CONFORMATIONAL ANALYSIS IN 18-MEMBERED MACROLIDE ANTIBIOTICS BASED ON MOLECULAR MECHANICS.

Conformational analysis of macrolides with 18-ring membered has been carried out using molecular mechanics calculations and molecular dynamics. A high conformational mobility of no complexed macrocycles has been obtained and an important stereoselectivity has been observed for the complexed macrocycles. For 18d macrolide, which was presented by a privileged conformer with 20.1% without complex, was populated with 50.1% in presence of Fe(CO)3. For the most privileged conformer geometry; the α,β-unsaturated ester group has an s-cis conformation with a torsion angle φ1: O19-C2-C3-C4 = 14.5° for macrocycle 18d macrolide and φ1: O19-C2-C3-C4 = 25.0° for 18s macrolide. The diene group has an s-trans conformation with a torsion angle φ2:C11-C12-C13-C14 = 169.4° for 18d macrolide and φ2:C10-C11-C12-C13 = 179.5° for 18s macrolide.  L’analyse conformationnelle des macrolides à 18 chaînons a été réalisée par des calculs de mécanique moléculaire et de dynamique moléculaire. Une mobilité conformationnelle élevée a été obtenue pour les macrocycles non complexés et une stéréosélectivité importante a été observé pour les macrocycles complexés. Pour le macrolide 18d, qui a été présenté par un conformère privilégié avec 20.1% sans complexe, est devenu 50.1% en présence de Fe(CO)3 Pour la géométrie du conformère le plus privilégiée; le système d’ester α,β-insaturé, a une conformation s-cis avec un angle de torsion φ1 : O19-C2-C3-C4 = 14.5° pour le macrolide 18d et φ1 : O19-C2-C3-C4 = 25.0° pour le macrolide 18s. Le système diène a une conformation s-trans avec un angle de torsion φ2 : C11-C12-C13-C14 = 169.4° pour macrolide 18d et φ2:C10-C11-C12-C13 = 179.5° pour macrolide 18s

Well-Posedness and Exponential Stability of the Von Kármán Beam With Infinite Memory

In the present work, we consider a one-dimensional Von kármán beam with infinite memory, we establish the well-posedness of the system using semigroup theory and prove the exponential stability under some conditions on the kernel of the infinite memory term

التأويل النحوي عند ابن عادل الحنبلي في تفسيره اللباب في علوم الكتاب

يهدف هذا البحث إلى تحديد مفهوم التأويل النحوي لدى النحاة واللغويين والمفسرين عامة، وابن عادل الحنبلي بشكل خاص، وبيان أهميته البالغة ودوره الكبير في فهم القرآن الكريم، وتفسيره وتأويله، والوقوف على المنهج الذي اتّبعه ابن عادل في عملية التأويل النحوي، في تفسيره "اللباب في علوم الكتاب". ومن مظاهر التأويل النحوي المشهورة بين المفسرين: الحذف والتقدير، والتقديم والتأخير، والتضمين، والحمل على المعنى، والزيادة. وهي تمثّل مباحثه وآلياته، إضافة إلى بعض المباحث الأخرى كالفصل والاعتراض، والعطف على الموضع وعلى التوهم. RESUME : La présente étude a pour objectif, d’une part, de définir le concept de l’interprétation grammaticale chez les grammairiens, linguistes et chez « Ibn Adel Al Hanbali » en particulier. D’autre part, elle tente de démontrer la grande importance que revêt l’interprétation grammaticale dans la compréhension du Coran ainsi que son exégèse. Cela en faisant la lumière sur la méthodologie adoptée par l’exégète suscité dans son approche interprétative de son œuvre « AL Loubab Fi Ouloum Al Kitab ». Parmi les nombreux aspects de l’interprétation grammaticale les plus connus, nous citons : l’omission, le sous-entendu, l’antéposition, la postposition, l’attribution du sens et l’addition. Ces aspects même constituent (avec d’autres chapitres tels que l’intercalation) les éléments et modalités

Existence and exponential stability of solutions for transmission system with varying delay in R

In the present paper we are going to consider in a one dimension bounded domain a transmission system with a varying delay. Under suitable assumptions on the weights of the damping and the delay terms, we prove the well-possedness and the uniqueness of solution using the semigroup theory. Also we show the exponential stability by introducing an appropriate Lyaponov functional

Improving ViBe-based Background Subtraction Techniques Using RGBD Information

International audienceIn this paper, we propose a framework for improving Background Subtraction techniques. This framework is based on two types of data, RGB and Depth. Our study stands for obtaining preliminary results of the background segmentation using Depth and RGB channels independently, then using an algorithm to fuse them to create the final results. The experiments on the SBM-RGBD dataset using four methods: ViBe, LOBSTER, SuBSENSE, and PAWCS proved that the proposed framework achieves an impressive performance compared to the original RGB-based techniques from the state-of-the-art

RGBD deep multi-scale network for background subtraction

International audienceThis paper proposes a novel deep learning model called deep multi-scale network (DMSN) for background subtraction. This convolutional neural network is built to use RGB color channels and Depth maps as inputs with which it can fuse semantic and spatial information. In comparison with previous deep learning background subtraction techniques that lack information due to its use of only RGB channels, our RGBD version is able to overcome most of the drawbacks, especially in some particular kinds of challenges. Further, this paper introduces a new protocol for the SBM-RGBD dataset, concerning scene-independent evaluation, dedicated to Deep Learning methods to set up a competitive platform that includes more challenging situations. The proposed method proved its efficiency in solving the background subtraction in complex situations at different levels. The experimental results verify that the proposed work outperforms the state of the art on SBM-RGBD and GSM datasets

Systemic Lupus Erythematosus in Children and Adolescents

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can involve any organ system with a wide range of disease manifestations, and can lead to significant morbidity and even mortality. This article reviews the epidemiology, common clinical features, complications of disease, and briefly discusses the available treatment options. In addition, important medical and psychosocial issues relevant to the pediatrician caring for children and adolescents with SLE are discussed