Understanding potential conflicts between human and non-human-primates: A large-scale survey in Malaysia

With increasing anthropogenic pressure, interactions between humans and wildlife may become more frequent, including conflictual ones. To reduce conflicts, it is important to understand how different factors (e.g. education, previous experience, demographic vari-ables) interplay with each other and contribute to the emergence of negative attitudes and behaviours toward wildlife in humans. To address this issue, we conducted a large-scale questionnaire in Malaysia, focusing on potential conflicts between human and other pri-mates. We used generalized linear mixed models to assess how formal education, knowl-edge about primates, negative experience and potential competition affected participants’ negative attitudes to primates (i.e. how humans perceive primates), their behavioural inten-tions (i.e. opinion on how to reduce conflicts) and behaviour (i.e. measures taken to reduce negative interactions). We found that negative experience and potential competition had a negative impact on participants’ attitude and behavior (i.e. primates were more likely perceived as filthy, as negatively affecting residents’ health and safety, and as an increas-ing problem, with participants more likely to use invasive methods, including captures). Both higher education and better knowledge of primates predicted more positive behav-ioural intentions (i.e. primates should be protected, non-invasive interventions should be used). Higher education, however, was also linked to more negative attitudes (i.e. primates negatively affect residents’ health and safety), and partly to negative behavior (e.g. use of invasive methods). In contrast, better knowledge about primates predicted positive behav-iour (i.e. exclusive use of non-invasive methods). Therefore, although better knowledge of primates had no clear effect on human attitudes, it may impact on their decisions to reduce potential conflicts with wildlife, and might be the most powerful tool to mitigate conflicts between humans and other specie

Shopping malls as catalyst for sub-urban development in Ghana

The concentration of population in major cities is usually the consequence of the concentration of employment opportunities, goods and services in such cities. These goods and services act as pull factors to the regional population, especially from the suburban or rural areas, to densely populated cities. The resulting migration creates congestion of all kinds in the cities. Suburban communities are, thus, rendered unattractive for living. This situation is prevalent in Ghana where 75% of migrants into major cities are from suburban areas and the rate of urbanization is 4.1%. Decentralizing amenities to suburban areas would initiate re-distribution of population and thus development. This study investigated the possibility of using the Shopping Mall concept as catalyst to both help develop the suburbia and decongest cities in Ghana. The West Hills Mall at Dunkonah, a suburb near Accra was selected for the study. A mixed research method including  questionnaires, interviews, and observations was used for data collection. Out of a total of 1,642 house owners 328 were sampled and interviewed with questionnaire that delved into their origins, whether they are migrants, and the reasons behind their movement. The study concluded that shopping malls could act as catalysts for development.Keywords: Shopping Malls, Catalyst, Decongestion, Suburbanization, Amenitie

Fluctuation induces evolutionary branching in a modeled microbial ecosystem

The impact of environmental fluctuation on species diversity is studied with a model of the evolutionary ecology of microorganisms. We show that environmental fluctuation induces evolutionary branching and assures the consequential coexistence of multiple species. Pairwise invasibility analysis is applied to illustrate the speciation process. We also discuss how fluctuation affects species diversity.Comment: 4 pages, 4 figures. Submitted to Physical Review Letter

Seasonal and Altitudinal Prevalence of Fascioliasis in Buffalo in Eastern Nepal

Buffalo is the most important livestock commodities for milk, meat production and several other multipurpose uses distributed densely from southern tarai to northern mid-hills in Nepal. Among several internal parasitic diseases fascioliasis is highly economic one caused by Fasciola in buffaloes. However, there are only few studies carried on prevalence of fascioliasis emphasizing buffaloes in relation to seasonal (summer and rainy, and winter) and altitudinal variations. Therefore, we examined prevalence of fascioliasis seasonally and vertically. For the purpose, we selected two districts of eastern Nepal and sampled from low altitude area known as Madhesha ranging from 175-200, Dhankuta from 800-1200 m, and Murtidhunga from 1800-2200 m elevation from the sea level, representing tarai, mid hills and high hills, respectively. Altogether from February 2013 to January 2014 at every two months interval we collected 798 fecal samples from buffaloes; 282 from Murtidhunga, 239 from Dhankuta and 277 from Madhesha. The samples were examined microscopically for the presence of Fasciola eggs using sedimentation technique. Results showed that overall prevalence of fascioliasis in buffaloes was 39.9% (319/798), ranging highest 42.6%in Madhesha followed by 39.7% in Murtidhunga and 37.2% in Dhankuta, respectively. The prevalence of fascioliasis was found to be significantly (p <0.05) high in winter (44.9%) comparing to rainy season (34.4%). The prevalence of fascioliasis in buffaloes was relatively higher in low altitude than high altitude, although it was not statistically significant (p <0.05). In our findings the female buffaloes showed higher prevalence for fascioliasis than in male. Since the fascioliasis in buffaloes is highly endemic, thus strategic deworming in high risk period is recommended along with measure to prevent pasture contamination with buffalo feces

On subgroups generated by small classes in finite groups

Let $G$ be a finite group and $M(G)$ be the subgroup of $G$ generated by all non-central elements of $G$ that lie in the conjugacy classes of the smallest size. Recently several results have been proved regarding the nilpotency class of $M(G)$ and $F(M(G))$, where $F(M(G))$ denotes the Fitting subgroup of $M(G)$. We prove some conditional results regarding the nilpotency class of $M(G)$.Comment: 5 pages, re-written in a new forma

Regulation of the volume-regulated anion channel pore-forming subunit LRRC8A in the intrahippocampal kainic acid model of mesial temporal lobe epilepsy

Volume-regulated anion channels (VRACs) are a group of ubiquitously expressed outwardly-rectifying anion channels that sense increases in cell volume and act to return cells to baseline volume through an efflux of anions and organic osmolytes, including glutamate. Because cell swelling, increased extracellular glutamate levels, and reduction of the brain extracellular space (ECS) all occur during seizure generation, we set out to determine whether VRACs are dysregulated throughout mesial temporal lobe epilepsy (MTLE), the most common form of adult epilepsy. To accomplish this, we employed the IHKA experimental model of MTLE, and probed for the expression of LRRC8A, the essential pore-forming VRAC subunit, at acute, early-, mid-, and late-epileptogenic time points (1-, 7-, 14-, and 30-days post-IHKA, respectively). Western blot analysis revealed the upregulation of total dorsal hippocampal LRRC8A 14-days post-IHKA in both the ipsilateral and contralateral hippocampus. Immunohistochemical analyses showed an increased LRRC8A signal 7-days post-IHKA in both the ipsilateral and contralateral hippocampus, along with layer-specific changes 1-, 7-, and 30-days post-IHKA bilaterally. LRRC8A upregulation 1 day post-IHKA was observed primarily in astrocytes; however, some upregulation was also observed in neurons. Glutamate-GABA/glutamine cycle enzymes glutamic acid decarboxylase, glutaminase, and glutamine synthetase were also dysregulated at the 7-day timepoint post status epilepticus. The timepoint-dependent upregulation of total hippocampal LRRC8A and the possible subsequent increased efflux of glutamate in the epileptic hippocampus suggest that the dysregulation of astrocytic VRAC may play an important role in the development of epilepsy

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood. Here, we show that this cell death is initiated by activation of G-protein-coupled inwardly rectifying potassium (GIRK/Kir3) channels and a consequent potassium efflux. Death signals stimulated by neurotrophin-mediated cleavage of p75(NTR) activate GIRK channels through the generation and binding of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2/PIP2] to GIRK channels. Both GIRK channel activity and p75(NTR)-mediated neuronal death are inhibited by sequestration of PtdIns(4,5)P2 and application of GIRK channel inhibitors, whereas pertussis toxin treatment has no effect. Thus, p75(NTR) activates GIRK channels without the need for G(i/o)-proteins. Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development