Use of 1-menthyl ester as chiral auxiliary in the synthesis of useful chiral synthons

A simple method has been developed for the access to useful chiral synthons involving alkylation and Michael addition to 1-menthyl esters of cycloalkanone carboxylic acids

Building sustainable digital communities: A five-pronged social-informatics research approach in Bangladesh

In a developing society, critical issues highlighted are not just about the technology, but with social factors such as culture, institutions, organizational issues, and individual identities. Understanding such factors is significant to illustrate how best to create sustainable communities using technology. Researchers at Monash University have collaborated with Oxfam International and developed a 5-year international development project known as PROTIC. This paper aims to give readers an overview of the PROTIC project and describe how the five doctoral research students are designing their research to achieve a common goal of developing sustainable digital communities in Bangladesh. The students follow different research methods in their respective projects, targeting overall long-term sustainability for the vulnerable communities identified in each of their studies. Although using five distinct research project approaches, the PROTIC project aims to use the exploratory study to make information and communication technologies (ICT) more sustainable for underserved communities. The findings from these researchers will impact on design and implementation of ICT-based socio-economic development projects undertaken by international development organizations

Loneliness and its correlates among Bangladeshi older adults during the COVID-19 pandemic

The present study aims to investigate the prevalence of loneliness and its associated factors among older adults during the COVID-19 pandemic in Bangladesh. This cross-sectional study was conducted in October 2020 among 1032 older Bangladeshi adults aged 60 years and above through telephone interviews. A semi-structured questionnaire was used to collect information on participants’ characteristics and COVID-19-related information. Meanwhile, the level of loneliness was measured using a 3-item UCLA Loneliness scale. More than half (51.5%) of the older adults experienced loneliness. We found that participants formally schooled [adjusted odds ratio (aOR = 0.62, 95% CI 0.43–0.88)] and received COVID-19-related information from health workers (aOR = 0.33, 95% CI 0.22–0.49) had lower odds of being lonely during the pandemic. However, older adults living alone (aOR: 2.57, 95% CI 1.34–4.94), residing distant from a health facility (aOR = 1.46, 95% CI 1.02–2.08) and in rural areas (aOR = 1.53, 95% CI 1.02–2.23) had higher odds of loneliness than their counterparts. Likewise, odds of loneliness were higher among those overwhelmed by COVID-19 (aOR = 1.93, 95% CI 1.29–2.86), who faced difficulty in earning (aOR = 1.77, 95% CI 1.18–2.67) and receiving routine medical care during pandemic (aOR = 2.94, 95% CI 1.78–4.87), and those perceiving requiring additional care during the pandemic (aOR = 6.01, 95% CI 3.80–9.49). The findings suggest that policies and plans should be directed to reduce loneliness among older adults who require additional care

Community Voice as Data: Affordances of Participatory Videos for International Program Development

International program development is a complex process involving many stakeholders. Current international practice affords limited, if any, opportunities for direct community-led input into the program commissioning process, resulting in programs that may not meet the specific needs of communities on the ground. Community voice is one source of data that could help focus the design of effective development programs and interventions. However, development programs are primarily formulated based on representative and often quantitative data conducted by experts from outside the community. Through a participatory video production process with disadvantaged women farmers in rural Bangladesh, we explore the opportunities for including meaningful community voices in these institutionalized processes. We present practical design implications for how community-generated voices can act as rich data, establishing confidence, community bonds and senses of accountability to inform early stages of project development, and to specifically augment and contextualize other data sources

Stigma toward people with COVID-19 among Bangladeshi older adults

The onset of the coronavirus disease (COVID-19) pandemic and its overwhelming physical and mental health burden can result in stigmatization toward the disease and those affected. This study aimed to measure the prevalence of COVID-19-related stigma and its associated factors among older people in Bangladesh. This cross-sectional study was conducted among 1,045 Bangladeshi older adults aged 60 years and above through telephone interviews in September 2021. The outcome was measured using an eight-point Stigma Scale, adapted to the Bengali language. Level of stigma was indicated by the cumulative score of the eight-items, ranging from 0 to 8, with a higher score indicating a higher level of stigma. On average, participants had stigmas on three of the eight items, and 62.6% had a high stigma score. The most prevalent stigmas were as follows: COVID-19 is a punishment from God (79.3%), patients with previous COVID-19 must be isolated (67.3%), and people infected with COVID-19 did not meet hygiene standards (63.9%). Participants who lived in rural areas (β: 0.67, 95% CI: 0.39 to 0.95) and who perceived needing additional care during the pandemic (β: 0.35, 95% CI: 0.09 to 0.60) had a higher average stigma score, whereas stigma scores were lower among unemployed/retired participants (β: −0.22, 95% CI: −0.45 to 0.00). The study findings suggest implementing interventions to raise awareness through appropriate health literacy interventions and mass media campaigns

Estimating mortality and disability in Peru before the COVID-19 pandemic: a systematic analysis from the Global Burden of the Disease Study 2019

"Background: Estimating and analyzing trends and patterns of health loss are essential to promote efficient resource allocation and improve Peru’s healthcare system performance. Methods: Using estimates from the Global Burden of Disease (GBD), Injuries, and Risk Factors Study (2019), we assessed mortality and disability in Peru from 1990 to 2019. We report demographic and epidemiologic trends in terms of population, life expectancy at birth (LE), mortality, incidence, prevalence, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) caused by the major diseases and risk factors in Peru. Finally, we compared Peru with 16 countries in the Latin American (LA) region. Results: The Peruvian population reached 33.9 million inhabitants (49.9% women) in 2019. From 1990 to 2019, LE at birth increased from 69.2 (95% uncertainty interval 67.8–70.3) to 80.3 (77.2–83.2) years. This increase was driven by the decline in under-5 mortality (−80.7%) and mortality from infectious diseases in older age groups (+60 years old). The number of DALYs in 1990 was 9.2 million (8.5–10.1) and reached 7.5 million (6.1–9.0) in 2019. The proportion of DALYs due to non-communicable diseases (NCDs) increased from 38.2% in 1990 to 67.9% in 2019. The all-ages and age-standardized DALYs rates and YLLs rates decreased, but YLDs rates remained constant. In 2019, the leading causes of DALYs were neonatal disorders, lower respiratory infections (LRIs), ischemic heart disease, road injuries, and low back pain. The leading risk factors associated with DALYs in 2019 were undernutrition, high body mass index, high fasting plasma glucose, and air pollution. Before the COVID-19 pandemic, Peru experienced one of the highest LRIs-DALYs rates in the LA region. Conclusion: In the last three decades, Peru experienced significant improvements in LE and child survival and an increase in the burden of NCDs and associated disability. The Peruvian healthcare system must be redesigned to respond to this epidemiological transition. The new design should aim to reduce premature deaths and maintain healthy longevity, focusing on effective coverage and treatment of NCDs and reducing and managing the related disability.

Manika Saha's Quick Files

The Quick Files feature was discontinued and it’s files were migrated into this Project on March 11, 2022. The file URL’s will still resolve properly, and the Quick Files logs are available in the Project’s Recent Activity

A simple, efficient, and selective method for tetrahydropyranylation of alcohols on a solid phase of alumina impregnated with zinc chloride

This article does not have an abstract

Surface-mediated solid phase reaction. Mukaiyama-Michael addition of silyl enol ethers to methyl vinyl ketone on the surface of alumina

Clean and efficient Michael addition of silyl enol ethers to methyl vinyl ketone has been achieved through a simple solvent-free reaction on the surfac