Evaluation of a new trauma-related drinking to cope measure: Latent structure and heritability

Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur, share latent genetic risk, and are associated with many negative public health outcomes. Via a self-medication framework, trauma-related drinking to cope (TRD), an unexplored phenotype to date, may help explain why these two disorders co-occur, thus serving as an essential target for treatment and prevention efforts. This study sought to create a novel measure of TRD and to investigate its indirect influences on the association between PTSD and AUD, as well as its potential shared molecular genetic risk with PTSD in a genetically-informative study of college students. A sample of 1,896 undergraduate students with a history of trauma and alcohol use provided genotypic data and completed an online assessment battery. The psychometric properties of TRD and how it relates to relevant constructs were examined using descriptive statistics and structural equation modeling. Results of a correlated multiple mediator model indicated that, while accounting for the effects of generalized drinking motives, TRD partially mediated the relation between PTSD and alcohol use problems (β = 0.213, p \u3c .001), consistent with the self-medication hypothesis, and that this relationship was stronger for males (β = 0.804, p \u3c .001) than for females (β = 0.463, p \u3c .001). Results were substantiated using longitudinal data. Genotypic analyses to be presented will include univariate genome wide complex trait analyses (GCTA) to establish SNP-based heritability associated with TRD and PTSD, separately, as well as bivariate GCTA to examine potential overlap in heritability between TRD and PTSD.https://scholarscompass.vcu.edu/gradposters/1047/thumbnail.jp

Triviality and the (Supersymmetric) See-Saw

For the D=5 Majorana neutrino mass operator to have a see-saw ultraviolet completion that is viable up to the Planck scale, the see-saw scale is bounded above due to triviality limits on the see-saw couplings. For supersymmetric see-saw models, with realistic neutrino mass textures, we compare constraints on the see-saw scale from triviality bounds, with those arising from experimental limits on induced charged-lepton flavour violation, for both the CMSSM and for models with split supersymmetry.Comment: 27 pages, 7 figures, references adde

Phenology differences between native and novel exotic‐dominated grasslands rival the effects of climate change

1. Novel ecosystems can differ from the native systems they replaced. We used phenology measures to compare ecosystem functioning between novel exotic-dominated and native-dominated grasslands in the central U.S. 2. Phenology, or timing of biological events, is affected by climate and land use changes. We assessed how phenology shifts are being altered by exotic species dominance by comparing remotely sensed Normalized Difference Vegetation Index within growing seasons at exotic- and native-dominated sites along a latitudinal gradient. Exotic species were dominated by the C3 species functional group in the north and the C4 species functional group in the south. 3. Date of senescence was an average of 36 days later in exotic than native-dominated grasslands, and this effect was consistent across latitudes. 4. Exotic-dominated grasslands greened-up an average of 10.7 days earlier than native- dominated grasslands, but this effect was highly dependent on latitude and the plant functional group that dominated at that latitude. Green-up differed between native and exotic sites the most in central and northern regions that had dominant C3 grasses. 5. We estimated the effects of an increase in global temperatures on green-up and senescence with a space-for-time substitution, and by comparing growing degree day differences between historical average temperatures and +2.5°C. Green-up was significantly earlier and senescence was significantly later with a 2.5°C increase in temperature. The native–exotic difference was significantly greater than the difference due to increased temperature for senescence, but not for green-up. 6. Synthesis and applications. Native to exotic plant conversions in central U.S. grasslands have led to highly altered phenology, especially in terms of senescence, and this effect should be considered along with global warming in models moving forward. This conversion will have to be considered in developing estimates of how global change will affect phenology in locations where exotics are present, especially in cases where their abundance is increasing concurrent with climate change. Global change models and policy should consider exotic species invasion as an additional widespread factor behind changes in phenology

Note and Comment

A Spurious Law Course; Railroad Taxation in Michigan and Wisconsin; Surgical Operation on Minor Without Consent of Parent; The Power of Municipal Corporations to Grant Exclusive Privileges; Inheritance Taxes and the Right to Transfer and Inherit Property; The Sovereign Power of a State to Prevent Election Frauds; Original Jurisdiction of Supreme Court in Election Cases

The Cool ISM in S0 Galaxies. I. A Survey of Molecular Gas

Lenticular galaxies remain remarkably mysterious as a class. Observations to date have not led to any broad consensus about their origins, properties and evolution, though they are often thought to have formed in one big burst of star formation early in the history of the Universe, and to have evolved relatively passively since then. In that picture, current theory predicts that stellar evolution returns substantial quantities of gas to the interstellar medium; most is ejected from the galaxy, but significant amounts of cool gas might be retained. Past searches for that material, though, have provided unclear results. We present results from a survey of molecular gas in a volume-limited sample of field S0 galaxies, selected from the Nearby Galaxies Catalog. CO emission is detected from 78 percent of the sample galaxies. We find that the molecular gas is almost always located inside the central few kiloparses of a lenticular galaxy, meaning that in general it is more centrally concentrated than in spirals. We combine our data with HI observations from the literature to determine the total masses of cool and cold gas. Curiously, we find that, across a wide range of luminosity, the most gas rich galaxies have about 10 percent of the total amount of gas ever returned by their stars. That result is difficult to understand within the context of either monolithic or hierarchical models of evolution of the interstellar medium.Comment: 26 pages of text, 15 pages of tables, 10 figures. Accepted for publication in the Astrophysical Journa

Deformation of a nearly hemispherical conducting drop due to an electric field: theory and experiment

We consider, both theoretically and experimentally, the deformation due to an electric field of a pinned nearly-hemispherical static sessile drop of an ionic fluid with a high conductivity resting on the lower substrate of a parallel plate capacitor. Using both numerical and asymptotic approaches we find solutions to the coupled electrostatic and augmented Young–Laplace equations which agree very well with the experimental results. Our asymptotic solution for the drop interface extends previous work in two ways, namely to drops that have zero-field contact angles that are not exactly π/2 and to higher order in the applied electric field, and provides useful predictive equations for the changes in the height, contact angle and pressure as functions of the zero-field contact angle, drop radius, surface tension and applied electric field. The asymptotic solution requires some numerical computations, and so a surprisingly accurate approximate analytical asymptotic solution is also obtained

Hydrodynamic Simulations for the Nuclear Morphology of NGC 4314

We performed SPH simulations to study the nuclear morphology of a barred galaxy NGC 4314. We have constructed the mass models based on the results of a profile decomposition into disk, bulge, and bar components. Our models have three different nuclear structures according to the assumption about the nuclear bar: no nuclear bar, a synchronous nuclear bar and a fast nuclear bar. Our SPH simulations show that the morphology of the nuclear region of NGC 4314 which is characterized by an elongated ring/spiral of newly formed stars and HII regions, aligned nearly parallel to the primary bar can be understood in terms of the secular evolution driven by the non-axisymmetric potential. The slightly elongated and aligned nuclear ring of NGC 4314 can be formed by the strong barred potential and the moderate central concentration of the bulge mass with and without a nuclear bar. However, the nuclear spiral pattern can not be developed without a nuclear bar. The nuclear bar of NGC 4314 seems to rotate faster than the primary bar since the nuclear morphology induced by the synchronous nuclear bar is much different from the observed one.Comment: 9 page

Methods to the prediction of phase behavior: Predicting phase behavior with digital computers

Commercially Available digital computing equipment of the punch-card type permits the expeditious direct application of relatively complex analytical expressions to the evaluation of the conventional thermodynamic properties of pure substances and mixtures. In the case of hydrocarbons, the Benedict equation is of particular utility in describing the effect of pressure, temperature, and composition upon the thermodynamic properties of a system. However, the complexity of such an expression makes this application time-consuming unless automatic computing equipment is employed. Beattie has outlined the general nature of the calculations associated with the evaluation of the thermodynamic properties of homogeneous and heterogeneous systems. These methods apply to pure substances and multicomponent systems alike