13 research outputs found
Quantitative determination of chemical and biochemical parameters during « soumbala » manufacturing process in two communities of Burkina Faso
« Soumbala » is traditionally used in Burkina Faso as a food condiment in different communities. This study was conducted to evaluate « soumbala » manufacturing process on its nutritional value in two communities. During this descriptive and analytical study, samples were taken in the « Gouin » and « Moose » communities. The results show that, the humidity rate was higher in « soumbala » and waste in the « Gouin » processus, whereas in the « Moose » one, the highest humidity rate was observed after the cooking step and in peeled boiled seeds. The ash level was higher in raw seeds and after cooking step in the « Gouin » community whereas in the « Moose » community, it was higher in raw seeds and waste. The pH determination showed a progressive increase in pH values during the « soumbala » manufacturing process in the two communities. Mineral elements assays showed a slight variation in grades along the « soumbala » manufacturing process. For biochemical analysis, lipids content increased during the « soumbala » production; protein levels increased a little at the early stages of « soumbala » manufacturing process in both communities and carbohydrates contents were higher in waste in the « Moose » community, whereas in the « Gouin » community, the highest contents were found in the raw seeds. The aflatoxins determination in « soumbala » showed levels below the detection limit of the used method. These results showed that it was imperative that approved standard protocols be adopted to maintain the nutritional quality of « soumbala » wherever it is produced
Lipoprotein (a) profile in HIV-1 infected patients treated with highly active antiretroviral therapy (HAART)
Lipoprotein (a) [Lp(a)] is recognized as an independent factor of
arteriosclerosis. The aim of this study was to appreciate the profile
of Lipoprotein (a) recognized as an independent factor of
arteriosclerosis in the monitoring of HIV-infected patients receiving
Nevirapine (NVP) regimens, an antiretroviral known to reduce
cardiovascular disease risk. The study population (136 subjects)
comprise of 106 HIV-infected subjects, and 30 HIV-negative individuals.
The 106 HIV-infected subjects were divided into groups as follows.
HAART-untreated (27), HIV-infected subjects that did not receive
antiretroviral treatment; HAART-6M (36), HIV-infected subjects on
antiretroviral treatment for six months; and HAART-12M (43),
HIV-infected subjects on antiretroviral treatment for twelve months.
All recruited patients had normal blood lipids values (Total
cholesterol 0.9
mmol/L). The Lp(a) levels were significantly higher in the HIV-infected
group compared to the control (p = 0.0036). Within the HIV-infected
subjects, Lp(a) level was found to be higher in HAART-treated group
compared to HAART naive group (p=0.004). Infected subjects on the
antiretroviral treatment for12 months had higher Lp(a) levels than
those treated for 6 months (p=0.034). This study shows that adequate
management of metabolic abnormalities of HAART-treated HIV-infected
patients must include periodic measurement of Lp(a) levels
Survey of urinary crystals identified in residents of Ouagadougou, Burkina Faso: Implications for the diagnosis and management of renal dysfunctions
The first step of renal lithiasis process is crystals formation.
Because of this link, a prospective study on the profile of urinary
crystals was conducted in Ouagadougou with the aim of describing
profiles of these crystals in the context of a Sahelian tropical
country. This study showed strong prevalence (78.69%) crystals within
the population from 15 to 59 years old. Male subjects were the most
concerned with 55.93 % prevalence. Among the crystals, we distinguished
those who were without compulsory pathological interest with strong
prevalence of the crystals of calcium oxalate (56.11%) and uric acid
(20.55%). Crystals with immediate pathological interest were bilirubin
(0.66%), the cystine (0.36%), leucine (0.06%) and tyrosine (0.06%).
Prevalence of crystals derived from drugs were sulfamides (0.18%) and
mycostatine (0.06%). Besides, 20.8% of the patients having urinary
crystals had urinary tract infection. Bacteriological analysis of
urines showed a presence of producing urease bacteria: Klebsiella
(12.96%), Proteus (3.0%), Enterobacter (1.66%) and, Pseudomonas
(1.66%). In conclusion, this work showed the interest to pay more
attention on urinary crystals. Indeed this study brought to light
crystals with compulsory pathological interest, in particular crystals
of bilirubin, cystine, leucine, tyrosine, evidence of abnormalities of
protein metabolism
Evolution des paramètres biochimiques et hématologiques chez les personnes vivant avec le VIH/SIDA sous traitement antirétroviral au Centre Médical du Camp General Aboubacar Sangoule Lamizana
Introduction: l'objectif de ce travail était d'évaluer l'impact du traitement sur les paramètres biochimiques et hématologiques des patients VIH positifs suivis au Centre Médical du Camp Général Aboubacar Sangoulé Lamizana (CMCGASL) au Burkina Faso. Méthodes: il s'agissait d'une étude rétrospective réalisée sur la période de Janvier 2010 à septembre 2015. Seuls les patients VIH positifs sous TARV ayant réalisé un bilan biologique à l'une des périodes suivantes : à l'initiation du traitement(M0), au sixième mois(M6) et au douzième mois(M12), ont été pris en compte. Résultats: le sex-ratio des patients était de 0,88 et la tranche d'âge des 45-55 ans était la plus importante. Les trithérapies incluant 2INTI + 1INNTI (74,5%), 2INTI+1 IP (14,9%) étaient les plus prescrites. La charge virale était peu demandée. Le taux des patients réguliers aux bilans biologiques avait connu une régression statistiquement significative entre M0 (70%), et M6 (13%) (p<0,05). Une augmentation significative de la valeur moyenne des lymphocytes TCD4 allant de 79,22 à M0 à 227,95 cellules/mm3 à M12 (p<0,05) était noté chez les patients sévèrement immunodéprimés. Ascension significative du taux d'hémoglobine moyen passant de 10,5 g/dl à M0 à 12,53 g/dl à M12 (p<0,05) chez les patients qui étaient anémiés. L'analyse des paramètres biochimiques n'a pu être réalisée à cause d'une insuffisance de données. Conclusion: l'ascension du taux de lymphocytes TCD4 et du taux d'hémoglobine oriente sur l'efficacité du TARV et la tolérance au traitement. Il importe de rendre accessible la charge virale et d'améliorer le suivi biologique
Reference Ranges of Cholesterol Sub-Fractions in Random Healthy Adults in Ouagadougou, Burkina Faso
<div><p>In Burkina Faso, the values that serve as clinical chemistry reference ranges are those provided by European manufacturers’ insert sheets based on reference of the Western population. However, studies conducted so far in some African countries reported significant differences in normal laboratory ranges compared with those of the industrialized world. The aim of this study was to determine reference values of cholesterol fractions in apparently normal adults in Burkina Faso that could be used to better assess the risks related to cardiovascular diseases. Study population was 279 healthy subjects aged from 15 to 50 years including 139 men and 140 women recruited at the Regional Center of Blood Transfusion of Ouagadougou, capital city of Burkina Faso (West Africa). Exclusion criteria based on history and clinical examination were used for defining reference individuals. The dual-step precipitation of HDL cholesterol sub-fractions using dextran sulfate was performed according to the procedure described by Hirano. The medians were calculated and reference values were determined at 2.5<sup>th</sup> and 97.5<sup>th</sup> percentiles. The median and upper ranges for total cholesterol, LDL cholesterol, total HDL cholesterol and HDL2 cholesterol were observed to be higher in women in comparison to men (p <0.05). These reference ranges were similar to those derived from other African countries but lower than those recorded in France and in USA. This underscores the need for such comprehensible establishment of reference values for limited resources countries. Our study provides the first cholesterol sub-fractions (HDL2 and HDL3) reference ranges for interpretation of laboratory results for cardiovascular risk management in Burkina Faso.</p></div
Clinical Laboratory Networks Contribute to Strengthening Disease Surveillance: The RESAOLAB Project in West Africa
Description of the first sleeping sickness case diagnosed in Burkina Faso since two decades.
Burkina Faso belongs to a group of countries in which human African trypanosomiasis (HAT), caused by Trypanosoma brucei gambiense, is no longer considered to be a public health problem. Although no native cases have been detected since 1993, there is still the risk of HAT re-emergence due to significant population movements between Burkina Faso and active HAT foci in Côte d'Ivoire. Since 2014, Burkina Faso receives support from the WHO to implement a passive surveillance program. This resulted in the detection in 2015 of the first putative native HAT case since two decades. However, epidemiological entomological and molecular biology investigations have not been able to identify with certainty the origin of this infection or to confirm that it was due to T. b. gambiense. This case emphasises the need to strengthen passive surveillance of the disease for sustained elimination of HAT as a public health problem in Burkina Faso
Dengue Fever in Burkina Faso, 2016
We report 1,327 probable cases of dengue in Burkina Faso in 2016. Of 35 serum samples tested by a trioplex test, 19 were confirmed dengue virus (DENV)‒positive: 11 DENV-2, 6 DENV-3, 2 nontypeable, and 1 DENV-2/DENV-3 co-infection. Molecular testing should be conducted to correctly identify causative agents in this complex infectious disease landscape