19 research outputs found

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    Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019

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    Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population

    Introducción a la historia de la aritmética práctica en la Corona de Aragón en el siglo XVI

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    Los rasgos más interesantes que muestra la evolución de la aritmética práctica en los reinos de la Corona de Aragón en el siglo XVI son 10s siguientes: 1. La segunda anmética impresa en el mundo fue eicrita por un autor catalán, pero su influencia Posterior entre los aritméticos esañol les fue ahogada por la enorme difusión de la Summa de fra Luca Pacioli. 2. Se encuentran representadas las tres corrientes matemáticas imperantes en el siglo. 3. Algunas de las aitméticas más relevantes de la España de la época se imprimieron en esta zona. 4. En Valencia apareció el primer manual de álgebra impreso en España Y en Barcelona, el primer libro de contabilidad. 5. Todos los aritméticos aceptaron la numeración posicional. 6. Los ejercicios incluidos aparecen como testimonios inestimables de la actividad económica del momento

    Cronos.

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