Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study

Background: The beneficial cardiovascular effects of vegetables may be underpinned by their high inorganic nitrate content. Objective: We sought to examine the effects of a 6-wk once-daily intake of dietary nitrate (nitrate-rich beetroot juice) compared with placebo intake (nitrate-depleted beetroot juice) on vascular and platelet function in untreated hypercholesterolemics. Design: A total of 69 subjects were recruited in this randomized, double-blind, placebo-controlled parallel study. The primary endpoint was the change in vascular function determined with the use of ultrasound flow-mediated dilatation (FMD). Results: Baseline characteristics were similar between the groups, with primary outcome data available for 67 patients. Dietary nitrate resulted in an absolute increase in the FMD response of 1.1% (an ∼24% improvement from baseline) with a worsening of 0.3% in the placebo group (P 1% of this change, with the proportions of Rothia mucilaginosa trending to increase and Neisseria flavescens (P < 0.01) increased after nitrate treatment relative to after placebo treatment. Conclusions: Sustained dietary nitrate ingestion improves vascular function in hypercholesterolemic patients. These changes are associated with alterations in the oral microbiome and, in particular, nitrate-reducing genera. Our findings provide additional support for the assessment of the potential of dietary nitrate as a preventative strategy against atherogenesis in larger cohorts. This trial was registered at clinicaltrials.gov as NCT01493752

Reducing attention bias in spider fear by manipulating expectancies

The present series of studies examines the causal interaction between expectancy and attention biases in spider fear. Previous studies found that a-priori expectancy does not affect attention bias toward spiders, as measured by detection of spider targets in a subsequent visual search array compared to detection of bird targets (i.e. neutral targets) that appeared equally often. In the present series of studies, target frequency was manipulated. Targets were preceded by a verbal cue stating the likelihood that a certain target would appear. The aim was to examine whether manipulation of expectancies toward either target affects attention bias. In Experiment 1, birds appeared more frequently than spiders. Among a representative sample of the student population, attention bias toward spiders was significantly reduced. Experiment 2 replicated these results with both low- and high-fearful participants. In Experiment 3, spiders appeared more frequently than birds. Attention bias was reduced among low- and high-fearful groups, but not as strongly as the reduction in Experiments 1 and 2. These results suggest that target salience plays a role in attention bias, in competition with expectancy. To our knowledge, this is the first study to show that varying expectancy can reduce attention bias, most importantly in high fear

Reappraising Negative Emotions Reduces Distress During the COVID-19 Outbreak

In two studies we examined the utility of intrinsic (i.e., self) vs extrinsic (i.e., other) reappraisal training for distress reduction during two consecutive COVID-19 lockdowns. In both Study 1 (n = 104) and Study 2 (n = 192), participants practiced the use of reappraisal for eight sessions across three weeks. Participants were trained to either reappraise a personal event (Self-reappraisal group) or an incident presumably written by another participant (Other-reappraisal group). Study 2 also included a no-training group. Outcome measures were daily negative mood and psychological distress immediately post-training and at a two-month follow-up. The results demonstrate a benefit for training compared to no-training in lowering immediate post-training distress and daily negative emotions. However, this advantage disappeared at two-month follow-up. In both studies, intrinsic reappraisal was associated with a lower post-training distress than extrinsic reappraisal. Findings suggest reappraising one’s own negative experience may lower distress at times of major contextual stress