DRIFTSONDES, Providing In Situ Long-Duration Dropsonde Observations over Remote Regions

A field-tested, balloon-borne dropsonde platform fills an important gap in in-situ research measurement capabilities by delivering high-resolution, MIST dropsondes to remote locations from heights unobtainable by research aircraft.National Science Foundation’s Division of Atmospheric and Geospace Sciences and Office of Polar ProgramsNational Oceanic and Atmospheric AdministrationNational Science Council of TaiwanTaiwan Central Weather BureauOffice of Naval ResearchThe national and international THORPEX project officesNational Science Foundation supported these field projects through their support of the U.S. THORPEX project Office, and the Lower Atmospheric Observing FacilitiesATM-0301213ATM-9732665ANT-0733007ANT-1002057AGS-0736003NA17GP1376NSC 96- 2745-M-002-004NSC 97-2111-M-002-005NSC 97-2111-M-002-016-MY3N00173-08-1-G007N00014- 09-WR20008MOTC-CWB-97-6M-0

Driftsondes: Providing In Situ Long-Duration Dropsonde Observations over Remote Regions

International audienceConstellations of driftsonde systems— gondolas floating in the stratosphere and able to release dropsondes upon command— have so far been used in three major field experiments from 2006 through 2010. With them, high-quality, high-resolution, in situ atmospheric profiles were made over extended periods in regions that are otherwise very difficult to observe. The measurements have unique value for verifying and evaluating numerical weather prediction models and global data assimilation systems; they can be a valuable resource to validate data from remote sensing instruments, especially on satellites, but also airborne or ground-based remote sensors. These applications for models and remote sensors result in a powerful combination for improving data assimilation systems. Driftsondes also can support process studies in otherwise difficult locations—for example, to study factors that control the development or decay of a tropical disturbance, or to investigate the lower boundary layer over the interior Antarctic continent. The driftsonde system is now a mature and robust observing system that can be combined with flight-level data to conduct multidisciplinary research at heights well above that reached by current research aircraft. In this article we describe the development and capabilities of the driftsonde system, the exemplary science resulting from its use to date, and some future applications

High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease

International audienceBackground & AimsLittle is known about the magnitude of the risk of anal and rectal cancer in patients with anal and/or perineal Crohn’s disease. We aimed to assess the risk of anal and rectal cancer in patients with Crohn’s perianal disease followed up in the Cancers Et Surrisque Associé aux Maladies Inflammatoires Intestinales En France (CESAME) cohort.MethodsWe collected data from 19,486 patients with inflammatory bowel disease (IBD) enrolled in the observational CESAME study in France, from May 2004 through June 2005; 14.9% of participants had past or current anal and/or perianal Crohn’s disease. Subjects were followed up for a median time of 35 months (interquartile range, 29–40 mo). To identify risk factors for anal cancer in the total CESAME population, we performed a case-control study in which participants were matched for age and sex.ResultsAmong the total IBD population, 8 patients developed anal cancer and 14 patients developed rectal cancer. In the subgroup of 2911 patients with past or current anal and/or perianal Crohn’s lesions at cohort entry, 2 developed anal squamous-cell carcinoma, 3 developed perianal fistula–related adenocarcinoma, and 6 developed rectal cancer. The corresponding incidence rates were 0.26 per 1000 patient-years for anal squamous-cell carcinoma, 0.38 per 1000 patient-years for perianal fistula–related adenocarcinoma, and 0.77 per 1000 patient-years for rectal cancer. Among the 16,575 patients with ulcerative colitis or Crohn’s disease without anal or perianal lesions, the incidence rate of anal cancer was 0.08 per 1000 patient-years and of rectal cancer was 0.21 per 1000 patient-years. Among factors tested by univariate conditional regression (IBD subtype, disease duration, exposure to immune-suppressive therapy, presence of past or current anal and/or perianal lesions), the presence of past or current anal and/or perianal lesions at cohort entry was the only factor significantly associated with development of anal cancer (odds ratio, 11.2; 95% CI, 1.18-551.51; P = .03).ConclusionsIn an analysis of data from the CESAME cohort in France, patients with anal and/or perianal Crohn’s disease have a high risk of anal cancer, including perianal fistula–related cancer, and a high risk of rectal cancer