Reliability Based Priority Allocation of Contingencies in a Complex Power System Network

Power system network consists ofsynchronous generators, transmission lines, shunt capacitors, transformers and loads. The reliability of a complete system depends on individual components reliability performance. Reliability study of a network deals with the interruptions of network. The failure of components depends on whether conditions, ageing effects, other components failure and parameter limit violation. The effect of failure on reliability performance of a system is different for every contingency. The only probability of a failure of a component does not decide the severity of failure on the power system but also depends on the rating of component. In this paper, the state probability and severity index due to the failure of each component of a thirty bus interconnected power system network is calculated and then the reliability performance based priority of contingency is investigated

ENDO-PERIO LESION: A CASE REPORT

The pulp and periodontium have embryonic, anatomic and functional interrelationships. The simultaneous existence of pulpal problems and inflammatory periodontal disease can complicate diagnosis and treatment planning. This case report evaluates the efficacy of G-Bone graft in the management of vertical bone loss associated with an endo-perio lesion in a left mandibular first molar and second molar. A 40 year-old male patient with an endo-perio lesion in the left mandibular first and second molars was initially treated with endodontic therapy. Following the endodontic treatment, the defect was treated using G-Bone graft. At the end of 6 months, there was a gain in the clinical attachment level and reduction in probing depth. Radiographic evidence showed that there was a significant bony fill. Keywords: Endo - perio lesion; Vertical bone loss; G - Bone graft

VERBAL-ARCHITECTURE TO REDUCE POWER INDULGENCE IN EQUAL RANKS

Within this paper, we advise a brand new CAM word architecture, known as master-slave match line (MSML) design, which aims to mix the actual-slave architecture and charge refill minimization method to lessen the CAM power dissipated within the match lines (MLs). Content-addressable memory (CAM) is really a hardware storage generally utilized in the short lookup applications. However, the parallel comparison feature costs the CAM memory large power consumption. Additionally, we further propose an altered CAM cell to facilitate the MSML match performance, i.e., MSMLhp design, which could even result energy-delay product improvement in contrast to the initial MSML and traditional CAM designs within the 128-bit word size situation. Unlike the traditional design, where just one single ML can be used, our design uses one master-ML (MML) and many slave-MLs (SMLs) to do looking operation. By discussing the MML charge with simply the mismatched SML, our design can minimize the MML charge refill swing, so that the ML power consumption could be reduced effectively. Theoretically, the ML power saving, that is in addition to the search pattern and match situation. In contrast to the traditional NOR-type CAM design, the simulation results reveal that the MSML design using the best configuration can help to eliminate the ML energy consumption with a range, which increases using the word size

Formulation and evaluation of atenolol oro dispersable tablets by co-processed super-disintegration process

Oral disintegrating tablet (ODT) is defined as A solid dosage form containing medical substances or active ingredient which disintegrates rapidly usually within a matter of seconds when placed upon the tongue. The aim of the present research is to formulate Atenolol oral disintegrating tablets.Atenolol is ?1- cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension, angina pectoris, arrhythmias and myocardial infarction. It works by slowing down the heart and reducing the work load of the heart.Atenolol was specifically developed so as to pass the blood brain barrier and overcome theside effects such as depression and nightmares.It has been reported that atenolol undergo extensive hepatic first pass metabolism following oral administration and has shorter biological half-life of 6 7 hours with oral bioavailability of 50%. The conventional tablets of atenolol are reported to exhibit fluctuations in the plasma drug levels after administration. Atenolol ODTs are prepared by novel co-processed super-disintegration process using Cross Povidone and Cross carmellose sodium, as the super disintegrants. The prepared tablets were characterized for their hardness, weight variation, disintegration time, wetting time, water absorption ratio friability, and in vitro dissolution studies.he ability of the tablet to release the drug faster depends on the concentration and type of super disintegrant. In this study the oral disintegrating tablets containing Cross carmellose sodium and Cross Povidone as the super disintegrant in the ratio of 1:1 shows better release of drug. About 99.5% of the drug was released from the tablets in 6 mins. Therefore, based on the physico chemical properties, in vitro drug release profile and mouth feel formulation F 1 containing 1:1 of Cross carmellose sodium and crospovidone is optimised as the best formulation

Design of PV fed single-switch transformer less topology powered electric vehicle

As a result of an increase in the availability of resources that were not harmful to the environment, solar energy applications shot to popularity. Photovoltaic cells power systems that necessitate DC-DC converters because of their low voltage output. This investigation uses photovoltaic cells (PV) to power a high-voltage gain design with just one switch and no transformer. The proposed circuit utilizes a single regulated switch, which contributes to a reduction in switching losses. It requires fundamental pulse regulation. The network used a switched capacitor cell and an LC passive filter to provide an accurate step-up voltage. We can obtain the equation for the step-up voltage gain from the steady-state continuous conduction mode. The equations used for the theoretical design of converters include energy. To show that the topology is comparable with other modern converters that have been published, a comparison was made between it and other converters. In order to validate the converter's effectiveness, simulations built in MATLAB and Simulink are used

Evaluation of potential role of R-loop and G-quadruplex DNA in the fragility of c-MYC during chromosomal translocation associated with Burkitt\u27s lymphoma

t(8;14) translocation is the hallmark of Burkitt\u27s lymphoma and results in c-MYC deregulation. During the translocation, c-MYC gene on chromosome 8 gets juxtaposed to the Ig switch regions on chromosome 14. Although the promoter of c-MYC has been investigated for its mechanism of fragility, little is known about other c-MYC breakpoint regions. We have analyzed the translocation break points at the exon 1/intron 1 of c-MYC locus from patients with Burkitt\u27s lymphoma. Results showed that the breakpoint region, when present on a plasmid, could fold into an R-loop confirmation in a transcription-dependent manner. Sodium bisulfite modification assay revealed significant single-strandedness on chromosomal DNA of Burkitt\u27s lymphoma cell line, Raji, and normal lymphocytes, revealing distinct R-loops covering up to 100 bp region. Besides, ChIP-DRIP analysis reveals that the R-loop antibody can bind to the breakpoint region. Further, we show the formation of stable parallel intramolecular G-quadruplex on non-template strand of the genome. Finally, incubation of purified AID in vitro or overexpression of AID within the cells led to enhanced mutation frequency at the c-MYC breakpoint region. Interestingly, anti-γH2AX can bind to DSBs generated at the c-MYC breakpoint region within the cells. The formation of R-loop and G-quadruplex was found to be mutually exclusive. Therefore, our results suggest that AID can bind to the single-stranded region of the R-loop and G4 DNA, leading to the deamination of cytosines to uracil and induction of DNA breaks in one of the DNA strands, leading to double-strand break, which could culminate in t(8;14) chromosomal translocation

Drought and salinity stresses induced physio-biochemical changes in sugarcane: an overview of tolerance mechanism and mitigating approaches

Sugarcane productivity is being hampered globally under changing environmental scenarios like drought and salinity. The highly complex nature of the plant responses against these stresses is determined by a variety of factors such as genotype, developmental phase of the plant, progression rate and stress, intensity, and duration. These factors influence plant responses and can determine whether mitigation approaches associated with acclimation are implemented. In this review, we attempt to summarize the effects of drought and salinity on sugarcane growth, specifically on the plant’s responses at various levels, viz., physiological, biochemical, and metabolic responses, to these stresses. Furthermore, mitigation strategies for dealing with these stresses have been discussed. Despite sugarcane’s complex genomes, conventional breeding approaches can be utilized in conjunction with molecular breeding and omics technologies to develop drought- and salinity-tolerant cultivars. The significant role of plant growth-promoting bacteria in sustaining sugarcane productivity under drought and salinity cannot be overlooked

HIV infection and drugs of abuse: role of acute phase proteins

Background HIV infection and drugs of abuse such as methamphetamine (METH), cocaine, and alcohol use have been identified as risk factors for triggering inflammation. Acute phase proteins such as C-reactive protein (CRP) and serum amyloid A (SAA) are the biomarkers of inflammation. Hence, the interactive effect of drugs of abuse with acute phase proteins in HIV-positive subjects was investigated. Methods Plasma samples were utilized from 75 subjects with METH use, cocaine use, alcohol use, and HIV-positive alone and HIV-positive METH, cocaine, and alcohol users, and age-matched control subjects. The plasma CRP and SAA levels were measured by ELISA and western blot respectively and the CD4 counts were also measured. Results Observed results indicated that the CRP and SAA levels in HIV-positive subjects who are METH, cocaine and alcohol users were significantly higher when compared with either drugs of abuse or HIV-positive alone. The CD4 counts were also dramatically reduced in HIV-positive with drugs of abuse subjects compared with only HIV-positive subjects. Conclusions These results suggest that, in HIV-positive subjects, drugs of abuse increase the levels of CRP and SAA, which may impact on the HIV infection and disease progression

Measurement of the production cross section of pairs of isolated photons in pp collisions at 13 TeV with the ATLAS detector

A measurement of prompt photon-pair production in proton-proton collisions at √s = 13 TeV is presented. The data were recorded by the ATLAS detector at the LHC with an integrated luminosity of 139 fb−1. Events with two photons in the well-instrumented region of the detector are selected. The photons are required to be isolated and have a transverse momentum of pT,γ1(2) > 40 (30) GeV for the leading (sub-leading) photon. The differential cross sections as functions of several observables for the diphoton system are measured and compared with theoretical predictions from state-of-the-art Monte Carlo and fixed-order calculations. The QCD predictions from next-to-next-to-leading-order calculations and multi-leg merged calculations are able to describe the measured integrated and differential cross sections within uncertainties, whereas lower-order calculations show significant deviations, demonstrating that higher-order perturbative QCD corrections are crucial for this process. The resummed predictions with parton showers additionally provide an excellent description of the low transverse-momentum regime of the diphoton system.publishedVersio