BUDDHIST STELE OF SWAT VALLEY: POINT CLOUD ANALYSIS AND INTERPRETATION

Abstract. With recent advancements on 3D sensors and cloud computing, high-speed, high-accuracy 3D measurement at micrometer level have been increase by scientists community and digital humanities researchers.The methodology proposed in this project aims to test some of the algorithms used in remote-sensing to the Buddhist sculptures from Swat Valley (Pakistan); these algorithms use high-resolution topographic data to identify, from DEMs, specific features like valleys, ridges, peaks, pits or surface anomalies.In the carved stone, the surface is analysed like a landscape, where carved areas are valleys bordered by slopes and crests. One of the simplest tools, the commonly used analytical hill-shading, which simulates artificial illumination on the DEM surface, is based on the same principle as the use of an oblique light source to highlight incisions in classic photography. Other families of algorithms that can be divided into three main groups (Slope and Curvature, Local Relief Model and Sky View Factor, Positive and Negative Openness and Geomorphons) are tested here

Effectiveness of a Federal Healthy Start Program in Reducing Infant Mortality

Objective: Infant mortality is an important indicator of the health status of a community. In this analysis, we aimed to evaluate temporal changes in infant mortality rates (IMR) in the Central Hillsborough Healthy Start (CHHS) program service area in Tampa, Florida compared to rates in the rest of Hillsborough County and the state. Method: We conducted a five-year (2010-2014) trends analysis using birth and infant death data extracted from the Florida Community Health Assessment Resource Tool Set (CHARTS). The number of infant deaths and live births were used to calculate and compare IMRs in the CHHS catchment area to those in the rest of Hillsborough County, and the state of Florida. Three-year centered moving averages were directly adjusted to account for differences in the racial/ethnic distribution of mothers across geographic areas. Results: Between 2010 and 2014, the IMR decreased 42.8% in the CHHS service area (from 14.5 to 8.3 per 1,000 live births) compared to decreases of 10.1% and 7.7% in the rest of Hillsborough County and the state of Florida, respectively. Additionally, the infant mortality gap in the CHHS catchment area narrowed from 72% in 2010 to 14% in 2014 compared to the rest of the state, and was eliminated when compared to the rest of Hillsborough County. Discussion: The absolute and relative decreases in IMR in the CHHS catchment area reflect the program’s effectiveness in decreasing disparity in infant mortality. The quality services provided by the CHHS program have had a significant positive impact on the families served

HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi's Sarcoma during AIDS.

Kaposi's sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer. KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected. In this study we tested if HIV evolutionary patterns distinguish KS tumor relatedness and progression. Multisite autopsies from participants who died from HIV-AIDS with KS prior to the availability of antiretroviral therapy were identified at the AIDS and Cancer Specimen Resource (ACSR). Two patients (KS1 and KS2) died predominantly from non-KS-associated disease and KS3 died due to aggressive and metastatic KS within one month of diagnosis. Skin and visceral tumor and nontumor autopsy tissues were obtained (n = 12). Single genome sequencing was used to amplify HIV RNA and DNA, which was present in all tumors. Independent HIV tumor clades in phylogenies differentiated KS1 and KS2 from KS3, whose sequences were interrelated by both phylogeny and selection. HIV compartmentalization was confirmed in KS1 and KS2 tumors; however, in KS3, no compartmentalization was observed among sampled tissues. While the sample size is small, the HIV evolutionary patterns observed in all patients suggest an interplay between tumor cells and HIV-infected cells which provides a selective advantage and could promote KS progression

Assessment of the intrinsic vulnerability of agricultural land to water and nitrogen losses: case studies in Italy and Greece

Abstract. LOS indices (abbr. of Losses) can be used for the assessment of the intrinsic vulnerability of agricultural land to water and nitrogen losses through percolation and runoff. The indices were applied on the lowland region of Ferrara Province (FP) in Italy and the upland region of Sarigkiol Basin (SB) in Greece. The most vulnerable zones in FP were the coastal areas consisting of high permeability sandy dunes and the areas close to riverbanks and palaeochannels, and in SB were the areas characterized by high slopes and high permeability soils at high altitude and areas belonging to the upper part of the alluvial plain close to the boundaries between agricultural land and mountainous regions. The application of LOS indices highlighted the specific features of both lowland and upland regions that contribute to water and nitrogen losses and showed their ability for use as tools in designing environmental management plans

Robust Chauvenet Outlier Rejection

Sigma clipping is commonly used in astronomy for outlier rejection, but the number of standard deviations beyond which one should clip data from a sample ultimately depends on the size of the sample. Chauvenet rejection is one of the oldest, and simplest, ways to account for this, but, like sigma clipping, depends on the sample's mean and standard deviation, neither of which are robust quantities: Both are easily contaminated by the very outliers they are being used to reject. Many, more robust measures of central tendency, and of sample deviation, exist, but each has a tradeoff with precision. Here, we demonstrate that outlier rejection can be both very robust and very precise if decreasingly robust but increasingly precise techniques are applied in sequence. To this end, we present a variation on Chauvenet rejection that we call "robust" Chauvenet rejection (RCR), which uses three decreasingly robust/increasingly precise measures of central tendency, and four decreasingly robust/increasingly precise measures of sample deviation. We show this sequential approach to be very effective for a wide variety of contaminant types, even when a significant -- even dominant -- fraction of the sample is contaminated, and especially when the contaminants are strong. Furthermore, we have developed a bulk-rejection variant, to significantly decrease computing times, and RCR can be applied both to weighted data, and when fitting parameterized models to data. We present aperture photometry in a contaminated, crowded field as an example. RCR may be used by anyone at https://skynet.unc.edu/rcr, and source code is available there as well.Comment: 62 pages, 48 figures, 7 tables, accepted for publication in ApJ

LDOC-1 and PARP-1 mRNA expression in leukocytes of father and son with cutaneous malignant melanoma

Abstract Apoptosis is central to the biology of cutaneous malignant melanoma (CMM). The leucine zipper, down regulated in cancer 1 (LDOC-1) gene, is known to be a regulator of the nuclear factor kappa B (NF-kB) through inhibition of the same NF-kB. The poly (ADP-ribose) polymerase-1 (PARP1) gene plays an important role for the efficient maintenance of genome integrity. PARP-1 protein is required for the apoptosis-inducing factor (AIF) translocation from the mitochondria to the nucleus. We report here two interesting cases of family melanoma, a father and son 84 and 40 years old, respectively. The histological evaluation of the lesions of both men revealed diffused superficial melanoma with epithelioid cells. We evaluated the differential expression of LDOC-1 and PARP-1 mRNA in peripheral blood leukocytes of both the father and son. We found that both LDOC-1 and PARP-1 genes were down-regulated in both patients compared with those of controls. These data suggest that low levels of expression of LDOC-1 and PARP-1 mRNA may be associated with familial melanoma

N-terminal prohormone brain natriuretic peptide (NT-proBNP) as a noninvasive marker for restrictive syndromes

Constrictive pericarditis (CP) and restrictive cardiomyopathy share many similarities in both their clinical and hemodynamic characteristics and N-terminal prohormone brain natriuretic peptide (NT-proBNP) is a sensitive marker of cardiac diastolic dysfunction. The objectives of the present study were to determine whether serum NT-proBNP was high in patients with endomyocardial fibrosis (EMF) and CP, and to investigate how this relates to diastolic dysfunction. Thirty-three patients were divided into two groups: CP (16 patients) and EMF (17 patients). The control group consisted of 30 healthy individuals. Patients were evaluated by bidimensional echocardiography, with restriction syndrome evaluated by pulsed Doppler of the mitral flow and serum NT-proBNP measured by immunoassay and detected by electrochemiluminescence. Spearman correlation coefficient was used to analyze the association between log NT-proBNP and echocardiographic parameters. Log NT-proBNP was significantly higher (P < 0.05) in CP patients (log mean: 2.67 pg/mL; 95%CI: 2.43-2.92 log pg/mL) and in EMF patients (log mean: 2.91 pg/mL; 95%CI: 2.70-3.12 log pg/mL) compared with the control group (log mean: 1.45; 95%CI: 1.32-1.60 log pg/mL). There were no statistical differences between EMF and CP patients (P = 0.689) in terms of NT-proBNP. The NT-proBNP log tended to correlate with peak velocity of the E wave (r = 0.439; P = 0.060, but not with A wave (r = -0.399; P = 0.112). Serum NT-proBNP concentration can be used as a marker to detect the presence of diastolic dysfunction in patients with restrictive syndrome; however, serum NT-proBNP levels cannot be used to differentiate restrictive cardiomyopathy from CP

Expression of SPANX proteins in normal prostatic tissue and in prostate cancer

The sperm protein associated with the nucleus in the X chromosome (SPANX) gene family encodes for proteins that are not only expressed in germ cells, but also in a number of tumors. In addition, SPANX genes map in an interval of the X chromosome (namely, Xq27), which has been found to be associated with familial prostate cancer by linkage analysis. The aim of this study was therefore to evaluate SPANX protein expression in normal prostate tissues and in prostate carcinoma. For this purpose, formalin-fixed and paraffin-embedded sections obtained from 15 normal (at autopsy) donors and 12 men with prostate cancer were analyzed by immunohistochemistry. About 40% of both normal and tumor prostate samples resulted SPANX positive. Signals were exclusively within the nucleus in normal prostate cells, whereas both nuclear and cytoplasmic positivity was observed in tumor cells. In conclusion, these findings showed that SPANX genes are expressed in both normal and tumor prostate gland, but the latter showed a peculiar cytoplasmic staining positivity. This suggests a possible association between SPANX over expression and prostate cancer development. Additional studies are needed to corroborate this hypothesis

MEDLAB Sicilia Le occasioni per l\u2019innovazione sociale e territoriale MEDLAB in Sicily An opportunity for social and territorial innovation

The volume contains written in italian and english language on the reflections and the final results of international partnership experience by Medlab (project promoted by European Commission, MED Program) concerning the case of Living Labs in Sicily. Gelardi and Salemi showed the action of the regional innovation instruments of urban and regional planning at institutional regional level and in particular the role of experience of international cooperation in the comparison of experiences of different kind of territorial innovation in the Euro-Mediterranean area. Marsh shows as the MedLab project has been to examine the current and potential role of Living Labs within regional development policy and the questions thrown up by considering Living Labs as a policy tool. This means looking at issues of development policy and linking their relevance to broader territorial innovation strategies. In addition, governance issues arise for coordinating different Living Lab initiatives within a territorial domain, with the aim of maximising benefits not only to ICT-based innovation and the local knowledge economy, but also to the fields of application that Living Labs address: the environment, the economy, social and government services, etc. The process has thus involved first looking at how these questions can be addressed from the standpoints of different types of actors and how they can engage in reciprocal learning processes. The idea is to develop a model of \u201cinnovation literacy\u201d for local authorities and policy makers, namely the capacity to structure the demand for and supply of ICT-based innovation in order to maximise the concrete benefits to specific policies and initiatives. The ultimate vision is of a virtuous circle whereby regional development authorities apply the Living Lab model in an increasing array of fields and the ICT industry increasingly recognises the value proposition of engaging in co-design processes in concrete local and regional development initiatives. In the following pages, we explore the experiences developed in the MedLab project according to three issues: a) a first exploration of the concept of \u201cterritorial innovation\u201d at the basis of the MedLab hypothesis, and its potential impact on policy and governance; b) The case story of the formation of the original TLL-Sicily partnership in 2007 and how that experience shaped the MedLab workplan; c) The summative conclusions of the MedLab project, exploring the concept of an emergent macro-regional Living Lab. Giambalvo e Lucido involved the analysis of urban change in a social and economic context particularly full of difficulties as the town of Favara. Their contribution tries to define the processes of social innovation when they born and move the first steps, this contribution aims to collect the challenge born inside the Medlab project \u2013 Mediterranean Living Lab for the Territorial Innovation to reflect on some of the outcomes of the Living Lab approach to support territorial innovation in the geographical areas of Sicily concerned by the pilot cases of MedLab (the spatial planning of the province of Ragusa and the strategic plan of the municipality of Favara). More specifically, the remark starts from a work of research on the field and facilitation of communicative processes aimed to identify what dynamics of social innovation, such as transactions among the social actors and what new micro-economic ecosystems are developing in the municipality of Favara, whose background has been explored and treated as territorial Living Lab. Di Bono e Parisi describe the way of the Province of Ragusa tried to initiate arrangements to create a Living Lab from experience of local planning and addressing to the involvement of the local firm to obtain a dinamic digital mapping of local creativity. In the contribution the autors try to show that the concept of innovation is still evolving and the market is not disappearing from this innovation concept, but it is one of its components; the social dimension is increasingly relevant, as well as the institutional innovation. In fact, public boards, dealing with the themes of territorial innovation, can re-design their role starting from networking open innovation approaches and building up public-private partnerships able to activate technological and social innovation processes in a participatory way. Trapani present a cotribution on theme about the report of launching a citizen initiative for the mobilization of the social capital in the second Constituency of Palermo; it includes the Brancaccio neighborhood very famous for the murder of Father Puglisi. The initiative is designed as an integrated program of architectural, urban, cultural, social, environmental and economic qualification for the development (also for touristic aims) of Castle Maredolce and (oncoming) park close the monument and the nearby gardens. The proposal which is maturing in this period, falls within the framework of infrastructural transformations taking place in the districts of Brancaccio and Bandita and compared to the new role of the metropolitan city in the new economies of the Mediterranean, namely in a context in which Sicily seems to remain more at the edge of Europe and see, in the cautious use of its cultural resources, a way of survival. The proposal initially moves from the definition of projects and visions for the architectural setting and the urban and social redefinition of a new square in front of an important Moorish Castle undergoing restoration. Furthermore, the interest is moved to the second municipal constituency. The integrated urban program consists of interventions which specify the contents of the strategic plan of Palermo for the second constituency. The urban part, specifically, is characterized by the presence of important infrastructure and services for the production of small and medium-sized enterprises. It has been possible to examine the characteristics of the citizens, their expectations in terms of their objectives and concerning the concrete possibilities of integrated planning and design within participatory and urban sphere on the background of the failure of urban traditional planning tools

Four cases of progressive multifocal leukoencephalopathy in iatrogenic immunocompromised patients

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system (CNS) caused by John Cunningham Virus (JCV). We report four PML cases in immunocompromised patients, respectively treated with (1) Natalizumab, (2) Rituximab, (3) autologous stem-cell transplantation, and (4) Tacrolimus. All patients underwent neurological examination, magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), JCV-DNA research on biological samples, and lymphocytes subpopulation study. All cases presented with motor, behavioural, and cognitive disorders. Visual, sensitive, and cerebellar deficits developed in three cases. MRI revealed widespread progressive demyelinating areas with active borders; three patients presented contrast enhancement. One patient developed inflammatory reconstitution syndrome (IRIS). At MRS, all cases presented decreased N-acetyl-aspartate (NAA) and three cases showed increased choline (Cho). In one patient, plasma and urine tested positive for JCV-DNA, while cerebrospinal fluid (CSF) analysis confirmed JCV in two patients. The fourth patient had a low JCV-DNA blood titer and brain biopsy showed subacute necrosis. Two patients had abnormal lymphocyte subpopulations. Three patients underwent therapy with Mirtazapine, one of whom received Mefloquine in add-on. No clinical response was registered. Clinical onset, MRI and MRS were highly suggestive of PML in all patients, despite three cases presented contrast enhancement. In three cases JCV-DNA detection in biological samples confirmed the diagnosis. The fourth patient fulfilled diagnosis of “presumptive PML”. Our data confirm the importance to complete the diagnostic workup despite the presence of findings not completely consistent with classical PML. We hypothesize that atypical characteristics could due to the clinical conditions leading to PML