Fibroblast growth factor 21 and its relation to metabolic parameters in women with polycystic ovary syndrome

Cure, Medine Cumhur/0000-0001-9253-6459WOS: 000342056100001PubMed: 24724557Objective. the aim of this study was to compare the serum levels of fibroblast growth factor 21 (FGF-21) between patients with polycystic ovary syndrome (PCOS) and control subjects and to assess the possible relation with the hormonal and metabolic parameters. Methods. A total of 91 patients with PCOS and 53 age- and body mass index (BMI)-matched healthy controls were included in the study. We evaluated anthropometric, hormonal and metabolic parameters in all the cases. Serum FGF-21 and high sensitive C-reactive protein (hsCRP) levels were measured by ELISA. Results. Mean fasting glucose and insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol, total testosterone, dehydroepiandrosterone sulfate (DHEAS) levels were significantly higher in PCOS patients. Serum FGF-21 levels were similar in PCOS (236.8 +/- 171.2 pg/ml) and the control (224.6 +/- 128.9 pg/ml) group (p = 0.654). FGF-21 level had no correlation with BMI, waist circumference, HOMA-IR, hsCRP and lipid parameters. However there was a significant negative correlation between FGF-21 and DHEAS levels (r = -0.309, p = 0.003). Conclusion. FGF-21 levels were similar in women with PCOS compared with those of age- and BMI-matched controls

Urinary Incontinence in Premenopausal Women: Prevalence, Risk Factors and Impact on Quality of Life

WOS: 000342624600005PubMed: 26663597ObjectivesTo determine the prevalence and risk factors of urinary incontinence (UI), and assess its impact on the quality of life (QOL) in premenopausal women. MethodsIn this cross-sectional study, 690 women aged from 18 to 53 were interviewed using a demographic questionnaire and the International Consultation on Incontinence Questionnaire Short Form. ResultsThe overall prevalence of any UI was 27.2%. of the 188 women reporting UI the types were: stress 36.7%, urgency 32.4% and mixed 30.9%. the mean value of the age and body mass index (BMI) of the cases with UI was statistically significantly higher than the group without UI (P35years had an odds ratio of 1.896 (95% confidence interval [CI]:1.29-2.80); the effect of the status of not attending a school or only attending primary school had an odds ratio 1.839 (95% CI: 1.23-2.75) and the number of pregnancies>2 had an odds ratio 1.495 (95% CI:1.00-2.26). ConclusionBeing older than 35, having a low educational level and a gravida greater than two are the independent risk factors in terms of the occurrence of UI in premenopausal women

Temperature-dependence of oxygen reduction activity on Pt/C and PtCr/C electrocatalysts synthesized from microwave-heated diethylene glycol method

International audienc

Lower Urinary Tract Symptoms and Urinary Incontinence During Pregnancy

WOS: 000374988000007PubMed: 27111624Objective: Lower urinary tract symptoms (LUTS) can frequently be seen in pregnant women. Pregnancy and delivery have been considered as risk factors in the occurrence of pelvic floor dysfunction and determinants of LUTS. the main associated risk factor is parity. in the present study, we aim to determine the frequency of LUTS and urinary incontinence (UI) during pregnancy and the associated risk factors. Methods: This prospective study was carried out in a total of 250 women during their 28- and 40-gestational week checks. the Urinary Distress Inventory-6, the Incontinence Impact Questionnaire-7, and International Consultation on Incontinence Questionnaire-Short Form were used to determine LUTS and its effect on quality of life. Results: the mean age and gestational age of the participants were 29.41 +/- 5.70 year (range 18-44) and 35.45 +/- 2.98 weeks (range 28-40), respectively. the prevalence of LUTS was 81.6%. the prevalence of UI during pregnancy was 37.2%. Stress urinary incontinence, urge urinary incontinence and mixed urinary incontinence were diagnosed as 15.6, 4.8 and 16.8%, respectively. We found that advanced age, smoking and multiparity were risk factors associated with incontinence. Incontinence reduced pregnant women's quality of life. Conclusions: Lower urinary tract symptoms are commonly seen among pregnant women and these symptoms negatively affect the quality of life of pregnant women. Advanced age, smoking and multiparity were risk factors associated with urinary incontinence and LUTS. Obstetricians should be on the lookout for individual urological problems in pregnancy. Resolving any urological issues and cessation of smoking for the affected individuals will help alleviate the problem