8 research outputs found
The use of advancedâplatelet rich fibrin (AâPRF) in the management of medicationârelated osteonecrosis of the jaw (MRONJ): A case report
Abstract Medicationârelated osteonecrosis of the jaws (MRONJ) is a serious debilitating disease resulting from longâterm treatment with Antiresorptive drugs such as Bisphosphonates or Denosumab, which significantly affects patients' quality of life. A 43âyearâold female patient with stage 4 breast cancer and treated with Zoledronic Acid for bone metastases was referred to the Department of Oral Medicine at the Faculty of Dentistry, Damascus University. The main complaint was pain in the right maxilla. Intraoral examination showed an exposure of necrotic bone in the right maxillary region with presence of purulent exudate. The treatment plan was discussed with the patient. Treatment included resection of all necrotic bone and application of Advanced plateletârich fibrin (AâPRF) clots and membranes. Followâup and outcome were conducted by clinical measures to assess healing and recurrence (6âmonth followâup). Topical treatment with AâPRF demonstrated a reduction in pain and resulted in complete wound healing within 30âdays. AâPRF stimulates the release of growth factors and chemotaxis involved in tissue repair mechanisms. This method seemed to be effective in the treatment of MRONJ