Short view of leukemia diagnosis and treatment in Iran

Background: Early diagnosis and treatment of leukemia patients remains a fundamental aim in clinical oncology, especially in developing country. Present study highlights the basic requirements of these patients in Iran. Better understanding of these issues may lead to improve the healthcare standards toward leukemia diagnosis and treatment. Methods: This descriptive study included 101 specialists in hematology-oncology and pathology serving in oncology centers. The participants were then asked to fill out a standard questionnaire on the issues around diagnosis and treatment of blood malignancies. Results: According to specialists, unfair distribution of facilities across the country, delayed diagnosis of disease, absence of psychological support for patients, and insufficient financial support were the main reasons of inappropriate diagnosis and treatment in leukemia patients. Conclusions: Our results show that making an amendment to health policies by preparing well-equipped medical centers in all provinces, improving the morale of patients through consultation during the process of treatment, and above all, subsiding leukemia patients' financial problems will promote the health standard regarding the leukemia diagnosis and treatment in Iran. © 2015, Tehran University of Medical Sciences (TUMS). All rights reserved

Study of Intraventricular Hemorrhage in VLBW Neonates Admitted in Al-Zahra Hospital, Tabriz, Iran

Introduction and Aim: Intra-ventricular hemorrhage (IVH) is an important predictor of adverse neurodevelopmental outcome. IVH risk factor identification may conduct improvement of quality of care in Neonatal Intensive Care Units. The aim of the current study was to determine possible risk factors associated with IVH in VLBW neonates admitted in our hospital. Patients and Methods: All neonates with birth weight below 1500 gr admitted to NICU. Cranial ultrasonography was done for premature neonates weighed <1000 g in 3 to 5 days and in 1 month again. In premature infants weighed >1000 g, sonography was done in 7 days and 30 days of life respectively. If there is any conditions such as apnea, seizure, significant decrease in level of hemoglobin, increased head circumference, increased oxygen consumption, and other significant changes another sonography was done again. Exclusion criteria were cerebral malformations, metabolic disturbances, chromosomal anomalies, central nervous system infection, and genetic syndromes. Data was analyzed by SPSS ver 16.0 (SPSS Inc, Chicago, IL, USA) Results: In this study 64 cases with IVH and 110 without IVH were included. Mean of gestational age was 28.78±2.08. From neonates, 54.6% were boys and 45.4% were girls. Vaginal delivery and cesarean section was done in 56 (32.2%) and 118(67.8%) cases respectively. Mean±SD of pH in cases with IVH and without IVH was 7.19±0.22 and 7.30±0.12 respectively(p=0.001). Mean ±SD of pco2 in cases with IVH and without IVH was 65.15±29.89 and 49.88±40.89 respectively(p=0.001). Mean of 5th min APGAR score in patients required CPR was 7.36±1.57 and in patients without CPR was 8.68±1.25(P=0.001). From cases with IVH, hydrocephaly was detected in 20 cases. From cases without IVH, hydrocephaly was detected in 6 cases. Result of chi-square showed significant correlation between IVH and prematurity( X2=21.94, df=1, P<0.001). From cases with IVH, 18 cases (28.1%) expired. From cases without IVH, 11 cases(10%) expired(X2=9.398, df=1, P=0.002). Results of chi-square test showed that there were a correlation between IVH and PDA, pressure support, surfactant therapy, inotrop drug administration, vaginal delivery, neonatal resuscitation, and antenatal corticosteroid therapy(p<0.05). Hyaline membrane disease, history of preclampsia in mother was significantly higher in cases without IVH(Chi-square, p<0.05). Conclusion: PDA, pressure support, surfactant therapy, inotrop drug administration, vaginal delivery, neonatal resuscitation, and antenatal corticosteroid therapy were significantly higher in cases with IVH. Hyaline membrane disease and preeclampsia in mother was significantly higher in cases without IVH.Keywords: Intraventricular hemorrhage, APGAR, low birth weight, hyaline membrane disease, corticosteroid, surfactant, inotrop, pre-eclampsi

Transcriptional regulation of Î6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: Role of MEK/ERK1/2 pathway

The Î6-desaturase (Î6D), also known as fatty acid desaturase 2, is a regulatory enzyme in de novo fatty acid synthesis, which has been linked to obesity and diabetes. The aim of the present study was to investigate the effect of peroxisome proliferative-activated receptor δ (PPARδ) agonist and MEK/ERK1/2-dependent pathway on the expression of Î6D in human pancreatic carcinoma cell line PANC-1. PANC-1 cells cultured in RPMI-1640 were exposed to the commonly used ERK1/2 pathway inhibitor PD98059 and PPARδ agonist GW0742. Changes in mRNA and protein expression of Î6D were then determined using real-time RT-PCR and Western blot, respectively. The expression of Î6D (P 40, P 25, P < 0.05) pretreatment. PPARδ and MEK/ERK1/2 signaling pathways affect differentially the expression of Î�6D in pancreatic cancer cells. Furthermore, there may be an inhibitory crosstalk between these two regulatory pathways on the mRNA expression of Î�6D and subsequently on Î�6D protein expression. © 2013 Maryam Darabi et al

Flexural Behavior of Functionally Graded-Graphene Reinforced Composite Plates

A first order shear deformation theory based finite element numerical investigation on flexure behaviour of functionally graded thin, moderately thick and thick composite plates reinforced with graphene platelets (GPLs) is presented in this paper. The maximum deflection plays a major role in the design of composite structures. Therefore, maximum deflection and percentage maximum deflection ratio of reinforced to unreinforced composite plate are investigated for a range of GPL distribution patterns along plan and thickness directions of the composite plate. Modified Halpin-Tsai equation is used to determine the effective Young’s modulus for each layer in thickness direction for different distribution patterns. The rule of mixture is used to calculate effective mass density and Poisson’s ratio for each layer. Initially, the results from this study are verified by comparing with the reported results from the literature. Thereafter, validated methodology is used to conduct case study for a simply supported plate, focusing on the effect of thickness, GPL distribution patterns along plan and thickness directions, percentage weight fraction of GPL on the maximum deflection and percentage maximum deflection ratio of reinforced to unreinforced composite plate. It is found that by adding just 1% weight fraction of GPL, the maximum deflection can be reduced by almost 65% to 90% for all thicknesses and distribution patterns considered

A high-order FEM formulation for free and forced vibration analysis of a nonlocal nonlinear graded Timoshenko nanobeam based on the weak form quadrature element method

The purpose of this paper is to provide a high-order finite element method (FEM) formulation of nonlocal nonlinear nonlocal graded Timoshenko based on the weak form quadrature element method (WQEM). This formulation offers the advantages and flexibility of the FEM without its limiting low-order accuracy. The nanobeam theory accounts for the von Kármán geometric nonlinearity in addition to Eringen’s nonlocal constitutive models. For the sake of generality, a nonlinear foundation is included in the formulation. The proposed formulation generates high-order derivative terms that cannot be accounted for using regular first- or second-order interpolation functions. Hamilton’s principle is used to derive the variational statement which is discretized using WQEM. The results of a WQEM free vibration study are assessed using data obtained from a similar problem solved by the differential quadrature method (DQM). The study shows that WQEM can offer the same accuracy as DQM with a reduced computational cost. Currently the literature describes a small number of high-order numerical forced vibration problems, the majority of which are limited to DQM. To obtain forced vibration solutions using WQEM, the authors propose two different methods to obtain frequency response curves. The obtained results indicate that the frequency response curves generated by either method closely match their DQM counterparts obtained from the literature, and this is despite the low mesh density used for the WQEM systems

Size-dependent nonlinear secondary resonance of micro-/nano-beams made of nano-porous biomaterials including truncated cube cells

© 2018, Springer-Verlag GmbH Austria, part of Springer Nature. Porous biomaterials have been utilized in cellular structures in order to mimic the function of bone as a branch of tissue engineering approach. With the aid of nano-porous biomaterials in which the pore size is at nanoscale, the capability of biological molecular isolation becomes more efficient. In the present study, first the mechanical properties of nano-porous biomaterials are estimated on the basis of a truncated cube cell model including a refined hyperbolic shear deformation for the associated lattice structure. After that, based upon a nonlocal strain gradient beam model, the size-dependent nonlinear secondary resonance of micro-/nano-beams made of the nano-porous biomaterial is predicted corresponding to both subharmonic and superharmonic excitations. The nonclassical governing differential equation of motion is constructed via Hamilton’s principle. By employing the Galerkin technique together with the multiple-timescale method, the nonlocal strain gradient frequency response and amplitude response of the nonlinear oscillation of micro-/nano-beams made of a nano-porous biomaterial under hard excitation are achieved. It is shown that in the superharmonic case, increasing the pore size leads to an enhancement of the nonlinear hardening spring-type behavior of the jump phenomenon and the height of limit point bifurcations. In the subharmonic case, higher pore size causes an increase in the gap between two branches associated with the high-frequency and low-frequency solutions