (p=0.05). There was a significant increase in patients endorsing the “too many medical problems” barrier, and a significant decrease in patients endorsing the “can’t afford to exercise” barrier. Nephrologists and nurses acknowledge the importance of exercise in HD patients, but the former do not prescribe it. Conclusions: Aerobic IDE and knowledge empowerment programs could help HD patients increase their knowledge about exercise benefits and safety and shed some barriers to exercise, although patients appear to easily fall back into their normal habits. Even after an IDE program was adopted in the unit, the medical team is still concerned about the risks of exercise in HD patients

Effects of intradialytic aerobic exercise on hemodialysis patients: a systematic review and meta-analysis

© 2019, The Author(s). Objective: Intradialytic exercise (IDE) is not yet a routine practice for hemodialysis patients, the lack of guidelines supporting it being a major reason. This systematic review and meta-analysis of aerobic IDE interventions examined the efficacy of IDE regarding quality of life (QOL), serum phosphorus, dialysis efficiency, inflammatory status, vitamin D3, parathyroid hormone, intake of phosphate binders, mortality and hospitalization rate. Methods: Pubmed, Medline (Ovid), Embase (Ovid), Cochrane, and Cinahl (EBSCO) databases were searched to retrieve studies up to June 12, 2018. A manual reference search was also performed. Studies were included if they evaluated (a) aerobic IDE effect on at least one of our study parameters, (b) adult hemodialysis patients, (c) patients for \u3e 1 month. Results: Twenty-two studies were retrieved (706 participants), of which 12 were eligible for meta-analysis. Aerobic IDE had a significant positive effect on the QOL physical component score (QOL-PSC) and on mental component score (QOL-MCS) of SF36, but not on serum phosphorus or Kt/V. Conclusions: IDE incorporation into clinical practice has a significant positive effect on QOL-PSC and QOL-MCS. In the reviewed studies, IDE did not result in any health hazard in hemodialysis patients. Nevertheless, future research should assess the long-term effectiveness and safety of IDE. The limitations of this review include the lack of quality analysis of the studies, the limited number of studies that could be included in the meta-analysis, the diversity in the exercise intensity, duration and modality, and the limited data for several outcomes. Prospero registration ID: CRD42016052062

Effect of intradialytic exercise on hyperphosphatemia and malnutrition

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Intradialytic exercise (IDE) is not routinely prescribed in hemodialysis (HD) units despite its potential benefits on patients’ outcomes. This study was the first in the United Arab Emirates to examine the effect of aerobic IDE on hyperphosphatemia, malnutrition, and other health outcomes among HD patients. Participants were chosen from the largest HD unit in Sharjah Emirate for a quasi-experimental intervention with pre and post evaluation. The study lasted for 12 months. Study parameters were collected at baseline, post intervention, and follow-up. The intervention included a moderate-intensity aerobic IDE of 45 min per HD session; intensity was assessed using the Borg Scale. Patients were educated on the importance of exercise. Study outcomes were serum phosphorus (P), malnutrition inflammation score (MIS), quality of life (QOL), and pertinent blood tests. Forty-one eligible consenting HD patients were included in the study. Results at follow-up showed a non-significant reduction in P (p = 0.06) in patients who were hyperphosphatemic at baseline, but not in the sample as whole. MIS did not deteriorate throughout the study (p = 0.97). IDE resulted in a non-significant increase in the QOL visual analogue scale (p = 0.34). To conclude, aerobic IDE for 45 min is safe and could be beneficial, especially for hyperphosphatemic patients

Preparing maximally entangled states by monitoring the environment–system interaction

A common assumption in an open quantum system is that the noise induced by the environment, due to the interaction between a quantum system and its environment, is responsible for the disappearance of quantum properties. Interestingly, Barreiro et al. (2011) show, experimentally, using an open-system quantum ion traps simulator, an environment state can be engineered and controlled to pump an arbitrary quantum system toward a maximally entangled state and thus can be considered a resource for quantum information processing. Here, we demonstrate this idea to pump an arbitrary maximally mixed state into Greenberger–Horne–Zeilinger (GHZ) state by simulating our quantum circuit using one of the IBM Q processors. Barreiro et al. (2011) offer the circuits for the execution of the GHZ pumping. Nevertheless, those are collected gates that are suitable to the trapped-ions platform, so their circuits implementation on the IBM Q devices would result in large depth circuits and thus requires many gates. Consequently, we suggest a different circuit structure that follow similar goals, but have been considered the features of the IBM Q platform.Moreover, we run the simulation of our circuit using the QASM simulator and free-web based interface, IBM Quantum Experience, with and without error mitigation, to investigate the effect of the noise on the preparation of the initial mixed states of the qubits in addition to the population of the target state of the system

Malnutrition-Inflammation Score VS Phase Angle in the Era of GLIM Criteria:A Cross-Sectional Study among Hemodialysis Patients in UAE

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. (1) Background: Malnutrition is prevalent in hemodialysis (HD) patients and is associated with an increased risk of morbidity and mortality. The aim of this study was to explore the prevalence of malnutrition using the malnutrition-inflammation score (MIS) and phase angle (PhA) and compare their concordance with the new Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition. (2) Methods: Seventy HD patients were assessed. Malnutrition was diagnosed based on the GLIM criteria and MIS questionnaire. The agreement between the diagnostic tools (MIS, PhA derived from the bioelectrical impedance analysis (BIA), and GLIM criteria) was assessed. The optimal gender-specific cutoff points were identified for the PhA according to the GLIM criteria. (3) Results: Almost half of the sample was diagnosed as malnourished according to the MIS (48.57%) and GLIM criteria (54.29%). A fair agreement was observed between the GLIM criteria, MIS (k = 0.202), and PhA (k = 0.279) among the malnourished patients. The PhA had better sensitivity but worse specificity compared to the MIS. The optimum cutoff points of PhA to detect malnutrition according to the GLIM criteria were a PhA value of ≤5.7° for males and ≤3.8° for females. (4) Conclusion: The MIS performed slightly better than PhA in the diagnosis of malnutrition among HD patients within the spectrum of the GLIM criteria

Malnutrition-inflammation score VS phase angle in the era of GLIM criteria: A cross-sectional study among hemodialysis patients in UAE

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. (1) Background: Malnutrition is prevalent in hemodialysis (HD) patients and is associated with an increased risk of morbidity and mortality. The aim of this study was to explore the prevalence of malnutrition using the malnutrition-inflammation score (MIS) and phase angle (PhA) and compare their concordance with the new Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition. (2) Methods: Seventy HD patients were assessed. Malnutrition was diagnosed based on the GLIM criteria and MIS questionnaire. The agreement between the diagnostic tools (MIS, PhA derived from the bioelectrical impedance analysis (BIA), and GLIM criteria) was assessed. The optimal gender-specific cutoff points were identified for the PhA according to the GLIM criteria. (3) Results: Almost half of the sample was diagnosed as malnourished according to the MIS (48.57%) and GLIM criteria (54.29%). A fair agreement was observed between the GLIM criteria, MIS (k = 0.202), and PhA (k = 0.279) among the malnourished patients. The PhA had better sensitivity but worse specificity compared to the MIS. The optimum cutoff points of PhA to detect malnutrition according to the GLIM criteria were a PhA value of ≤5.7° for males and ≤3.8° for females. (4) Conclusion: The MIS performed slightly better than PhA in the diagnosis of malnutrition among HD patients within the spectrum of the GLIM criteria