VALIDATED STABILITY INDICATING HPLC APPROACH FOR QUANTIFYING TRICHOLINE CITRATE AND CYPROHEPTADINE SIMULTANEOUSLY IN SYRUP FORMS

Objective: This investigation demonstrates a stability-indicating and reliable “high-performance liquid chromatography” method to simultaneously quantify tricholine citrate (TEC) and cyproheptadine (CRH) in the syrup form and bulk form. Methods: Successful separation was accomplished using C18 “Agilent column (250 mm × 4.6 mm, 5 μm)” with isocratic type of elution using mobile phase containing 0.1 M NaH2PO4 buffer and acetonitrile at 55% volume and 45% volume ratio, respectively with 1.0 ml/min flow rate. The wavelength sensor was attuned at 263 nm to quantify TEC and CRH. Results: TEC and CRH peaks were eluted with fine resolution at retention times 1.837 min and 2.936 min, respectively. In the 137.5-412.5 μg/ml and 1-3 μg/ml concentration ranges for TEC and CRH, the calibration graphs were linear, with regression coefficients of 0.9999 and 0.9998, respectively. The suggested "high-performance liquid chromatography" approach has been shown as sensitive, precise, robust, accurate, specific and stability indicating through the resolution of TEC and CRH from its degradation-based compounds. Conclusion: The established high-performance liquid chromatography technique was effectively extended to the evaluation of TEC and CRH in the combined syrup form and the test results appeared satisfactory

Molecular Association of Platinum Acetylacetonate with Halogens

916-91

Boreal summer intraseasonal oscillations and seasonal Indian monsoon prediction in DEMETER coupled models

Even though multi-model prediction systems may have better skill in predicting the interannual variability (IAV) of Indian summer monsoon (ISM), the overall performance of the system is limited by the skill of individual models (single model ensembles). The DEMETER project aimed at seasonal-to-interannual prediction is not an exception to this case. The reasons for the poor skill of the DEMETER individual models in predicting the IAV of monsoon is examined in the context of the influence of external and internal components and the interaction between intraseasonal variability (ISV) and IAV. Recently it has been shown that the ISV influences the IAV through very long breaks (VLBs; breaks with duration of more than 10 days) by generating droughts. Further, all VLBs are associated with an eastward propagating Madden-Julian Oscillation (MJO) in the equatorial region, facilitated by air-sea interaction on intraseasonal timescales. This VLB-drought-MJO relationship is analyzed here in detail in the DEMETER models. Analyses indicate that the VLB-drought relationship is poorly captured by almost all the models. VLBs in observations are generated through air-sea interaction on intraseasonal time scale and the models' inability to simulate VLB-drought relationship is shown to be linked to the models' inability to represent the air-sea interaction on intraseasonal time scale. Identification of this particular deficiency of the models provides a direction for improvement of the model for monsoon prediction

A collimated, ionized bipolar structure and a high density torus in the young planetary nebula IRAS 17347-3139

We present observations of continuum (lambda = 0.7, 1.3, 3.6 and 18 cm) and OH maser (lambda = 18 cm) emission toward the young planetary nebula IRAS 17347-3139, which is one of the three planetary nebulae that are known to harbor water maser emission. From the continuum observations we show that the ionized shell of IRAS 17347-3139 consists of two main structures: one extended (size ~1". 5) with bipolar morphology along PA=-30 degrees, elongated in the same direction as the lobes observed in the near-infrared images, and a central compact structure (size ~0". 25) elongated in the direction perpendicular to the bipolar axis, coinciding with the equatorial dark lane observed in the near-infrared images. Our image at 1.3 cm suggests the presence of dense walls in the ionized bipolar lobes. We estimate for the central compact structure a value of the electron density at least ~5 times higher than in the lobes. A high resolution image of this structure at 0.7 cm shows two peaks separated by about 0". 13 (corresponding to 100-780 AU, using a distance range of 0.8-6 kpc). This emission is interpreted as originating in an ionized equatorial torus-like structure, from whose edges the water maser emission might be arising. We have detected weak OH 1612 MHz maser emission at VLSR ~ -70 km/s associated with IRAS 17347-3139. We derive a 3 sigma upper limit of < 35% for the percentage of circularly polarized emission. Within our primary beam, we detected additional OH 1612 MHz maser emission in the LSR velocity ranges -5 to -24 and -90 to -123 km/s, associated with the sources 2MASS J17380406-3138387 and OH 356.65-0.15, respectively.Comment: 26 pages, 8 figures. Accepted for publication in Ap

Understanding pelvic floor in women

Change from quadruped to erect posture has resulted in changes in the human pelvis. This has resulted in pelvis supporting the abdominal viscera. The bony pelvis is deficient on inferior aspect. Muscles covered by fascia on superior and inferior aspect. A good knowledge of pelvic floor is very basic and mandatory for any gynecologist as pelvic floor is crucial to support the pelvic organs and is required to maintain urinary and fecal continence

Complexes of Mn(II) with Benzotriazole

360-36

Can El Nino-Southern Oscillation (ENSO) events modulate intraseasonal oscillations of Indian summer monsoon?

Prediction of interannual variability (IAV) of Indian summer monsoon (ISM) rainfall is limited by "internal" dynamics, and the monsoon intraseasonal oscillations (MISOs) seems to be at the heart of producing internal IAV of the ISM. If one could find an identifiable way through which these MISOs are modulated by slowly varying "external" forcing, such as El Nino-Southern Oscillation (ENSO), the uncertainty in the prediction of IAV could be reduced, leading to improvement of seasonal prediction. Such efforts, so far, have been inconclusive. In this study, the modulation of MISOs by ENSO is assessed by using a nonlinear pattern recognition technique known as the Self-Organizing Map (SOM). The SOM technique is efficient in handling the nonlinearity/event-to-event variability of the MISOs and capable of identifying various shades of MISO from large-scale dynamical/thermodynamical indices, without providing information on rainfall. It is shown that particular MISO phases are preferred during ENSO years, that is, the canonical break phase is preferred more in the El Nino years and the typical active phase is preferred during La Nina years. Interestingly, if the SOM clustering is done by removing the ENSO effect on seasonal mean, the preference for the break node remains relatively unchanged; whereas, the preference reduces/vanishes for the active node. The results indicate that the El Nino-break relationship is almost independent of the ENSO-monsoon relationship on seasonal scale whereas the La Nina-active association seems to be interwoven with the seasonal relationship

Spectral signatures of moisture-stressed wheat

One of the important parameters affecting crop yield is the availability of soil moisture to the crop. Lackof it may bring about moistur~ stress in plants which manifests itself in terms of changes in the spectral reflectance and emittence properties of plants. An experiment involving radiometric measurements over six wheat plots subjected to different irrigation schedules was conducted to test this hypothesis, Vegetation index defined in terms of cropreflectances in 0.6 to 0.7 and 0.8 to 1,1 micrometer bands was found to ben sensitive parameter to distinguish normal plants from moisture-stressed plants. The optimum period for the discrimination of such plants through remote sensing techniques has been indicated to be 45-80 days after sowing. The experiment also demonstrates that yield per unit area is linearly related to the maximum leaf-area index of the crop thus providing a possible method of crop yield prediction