Religiosity and Depression: A Ten-Year Follow-up of Offspring at High and Low Risk for Depression

One of the most thoroughly researched areas of mental illness in the context of its association with religiosity is depression. The thrust of studies published over the last century found religious/spiritual factors to be generally associated with lower rates of depression. The majority of studies on religion and depression have been cross-sectional. The primary aims of this study are to investigate the relationship between religiosity and depression longitudinally, utilizing a 10-year follow-up, and to explore the potential differential impact of religiosity on the prevalence of depression in those at high versus low risk for depression. Results suggest that 1) prospectively, a personal importance of religion is protective against MDD over a 10-year period; 2) prospectively, there exists a differential effect of religious belief on MDD in individuals at high versus low risk for depression; 3) prospectively, the protective effect of religious/spiritual importance against MDD is exclusive to individuals at high risk for depression based on parental MDD status; 4) Time 10 Catholicism is protective against MDD cross-sectionally 5) The protective effect of Catholicism may be more prevalent in individuals at low risk for depression than in individuals at high risk for depression; 5) cross-sectionally, there exists a differential impact of religious attendance on the prevalence of MDD in those at high risk versus those at low risk for depression at Time 10: for those at high risk for depression, religious attendance is associated with increased rates of MDD; 6) cross-sectionally, after controlling for social support there exists a differential impact of religious attendance on MDD in those at high versus low risk for depression: in individuals at high risk for depression, after controlling for social functioning, religious importance becomes a risk factor for MDD

Summary review and synthesis: Effects on habitats and wildlife of the release and management of pheasants and red-legged partridges on UK lowland shoots

This is the final version. Available on open access from the Nordic Council for Wildlife Research via the DOI in this recordThis review examines 128 items of primary and other literature to provide an insight into current knowledge of the effects of pheasant and red-legged partridge releasing and associated management for shooting on habitats and wildlife in the UK. It summarizes key findings and uses them to define sub-topic sections for which the effects are classified as positive, neutral or negative. This forms the basis of a numerical synthesis of effects and some overall conclusions. Fifty-four directly related studies were identified, which defined 25 sub-topics or effects. A mix of positive, neutral and negative ecological consequences of releasing are described, for which the corresponding number of sub-topics approximately balance each other. Positive effects are usually a consequence of gamebird management activities, most negative effects are caused by the released birds themselves. The different spatial scales at which effects are likely to operate are identified, for example effects on generalist predators or of gamecrops occur at the landscape scale, while many habitat effects have a local impact. Some local negative effects have relatively straightforward management solutions for example, by identifying and avoiding especially sensitive sites when locating release pens. The synthesis identifies seven negative effects associated with the increasing scale of releasing. Several positive effects are linked to economic considerations and are more likely to have greater impact at larger shoots. Pheasants released into woodland have more direct local effects than partridge releases on farmland. The framework of sub-sections could be used as the basis for a more complex synthesis or weighted analysis for a particular set of ecological priorities. The review findings should be interpreted as representing a median type of shoot in terms of size and adherence to good practice over recent decades. They increase the awareness of potential conflicts, highlighting the need for best practice and what factors to consider for mitigation

Religiosity And Major Depression In Adults At High Risk: A Ten-year Prospective Study

Objective: Previously the authors found that personal importance of religion or spirituality was associated with a lower risk for major depression in a study of adults with and without a history of depression. Here the authors examine the association of personal importance of religion or spirituality with major depression in the adult offspring of the original sample using a 10-year prospective longitudinal design. Method: Participants were 114 adult offspring of depressed and nondepressed parents, followed longitudinally. The analysis covers the period from the 10-year to the 20-year follow-up assessments. Diagnosis was assessed with the Schedule for Affective Disorders and Schizophrenia–Lifetime Version. Religiosity measures included personal importance of religion or spirituality, frequency of attendance at religious services, and denomination (all participants were Catholic or Protestant). In a logistic regression analysis, major depression at 20 years was used as the outcome measure and the three religiosity variables at 10 years as predictors. Results: Offspring who reported at year 10 that religion or spirituality was highly important to them had about one-fourth the risk of experiencing major depression between years 10 and 20 compared with other participants. Religious attendance and denomination did not significantly predict this outcome. The effect was most pronounced among offspring at high risk for depression by virtue of having a depressed parent; in this group, those who reported a high importance of religion or spirituality had about one-tenth the risk of experiencing major depression between years 10 and 20 compared with those who did not. The protective effect was found primarily against recurrence rather than onset of depression. Conclusions: A high self-report rating of the importance of religion or spirituality may have a protective effect against recurrence of depression, particularly in adults with a history of parental depression

Bringing People Back into Public Health Data: Community Feedback on a Set of Visualization Tools - Summary Report

This course-based study is a product of the University of Denver’s Spring 2022 The Social Determination of Health (ANTH 2424) class. The study aimed to understand how well a set of public health visualization tools tells the data stories about people in Colorado, and about important public health problems. For this, a team of almost sixty undergraduate students taking the class, coordinated by three graduate teaching assistants, and directed by the course instructor interviewed a total of fifty-six people from Colorado, qualitatively analyzed those interviews, and wrote reports that draw conclusions and recommendations

Disordered T cell-B cell interactions in autoantibody-positive inflammatory arthritis

T peripheral helper (Tph) cells, identified in the synovium of adults with seropositive rheumatoid arthritis, drive B cell maturation and antibody production in non-lymphoid tissues. We sought to determine if similarly dysregulated T cell-B cell interactions underlie another form of inflammatory arthritis, juvenile oligoarthritis (oligo JIA). Clonally expanded Tph cells able to promote B cell antibody production preferentially accumulated in the synovial fluid (SF) of oligo JIA patients with antinuclear antibodies (ANA) compared to autoantibody-negative patients. Single-cell transcriptomics enabled further definition of the Tph gene signature in inflamed tissues and showed that Tph cells from ANA-positive patients upregulated genes associated with B cell help to a greater extent than patients without autoantibodies. T cells that co-expressed regulatory T and B cell-help factors were identified. The phenotype of these Tph-like Treg cells suggests an ability to restrain T cell-B cell interactions in tissues. Our findings support the central role of disordered T cell-help to B cells in autoantibody-positive arthritides

Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ):Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.</p